Name of Division: Anesthesiology

　　　Under Dr. Morio Koike, Director of Surgical Pathology, the Department offers comprehensive services in surgical pathology, cytology, and autopsy pathology. The scale of these activities currently exceed 6,500 surgical, 7,500 cytology and 95 autopsy examinations.

　

Staff

Education

　　Undergraduate Course

　17 Units lectures on basic and clinical sciences of anesthesia to 4th grade students and bed side learning for 1 week at 5th and 6th grade

　　Graduate Course

　Animal researches according to individual interests

　

Research Subjects

1) Partial liquid ventilation and lung protection

2) Cerebral ischemia and magnetic resonance imaging

3) Cerebral protective effect of ischemic preconditioning

4) Gravity stress and nociception

5) Endotoxin shock and nitric oxide

　

Publications

2001

　　１）Yuhji Saitoh, Koh Kaneda : Nicorandil accelerates recovery of neuromuscular block caused by vecuronium. Can J Anesth 48: 28-33, 2001

　　2）Uchida T, Yokoyama K, Nakazawa K, Makita K,：Partial pressure of oxygen and partial pressure of carbon dioxide of perfluorocarbon liquid during partial liquid ventilation: their regional difference and their dependence on tidal volume and and positive end-expiratory pressure level. Intensive Care Med 27:36-41, 2001

　　3) Nakazawa K, Yokoyama K, Matsuzawa Y, Makita K, Amaha K: Pulmonary administration of prostacycline (PGI2) during partial liquid ventilation in an oleic acid-induced lung injury: inhalation of aerosol or intratracheal instillation. Intensive Care Med 27:243-250, 2001

　　4) Kaneko T, Saito Y, Hikawa Y, Yasuda K, Makita K: Dose-dependent prophylactic effect of nicorandil, an ATP-dependent potassium channel opener, on intra-oerative myocardial ischaemia in patients undergoing major abdominal surgery. Br J Anaesthesia 86:332-7,2001

　　5）Ishikawa S, Yokoyama K, Kuroiwa T, Makita K：Evolution of cerebral ischaemia induced by thromboembolism in rats detected by early sequential MR imaging. Brit J Anaesthesia 87: 469-476, 2001

　　6) Chieko Mitaka, Yukiko Hirata, Kuninori Yokoyanma, Koshi Makita, Takesuke Imai: A selective inhibitor for inducible nitric oxide synthase improves hypotension and lactic acidosis in canine endotoxic shock. Crit Care Med 2001; 29: 2156-2161

　　7) Kumei Y, Shimokawa R, Toda K, Kawauchi Y, Makita K, Shimokawa H: Hypergravity modulates rat hypothalamic response. Space Utilization Res 17; 35-38, 2001

　　8) Yasuhiro Kumei, Reiko Shimokawa, Mari Kimoto, Yasuko Kawauchi, Hitoyata Shimokawa, Koshi Makita, Keiichi Ohya, Kazuo Toda, Gravity stress elevates the nociceptive threshold level with immunohistochemical changes in the rat brain, Acta Astronautica 49 (3-10) (2001) pp. 381-390.

　　9) Chieko Mitaka, Yukio Hirata, Kuninori Yokoyama, Takesuke Imai: L-Canabanine, a selective inhibitor of inducible NO synthase, increases plasma endotheline-1 concentrations in dogs with endotoxic shock. Journal of Critical Care 16; : 2001

2000

　　１） Kawauchi Y, Oshima T, Suzuki S, Saitoh Y, Toyooka H: 　Advancement of the mandible facilitates nasal breathing in human subjects sedated with midazolam. Can.J.Anesth. 2000; 47: 215-219

　　2) Takeda T, Makita K, Ishikawa S, Kaneda K, Yokoyama K, Amaha K: Uptake and elimination of sevoflurane in rabbit tissues - an invivo magnetic resonance spectroscopy study. Can.J.Anesth. 2000; 47: 579-584

　　3) Ishik awa S, Ohmi S, Nakazawa K, Makita K: Continuous intra-arterial blood gas monitoring during thoracic surgery. J. Anesth. 2000;14:119-123

　　4) Uchida T, Yokoyama K, Nakazawa K, Makita K: inhaled nitric oxide during partial liquid ventilation shifts pulmonary blood flow to the non-dependent lung regions. Intensive Care Med 2000; 26:764-769

　　5) Uchida T, Makita K, Nakazawa K, Yokoyama K: Relationship between airway pressure and the distribution of gas-liquid interface during partial liquid ventilation in the oleic acid lung injury model: Fluorine-19 magnetic resonance imaging study. Crit Care Med 2000; 28: 2904-2908

　　6) Sakai F, Amaha K: Effects of hypothermia on a cloned human brain glutamate transporter (GLT-1) expressed in CHO cells. A patch-clamp study. J. Neurosurgical Anesthesiology, 2000; 12: 240-246

　　7) Sakai F, Amaha K: Midazolam and ketamine inhibit glutamate release via a cloned human brain glutamate transporter. Canadian J.Anesth.2000;47:800-806

　　8)Endo H, Kaneko T, Nakamura H: Improved cardiac contrctile function in hypoxia-reoxgenation in rats treated with low concentration Co2+. Am J Physiol Heart Circ Physiol, 2000;279: H2713-2719

　　9) Mitaka C, Hirata Y, Masaki Y, Takei T, Yokoyama K, Imai T: S-Methylisothiourea sulfate improves renal, but not hepatic dysfunction in canine endotoxic shock model. Intensive Care Med, 2000; 26:117-124

1999

　　１） Nakazawa K, Hikawa Y, Maeda M, Tanaka N, Ishikawa S, Makita K, Amaha K. Laryngeal mask airway insertion using propofol without muscle relaxants: A comparative study of pretreatment of midazolam and fentanyl. Eur J Anaesth 1999; 16:550-555

　　２） Nakazawa K, Tanaka N, Ishikawa S, Ohmi S, Ueki M, Saitoh Y, Makita K, Amaha K. Using the intubating laryngeal mask airway (LMA-Fastrach) for blind endotracheal intubation in patients undergoing cervical spine operation. Anesth & Analg 1999;89:1319-21

　　３） Sakai F, Amaha K. The effects of hypothermia on a cloned human brain glutamate transporter (hGLT-1) expressed in Chinese hamster ovary cells: [3H]L-glutamate uptake study. Anesth Analg 1999;89:1546-1550

　　４) Saitoh Y, Narumi Y, Fujii Y, Ueki M, Makita K. Electromyographic assessment of neuromuscular block at the gastrocnemius muscle. Br J Anaesth 1999; 82: 329-32.

　　５）Saitoh Y, Narumi Y, Fujii Y, Ueki M. Tactile evaluation of fade of the train-of-four and double-burst stimulation using the anaesthetist's non-dominant hand. Br J Anaesth 1999; 83: 275-8.

　　６） Saitoh Y, Narumi Y, Fujii Y. Post-tetanic count and train-of-four responses during neuromuscular block produced by vecuronium and infusion of nicardipine. Br J Anaesth 1999; 83: 340-2.

　　７) Saitoh Y, Narumi Y, Fujii Y, Ueki M. Relationship between stimulating current and accelographic train-of-four response at the great toe. Anaesthesia 1999; 54: 1099-103.

　　８) Saitoh Y, Fujii Y, Oshima T. The ulinastatin-induced effect on neuromuscular block caused by vecuronium. Anesth Analg 1999; 89: 1565-9.

　　９）Mitaka C, Hirata Y, Yokoyama K, Nagura T, Tsunoda Y, Amaha K. Improvement of renal dysfunction in dogs with endotoxemia by a nonselective endothelin receptor antagonist. Crit Care Med 1999;27,146-153

　 10) Ishikawa S. Is continuous intraarterial blood gas monitoring reliable during onelung ventilation? [letter] Anesth Analg 1999;88:1192

　 11) Ishikawa S. Oxygenation may improve with time during one-lung ventilation.[letter] Anesth Analg 1999;89: 258-259

　 12) Oshima T, Masaki .Y, Toyooka H.　Flumazenil antagonized midazolam-induced airway narrowing during nasal breathing in humans. Br J Anaesth 1999;82:698-702

　

[Graduate School, School of Medicine]

［TOKYO MEDICAL AND DENTAL UNIVERSITY］