[60]Kannagi
M*, Hasegawa A, Nagano Y, Iino T, Okamura J, Suehiro Y.
Maintenance of long remission in adult T-cell leukemia by
Tax-targeted vaccine: a hope for disease-preventive therapy. Cancer
Sci. 2019, in press.
2017
[59] Sawada L, Nagano Y, Hasegawa
A, Kanai H, Nogami K, Ito S, Sato T, Yamano Y, Tanaka Y, Masuda
T,Kannagi M*. IL-10-mediated signals act as a
switch for lymphoproliferation in Human T-cell leukemia virus
type-1 infection by activating the STAT3 and IRF4 pathways. PLoS
Pathog. 13(9):e1006597, 2017
[58] Murakami Y, Hasegawa A*, Ando S, Tanaka R,
Masuda T, Tanaka Y, Kannagi M. A novel mother-to-child human
T-cell leukaemia virus type 1 (HTLV-1) transmission model for
investigating the role of maternal anti-HTLV-1 antibodies using
orally infected mother rats. J Gen Virol.
98(4):835-846, 2017
[57] Ando S,Hasegawa A*, Murakami Y, Zeng
N, Takatsuka N, Maeda Y, Masuda T, Suehiro Y, Kannagi M. HTLV-1
Tax-Specific CTL Epitope-Pulsed Dendritic Cell Therapy Reduces
Proviral Load in Infected Rats with Immune Tolerance against
Tax. J Immunol. 198(3):1210-1219, 2017
2016
[56] Takahata T, Takeda E, Tobiume
M, Tokunaga K, Yokoyama M, Huang YL, Hasegawa A, Shioda T, Sato
H, Kannagi M, Masuda T*. Critical Contribution of Tyr15
in the HIV-1 Integrase (IN) in Facilitating IN Assembly and
Nonenzymatic Function through the IN Precursor Form with Reverse
Transcriptase. J Virol. 91(1) pii: e02003-16,
2016
2015
[55] Masuda T*, Sato Y,
Huang YL, Koi S, Takahata T, Hasegawa A, Kawai G, Kannagi M.
Fate of HIV-1 cDNA intermediates during reverse transcription is
dictated by transcription initiation site of virus genomic RNA.
Sci Rep. 5:17680, 2015
[54] Suehiro Y, Hasegawa A, Iino T, Sasada A, Watanabe N,
Matsuoka M, Takamori A, Tanosaki R, Utsunomiya A, Choi I, Fukuda
T, Miura O, Takaishi S, Teshima T, Akashi K, Kannagi M*,
Uike N, Okamura J. Clinical outcomes of a novel therapeutic
vaccine with Tax peptide-pulsed dendritic cells for adult T cell
leukaemia/lymphoma in a pilot study. Br J Haematol.
169(3):356-67, 2015
[53] Kinpara S, Ito S, Takahata T, Saitoh Y, Hasegawa A,
Kijiyama M, Utsunomiya A, Masuda M, Miyazaki Y, Matsuoka M,
Nakamura M, Yamaoka S, Masuda T, Kannagi M*. Involvement
of double-stranded RNA-dependent protein kinase and antisense
viral RNA in the constitutive NFκB activation in adult T-cell
leukemia/lymphoma cells. Leukemia. 29(6):1425-9, 2015
2014
[52] Araya N, Sato T, Ando H,
Tomaru U, Yoshida M, Coler-Reilly A, Yagishita N, Yamauchi J,
Hasegawa A, Kannagi M, Hasegawa Y, Takahashi K, Kunitomo Y,
Tanaka Y, Nakajima T, Nishioka K, Utsunomiya A, Jacobson S,
Yamano Y. HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells.
J Clin Invest. 124(8):3431-42, 2014
[51] Tanaka Y, Takahashi Y, Tanaka R, Kodama A, Fujii H,
Hasegawa A, Kannagi M, Ansari AA, Saito M. Elimination of human
T cell leukemia virus type-1-infected cells by neutralizing and
antibody-dependent cellular cytotoxicity-inducing antibodies
against human t cell leukemia virus type-1 envelope gp46. AIDS
Res Hum Retroviruses. 30(6):542-52, 2014
2013
[50] S. Kinpara, M. Kijiyama, A.
Takamori, A. Hasegawa, A. Sasada, T. Masuda, Y. Tanaka, A.
Utsunomiya and M. Kannagi*. Interferon-α (IFN-α)
suppresses HTLV-1 gene expression and cell cycling, while IFN-α
combined with zidovudin induces p53 signaling and apoptosis in
HTLV-1-infected cells. Retrovirology. 10: 52,
2013.
[49] Tamai, Y., A. Hasegawa*, A. Takamori, A. Sasada, R.
Tanosaki, I. Choi, A. Utsunomiya, Y. Maeda, Y. Yamano, T. Eto,
K. R. Koh, H. Nakamae, Y. Suehiro, K. Kato, S. Takemoto, J.
Okamura, N. Uike, and M. Kannagi. Potential Contribution of a
Novel Tax Epitope-Specific CD4+ T Cells to Graft-versus-Tax
Effect in Adult T Cell Leukemia Patients after Allogeneic
Hematopoietic Stem Cell Transplantation. J Immunol.
190(8): 4382-92. 2013 (学位論文)
2012
[48] Kannagi, M*, A.
Hasegawa, A. Takamori, S. Kinpara, and A. Utsunomiya. The roles
of acquired and innate immunity in human T-cell leukemia virus
type 1-mediated diseases. Front Microbiol 3:323.
2011
[47] Masuda T*.
Non-Enzymatic Functions of Retroviral Integrase: The Next
Targetfor Novel Anti-HIV Drug Development. Front
Microbiol. 2, 210. 2011
[46] Takamori A, Hasegawa A*, Utsunomiya A, Maeda Y,
Yamano Y, Masuda M, Shimizu Y, Tamai Y, Sasada A, Zeng N, Choi
I, Uike N, Okamura J, Watanabe T, Masuda T, Kannagi M.
Functional impairment of Tax-specific but not
cytomegalovirus-specific CD8+ T lymphocytes in a minor
population of asymptomatic human T-cell leukemia virus type
1-carriers. Retrovirology. 8: 100. (PubMed)
[45] Kannagi M*, Hasegawa A, Kinpara S, Shimizu Y,
Takamori A, Utsunomiya A. Double control systems for human
T-cell leukemia virus type 1 by innate and acquired immunity. Cancer
Sci., 102(4):670-6.
2010
[44] Ahmed N, Hayashi T, Hasegawa A,
Furukawa H, Okamura N, Chida T, Masuda T, Kannagi M*.
Suppression of human immunodeficiency virus type 1 replication
in macrophages by commensal bacteria preferentially stimulating
Toll-like receptor 4. J Gen Virol., 91(Pt
11):2804-13.
[43] Hayashi T, Nishitsuji H, Takamori A, Hasegawa A, Masuda
T*, Kannagi M. DNA-dependent activator of IFN-regulatory
factors enhances the transcription of HIV-1 through NF-κB. Microbes
Infect., 12(12-13):937-47.
2009
[42]
Nishitsuji H, Hayashi T, Takahashi T, Miyano M, Kannagi M, Masuda
T*. Augmentation of reverse transcription by integrase
through an interaction with host factor, SIP1/Gemin2 Is critical
for HIV-1 infection. PLoS One.(PubMed)
[41] N.Takatsuka, A. Hasegawa, A. Takamori, Y. Shimizu, H. Kato,
T. Ohashi, T. Amagasa, T. Masuda, M. Kannagi*. Induction
of IL-10- and IFN-g-producing T-cell responses by autoreactive
T-cells expressing human T-cell leukemia virus type I Tax.
Int. Immunol., 21(9):1089-100.
[40] S. Obitsu, N. Ahmed, H. Nishitsuji, A. Hasegawa, K.
Nakahama, I. Morita, K. Nishigaki, T. Hayashi, T. Masuda, M. Kannagi*.
Potential enhancement of osteoclastogenesis by severe acute
respiratory syndrome coronavirus 3a/X1 protein. Arch.
Virol., 154(9):1457-64.
[39] S. Kinpara, A. Hasegawa, A. Utsunomiya, H. Nishitsuji, H.
Furukawa, T. Masuda, and M. Kannagi*. Stromal
cell-mediated suppression of human T-cell leukemia virus type-1
expression in vitro and in vivo through type-I interferon. J
Virol. 83: 5101-5108.(PubMed)
[38] Y. Shimizu, A. Takamori, A. Utsunomiya, M. Kurimura,
Y.Yamano, M. Hishizawa, A. Hasegawa, F. Kondo, K. Kurihara, N.
Harashima, T. Watanabe, J. Okamura, T. Masuda, and M. Kannagi*.
Impaired Tax-specific T-cell responses with insufficient control
of HTLV-1 in a subgroup of individuals at asymptomatic and
smoldering stages. Cancer Sci., 100: 481-489. (PubMed)
2007
[37]
M. Washiyma, K. Nishigaki, N. Ahmed, S. Kinpara, Y. Ishii, N.
Kanzawa, T. Masuda, and M. Kannagi*. IL-2 withdrawal
induces HTLV-1 expression through p38 activation in ATL cell
lines. FEBS Letters, 581: 5207-5212. (PubMed)
[36] Mari Kannagi*. Immunologic control of HTLV-I and
Adult T-cell Leukemia. Int. J. Hematol. 86:
113-117. (PubMed)
2006
[35]
Kanzawa N, Nishigaki K, Hayashi T, Ishii Y, Furukawa S, Niiro A,
Yasui F, Kohara M, Morita K, Matsushima K, Le MQ, Masuda T, Kannagi
M*. Augmentation of chemokine production by severe acute
respiratory syndrome coronavirus 3a/X1 and 7a/X4 proteins
through NF-kappaB activation. FEBS Lett.,
580(30):6807-12. (PubMed)
[34] Nishitsuji H, Kohara M, Kannagi M, Masuda T*.
Effective suppression of human immunodeficiency virus type 1
through a combination of short- or long-hairpin RNAs targeting
essential sequences for retroviral integration. J Virol.,
80(15):7658-66. (PubMed)
[33] Komori K, Hasegawa A, Kurihara K, Honda T, Yokozeki H,
Masuda T, Kannagi M*. Reduction of human T-cell leukemia
virus type 1 (HTLV-1) proviral loads in rats orally infected
with HTLV-1 by reimmunization with HTLV-1-infected cells. J
Virol., 80(15):7375-81. (PubMed)
[32] Hamamoto S, Nishitsuji H, Amagasa T, Kannagi M, Masuda
T*. Identification of a novel human immunodeficiency virus
type 1 integrase interactor, Gemin2, that facilitates efficient
viral cDNA synthesis in vivo. J Virol.,
80(12):5670-7. (PubMed)
[31] Kurihara K, Shimizu Y, Takamori A, Harashima N, Noji M,
Masuda T, Utsunomiya A, Okamura J, Kannagi M*. Human
T-cell leukemia virus type-I (HTLV-I)-specific T-cell responses
detected using three-divided glutathione-S-transferase (GST)-Tax
fusion proteins. J Immunol Methods.,
313(1-2):61-73. (PubMed)
[30] Kubo M, Nishitsuji H, Kurihara K, Hayashi T, Masuda T, Kannagi
M*. Suppression of human immunodeficiency virus type 1
replication by arginine deiminase of Mycoplasma arginini. J
Gen Virol., 87(Pt 6):1589-93. (PubMed)
2005
[29]
Harashima N, Tanosaki R, Shimizu Y, Kurihara K, Masuda T,
Okamura J, Kannagi M. Identification of two new
HLA-A*1101-restricted tax epitopes recognized by cytotoxic T
lymphocytes in an adult T-cell leukemia patient after
hematopoietic stem cell transplantation. J Virol.,
79(15):10088-92.2005. (PubMed)
[28] Kannagi M, Harashima N, Kurihara K, Ohashi T, Utsunomiya A,
Tanosaki R, Masuda M, Tomonaga M, Okamura J. Tumor immunity
against adult T-cell leukemia. Cancer Sci.,
96(5):249-55.2005. (PubMed)
[27] Kurihara K, Harashima N, Hanabuchi S, Masuda M, Utsunomiya
A, Tanosaki R, Tomonaga M, Ohashi T, Hasegawa A, Masuda T,
Okamura J, Tanaka Y, Kannagi M. Potential immunogenicity of
adult T cell leukemia cells in vivo. Int J Cancer.,
114(2):257-67.2005. (PubMed)
2004
[26]
Ikeda T, Nishitsuji H, Zhou X, Nara N, Ohashi T, Kannagi M,
Masuda T. Evaluation of the functional involvement of human
immunodeficiency virus type 1 integrase in nuclear import of
viral cDNA during acute infection. J Virol.,
78(21):11563-73.2004.(PubMed)
[25] Emori Y, Ikeda T, Ohashi T, Masuda T, Kurimoto T, Takei M,
Kannagi M. Inhibition of human immunodeficiency virus type 1
replication by Z-100, an immunomodulator extracted from
human-type tubercle bacilli, in macrophages. J Gen Virol.,
85(Pt 9):2603-13, 2004.(PubMed)
[24] Zhou X, Kubo M, Nishitsuji H, Kurihara K, Ikeda T, Ohashi
T, Azuma M, Masuda T, Kannagi M. Inducible-costimulator-mediated
suppression of human immunodeficiency virus type 1 replication
in CD4+ T lymphocytes. Virology., 325(2):252-63,
2004. (PubMed)
[23] Kannagi M, Ohashi T, Harashima N, Hanabuchi S, Hasegawa A.
Immunological risks of adult T-cell leukemia at primary HTLV-I
infection. Trends Microbiol., 12(7):346-52, 2004.
(PubMed)
[22] Kannagi M, Harashima N, Kurihara K, Utsunomiya A, Tanosaki
R, Masuda M. Adult T-cell leukemia: future prophylaxis and
immunotherapy. Expert Rev Anticancer Ther.,
4(3):369-76, 2004. (PubMed)
[21] Nomura M, Ohashi T, Nishikawa K, Nishitsuji H, Kurihara K,
Hasegawa A, Furuta RA, Fujisawa J, Tanaka Y, Hanabuchi S,
Harashima N, Masuda T, Kannagi M. Repression of tax expression
is associated both with resistance of human T-cell leukemia
virus type 1-infected T cells to killing by tax-specific
cytotoxic T lymphocytes and with impaired tumorigenicity in a
rat model. J Virol., 78(8):3827-36, 2004.
(PubMed)
[20] Nishitsuji H, Ikeda T, Miyoshi H, Ohashi T, Kannagi M,
Masuda T. Expression of small hairpin RNA by lentivirus-based
vector confers efficient and stable gene-suppression of HIV-1 on
human cells including primary non-dividing cells. Microbes
Infect., 6(1):76-85, 2004. (PubMed)
[19] Harashima N, Kurihara K, Utsunomiya A, Tanosaki R,
Hanabuchi S, Masuda M, Ohashi T, Fukui F, Hasegawa A, Masuda T,
Takaue Y, Okamura J, Kannagi M. Graft-versus-Tax response in
adult T-cell leukemia patients after hematopoietic stem cell
transplantation.Cancer Res.,
;64(1):391-9, 2004. (PubMed)
2003
[18]
Liu H, Ohashi T, Masuda T, Zhou X, Kubo M, Kannagi M.
Suppression of HIV-1 replication by HIV-1-irrelevant CD8+
cytotoxic T lymphocytes resulting in preservation of
persistently HIV-1-infected cells in vitro. Viral
Immunol., 16(3):381-93, 2003. (PubMed)
[17] Hasegawa A, Ohashi T, Hanabuchi S, Kato H, Takemura F,
Masuda T, Kannagi M. Expansion of Human T-Cell Leukemia Virus
Type 1 (HTLV-1) Reservoir in Orally Infected Rats: Inverse
Correlation with HTLV-1-Specific Cellular Immune Response. J
Virol.,77:2956-63, 2003. (PubMed)
2002
[16]
Ohashi T, Hanabuchi S, Suzuki R, Kato H, Masuda T, Kannagi M.
Correlation of major histocompatibility complex class I
downregulation with resistance of human T-cell leukemia virus
type 1-infected T cells to cytotoxic T-lymphocyte killing in a
rat model. J Virol.,76:7010-7019, 2002. (PubMed)
2001
[15] Hanabuchi S, Ohashi T, Koya Y,
Kato H, Hasegawa A, Takemura F, Masuda T, Kannagi M. Regression
of human T-cell leukemia virus type I (HTLV-I)-associated
lymphomas in a rat model: peptide-induced T-cell immunity. J
Natl Cancer Inst.,93:1775-83, 2001. (PubMed)
2000
[14]
Kannagi M, Ohashi T, Hanabuchi S, Kato H, Koya Y, Hasegawa A,
Masuda T, Yoshiki T. Immunological aspects of rat models of HTLV
type 1-infected T lymphoproliferative disease. AIDS Res
Hum Retroviruses,16:1737-40, 2000. (PubMed)
[13] T. Ohashi, S. Hanabuchi, H. Kato, H. Tateno, F. Takemura,
T. Tsukahara, Y. Koya, A. Hasegawa, T. Masuda, and M. Kannagi.
Prevention of Adult T cell leukemia-like lymphoproliferative
disease in rats by adoptively transferred T cells from a donor
immunized with HTLV-I Tax-coding DNA vaccine. J Virol.,74:9610-9616,
2000. (PubMed)
[12] S. Hanabuchi, T. Ohashi, Y. Koya, H. Kato, F. Takemura, K.
Hirokawa, T. Yoshiki, H. Yagita, K. Okumura, and M. Kannagi.
Development of human T cell leukemia virus type I
(HTLV-I)-transformed tumor in rats following suppression of T
cell immunity by CD80 and CD86 blockade. J Virol.,74:
428-435, 2000. (PubMed)
[11] N. Tsurutani, M. Kubo, Y. Maeda, N. Yamamoto, M. Kannagi,
and T. Masuda. Identification of critical amino acid residues in
IN required for efficient proviral DNA formation at steps prior
to integration in dividing and non-dividing cells. J
Virol.,74: 4795-4806, 2000. (PubMed)
1999
[10]
T. Ohashi, S. Hanabuchi, H. Kato, Y. Koya, F. Takemura, K.
Hirokawa, T. Yoshiki, Y. Tanaka, M. Fujii, and M. Kannagi.
Induction of ATL-like lymphproliferative disease and its
inhibition by adoptive immunotherapy in T-cell deficient nude
rats inoculated with syngenic HTLV-I-immortalized cells. J
Virol.,73: 6031-6040, 1999. (PubMed)
[9] Y. Koya, T. Ohashi, H. Kato, S. Hanabuchi, T. Tsukahara, F.
Takemura, K. Etoh, M. Matsuoka, M. Fujii, and M. Kannagi.
Establishment of a seronegative HTLV-I-carrier state in rats
inoculated with a syngeneic HTLV-I-immortalized T cell line
preferentially expressing Tax. J Virol.,73:
6436-6443, 1999. (PubMed)
[8] T. Tsukahara, M. Kannagi, T. Ohashi, H. Kato, M. Arai, G.
Nunez, Y. Iwanaga, N. Yamamoto, K. Ohtani, M. Nakamura, and M.
Fujii. Induction of Bcl-xL expression by HTLV-I Tax through
NF-kB in apoptosis-resistant T-cell transfectants with Tax. J
Virol.,73: 7981-7987, 1999. (PubMed)
[7] T. Ohashi, M. Kubo, H. Kato, A. Iwamoto, H. Takahashi, M.
Fujii, and M. Kannagi. Role of class I major histcompatibility
complex-restricted and -unrestricted suppression of human
immunodeficiency virus type 1 (HIV-1) replication by CD8+ T
lymphocytes. J Gen Virol.,80: 209-216, 1999.
(PubMed)
1998
[6]
T. Ohashi, M. Arai, H. Kato, M. Kubo, M. Fujii, N. Yamamoto, A.
Iwamoto, M. Kannagi. High SDF-1 expression in HIV-1 carriers
does not correlate with CD8+ T cell-mediated suppression of
viral replication. Virology, 244: 467-472, 1998.
(PubMed)
[5] H. Kato, Y. Koya, T. Ohashi, S. Hanabuchi, F. Takemura, M.
Fujii, H. Tsujimoto, A. Hasegawa, and M Kannagi. Oral
administration of HTLV-I induces immune unresponsivenesswith
persistent infection in adult rats. J Virol., 72.
7289-7293, 1998. (PubMed)
[4] M. Arai, T. Ohashi, T. Tsukahara, T. Murakami, T Hori, T.
Uchiyama, N. Yamamoto, M. Kannagi, M. Fujii. Human T cell
leukemia virus type 1 Tax protein induces the expression of
lymphocyte chemoattractant SDF-1/PBSF. Virology,
241: 298-303, 1998. (PubMed)
1997
[3]
Kubo M, Ohashi T., Fujii M., Oka S., Iwamoto S., Harada S., and
Kannagi M. Abrogation ofin vitro suppression of HIV-1
replication mediated by CD8+ T lymphocytes of asymptomatic HIV-1
carrers by staphylococcal enterotoxin B and phorbol esters
hrough induction of TNF-a. J Virol.,71: 7560-7566,
1997. (PubMed)
[2] Kishi S, Saijo S., Arai M., Karasawa S., Ueda S., Kannagi
M., Iwakura Y., Fujii M., and Yonehara S. Resistance to
Fas-mediated apoptosis of peripheral T cells in human T
lymphocyte virus type I (HTLV-I) transgenic mice with autoimmune
arthropathy. J Exp Med.,186: 57-64, 1997. (PubMed)
[1] Arai, M., Kannagi, M., Matsuoka, M., Sato, T., Yamamoto, N.,
Fujii, M. Expression of FAP-1(Fas-associated phosphatase) and
resistance to Fas-mediated apoptosis in T-cell lines derived
from human T-cell leukemia virus type 1 associated
myelopathy/tropical spastic paraparesis. AIDS
Res.Hum.Retroviruses, 14: 261-267, 1997. (PubMed)