MIZUSHIMA Laboratory | Our research focuses on "AUTOPHAGY", an intracellular bulk degradation process and "PROTEIN METABOLISM".

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Recent publication of the article [Backnumber]

Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection (2010).

Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins (2010).

Inhibition of autophagy in the heart induces age-related cardiomyopathy (2010).

Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly (2010).

In vivo requirement for Atg5 in antigen presentation by dendritic cells (2010).

Autophagy influences glomerular disease susceptibility, and maintains podocyte homeostasis in aging mice (2010).

Dynein- and activity-dependent retrograde transport of autophagosomes in neuronal axons (2010).

Reevaluation of neurodegeneration in lurcher mice: Constitutive ion fluxes cause cell death with, not by, autophagy (2010).

Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo (2010).