Glutamate is a major excitatory neurotransmitter and plays an important role in neuronal plasticity and neurotoxicity in the central nervous system. Glutamate transport proteins provide the mechanism by which synaptically released glutamate is inactivated and kept below toxic levels in the extracellular space. By now, five subtypes of high-affinity glutamate transporters have been identified in the mammalian central nervous system: GLT1, GLAST, EAAC1, EAAT4 and EAAT5. Our lab studies the physiological and pathological roles of glutamate transporter subtypes in the brain by combining molecular genetics, physiological and behavioral methods.

The discovery of neural stem cells raises the enticing possibility of brain repair in human disorders of the central nervous system. However, there are many obstacles for regeneration of damaged brain. One objective of this project is to understand molecular mechanisms underlying stem cell differentiation. The second objective of this project is to examine how the newly formed neurons are integrated into established brain circuitries. This project will provide a powerful tool for brain repair in neurological diseases.

The central nervous system (CNS) houses two main kinds of cells, neurons and glia. According to the classical view of the CNS, glial cells merely provide structural and trophic support for neurons. Recent studies suggest that the active brain should no longer be regarded as a circuity of neuronal contacts, but as an integrated network of interactive neurons and glia. Our lab studies the roles of glia-neuron interactions in brain development, higher brain function and mental diseases.