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生体・生理工学シンポジウム （大阪、2004年11月） ・ネコの腓腹筋を支配する運動神経プールのモデル：Renshaw細胞による反回抑制とmotoneuronのsynchronization ഀ内山孝憲（慶大），Uwe Windhorst（Universitat Gottingen） ഀ Abstract The purpose of this study is to investigate synchronization of motoneurons subjected to recurrent inhibitionഀ with an aid of computer simulation. The model of feline medial gastrocnemius muscle and its motoneuron pool, whichഀ provided good static and dynamic characteristics, consists three hundred α motoneurons (α-MN), Renshaw cells (RC)ഀ and muscle Þbres. Two types of descending command signal, synchronous DCS and asynchronous DCS, were appliedഀ to the model with and without recurrent inhibition. The inter-pulse intervals of the DCS distributed uniformly. Theഀ cross-correlogams between DCS and α-MN discharges, between discharges of adjacent α-MNs, and between α-MNഀ and RC discharges were calculated. When the asynchronous DCS was applied to the model, the cross-correlogramഀ between adjacent α-MNs did not show any synchronization. The cross-correlogram between α-MN and RC dischargesഀ show a strong peak at 1 ms after the RC receives impulse from the α-MN. When the synchronous DCS was applied toഀ the models, the cross-correlogram between adjacent α-MNs had strong peaks at 0 ms. For FF-type MNs, the peak withഀ recurrent inhibition was much higher than that without recurrent inhibition. However peak height of S-type MNs wereഀ not as different as those of FF-type MNs. This means that recurrent inhibition enhances synchronization of FF-typeഀ MN. This enhancement of synchronization of FF-type MNs might be one of the mechanism underlayig tremor.ഀ ഀ | ഀ
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