Abstract
The effects of Juzen-taiho-to (TJ-48) on the course of non-lethal Plasmodium berghei XAT (Pb XAT) infection in CBA mice were examined. Administration of TJ-48 at a dose of 3 g/Kg body weight orally once a day during the observation period suppressed the development of parasitaemia of mice infected with Pb XAT. Mice treated with TJ-48 showed higher levels of specific antibody titers especially IgG2a isotypes of immunoglobulines in the serum compared with the control mice. Production of IFN-gamma by spleen cells of mice treated with TJ-48 was also higher than that of the control. These findings suggest that TJ-48 has suppressive effect on the course of parasitaemia caused by stimulation of host immunity.
Key word: Plasmodium berghei XAT; traditional oriental herbal medicine; Juzen-taiho-to; IFN-gamma; immunoglobulines; anti-malarials.