Abstract
PF1022A is recently developed as an anthelmintic drug with a structure with of cyclic depsipeptide isolated from Mycelia sterilia. Effects of PF1022A were examined in rats infected with Nippostrongylus brasiliensis and in mice infected with Hymenolepis nana. When PF1022A was orally administered for 3 successive days from day 5 post infection (PI) to adults of N. brasiliensis in the intestine, almost complete elimination of adult worms was observed at the dose of 2.5 mg/Kg/day or higher. To test the effect on developing larvae in the lung, PF1022A was intraperitoneally administered for 2 days from day 1 PI. No effect was found even at a dose of 10 mg/Kg/day. In the case of H. nana, PF1022A was orally administered at a dose of 10 mg/Kg/day for 2 days from day 5 or day 10 PI to cysticercoids of adult worms, respectively. Similar number of worms was recovered from mice with and without N. brasiliensis of intestinal phase but not against the larva of tissue phase in rats, and that PF1022A can not eliminate the cysticercoid and the adult of H. nana from the intestine of mice.
Key words
PF1022A; chemothrepy; Nippostrongylus brasiliensis; Hymenolepis nana; infection.