Digestive Surgery

Name of Division: Digestive Surgery

　　　

Staff

Kenichi Sugihara, Satoshi Okabe, Masayuki Enomoto, Kazuyuki Kojima, Tetsuro Higuchi, Takayuki Osanai, Toshiki Yamashita, Tsuyoshi Gonda, Hiroyuki Uetake, Hiroyuki Yamada

Research Subjects

・Nerve-preserving surgery for colorectal cancer

・Local excision with partial mesorectomy for early invasive low rectal cancer

・Staging of liver metastasis from colorectal cancer

・Laparoscopic surgery for gastrointestinal cancer

・Diagnostic laparoscopy and intraperitoneal administration of anti-cancer agent for far advanved gastric cancer

・Nerve-preserving surgery for gastric cancer

・Tailor-made therapy for breast cancer, including primary reconstruction after resection of the breast

・Molecular detection of predictive markers in chemotherapy for gastrointestinal and breast cancer

・Analysis of intratumoral Cox-II expression in relation to tumor progression, metastasis and Cox-II inhibitor effectiveness

・Clinical trials of chemotherapy for gastrointestinal cancer

　

Publications

　 1) K Yoshinaga, T Iwama, H Ishida, T Hayashi, T Gonda, K Sugihara A simple method to avoid contamination while performing an immediate mucocutaneous suture of the intestinal stoma Surgery Today 1998;28:475-477.

　 2) T Yamao, Y Matumura, Y Shimada, Y Moriya, K Sugihara, T Akasu, S. Fujita, T Kaikizoe Abnormal expression of CD44 variants in the exfoliated cells in the feces of patients with colorectal cancer Gastroenterology 1998;114(6);1196-1205.

　 3) K. Kubota, T. Akasu, Y. Makanishi, K. Sugihara, S. Fujita, Y. Moriya Perianal Paget's disease associated with rectal carcinoma: A case report Jpn J Clin Oncol 1998;28(5):347-350.

　 4) Zhang Y, Iwama T, Sugihara K Histochemical study of apoptosis and cell proliferation in hereditary intestinal disease J Med Dent Sci 1998;45(2):77-84.

　 5) Murata S, Moriya Y, Akasu T, Sugihara K Resection of both hepatic and pulmonary metastases in patients with colorectal carcinoma Cancer 1998 83(6):1086-1093.

　 6) Akasu T, Sugihara K. Solitary peritoneal metastasis from colon carcinoma Surgery 1998 124(5):938-940

　 7) Fujita T, Matsui M, Takaku K, Uetake H, Ichikawa W, Taketo MM, Sugihara K. Size- and Invasion-dependent Increase in Cyclooxygenase 2 Levels in Human Colorectal carcinomas Cancer Res. 1998 58(November): 4823-4826.

　 8) Sugihara K Ulcerative colitis and carcinogenesis Asian Medical Journal 42(5):232-238,1999

　 9) Iida S, Akiyama Y, Ichikawa W. Yamashita T, Nomizu T, Nihei Z, Sugihara K, Yuasa Y Infrequent germ-line mutation of the E-cadherin gene in Japanese familial gastric cancer kindreds. Clinical Cancer Research 5:1445-1447,1999

　10) Uetake H, Ichikawa W, Takechi T, Fukushima M, Nihei Z, Sugihara K. Relationship between intratumoral dehidropyrimidine dehidorogenase activity and　gene expression in human colorectal cancer. Clinical Cancer Research 5:2836-2839,1999

　11) Murayama Y, Sugihara K. SHBG gene is a key gene of hormone dependent cell growth in MCF-7 breast cancer cells. Proc Am Assoc Cancer Res 40:159,1999

　12) Murayama Y, Hammond GL, Sugihara K. The shbg gene and hormone dependence of breast cancer: a novel mechanism of hormone dependence of MCF-7 human breast cancer cells based upon SHBG. Breast Cancer 6(4): 338-343,1999

　13) Yamamoto J, Kosuge T, Shimada K, Yamasaki S, Moriya Y, Sugihara K. Repeat liver resection for recurrent colorectal liver metastases. Am J Surg 178:275-281,1999

　14）Yanagisawa Y, Akiyama Y, Iida S, Ito E, Nomizu T, Sugihara K, Yuasa Y,　Maruyama K. Methylation of the hMSH1 promoter in familial gastric cancer with microsatellite instability. Int J Cancer 85:50-53,2000

　15) Zhi-Qiang Ma, Toru Tanizawa, Zenro Nihei, Kenichi Sugihara, Kyoichi Nakamura Follicular gastritis associated with Helicobacter pylori. J Med Den Science 47(1):1-9,2000

　16) Osanai T, Gomi N, Wakita T, Yamashita T, Ichikawa W, Nihei Z, Sugihara K. Ultrasound-guided core needle biopsy for breast cancer: Preliminary report. Jpn J Clin Oncol 30(2): 65-67,2000.

　17) Enomoto M, Konishi M, Iwama T, Utsunomiya J, Sugihara K, Miyaki M. The relationship between frequency of extrcolonic manifestations and the position of APC germline mutation in patients with familial adenomatosis coli. Jpn J Clin Oncol 30(2): 82-88,2000.

　18) Shoji Y, Yoshinaga K, Inoue J, Iwasaki A, Sugihara K Quantification of teromerase activity in sporadic colorectal carcinoma Cancer 88(6): 1304-1309,2000

　19) Iida S, Akiyama Y, Nakajima T, Ichikawa W, Nihei Z, Sugihara K, Yuasa Y Alterations and hypermethylation of the p14ARF gene in gastric cancer Int J Cancer 87:645-658,2000

　20) Koseki K, Takizawa T, Koike M, Ito M, Nihei Z, Sugihara K. Distinction of differentiated type early gastric carcinoma with gastric type mucinexpression. Cancer 89(4):724-732,2000

　21) Sugihara K, Yamamoto J Surgical treatment of colorectal liver metastases Annales Chirurgiae et Gynaecologiae 89(3):221-224,2000

　22) Akasu T, Kondo H, Moriya Y, Sugihara K, Gotoda T, Fujita S, Muto T, Kakizoe T. Endorectal ultrasonography and treatment of early stage rectal cancer World J Surg 24(9):1061-1068,2000

　23) Ichikawa W, Nihei Z, Uetake H, Yamada H, Shirota Y, Sugihara K UFT plus leucovorin for metastatic colorectal cancer: Japanese experience. Oncology 14 (9), 41-43,2000

　24) Ando M, Ito M, Nihei Z, Sugihara K Assessment of intestinal viability using a non-contact laser tissue blood flowmeter. Am J Surg 180(3): 176-180,2000

　25) Gonda T, Ishida H, Yoshinaga K, Sugihara K Microvasculature of small liver metastases in rats J Surg Research 94(1): 43-48,2000

　26) Sugihara K, Kaneko J, Hayashi T, Enomoto M, Yoshinaga K. A new surgical strategy for early invasive low rectal cancer. Ospedali D'Italia Chirurgia 6(6): 583-586,2000

　27) Enomoto M, Sugihara K Case of the Month: Non-polypoid growth cancer arising in the rectum of a patient with familial adenomatous polyposis after total colectomy and ireorectal anastomosis. Jpn J Clin Oncol 31(3): Cover illustration, 2001.

　28) Ohno R, Yoshinaga K, Fujita T, Hasegawa K, Iseki H, Tsunozaki H, Ichikawa W, Nihei Z, Sugihara K. Depth of invasion parallels increased cyclooxygenase-2 levels in patients with gastric carcinoma. Cancer 91:1876-1881,2001.

　29) Hasegawa K, Ichikawa W, Fujita T, Ohno R, Okusa T, Yoshinaga K, Sugihara K Expression of cyclooxygenase-2 (COX-2) mRNA in human colorectal adenomas Eur J Cancer 37:1469-1474,2001

　30) Osanai T, Ichikawa W, Takagi Y, Uetake H, Nihei Z, Sugihara K Expression of Pyrimidine Nucleoside Phosphorylase (PyNPase) in colorectal cancer Jpn J Clin Oncol 31(10):500-505,2001

　31) Shirota Y, Stoehlmacher J, Brabender J, Xiong YP, Uetake H, Danenberg D, Groshen S, Tsao-Wei DD, Danenberg PV, Lenz HJ. ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fuluorouracil chemotherapy J Clin Oncol 19(23): 7298-4304, 2001

　32) Yamada H, Ichikawa W, Uetake H, Shirota Y, Nihei Z, Sugihara K, Hirayama R Thymidylate synthase expression in primary colorectal cancer and metastatic sites. Clin Colorectal Cancer 1(3):169-173, 2001

　

[Graduate School, School of Medicine]

［TOKYO MEDICAL AND DENTAL UNIVERSITY］