Name of Division: Surgical Oncology

Staff

    Kenichi Sugihara, Masayuki Enomoto, Kazuyuki Kojima, Hiroyuki Uetake, Masamichi Yasuno, Tetsuro Higuchi, Satoru Iida, Hiroyuki Yamada, Mikito Inokuchi, Takanobu Sato, Toshiaki Ishikawa, Hirotoshi Kobayashi, Tsuyoshi Nakagawa, Megumi Ishiguro


Research Subjects

ENerve-preserving surgery for colorectal cancer

ELocal excision with partial mesorectomy for early invasive low rectal cancer

EStaging of liver metastasis from colorectal cancer

ELaparoscopic surgery for gastrointestinal cancer

EDiagnostic laparoscopy and intraperitoneal administration of anti-cancer agent for far advanved gastric cancer

ENerve-preserving surgery for gastric cancer

ETailor-made therapy for breast cancer, including primary reconstruction after resection of the breast

EMolecular detection of predictive markers in chemotherapy for gastrointestinal and breast cancer

EAnalysis of intratumoral Cox-II expression in relation to tumor progression, metastasis and Cox-II inhibitor effectiveness

EClinical trials of chemotherapy for gastrointestinal cancer


Publications

<-1999>

  1) K Yoshinaga, T Iwama, H Ishida, T Hayashi, T Gonda, K Sugihara A simple method to avoid contamination while performing an immediate mucocutaneous suture of the intestinal stoma Surgery Today 1998;28:475-477.

@ 2) T Yamao, Y Matumura, Y Shimada, Y Moriya, K Sugihara, T Akasu, S. Fujita, T Kaikizoe Abnormal expression of CD44 variants in the exfoliated cells in the feces of patients with colorectal cancer Gastroenterology 1998;114(6);1196-1205.

@ 3) K. Kubota, T. Akasu, Y. Makanishi, K. Sugihara, S. Fujita, Y. Moriya Perianal Paget's disease associated with rectal carcinoma: A case report Jpn J Clin Oncol 1998;28(5):347-350.

@ 4) Zhang Y, Iwama T, Sugihara K Histochemical study of apoptosis and cell proliferation in hereditary intestinal disease J Med Dent Sci 1998;45(2):77-84.

@ 5) Murata S, Moriya Y, Akasu T, Sugihara K Resection of both hepatic and pulmonary metastases in patients with colorectal carcinoma Cancer 1998 83(6):1086-1093.

@ 6) Akasu T, Sugihara K. Solitary peritoneal metastasis from colon carcinoma Surgery 1998 124(5):938-940

@ 7) Fujita T, Matsui M, Takaku K, Uetake H, Ichikawa W, Taketo MM, Sugihara K. Size- and Invasion-dependent Increase in Cyclooxygenase 2 Levels in Human Colorectal carcinomas Cancer Res. 1998 58(November): 4823-4826.

  8) Sugihara K Ulcerative colitis and carcinogenesis Asian Medical Journal 42(5):232-238,1999

@ 9 Iida S, Akiyama Y, Ichikawa W. Yamashita T, Nomizu T, Nihei Z, Sugihara K, Yuasa Y Infrequent germ-line mutation of the E-cadherin gene in Japanese familial gastric cancer kindreds. Clinical Cancer Research 5:1445-1447,1999

@10) Uetake H, Ichikawa W, Takechi T, Fukushima M, Nihei Z, Sugihara K. Relationship between intratumoral dehidropyrimidine dehidorogenase activity and@gene expression in human colorectal cancer. Clinical Cancer Research 5:2836-2839,1999

@11) Murayama Y, Sugihara K. SHBG gene is a key gene of hormone dependent cell growth in MCF-7 breast cancer cells. Proc Am Assoc Cancer Res 40:159,1999

@12) Murayama Y, Hammond GL, Sugihara K. The shbg gene and hormone dependence of breast cancer: a novel mechanism of hormone dependence of MCF-7 human breast cancer cells based upon SHBG. Breast Cancer 6(4): 338-343,1999

@13) Yamamoto J, Kosuge T, Shimada K, Yamasaki S, Moriya Y, Sugihara K. Repeat liver resection for recurrent colorectal liver metastases. Am J Surg 178:275-281,1999

<2000>

  1jYanagisawa Y, Akiyama Y, Iida S, Ito E, Nomizu T, Sugihara K, Yuasa Y,@Maruyama K. Methylation of the hMSH1 promoter in familial gastric cancer with microsatellite instability. Int J Cancer 2000;85:50-53

@2) Zhi-Qiang Ma, Toru Tanizawa, Zenro Nihei, Kenichi Sugihara, Kyoichi Nakamura Follicular gastritis associated with Helicobacter pylori. J Med Den Science 2000; 47(1):1-9

@3) Osanai T, Gomi N, Wakita T, Yamashita T, Ichikawa W, Nihei Z, Sugihara K. Ultrasound-guided core needle biopsy for breast cancer: Preliminary report. Jpn J Clin Oncol 2000;30(2): 65-67

@4) Enomoto M, Konishi M, Iwama T, Utsunomiya J, Sugihara K, Miyaki M. The relationship between frequency of extrcolonic manifestations and the position of APC germline mutation in patients with familial adenomatosis coli. Jpn J Clin Oncol 2000;30(2): 82-88

@5) Shoji Y, Yoshinaga K, Inoue J, Iwasaki A, Sugihara K Quantification of teromerase activity in sporadic colorectal carcinoma Cancer 2000;88(6): 1304-1309

@6) Iida S, Akiyama Y, Nakajima T, Ichikawa W, Nihei Z, Sugihara K, Yuasa Y Alterations and hypermethylation of the p14ARF gene in gastric cancer Int J Cancer 2000;87:645-658

@7) Koseki K, Takizawa T, Koike M, Ito M, Nihei Z, Sugihara K. Distinction of differentiated type early gastric carcinoma with gastric type mucinexpression. Cancer 2000; 89(4):724-732

@8) Sugihara K, Yamamoto J Surgical treatment of colorectal liver metastases Annales Chirurgiae et Gynaecologiae 2000;89(3):221-224

@9) Akasu T, Kondo H, Moriya Y, Sugihara K, Gotoda T, Fujita S, Muto T, Kakizoe T. Endorectal ultrasonography and treatment of early stage rectal cancer World J Surg 2000;24(9):1061-1068

@10) Ichikawa W, Nihei Z, Uetake H, Yamada H, Shirota Y, Sugihara K UFT plus leucovorin for metastatic colorectal cancer: Japanese experience. Oncology 2000;14 (9): 41-43

@11) Ando M, Ito M, Nihei Z, Sugihara K Assessment of intestinal viability using a non-contact laser tissue blood flowmeter. Am J Surg 2000;180(3): 176-180

@12) Gonda T, Ishida H, Yoshinaga K, Sugihara K Microvasculature of small liver metastases in rats J Surg Research 2000;94(1): 43-48

@13) Sugihara K, Kaneko J, Hayashi T, Enomoto M, Yoshinaga K. A new surgical strategy for early invasive low rectal cancer. Ospedali D'Italia Chirurgia 2000;6(6): 583-586

<2001>

  1) Ohno R, Yoshinaga K, Fujita T, Hasegawa K, Iseki H, Tsunozaki H, Ichikawa W, Nihei Z, Sugihara K. Depth of invasion parallels increased cyclooxygenase-2 levels in patients with gastric carcinoma. Cancer 2001;91:1876-1881

@2) Hasegawa K, Ichikawa W, Fujita T, Ohno R, Okusa T, Yoshinaga K, Sugihara K Expression of cyclooxygenase-2 (COX-2) mRNA in human colorectal adenomas Eur J Cancer 2001;37:1469-1474

@3) Osanai T, Ichikawa W, Takagi Y, Uetake H, Nihei Z, Sugihara K Expression of Pyrimidine Nucleoside Phosphorylase (PyNPase) in colorectal cancer Jpn J Clin Oncol 2001;31(10):500-505

@4) Shirota Y, Stoehlmacher J, Brabender J, Xiong YP, Uetake H, Danenberg D, Groshen S, Tsao-Wei DD, Danenberg PV, Lenz HJ. ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fuluorouracil chemotherapy J Clin Oncol 2001;19(23): 7298-4304

@5) Yamada H, Ichikawa W, Uetake H, Shirota Y, Nihei Z, Sugihara K, Hirayama R Thymidylate synthase expression in primary colorectal cancer and metastatic sites. Clin Colorectal Cancer 2001;1(3):169-173

<2002>

1)      Osanai T, Nihei Z, Ichikawa W, Sugihara K Endoscopic Resection of Benign Breast Tumors. Surg Laparosc Endosc 2002;12(2): 100-103

2)      Shichiri M, Yoshinaga K, Hisatomi H, Sugihara K. Hirata Y Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival. Cancer Res 2002;62(1): 13-17

3)      Ono C, Yoshinaga K, Enomoto M, Sugihara K Discontinuous ectal cancer spread in the mesorectum and the optimal distal clearance margin in situ. Dis Colon Rectum 2002;45(6):744-749

4)      Tsunozaki H, Yoshinaga K, Kumagai J, Sugihara K Cyclooxygenase-2 overexpresion in colorectal cancer is associated with non-polypoid growth. Jpn J Clin Oncol 2002;32(5):167-171

5)      Shirota Y, Ichikawa W, Uetake H, Yamada H, Nihei Z, Sugihara K Intratumoral Dihidropyrimidine Dehydrogenase messenger RNA level reflects tumor progession in human colorectal cancer. Ann Surg Oncol 2002;9(6):599-603

6)      Kojima K, Yamashita T, Inokuchi M, Sugihara K Technique of Vagus-nerve sparing laparoscopy-assisted distal gastrectomy. Digestive Endoscopy 2002;14:103-106

7)      Okabe S, Sugihara K Investigation into the usefulness and adverse events of PFL-therapy for advanced colorectal cancer. J Med and Dent Sci 2002; 49: 77-84

8)      Sonoshita M, Takaku K, Oshima M, Sugihara K, Taketo MM Cyclooxygenase-2 expression in fibroblasts and endothelial cells of intestinal polyps. Cancer Res 2002;62:6846-6849

9)      Kawakami K, Salonga D, Park JM, Danenberg KD, Uetake H, Brabender J, Omura K, Watanabe G, Danenberg PV Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression. Clin Can Res 2002;7(12);4096-4101

10)  Brabender J, Lord RV, Danenberg KD, Metzger R, Schneider PM, Uetake H, Kawakami K, Park JM, Salonga D, Peters JH, DeMeester TR, Holscher AH, Danenberg PV Upregulation of ornithine decarboxylase mRNA expression in Barrett's esophagus and Barrett's - Associated adenocarcinoma. J Gastrointest Surg 2002; 5(2):174-181

<2003>

1)      Higuchi T, Sugihara K Cover Illustration: Case of the month: Hereditary nonpolyposis colorectal cancer (HNPCC) with small bowelcarcinoma. Jpn J Clin Oncol 2003; 33 (1)

2)      Ichikawa W, Uetake H, Shirota Y, Yamada H, Nishi N, Nihei Z, Sugihara K, Hirayama R. Combination of dyhydropyrimidine dehydrogenase and thymidylate synhtase gene expression in primary tumors as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer. Clin Cancer Res 2003; 9 (2): 786-91

3)      Fukunari H, Iwama T, Sugihara K, Miyaki M. Intratumoral heterogeneity of genetic changes in primary colorectal carcinoma with metastasis. Surg Today 2003; 33 (6): 408-13

4)      Sato, T, Yoshinaga K, Okabe S, Okawa T, Enomoto M, Takizawa T, Sugihara K. Cyclooxygenase-2 expression in colorectal adenomas. Dis Colon Rectum 2003; 46 (6): 786-92

5)      Okabe S, Arai T, Yamashita H, Sugihara K. Adenovirus-mediated prodrug-enzyme therapy for CEA-producing colorectal cancer cells. J Cancer Res Clin 2003; 129 (6): 367-73

6)      Enomoto M, Kojima K, Sugihara K. Laparoscopic anterior resection with pelvic autonomic nerve preservation for rectal cancer. Ospedali DfbItalia Chirurgia 2003; 9 (2): 245-8

7)      Takeda H, Sonoshita M, Oshima H, Sugihara K, Chulada PC, Langenbach R, Oshima M, Taketo MM. Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis. Cancer Res 2003; 63: 4872-7

8)      Kato T, Yasui K, Hirai T, Kanemitsu Y, Mori T, Sugihara K, Mochizuki H, Yamamoto J. Therapeutic results for hepatic metastasis of colorectal cancer with special reference to effectiveness of hepatectomy: analysis of prognosis factors for 763 cases recorded at 18 institutions. Dis Colon Rectum 2003; 46 (Suppl): s22-31

9)      Kotake K, Honjyo S, Sugihara K, Kato T, Kodaira S, Takahashi T, Yasutomi M, Muto T, Koyama Y. Changes in colorectal cancer during a 20-year period: an extended report from the multi-institutional registry of large bowel cancer, Japan. Dis Colon Rectum 2003; 46 (Suppl): s32-43

10)  Higuchi T, Iwama T, Yoshinaga K, Toyooka M, Taketo MM, Sugihara K. A randomized, double-blind, placebo-controlled trial of the effects of Rofecoxive, a selective cyclooxygenase-2 inhibitor, on rectal polyps in familial adenomatous polyposis patients. Clin Cancer Res 2003; 9: 4756-60

11)  Siqueira MA Hayashi, Yoshinaga K, Saisho S, Utsunomiya J, Sugihara K. Colon cancer in a 14-year-old female with Turner syndrome. Dis Colon Rectum 2003; 46: 1560-2

12)  Ohtsukasa S, Okabe S, Yamashita H, Iwai T, Sugihara K. Increased expression of CEA and MHC class I in colorectal cancer cell lines exposed chemotherapy drugs. J Cancer Res Clin Oncol 2003; 129: 719-26

<2004>

1) Soumaoro Labile Togba, Uetake H, Higuchi T, Takagi Y, Enomoto M, Sugihara K. Cyclooxygenase-2 expression: a significant prognostic indicator for patients with colorectal cancer.Clin Cancer Res 2004; 10 (24): 8465-71.

2) Minakuchi H, Iwai T, Inoue Y, Sugano N, Takiguchi N.     Complete resection of leimyosarcoma of the suprarenal inferior vena cava without caval replacement. Phlebology 2004; 19(1): 47-51.

3) Ishida H, Shirakawa K, Nakada H, Yokoyama M, Ohsawa T, Inokuma S, Hashimot D. Plasma levels of big endothelin-1 in patients with colorectal cancer: Correlation with liver metastasis.“ϊ–{ŠO‰ΘŒn˜A‡Šw‰οŽ2004; 29(6):980-987.

4) Higuchi T, Jass JR. Review: My approach to serrated polyps of the colorectum          J Clin Pathol     2004; 57: 682-686.

5) Inokuchi M, Uetake H, Shirota Y, Yamada H, Tajima M, Sugihara K. Gene expression of 5-fluorouracil metabolic enzymes in primary colorectal cancer and corresponding liver metastasis.      Cancer Chemother Pharmacol 2004; 53: 391-396      .

6) Iwama T, Tamura K, Morita T, Hirai T, Hasegawa, H, Koizumi K, Shirouzu, K, Sugihara K, Yamamura T, Muto T, Utsunomiya J. A clinical overview of familial adenomatous polyposis derived from the database of the Polyposis Registry of Japan. Int J Clin Oncol           2004; 9: 308-316.

7) Kambara T, Simms LA, Whitehall VL, Spring KJ, Wynter CV, Walsh MD, Barker MA, Arnold S, McGivern A, Matsubara N, Tanaka N, Higuchi T, Young J, Jass JR, Leggett BA. BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum. Gut 2004; 53(8):           1137-1144.

8) Kobayashi H, Gonda T, Uetake H, Higuchi T, Enomoto M, Sugihara K. JTE-522 a selective COX-2 inhibitor, interferes with the growth of lung metastases from colorectal cancer in rats due to inhibition of neovascularization: a vascular cast model study. Int J Cancer 2004; 112: 920-926.

9) Kubota K, Akasu T, Fujita S, Sugihara K, Moriya Y, Yamamoto S. Clinical and pathological prognostic indications with colorectal mucinous carcinomas. Hepato-gastroenterorogy 2004; 22: 142-146.

10) Nariai T, Matsushima Y , Imae S , Tanaka Y , Ishii K , Senda M , Ohno K. Hemodynamic stress in selected subtypes of patients with moyamoya disease – A positron emission tomography study.  J Neurology Neurosurgery Psychiatry in press.

11) Odaka A, Takahashi S, Tanimizu T, Kawashima H, Okada N, Inokuma S, Yamada H,  Ishida H, Hoshino H,  Satomi A , Hashimoto D. Anorectal agenesis with a rectourethral fistula diagnosed in an adult: report of a case. Surgery Today 2004; 34(2): 170-172.

12) Ohasawa T, Ishida H, Odaka A, Hashimoto D, Fujioka M. Gastrointestinal stromal tumor arising in the pelvic cavity-A case report. “ϊ–{ŠO‰ΘŒn˜A‡Šw‰οŽ2004; 29(4): 811-815.

13) Takeuchi A,   Ishida H, Mori T,  Hashimoto D. Comparison of the effects of gasless procedure, CO2-pneumoperitoneum, and laparotomy on splenic and hepatic natural killer activity in rats. Surgical Endoscopy 2004; 18(2): 255-260.

14) Tanami T, Imoto I, Hirasawa A, Yuki Y, Sonoda I, Inoue J, Yasui K, Misawa-Furihata A, Kawakami Y, Inazawa J. Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines. Oncogene 2004; 23: 8796-8804.

15) Wynter CV    Walsh MD, Higuchi T, Leggett BA, Young J, Jass JR. Methylation patterns define two types of hyperplastic polyp associated with colorectal cancer. Gut 2004; 53(4): 573-580.

<2005>

1) Kobayasi H, Uetake H, Higuchi T, Enomoto M, Sugihara K. JTE-522, a selective COX-2 inhibitor, inhibits growth of pulmonary metastases of colorectal cancer in rats. BMC Cancer 2005; 5: 26

2) Yasuno M, Mori T, Koike M, Takahashi K, Toi M, Takizawa T, Shimizu S, Yamaguchi T,  Matsumoto1 H. Importance of thymidine phosphorylase expression in tumor stroma for as a predicting prognostic factoris in patients with advanced colorectal carcinoma. Oncology Reports 2005; 13: 405-412       

3) Higuchi T, Sugihara K, Jass JR. Demographic and pathological characteristics of serrated polyps of colorectum. Histopathology 2005;        47: 32-40          

4) Wynter CVA, Walsh MD, Higuchi T, Leggett BA, Jass JR. Methylation patterns define two types of hyperplastic polyp associated with colorectal cancer. Gut              2004; 53              : 573-508 5) Nariai T, Matsushima Y, Imae S, Tanaka Y, Ishii K, Senda M, Ohno K. Severe haemodynamic stress in selected subtypes of patients with moyamoya disease: a positron emission tomography study. J. Neurol. Neurosurg. Psychiatry 2005; 76: 663-666

6) Tanami H, Tsuda H, Okabe S, Iwai T, Sugihara K, Inomoto I, Inazawa J. Involvement of cyclin D3 in liver metastasis of colorectal cancer, revealed by genome-wide copy-number analysis. Laboratory Investigation 2005; 85: 1118-1129

7) Ichikawa W, Uetake H, Shirota Y, Yamada H, Takahasi  T, Sugihara K, Sasaki Y, Hirayama R. Both gene expression for orotate phosphoribosyltransferase and its ratio to dehidropyrimidine dehydrogenase influence outcome following fluoropyrimidine-based chemotherapy for metastatic colorectal cancer. Br. J Cancer    2003; 89: 1486-1492

8) Tanaka Y, Nariai T, Nagaoka T, Akimoto H, Ishiwata K, Ishii K, Matsushima Y, Ohno K. Quantitative evaluation of cerebral hemodynamics in patients with moyamoya disease by dynamic susceptibility contrast magnetic resonance imaging-comparison with positron emission tomography. J Cereb Blood Flow Metab 2005;          27-Jul: PMID16049427

9) Yuasa Y, Nagasaki H, Akiyama Y, Sakai H, Nakajima T, Ohkura Y, Takizawa T, Koike M, Tani M, Iwai T, Sugihara K, Imai K , Nakachi K. Relationship between CDX2 gene methylation and dietary factors in gastric cancer patients. Carcinogenesis 2005; 26(1):193-200

10) Yamada H, Kojima K, Yamashita T, Kawano T, Sugihara K, Nihei Z. Laparoscopy-assisted resection gastric remnant cancer. Surg Laparosc Endosc Percutan Tech. 2005; 15 (4): 226-9

11) Okawa T, Yoshinaga K, Uetake H, Sato T, Higuchi T, Nemoto T, Sugihara K. Cyclooxygenase-2 overexpression is related to polypoid growth and k-ras gene mutation in T1 colorectal carcinoma. Dis Colon Rectum 2004; 47(11): 1915-1921

12) Osanai T, Takagi Y, Toriya Y, Nakagawa T, Aruga T, Iida S, Uetake H, Sugihara K. Inverse correlation between the expression of O6-methylguanine-DNA methyl transferase (MGMT) and p53 in breast cancer. Jpn J Clin Oncol 2005; 53(3): 121-125

13) Soumaoro LT, Teramoto K, Kawamura T, Nakamura N, Sanada T, Sugihara K, Arii S. Benign Schwanoma of the pancreas. J Gastrointest Surg 2005; 9(2): 288-290

14) Kakimoto M, Uetake H, Osanai T, Shirota Y, Takagi Y, Takesita E, Toriya Y, Danenberg K, Danenberg PV, Sugihara K.        Thymidylate synthase and dehydoropyrimidine dehydrogenase gene expression in breast cancer predicts 5-FU sensitivity by a histocultural drug sensitivity test. Cancer Lett 2005;       223: 103-11

<2006>

1) Hayashi T, Arai M, Ueno M, Kinoshita H, Tada Y, Koizumi K, Miki Y, Yamaguchi H, Tato Y, Utsunomiya J, Muto T, Sugihara K. Frequency og immunohistochemical loss of mismatch repair protein in double primary cancers of the colorectum and stomach in Japan. Dis Colon Rectum2006; 49(10 suppl), s23-s29

2) Soumaoro LT,  Uetake H, Takagi Y, Iida S, Higuchi T, Yasuno M, Enomoto M, Sugihara K. Coexpression of VEGF-C and Cox-2 in Human Colorectal Cancer and its Association With Lymph Node Metastasis. Dis Colon Rectum2006; 49(3), 392-398

3) Yamamoto J, Nagai M, SmithT. B, Tamaki S, Kubota T, Sasaki K, Ohmori T, Maeda K. Adaptation of the Pursestring Suture Anoscope with a small hole in a case of Stapled Hemorrhoidectomy. Dis Colon Rectum2006; 49(6), 1520-1525

4) Kinugasa Y, Murakami G, Uchimoto K, Takenaka A, Yajima T, Sugihara K. Operating Behind Denonvilliersf Fascia for Reliable Preservation of Urogenital Autonomic Nerves in Total Mesorectal Excision: A Histologic Study Using Cadaveric Specimens, Including a Surgical Experiment Using Fresh Cadaveric Models. Dis Colon Rectum 2006; 49(7), 1024-1032

5) Sugihara K, Kobayashi H, Kato T, Mori T, Mochizuki H, Kameoka S, Schirouzu K, Muto T. Indication and benefit of pelvic sidewall dissection for rectal cancer. Dis Colon Rectum2006; 49, 1663-1672

6) Yamamoto J, Nagai M, SmithT. B, Tamaki S, .Kubota T, Sasaki K, Ohmori T, Maeda K. Hand-assisted laparoscopic splenectomy and devascularization of the upper stomach in the management of gastric varices. World J Surg2006; 30(8), 925-926

7) Soumaoro LT,  Iida S, Uetake H, Ishiguro M, Takagi Y, Higuchi T, Yasuno M, Enomoto M, Sugihara K. Expression of 5-Lipoxygenase in human colorectal cancer. World J Gastroenterol2006; 12(39), 6355-6360

8) Ishiguro M,     Soumaoro LT,  Uetake H, Takagi Y, Iida S, Takagi Y, Higuchi T, Yasuno M, Sugihara K. Effect of combined therapy with low dose 5-Aza-2f-deoxycytidine and irrinotecan on colorectal cancer cell line HCT-15. Ann Surg Oncol2006; 13(2), 57

9) Ishiguro M, Iida S, Uetake H, Morita S, Makino H, Kato K, Takagi Y, Enomoto M, Sugihara K  Effect of Combined Therapy With Low-Dose 5-Aza-2'-Deoxycytidine and Irinotecan on Colon Cancer Cell Line HCT-15. Ann Surg Oncol(Epub ahead of print)2006

10) Inokuchi M,  Yamashita T, Yamada H, Kojima K, Ichikawa W, Nihei Z, Kawano T, Sugihara K. Phase I/II study of S-1 combined with irinitecan for metastatic advanced gastric cancer. Br J Cancer2006; 94, 1130-1135

11) Kobayashi H,              Ueno H, Hashiguchi Y, Mochizuki H  Distribution of lymph node metastasis is a prognostic index in patients with stage III colon cancer. Surgery2006; 139(4), 516-522

12) Kuramochi J,              Arai T, Ikeda S, Kumagai J, Uetake H, Sugihara K. High Pin1 expression is associated with tumor progression in colorectal cancer. J Surg Oncol2006; 94(2), 155-160

13) Jass JR,Baker K, Zlobec I, Higuchi T, Barker M,  Buchanan D, Young J. Advanced colorectal polyps with the molecular and morphological features of serrated polyps and adenomas: concept of a 'fusion' pathway to colorectal. Histopathology2006; 49(2), 121-131

<2007>

1)      Kobayashi H, Mochizuki H, Sugihara K, Morita T, Kotake K, Teramoto T, Kameoka S, Saito Y, Takahashi K, Hase K, Oya M, Maeda K, Hirai T, Kameyama M, Shirouzu K, Muto T. Characteristics of recurrence and surveillance tools after curative resection for colorectal cancer: A multicenter study. Surgery. 141 (1): 67-75, 2007

2)      Kitano S, Shiraishi N, Uyama I, Sugihara K, Tanigawa N; Japanese Laparoscopic surgery Study Group. A multicenter study on oncologic outcome of laparoscopic gastrectomy for early gastric cancer in Japan. Ann Surg.        245 (1): 68-72, 2007        

3)      Taniguchi K, Kakinuma S, Tokairin Y, Arai M, Kohno H, Wakabayashi K, Imaoka T, Ito E, Koike M, Uetake H, Nishimura M, Yamauchi K, Sugihara K, Shimada Y. Mild inflammation accelerates colon carcinogenesis in Mlh1-deficient mice. Oncology. 71(1-2): 124-30,2006

4)      Hirasaki S, Noguchi T, Mimori K, Onuki J, Morita K, Inoue H, Sugihara K, Mori M, Hirano T. BAC clones related to prognosis in patients with esophageal squamous carcinoma: an array comparative genomic hybridization study.Oncologist. 12(4): 406-17, 2007

5)      Ishiguro M, Iida S, Uetake H, Morita S, Makino H, Kato K, Takagi Y, Enomoto M, Sugihara K."        Effect of Combined Therapy With Low-Dose 5-Aza-2'-Deoxycytidine and Irinotecan on Colon Cancer Cell Line HCT-15. Ann Surg Oncol. 14 (5): 1752-62, 2007

6)      Kinugasa Y, Murakami G, Suzuki D, Sugihara K. Histological identification of fascial structures posteriorolateral to the rectum. Br J Surg. 94 (5): 620-6, 2007

7)      Morita S, iida S, Kato K, Takagi Y, Uetake H, Sugihara K.The synergistic effect of 5-aza-2'-deoxycytidine and 5-fluorouracil on drug-resistant tumors. Oncology. 71 (5-6): 437-45,           2006

8)      Kolev Y, Uetake H, Iida S, Ishikawa T, Kawano T, Sugihara K. Prognostic significance of VEGF expression in correlation with COX-2, microvessel density, and clinicopathological characteristics in human gastric carcinoma. Ann Surg Oncol. 14 (10):         2738-47, 2007

9)      Kobayashi H, Hashiguchi Y, Ueno H, Shinto E, Kajiwara Y, Mochizuki H. Absence of Cyclooxygenase-2 Protein Expression is a Predictor of Tumor Regression in Rectal Cancer Treated with Preoperative Short-Term Chemoradiotherapy. Dis Colon Rectum. 50 (9): 1354-62, 2007

10)  Nakamoto RH, Uetake H, Iida S, Kolev YK, Soumaoro LT, Takagi Y, Yasuno M, Sugihara K. Correlations between cyclooxygenase-2 expression and angiogenic factors in primary tumors and liver metastases in colorectal cancer. Jpn J Clin Oncol. 37 (9):          679-85,  2007

11)  Iwase N, Higuchi T, Gonda T, Kobayashi H, Uetake H, Enomoto M, Sugihara K. The effect of meloxicam, a selective COX-2 inhibitor, on the microvasculature of small metastatic liver tumors in rats. Jpn J Clin Oncol. 37 (9):   673-8, 2007

12)  Kato S, Iida S, Higuchi T, Ishikawa T, Takagi Y, Yasuno M, Enomoto M, Uetake H, Sugihara K.        PIK3CA mutation is predictive of poor survival in patients with colorectal cancer. Int J Cancer. 121 (8): 1771-78, 2007

13)  Yamada H, Kojima K, Inokuchi M, Kawano T, Sugihara K. Effect of Obesity on Technical Feasibility and Postoperative Outcomes of Laparoscopy-Assisted Distal Gastrectomy-Comparison with Open Distal Gastrectomy. J Gastrointest Surg. 2007 Oct 23

<2008>

1)      Nakagawa T, Iida S, Osanai T, Uetake H, Aruga T, Toriya Y, Takagi Y, Kawachi H, Sugihara K. Decreased expression of SOCS-3 mRNA in breast cancer with lymph node metastasis. Oncol Rep. 19 (1): 33-9, 2008

2)      Yamada I, Okabe S, Enomoto M, Sugihara K, Yoshino N, Tetsumura A, Kumagai J, Shibuya H. Colorectal carcinoma: in vitro evaluation with high-spatial-resolution 3D constructive interference in steady-state MR imaging. Radiology. 246 (2): 444-53, 2008    

3)      Kato S, Iida S, Uetake H, Takagi Y, Yamashita Y, Inokuchi M, Yamada H, Kojima K, Sugihara K. "  Methylated TMS1 and DAPK genes predict prognosis and response to chemotherapy in gastric cancer. Int J Cancer. 122 (3): 603-8, 2008           

4)      Yamada H, Kojima K, Inokuchi , M, Kawano T, Sugihara K, Nihei Z. Preliminary experience using a computer-mediated flexible circular stapler in laparoscopic esophagogastrostomy. Surg Laparosc Endosc Percutan Tech 2008; 8: 59-63

5)      Motoyama K, Tanaka F, Kosaka Y, Mimori K, Uetake H, Inoue H, Sugihara K, Mori M. Clinical significance of BMP7 in human colorectal cancer. Ann Surg Oncol 2008; 15(5): 1530-7                          

6)      Motoyama K, Inoue H, Nakamura Y, Uetake H, Sugihara K, Mori M. Clinical significance of high mobility group A2 in human gastric cancer and its relationship to let-7 microRNA family. Clin Cancer Res. 2008; 14 (8): 2334-40                

7)      Kobayashi H, Sugihara K, Uetake H, Higuchi T, Yasuno M, Enomoto M, Kuramochi H, Lenz HJ, Danenberg KD, Danenberg PV. Messenger RNA expression of vascular endothelial growth factor and its receptors in primary colorectal cancer and corresponding liver metastasis. Ann Surg Oncol 2008; 15(4): 1232-8             

8)      Hirokawa K, Utsuyama M, Ishikawa T, Kikuchi Y, Kitagawa M, Fujii Y, Nariuchi H, Uetake H, Sugihara K. Decline of T cell-related immune functions in cancer patients and attempt to restore them through infusion of activated autologous T cell. Mechanisms of Aging and Development 2008; 10524: 1-6                  

9)      Enjoji M, Ohtsukasa S, Nagano H, Matsui M, Kawachi Y, Kurisu A, Maruyama H, Kusakabe M, Nagata K, Hamaguchi H, Taki K. Localized small-bowel infarction caused by Aspergillus during chemotherapy for acute leukemia: Report of a case. Surg Today 2008; 38: 449-52                      

10)  Kojima K, Yamada H, Inokuchi M, Kawano T, Sugihara K. A comparison of Roux-en-Y and Billroth-I reconstruction after laparoscopic-assisted distal gastrectomy.   Ann Surg 2008; 247: 962-7                         

11)  Yamada H, Kojima K, Inokuchi M, Kawano T, Sugihara K. Effect of obesity on technical feasibility and postoperative outcomes of laparoscopy-assisted distal gastrectomy-comparison with open distal gastrectomy. J Gastrointest Surg 2008; 12 (6): 997-1004                   

12)  Makino H, Uetake H, Danenberg K, Danenberg PV, Sugihara K. Efficacy of laser capture microdissection plus RT-PCR technique in analyzing gene expression levels in human gastric cancer and colon cancer. BMC Cancer 2008; 8 (210):                     

13)  Wanajo A, Sasaki A, Nagasaki H, Shimada S, Otsubo T, Owaki S, Shimizu Y, Eishi Y, Kojima K, Nakajima Y, Kawano T, Yuasa Y, Akiyama Y. Methylation of the calcium channel-related gene, CACNA2D3, is@frequent@and poor prognostic factor in Gastric Cancer. Gastroenterology 2008; 135: 580-90                        

14)  Kinugasa Y, Niikura H, Murakami G, Suzuki D, Saito S, Tatsumi H, Ishii M. Development of the human hypogastric nerve sheath with special reference to the topohistology between the nerve sheath and other prevertebral fascial structures. Clin Anat 2008; 21: 558-67                   

15)  Kojima K, Yamada.H, Inokuchi M, Kawano T, Sugihara K. Functional evaluation after vagus nerve-sparing laparoscopically assisted distal gastrectomy.  Surg Endosc 2008; 22: 2003-8                    

16)  Kondo I, Iida S, Takagi Y, Sugihara K. MDM2 mRNA expression in the p53 pathway may predict the potential of invasion and liver metastasis in colorectal cancer. Dis Colon Rectum 2008; 51 (9): 1395-402                  

17)  Tsukamoto S, Fujita S, Yamaguchi T, Yamamoto S, Akasu T, Moriya Y, Taniguchi H, Shioda T. Clinicopathological characteristics and prognosis of rectal well-differenciated nuroendocrine tumors. Int J Colorectal Dis 2008; 23: 1109-13

18)  Hayashi M, Inokuchi M, Takagi Y, Yamada H, Kojima K, Kumagai J, Kawano T, Sugihara K. High expression of HER3 is associated with a decreased survival in gastric cancer.  Clin Cancer Res 2008; 14 (23): 7843-9               

19)  Kobayashi H, Sugihara K, Uetake H, Higuchi T, Yasuno M, Enomoto M, Iida S, Azuma M, Mori R, Omori A, Lenz HJ, Danenberg K, Danenberg P. Messenger RNA expression of TS and ERCC1 in colorectal cancer and matched liver metastasis. Int J Oncol 2008; 33: 1257-62                       

20)  Kojima K, Yamada H, Inokuchi M, Hayashi M, Kawano T, Sugihara K. Current status and evaluation of laparoscopic surgery for gastric cancer. Digestive Endoscopy 2008; 20: 1-5