Name of Division: Medical Biochemistry

Staff

　　　Yutaka Hata, M.D., Ph.D.
　　　Wataru Nishimura, M.D.

Education

　　Undergraduate Course

　　　Medical Biochemistry

　　Graduate Course

　　　Graduate students participate in the following research projects (refer to the research subjects.)

Research Subjects

　　　Our main interests are the molecular structures of synaptic and epithelial junctions. Both junctions have cell adhesion molecules and receptors, which are associated with various signaling molecules and cytoskeletons. These molecules are assembled through the protein-protein interactions in a regulated manner. Furthermore, these components dynamically move in and out the junctions in response to extracellular stimuli. We currently focus on two subjects; 1) to determine the molecular hierarchy in the assembly of junctional components; and 2) to reveal how the cell adhesion at junctions triggers the signals to induce the gene transcriptions.

Publications

　1) Nishimura et al. (2002) Interaction of synaptic scaffolding molecule and -catenin. J.Neurosci. 22; 757-765.

　2) Hirabayashi et al. C2PA is a nuclear protein implicated in heat shock response. J. Cell. Biochem. in press.

　3) Iida et al. Synaptic localization of membrane-associated guanylate kinase-interacting protein mediated by the pleckstrin homology domain. Europ. J. Neurosci. in press.

　4) Nishimura et al. (2000) Localization of BAP1/MAGI-1 at adherens junctions in NRK cells: the polarized targeting mediated by the carboxyl-terminal PDZ domains. J. Cell. Physiol. 185, 358-365.

　5) Deguchi et al. (2000) PAPIN: a novel multiple PDZ protein interacting with neural plakophilin-related armadillo-repeat protein/?-catenin and p0071. J. Biol. Chem. 275; 29875-29880.

　

[Graduate School, School of Medicine]

［TOKYO MEDICAL AND DENTAL UNIVERSITY］