水島研究室　細胞生理学分野｜オートファジー （自食作用） と呼ばれる細胞内の大規模な分解系を中心に、タンパク質代謝、栄養シグナル、細胞内品質管理、ミトコンドリア膜動態などの研究をしています。

2011

Mizushima N, Komatsu M.

2010

Mizushima N

Noboru Mizushima: All about autophagy. Interview by Caitlin Sedwick.

J Cell Biol. 2010 Sep 20;190(6):946-7.

Mizushima N, Levine B.

Autophagy in mammalian development and differentiation.

Nat Cell Biol. 2010 Sep;12(9):823-30.

Itakura E, Mizushima N.

Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins.

Autophagy. 2010 Aug 16;6(6):764-76.

Kaizuka T, Hara T, Oshiro N, Kikkawa U, Yonezawa K, Takehana K, Iemura SI, Natsume T, Mizushima N.

Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.

J Biol Chem. 2010 Jun 25;285(26):20109-16. Epub 2010 Apr 28.

Kuma A, Mizushima N.

Physiological role of autophagy as an intracellular recycling system: with an emphasis on nutrient metabolism.

Semin Cell Dev Biol. 2010 Sep;21(7):683-90. Epub 2010 Mar 17.

Mizushima, N.

Autophagy.

FEBS Lett. 2010 Apr 2;584(7):1279.

Mizushima, N., Yoshimori, T. and Levine, B.

Methods in mammalian autophagy research.

Cell 2010 Feb 5;140(3):313-26.

Mizushima, N.

The role of the Atg1/ULK1 complex in autophagy regulation.

Curr Opin Cell Biol. 2010 Apr;22(2):132-9. Epub 2010 Jan 6.

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Riley BE, Kaiser SE, Shaler TA, Ng AC, Hara T, Hipp MS, Lage K, Xavier RJ, Ryu KY, Taguchi K, Yamamoto M, Tanaka K, Mizushima N, Komatsu M, Kopito RR.

Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection.

J Cell Biol. 2010 Nov 1;191(3):537-52.

Stappenbeck TS, Rioux JD, Mizoguchi A, Saitoh T, Huett A, Darfeuille-Michaud A, Wileman T, Mizushima N, Carding S, Akira S, Parkes M, Xavier RJ.

Crohn disease: A current perspective on genetics, autophagy and immunity.

Autophagy. 2010 Feb 17;7(2).

Klionsky DJ, Codogno P, Cuervo AM, Deretic V, Elazar Z, Fueyo-Margareto J, Gewirtz DA, Kroemer G, Levine B, Mizushima N, Rubinsztein DC, Thumm M, Tooze SA.

A comprehensive glossary of autophagy-related molecules and processes.

Autophagy. 2010 May 6;6(4).

Taneike M, Yamaguchi O, Nakai A, Hikoso S, Takeda T, Mizote I, Oka T, Tamai T, Oyabu J, Murakawa T, Nishida K, Shimizu T, Hori M, Komuro I, Shirasawa T, Mizushima N, Otsu K.

Inhibition of autophagy in the heart induces age-related cardiomyopathy..

Autophagy. 2010 Jul 1;6(5).

Hartleben B, Godel M, Meyer-Schwesinger C, Liu S, Ulrich T, Kobler S, Wiech T, Grahammer F, Arnold SJ, Lindenmeyer MT, Cohen CD, Pavenstadt H, Kerjaschki D, Mizushima N, Shaw AS, Walz G, Huber TB.

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice.

J Clin Invest. 2010 Apr 1;120(4):1084-96.

Lee HK, Mattei LM, Steinberg BE, Alberts P, Lee YH, Chervonsky A, Mizushima N, Grinstein S, Iwasaki A.

In Vivo Requirement for Atg5 in Antigen Presentation by Dendritic Cells.

Immunity. 2010 Feb 26;32(2):227-239.

Nishiyama J, Matsuda K, Kakegawa W, Yamada N, Motohashi J, Mizushima N, Yuzaki M.

Reevaluation of Neurodegeneration in lurcher Mice: Constitutive Ion Fluxes Cause Cell Death with, Not by, Autophagy.

J Neurosci. 2010 Feb 10;30(6):2177-87.

Katsumata K, Nishiyama J, Inoue T, Mizushima N, Takeda J, Yuzaki M.

Dynein- and activity-dependent retrograde transport of autophagosomes in neuronal axons.

Autophagy. 2010 Apr;6(3):378-85. Epub 2010 Apr 20.

[ ページ先頭へ戻る ]

2009

Hosokawa, N., Sasaki, T., Iemura, S., Natsume, T., Hara, T., Mizushima, N.

Atg101, a novel mammalian autophagy protein interacting with Atg13.

Autophagy 5:973-9 (2009)

Ishihara, N., Nomura, M., Jofuku, A., Kato, H., Suzuki, S.O., Masuda, K., Otera, H., Nakanishi, Y., Nonaka, I., Goto, Y.I., Taguchi, N., Morinaga, H., Maeda, M., Takayanagi, R., Yokota, S., Mihara, K.

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice.

Nat. Cell Biol. 11:958-966 (2009)

Hosokawa, N., Hara, T., Kaizuka, T., Kishi, C., Takamura, A., Miura, Y., Iemura, S., Natsume, T., Takehana, K., Yamada, N., Guan, J.L., Oshiro, N., Mizushima, N.

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.

Mol. Biol. Cell 20: 1981-1991 (2009)

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Inoue K, Kuwana H, Shimamura Y, Ogata K, Taniguchi Y, Kagawa T, Horino T, Takao T, Morita T, Sasaki S, Mizushima N, Terada Y.

Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo.

Clin Exp Nephrol. 2009 Dec 15.

Satoo, K., Noda, N.N., Kumeta, H., Fujioka, Y., Mizushima, N., Ohsumi, Y., Inagaki, F.

The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy.

EMBO J. 28: 1341-50 (2009)

Stephenson, L.M., Miller, B.C., Ng, A., Eisenberg, J., Zhao, Z., Cadwell, K., Graham, D.B., Mizushima, N., Xavier, R., Virgin, H.W., Swat, W.

Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes.

Autophagy 5: 625-35 (2009)

2008

Itakura, E., Kishi, C., Inoue, K., Mizushima, N.

Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14and UVRAG.

Mol. Biol. Cell 19: 5360-5372 (2008)

Tsukamoto, S., Kuma, A., Murakami, M., Kishi, C., Yamamoto, A., Mizushima, N.

Autophagy is essential for preimplantation development of mouse embryos.

Science 321: 117-120 (2008)

Hara, T., Takamura, A., Kishi, C., Iemura, S., Natsume, T., Guan, J.L., Mizushima, N.

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells.

J. Cell Biol. 181:497-510 (2008)

Kuma, A., Mizushima, N.

Chromosomal mapping of the GFP-LC3 transgene in GFP-LC3 mice

Autophagy 4:61-62 (2008)

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Zhao, Z., Fux, B., Goodwin, M., Dunay, I.R., Strong, D., Miller, B.C., Cadwell, K., Delgado, M.A., Ponpuak, M., Green, K.G., Schmidt, R.E., Mizushima, N., Deretic, V., Sibley, L.D., Virgin, IV H.W.

Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens.

Cell Host Microbe. 4: 458-469 (2008)

Cadwell, K., Liu, J.Y., Brown, S.L., Miyoshi, H., Loh, J., Lennerz, J.K., Kishi, C., Kc, W., Carrero, J.A., Hunt, S., Stone, C.D., Brunt, E.M., Xavier, R.J., Sleckman, B.P., Li, E., Mizushima, N., Stappenbeck, T.S., Virgin, IV H.W.

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.

Nature. 456: 259-263 (2008)

Ohne, Y., Takahara, T., Hatakeyama, R., Matsuzaki, T., Noda, M., Mizushima, N., Maeda, T.

Isolation of hyperactive mutants of mammalian target of rapamycin.

J. Biol. Chem. 283: 31861-31870 (2008)

Gozuacik, D., Bialik, S., Raveh, T., Mitou, G., Shohat, G., Sabanay, H., Mizushima, N., Yoshimori, T., Kimchi, A.

DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death.

Cell Death Differ. 15: 1875-1886 (2008)

Raben, N., Hill, V., Shea, L., Takikita, S., Baum, R., Mizushima, N., Ralston, E., Plotz, P.

Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease.

Hum Mol Genet. 17: 3897-3908 (2008)

Sou, Y.S., Waguri, S., Iwata, J.I., Ueno, T., Fujimura, T., Hara, T., Sawada, N., Yamada, A., Mizushima, N., Uchiyama, Y., Kominami, E., Tanaka, K., Komatsu, M.

The Atg8 Conjugation System Is Indispensable for Proper Development of Autophagic Isolation Membranes in Mice.

Mol Biol Cell. 19: 4762-4775 (2008)

Nedjic, J., Aichinger, M., Emmerich, J., Mizushima, N., Klein, L.

Macroautophagy in thymic epithelial cells shapes the T cell repertoire and is essential for self-tolerance.

Nature 455: 396-400 (2008)

Hashimoto, D., Ohmuraya, M., Hirota, M., Yamamoto, A., Suyama, K., Ida, S., Okumura, Y., Takahashi, E., Kido, H., Araki, K., Baba, H., Mizushima, N., Yamamura, K.,

Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells.

J. Cell Biol. 181: 1065-1072 (2008)

Kaushik, S., Massey, A. C., Mizushima, N., Cuervo, A. M.

Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy.

Mol. Biol. Cell 19:2179-2192 (2008)

Talloczy, Z., Martinez, J., Joset, D., Ray, Y., Gacser, A., Toussi, S., Mizushima, N., Nosanchuk, J., Goldstein, H., Loike, J., Sulzer, D., Santambrogio, L.

Methamphetamine Inhibits Antigen Processing, Presentation, and Phagocytosis.

PLoS Pathog. 4:e28 (2008)

Katayama, H., Yamamoto, A., Mizushima, N., Yoshimori, T., Miyawaki, A.

GFP-like Proteins Stably Accumulate in Lysosomes.

Cell Struct. Funct. 33:1-12 (2008)

King, M.A., Hands, S., Hafiz, F., Mizushima, N., Tolkovsky, A.M., Wyttenbach, A.

Rapamycin inhibits polyglutamine aggregation independently of autophagy by reducing protein synthesis.

Mol. Pharmacol. 73:1052-63 (2008)

Miller, B.C., Zhao, Z., Stephenson, L.M., Cadwell, K., Pua, H.H., Lee, H.K., Mizushima, N., Iwasaki, A., He, Y.W., Swat, W., Virgin, H.W.

The autophagy gene ATG5 plays an essential role in B lymphocyte development.

Autophagy 4:309-14 (2008)

2007

Kuma, A., Matsui, M. and Mizushima, N.

LC3, an autophagosome marker, can be incorporated into protein aggregates independent ofautophagy: Caution in the interpretation of LC3 localization.

Autophagy 3:323-328 (2007)

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Nishiyama J, Miura E, Mizushima N, Watanabe M, Yuzaki M.

Aberrant membranes and double-membrane structures accumulate in the axons of Atg5-null Purkinje cells before neuronal death.

Autophagy 3:591-596 (2007)

Komatsu, M., Waguri, S., Koike, M., Sou, Y.S., Ueno, T., Hara, T., Mizushima, N., Iwata, J.I., Ezaki, J., Murata, S., Hamazaki, J., Nishito, Y., Iemura, S.I., Natsume, T., Yanagawa, T., Uwayama, J., Warabi, E., Yoshida, H., Ishii, T., Kobayashi, A., Yamamoto, M., Yue, Z., Uchiyama, Y., Kominami, E., Tanaka, K.

Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice.

Cell 131:1149-1163 (2007)

Alexander, D.E., Ward, S.L., Mizushima, N., Levine, B., Leib, D.A.

An analysis of the role of autophagy in replication of herpes simplex virus in cell culture.

J. Virol. 81:12128-12134 (2007)

Zhao, Z., Thackray, L.B., Miller, B.C., Lynn, T.M., Becker, M.M., Ward, E., Mizushima, N., Denison, M.R., Virgin, H.W. 4th.

Coronavirus Replication Does Not Require the Autophagy Gene ATG5.

Autophagy 3:581-585 (2007)

Nakai, A., Yamaguchi, O., Takeda, T., Higuchi, Y., Hikoso, S., Taniike, M., Omiya, S., Mizote, I., Matsumura, Y., Asahi, M., Nishida, K., Hori, M., Mizushima, N., Otsu, K.

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress.

Nat. Med. 13:619-24 (2007)

Marino, G., Salvador-Montoliu, N., Fueyo, A., Knecht, E., Mizushima, N., Lopez-Otin, C.

Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in ATG4C/autophagin-3.

J. Biol. Chem. 282:18573-18583 (2007)

Lee, H.K., Lund, J.M., Ramanathan, B., Mizushima, N., Iwasaki, A.

Autophagy-dependent viral recognition by plasmacytoid dendritic cell.

Science 315:1398-1401 (2007)

Satoo, K., Suzuki, N.N., Fujioka, Y., Mizushima, N., Ohsumi, Y., Inagaki, F.

Crystallization and preliminary crystallographic analysis of human Atg4B?LC3 complex. Acta Crystallograph.

Sect. F Struct. Biol. Cryst. Commun. 63:99-102 (2007)

Pua, H.H., Dzhagalov, I., Chuck, M., Mizushima, N., He, Y-W.

A critical role for the autophagy gene Atg5 in T cell survival and proliferation.

J. Exp. Med. 204:25-31 (2007)

2006

Hosokawa, N., Hara, Y., Mizushima, N.

Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size.

FEBS Lett. 580, 2623-2629 (2006).

Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R. Yokoyama, M., Mishima, K., Saito, I., Okano, H., Mizushima, N.

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice.

Nature 441, 885-889 (2006).

Matsui, M., Yamamoto, A., Kuma, A., Ohsumi, Y., Mizushima, N.

Organelle degradation during the lens and erythroid differentiation is independent of autophagy.

Biochem. Biophys. Res. Commun. 339, 485-489 (2006).

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Adhami, F., Liao, G., Morozov, Y. M., Schloemer, A., Schmithorst, V. J., Lorenz, J. N., Dunn, R. S., Vorhees, C. V., Wills-Karp, M., Degen, J. L., Davis, R. J., Mizushima, N., Rakic, P., Dardzinski, B. J., Holland, S. K., Sharp, F. R., Kuan, C.-Y.

Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy.

Am. J. Pathol. 169, 566-583 (2006)

Wang, Q.J., Ding, Y., Zhong, Y., Kohtz, S., Mizushima, N., Cristea, I.M., Rout, M.P., Chait, B.T., Heintz, N. and Yue, Z.

Induction of autophagy in axonal dystrophy and degeneration.

J. Neurosci. 26, 8057-8068 (2006).

Szeto, J., Kaniuk, N.A., Canadien, V., Nisman, R., Mizushima, N., Yoshimori, T., Bazett-Jones, D.P., Brumell, J.H. ALIS are stress-induced protein storage compartments for substrates of the proteasome and autophagy.

Autophagy 2, 189-199 (2006).

Shibata. M., Lu, T., Furuya, T., Degterev, A., Mizushima, N., Yoshimori, T., Macdonald, M., Yankner, B., Yuan, J. Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1.

J. Biol. Chem.281, 14474-14485 (2006)

Zhang, H., Monken, C.E., Zhang, Y., Lenard, J., Mizushima, N., Lattime, E.C., Jin, S.

Cellular autophagy machinery is not required for vaccinia virus replication and maturation.

Autophagy 2, 91-95 (2006).

Kamimoto, T., Shoji, S., Hidvegi, T., Mizushima, N., Umebayashi, K., Perlmutter, D.H., Yoshimori, T.

Intracellular inclusions containing mutant alpha 1-antitrypsin Z are propagated in the absence of autophagic activity.

J. Biol. Chem.281, 4467-4476 (2006).

2005

Koike, M., Shibata, M., Waguri, S., Yoshimura, K., Tanida, I., Kominami, E., Gotow, T., Peters, C., von Figura, K., Mizushima, N., Saftig, P., Uchiyama, Y.

Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (batten disease).

Am. J. Pathol. 167, 1713-28 (2005).

Hara, T., Kamura, T., Kotoshiba, S., Takahashi, H., Fujiwara, K., Onoyama, I., Shirakawa, M., Mizushima, N., Nakayama, K.I.

Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle.

Mol. Cell. Biol.25, 9292-9303 (2005).

Sugawara, K., Suzuki, N.N., Fujioka, Y., Mizushima, N., Ohsumi, Y., Inagaki, F.

Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy.

J Biol Chem. 280, 40058-40065 (2005).

Pattingre, S., Tassa, A., Qu, X., Garuti, R., Huan Liang, X., Mizushima, N., Packer, M., Schneider, M.D., Levine, B.

Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy.

Cell 122, 927-939 (2005).

Ohmuraya, M., Hirota, M., Araki, M., Mizushima, N., Matsui, M., Mizumoto, T., Haruna, K., Kume, S., Takeya, M., Ogawa, M., Araki, K., Yamamura, K.

Autophagic cell death of pancreatic acinar cells in serine protease inhibitor kazal type 3-deficient mice.

Gastroenterology 129, 696-705 (2005).

Degterev, A., Huang, Z., Boyce, M., Li, Y., Jagtap, P., Mizushima, N., Cuny, G.D., Mitchison, T.J., Moskowitz, M.A., Yuan, J.

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury.

Nat. Chem. Biol. 1, 112-119 (2005)

Komatsu, M., Waguri, S., Ueno, T., Iwata, J., Murata, S., Tanida, I., Ezaki, J., Mizushima, N., Ohsumi, Y., Uchiyama, Y., Kominami, E., Tanaka, K., Chiba, T.

Impairment of starvation-induced and contitutive autophagy in Atg7-deficient mice.

J. Cell Biol. 169, 425-434 (2005)

Pyo, J.O., Jang, M.H., Kwon, Y.K., Lee, H.J., Jun, J.I., Woo, H.N., Cho, D.H., Choi, B., Lee, H., Kim, J.H., Mizushima, N., Oshumi, Y., Jung, Y.K.

Essential roles of Atg5 and FADD in autophagic cell death: Dissection of autophagic cell death into vacuole formation and cell death.

J Biol Chem. 280, 20722-20729 (2005)

Bampton, E.T.W., Goemans, C.G., Niranjan, D., Mizushima, N., Tolkovsky, A.M.

The dynamics of autophagy visualised in live cells: from autophagosome formation to fusion with endo/lysosomes.

Autophagy 1, 23-36 (2005)

Ogawa, M., Yoshimori, T., Suzuki, T., Sagara, H., Mizushima, N., Sasakawa, C.

Escape of Intracellular Shigella from Autophagy.

Science 307, 727-731 (2005)

2004

Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T., Mizushima, N.

The role of autophagy during the early neonatal starvation period.

Nature 432, 1032-1036 (2004).

Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T. and Ohsumi, Y.

In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker.

Mol. Biol. Cell 15, 1101-1111 (2004).

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Shimizu, S., Kanaseki, T., Mizushima, N., Mizuta, T., Arakawa-Kobayashi, S., Thompson, C.B., Korsmeyer, S.J. Tsujimoto, Y.

A role of Bcl-2 family of proteins in non-apoptotic programmed cell death dependent on autophagy genes.

Nat. Cell Biol. 12,1221-1228 (2004)

Nakagawa, I., Amano, A., Mizushima, N., Yamamoto, A., Yamaguchi, H., Kamimoto, T., Nara, A., Funao, J., Nakata, M., Tsuda, K., Hamada, S., Yoshimori, T.

Autophagy defends cells against invading group A Streptococcus.

Science 306, 1037-1040 (2004).

Prentice,E., Jerome, WG, Yoshimori, T., Mizushima, N., Denison, MR.

Coronavirus Replication Complex Formation Utilizes Components of Cellular Autophagy

J. Biol. Chem. 279, 10136-10141 (2004).

Kabeya, Y., Mizushima, N., Yamamoto, A., Oshitani-Okamoto, S., Ohsumi, Y. and Yoshimori, T.

LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation.

J. Cell Sci. 117, 2805-2812 (2004).

Birkeland, H., Simonsen, A., Gillooly, D.J., Mizushima, N., Kuma, A., Yoshimori, T., Slagsvold, T., Brech, A., Stenmark, H.

Alfy, a novel FYVE domain-containing protein associated with protein granules and autophagic membranes.

J. Cell Sci. 117, 4239-4251 (2004).

Shitara, H., Sato, A., Hayashi, J., Mizushima, N., Yonekawa, H., Taya, C.

Simple method of zygosity identification in transgenic mice by real-time quantitative PCR.

Transgenic Research 13, 191-194 (2004).

Sugawara K, Suzuki NN, Fujioka Y, Mizushima N, Ohsumi Y, Inagaki F.

The crystal structure of microtubule-associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8.

Genes Cells 9, 611-618 (2004).

-2003 (selected)

Mizushima, N., Kuma, A., Kobayashi, Y., Yamamoto, A., Matsubae, M., Takao, T., Natsume, T., Ohsumi, Y. and Yoshimori, T.

Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate

J. Cell Sci. 116, 1679-1688. (2003)

Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A, Rosen J, Eskelinen EL, Mizushima N, Ohsumi Y, Cattoretti G, Levine B.

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene.

J. Clin. Invest. 112, 1809-1820. (2003)

Ohashi, M., Mizushima, N., Kabeya, Y. and Yoshimori, T.

Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets

J. Biol. Chem. 278, 36819-36829.(2003)

Mizushima, N., Yoshimori, T. and Ohsumi, Y.

Mouse Apg10 as an Apg12 conjugating enzyme: Analysis by the conjugation-mediated yeast two-hybrid method

FEBS Lett. 532, 450-454. (2002)

Kuma, A., Mizushima, N., Ishihara, N. and Ohsumi, Y.

Formation of the ~350 kD Apg12-Apg5-Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast

J. Biol. Chem. 277, 18619-18625. (2002)

Suzuki, K., Kirisako, T., Kamada, Y., Mizushima, N., Noda, T. and Ohsumi, Y.

The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation

EMBO J. 20, 5971-5981. (2001)

Mizushima, N., Yamamoto, A., Hatano, M., Kobayashi, Y., Kabeya, Y., Suzuki, K., Tokuhisa, T., Ohsumi, Y. and Yoshimori, T.

Dissection of Autophagosome Formation using Apg5-Deficient Mouse Embryonic Stem Cells

J. Cell Biol. 152, 657-667. (2001)

Yoshimori, T., Yamagata, F., Yamamoto, A., Mizushima, N., Kabeya, Y., Nara, A., Miwako, I., Ohashi, M., Ohsumi, M. and Ohsumi, Y.

The mouse SKD1, a homologue of yeast Vps4p, is required for normal endosomal trafficking and morphology in mammalian cells

Mol. Biol. Cell 11, 747-63. (2000)

Kirisako, T., Ichimura, Y., Okada, H., Kabeya, Y., Mizushima, N., Yoshimori, T., Ohsumi, M., Takao, T., Noda, T. and Ohsumi, Y.

The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway

J. Cell Biol. 151, 263-275. (2000)

Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y. and Yoshimori, T.

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

EMBO J. 19, 5720-5728. (2000)

Ichimura, Y., Kirisako, T., Takao, T., Satomi, Y., Shimonishi, Y., Ishihara, N., Mizushima, N., Tanida, I., Kominami, E., Ohsumi, M., Noda, T. and Ohsumi, Y.

A ubiquitin-like system mediates protein lipidation

Nature 408, 488-492. (2000)

George, M. D., Baba, M., Scott, S. V., Mizushima, N., Garrison, B. S., Ohsumi, Y. and Klionsky, D. J.

Apg5p functions in the sequestration step in the cytoplasm-to-vacuole targeting and macroautophagy pathways

Mol. Biol. Cell 11, 969-82. (2000)

Furukawa, K., Mizushima, N., Noda, T. and Ohsumi, Y.

A Protein Conjugation System in Yeast with Homology to Biosynthetic Enzyme Reaction of Prokaryotes

J. Biol. Chem 275, 7462-7465. (2000)

Tanida, I., Mizushima, N., Kiyooka, M., Ohsumi, M., Ueno, T., Ohsumi, Y. and Kominami, E.

Apg7p/Cvt2p: a novel protein activating enzyme essential for autophagy

Mol. Biol. Cell 10, 1367-1379. (1999)

Shintani, T., Mizushima, N., Ogawa, Y., Matsuura, A., Noda, T. and Ohsumi, Y.

Apg10p, a novel protein-conjugating enzyme essential for autophagy in yeast

EMBO J. 18, 5234-5241. (1999)

Mizushima, N., Noda, T. and Ohsumi, Y.

Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway

EMBO J. 18, 3888-3896. (1999)

Mizushima, N., Sugita, H., Yoshimori, T. and Ohsumi, Y.

A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy

J. Biol. Chem. 273, 33889-33892. (1998)

Mizushima, N., Noda, T., Yoshimori, T., Tanaka, Y., Ishii, T., George, M. D., Klionsky, D. J., Ohsumi, M. and Ohsumi, Y.

A protein conjugation system essential for autophagy

Nature 395, 395-398. (1998)

Review

Mizushima, N.

Physiological functions of autophagy.

Curr Top Microbiol Immunol. 335: 71-84 (2009)

Ishihara, N. Mizushima, N.

A receptor for eating mitochondria.

Dev. Cell. 17: 1-2 (2009)

Nedjic, J., Aichinger, M., Mizushima, N., Klein, L.

Macroautophagy, endogenous MHC II loading and T cell selection: the benefits of breaking the rules.

Curr Opin Immunol. 21: 92-97 (2009)

Mizushima, N.

Methods for monitoring autophagy using GFP-LC3 transgenic mice.

Methods Enzymol. 2009;452:13-23.

Itakura, E., Mizushima, N.

Atg14 and UVRAG: Mutually exclusive subunits of mammalian Beclin 1-PI3K complexes.

Autophagy 5:534-536 (2009)

Hara, T., Mizushima, N.

Role of ULK-FIP200 complex in mammalian autophagy: FIP200, a counterpart of yeast Atg17?

Autophagy 5: 85-87 (2009)

Raben, N., Baum, R., Schreiner, C., Takikita, S., Mizushima, N., Ralston, E., Plotz, P.

When more is less: Excess and deficiency of autophagy coexist in skeletal muscle in Pompe disease.

Autophagy. 5: 111-113 (2009)

Tsukamoto, S., Kuma, A., Mizushima, N.

The role of autophagy during the oocyte-to-embryo transition.

Autophagy. 4: 1076-1078 (2008)

Mizushima, N., Kuma, A.

Autophagosomes in GFP-LC3 transgenic mice.

Methods Mol. Biol. 445: 119-124 (2008)

Mizushima, N., Levine, B., Cuervo, A.M., Klionsky, D.J.

Autophagy fights disease through cellular self-digestion

Nature 451:1069-1075 (2008)

Klionsky, D.J. et al.

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.

Autophagy 4:151-75 (2008)

Mizushima, N.

Autophagy: process and function

Genes Dev. 21: 2861-2873 (2007)

Mizushima, N., Yoshimori, T.

How to interpret LC3 immunoblotting

Autophagy 3:542-545 (2007)

Mizushima, N.

Collaboration of proteolytic systems.

Autophagy 3:179-180 (2007)

Mizushima, N., Klionsky, D.J.

Protein turnover via autophagy: Implications for metabolism.

Annu. Rev. Nutr. 27:19-40 (2007)

Mizushima, N., The pleiotropic role of autophagy: from protein metabolism to bactericide.

Cell Death Differ 12, 1535 1541 (2005).

Mizushima, N., Aβ generation in autophagic vacuoles.

J. Cell Biol. 171, 15-17 (2005).

Ohsumi, Y., Mizushima, N.

Two ubiquitin-like conjugation systems essential for autophagy.

Semin Cell Dev Biol. 15, 231-236 (2004).

Mizushima, N.

Methods for monitoring autophagy.

Int. J. Biochem. Cell Biol. 36, 2491-2502 (2004).

Mizushima, N., Yoshimori, T., Ohsumi, Y.

Role of the Apg12 conjugation system in mammalian autophagy.

Int. J. Biochem. Cell Biol. 35, 553-561 (2003).

Mizushima, N., Ohsumi, Y., Yoshimori, T.

Autohpagosome formation in mammalian cells.

Cell Struct. Funct. 27, 421-429 (2002).

日本語総説（抜粋）

高村聡人、水島昇　

がんとオートファジー

 

          Bio Clinica　25, 227-232 (2010)

渡邉（浅野）貴子、水島昇

オートファジー　

肥満症　69, 211-215 (2010)

水島昇

オートファジー研究の多様化と現在求められていること　

臨床検査　53, 1517-1518 (2009)

岸千絵子、板倉英介、水島昇　

オートファジーの分子機構

臨床検査　53, 1519-1525 (2009)

高村聡人、水島昇　

発癌とオートファジー

臨床検査　53, 1557-1561 (2009)

板倉英介、水島昇　

哺乳類オートファジーの制御と生理機能　

実験医学　27, 2937-2942 (2009)

水島昇、小川佳宏

栄養シグナルの感じ方・伝え方　基礎の基礎

細胞工学 28, 754-759 (2009)

原太一、水島昇

栄養飢餓とオートファジー

細胞工学 28, 784-788 (2009)

水島昇、鈴木邦律

蛍光顕微鏡データの誤った解釈

蛋白質核酸酵素 54, 185-192 (2009)

水島昇、塚本智史、久万亜紀子

発生・分化とオートファジー

蛋白質核酸酵素 53, 2170-2174 (2008)

塚本智史、久万亜紀子、水島昇

オートファジーはマウス着床前胚の発生に必須である

細胞工学 27, 1032-1033 (2008)

水島昇

オートファジーの新たな側面

炎症と免疫 16:379 (2008)

高村聡人、水島昇

オートファジーによる抗原提示

炎症と免疫 16:399-403 (2008)

水島昇

オートファジーとアンチエイジング

アンチ・エイジング医学　日本抗加齢医学会雑誌 4:485-491 (2008)

水島昇

オートファジーを介した新しい抗原提示経路

生体の科学 59:454-455 (2008)

高村聡人、水島昇

オートファジーと疾患

細胞 40:29-31 (2008)

水島昇

オートファジー概論

実験医学 26:255-260 (2008)

水島昇

オートファジーの生理および病態生理学的意義

実験医学 26:272-276 (2008)

水島昇

神経細胞内品質管理におけるオートファジーの役割

臨床神経 46:885-886 (2006)

原太一、水島昇

神経細胞内浄化機構としてのオートファジー

細胞工学 25, 644-645（2006)

水島昇

オートファジー

炎症と免疫 121, 569-571 (2006)

久万亜紀子、水島昇

哺乳動物におけるオートファジーの可視化

顕微鏡　41, 87-89 (2006)

小松雅明、千葉智樹、水島昇

オートファジーによる細胞内品質管理

蛋白質核酸酵素 51, 1515-1518 (2006)

水島昇

オートファジーのモニター方法：現状と課題

蛋白質核酸酵素 51, 1542-1548 (2006)

水島昇

オートファジーを介した抗原提示

蛋白質核酸酵素 51, 1550 (2006)

水島昇、鈴木邦律

オートファジー用語解説

蛋白質核酸酵素 51, 1551-1553 (2006)

久万亜紀子、水島昇

発生・分化におけるオートファジーの役割

蛋白質核酸酵素 51, 1503-1506 (2006)

原　太一、水島昇

哺乳類オートファジーの制御因子

蛋白質核酸酵素 51, 1484-1489 (2006)

水島昇

オートファジーの生理学：タンパク質代謝システムとしての役割

医学のあゆみ 216, 509-513 (2006).

水島昇

オートファジーを介する内因性抗原のMHCクラスIIによる提示

臨床免疫 44, 459-464 (2005).

大隅良典、水島昇

オートファジー研究の展開

実験医学 23, 1583-1588 (2005)

水島昇

オートファジー：内なる分解がいま明らかに（特集序文)

細胞工学 24, 558-561 (2005)

水島昇、久万亜紀子

オートファジーの代謝生理学的意義

細胞工学 24, 567-571 (2005)

水島昇

オートファジー：細胞の新生戦略

蛋白質核酸酵素 50, 393-402 (2005)

水島昇

細胞の品質管理機構（特集序文）

炎症と免疫 13, 237-238 (2005)

水島昇

オートファジーによる細胞質分解の意義

炎症と免疫 13, 255-262 (2005)

久万亜紀子、水島昇

新生児は出生に伴う飢餓をオートファジーで乗り越える

細胞工学 24, 48-49 (2004)

原太一、水島昇

細胞内品質管理機構

最新医学 59, 1976-1981 (2004)

水島昇

オートファジーを伴う細胞死

実験医学 22, 1577-1583 (2004)

水島昇

自食の瞬間：オートファゴソーム形成の可視化

実験医学 22, 1010-1011 (2004)

水島昇

タイプ２細胞死：オートファジーを伴う細胞死の検証

臨床免疫　41, 167-174 (2004)

水島昇

動物細胞および個体におけるオートファジー

実験医学 22, 261-267 (2004)

水島昇, 大隅良典

オートファジーによるバルク分解とそのモニター方法

神経研究の進歩 48, 97-109 (2004)

久万亜紀子、水島昇

生細胞におけるオートファゴソーム形成の可視化

生体と科学 54, 501-506 (2003)

水島昇

オートファジーの分子機構：Apg12結合システムの発見とその役割

生化学 74, 523-537 (2002)

久万亜紀子、水島昇

オートファジーの分子機構

医学のあゆみ 200, 287-291 (2002)

水島昇, 大隅良典 & 吉森保.

動物細胞オートファジーの分子機構.

実験医学 19, 294 299 (2001)

水島昇, 古川和明, 野田健司 & 大隅良典.

Urm1システム：ユビキチンシステムと硫黄原子転移反応との架け橋.

実験医学 19, 225-230 (2001)

水島昇, 吉森保 & 大隅良典

オートファジーの分子機構

臨床免疫 35, 797-806 (2001)