Name of Division: Human Pathology

　　　A group of pathology departments of our university consists of five of each independent section of the departments; i.e. department of human pathology including a surgical pathology branch inside the university hospital and other four specialized departments of immunopathology, neuropathology, hematopathology, and oral pathology. All of these five departments share the routine performance of autopsy and diagnostic functions of surgical pathology based on their specialty, and they are focusing some of the research topics respectively depending upon each Professor's specialty. Our department of Human Pathology specializes the gastro-intestinal pathology, and so far has been focusing on the diagnostic problems among border-line cases of malignancy of the esophagus, stomach, and colon, with several types of technical approach such as morphometry, immunopathology, and molecular biology.

Staff

Education

　　Undergraduate Course

　 General knowledges on pathology are given to the students through the lectures that are concentrated on 4th and 5th years of the undergraduate course, and accompanied by well-organized training practices with enough volume of surgical and autopsy materials. Clinico-pathological conferences (CPC) are carried out every two weeks by a group of the students of 6th year on the pathology side under the supervision of the teaching staffs. They are full-educated so that they can explain the pathological findings by themselves and answer the questions proposed by another group of the students of 5th year on the clinical side. They are sometimes in hot debate against each other just like the CPC among specialists.

　　Graduate Course

　Further-advanced trainings heading to being a pathologist are fully organized during 4 years of this course, including routine diagnostic functions for the autopsy and surgical materials. They are educated so that they can manage all of these routine functions, and also educated by each technical and research experts so that they can carry out medical researches on their interests and publish at least one paper in some fo the excellent international journals before they finish the course.

Research Subjects

　1. Studies on histogenesis and border-line lesions of the carcinomas of the stomach, colon, and esophagus.

　2. Development of morphometric parameters in cancer diagnosis.

　3. Analysis on alterations of cancer genes in pre-cancerous and cancer lesions of the stomach and colon.

　4. Studies on mechanisms of hematogenous and lymphogenous metastasis of the cancer cells.

　5. Development of the methods to sequestrate cancer tissues by the tumor-specific induction of calcifilaxis.

　6. Studies on H. pylori in mechanisms of the gastric ulcer and cancer.

　7. Pathogenesis of chronic inflammatory diseases such as sarcoidosis, ulcerative coltis, and Crohn's disease.

　

Publications (selected papers, 2000〜2002)

　 1. Kobayshi D, Eishi Y, Ohkusa T, Ishige I, Suzuki T, Minami J, Yamada T, Takizawa T, Koike M Gastric mucosal density of Helicobacter pylori estimated by real-time PCR compared with results of urea breath test and histological grading. J. Med. Microbiol. 2002; 51: 1-7.

　 2. Bai YQ, Yamamoto H, Akiyama Y, Tanaka H, Takizawa T, Koike M, Kenji Yagi O, Saitoh K, Takeshita K, Iwai T, Yuasa Y. Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach. Cancer Lett. 2002 Feb 8;176(1):47-55.

　 3. Eishi Y, Suga M, Ishige I, Kobayashi D, Yamada T, Takemura T, Takizawa T, Koike M, Kudoh S, Costabel U, Guzman J, Rizzato G, Gambacorta M, du Bois R, Nicholson AG, Sharma OP, Ando M. Quantitative analysis of mycobacterial and propionibacterial DNA in lymph nodes of Japanese and European patients with sarcoidosis. J Clin Microbiol. 2002 Jan;40(1):198-204.

　 4. Mikami S, Ohashi K, Usui Y, Nemoto T, Katsube K, Yanagishita M, Nakajima M, Nakamura K, Koike M. Loss of syndecan-1 and increased expression of heparanase in invasive esophageal carcinomas. Jpn J Cancer Res. 2001 Oct;92(10):1062-73.

　 5. Shiraishi J, Utsuyama M, Akashi T, Nemoto T, Ohashi K, Akamatsu H, Sunamori M, Kitagawa M, Hirokawa K. Immunohistological analysis of thymoma by molecules differentially expressed in the thymic cortex and medulla, and its application in the differential diagnosis of thymoma from esophageal and lung cancer. Pathol Res Pract. 2001;197(9):611-9.

　 6. Edamatsu H, Gau CL, Nemoto T, Guo L, Tamanoi F. Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines. Oncogene. 2000 Jun 22; 19(27):3059-68.

　 7. Nonomura Y, Yasumoto M, Yoshimura R, Haraguchi K, Ito S, Akashi T, Ohashi I. Relationship between bone marrow cellularity and apparent diffusion coefficient. J Magn Reson Imaging. 2001 May;13(5):757-60.

　 8. Ohashi K, Nemoto T, Nakamura K, Nemori R. Increased expression of matrix metalloproteinase 7 and 9 and membrane type 1-matrix metalloproteinase in esophageal squamous cell carcinomas. Cancer. 2000 May 15;88(10):2201-9.

　 9. Koseki K, Takizawa T, Koike M, Ito M, Nihei Z, Sugihara K. Distinction of differentiated type early gastric carcinoma with gastric type mucin expression. Cancer. 2000 Aug 15;89(4):724-32.

　10. Warabi M, Nemoto T, Ohashi K, Kitagawa M, Hirokawa K. Expression of protein tyrosine phosphatases and its significance in esophageal cancer. Exp Mol Pathol. 2000 Jun;68(3):187-95.

　11. Akashi T, Ito E, Eishi Y, Koike M, Nakamura K, Burgeson RE. Reduced expression of laminin alpha 3 and alpha 5 chains in non-small cell lung cancers. Jpn J Cancer Res. 2001 Mar;92(3):293-301.

　12. Horiuchi T, Ohkusa T, Watanabe M, Kobayashi D, Miwa H, Eishi Y. Helicobacter pylori DNA in drinking water in Japan. Microbiol Immunol. 2001;45(7):515-9.

　13. Ohkusa T, Fujiki K, Takashimizu I, Kumagai J, Tanizawa T, Eishi Y, Yokoyama T, Watanabe M. Improvement in atrophic gastritis and intestinal metaplasia in patients in whom Helicobacter pylori was eradicated. Ann Intern Med. 2001 Mar 6;134(5):380-6.

　14. Ebe Y, Ikushima S, Yamaguchi T, Kohno K, Azuma A, Sato K, Ishige I, Usui Y, Takemura T, Eishi Y. Proliferative response of peripheral blood mononuclear cells and levels of antibody to recombinant protein from Propionibacterium acnes DNA expression library in Japanese patients with sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2000 Oct;17(3):256-65.

　15. Ohkusa T, Fujiki K, Takashimizu I, Kumagai J, Tanizawa T, Eishi Y. Endoscopic and histological comparison of nonulcer dyspepsia with and without Helicobacter pylori infection evaluated by the modified Sydney system. Am J Gastroenterol. 2000 Sep;95(9):2195-9.

　16. Kato C, Sato K, Wakabayashi A, Eishi Y. The effects of allopurinol on immune function in normal BALB/c and SCID mice. Int J Immunopharmacol. 2000 Jul;22(7):547-56.

　17. Mimura M, Tanaka N, Kimijima Y, Eishi Y, Amagasa T, Okada N. Melanotic neuroectodermal tumor of infancy -immunohistochemical and ultrastructural study-. Asian J Oral Maxillofac Surg 2000; 12: 217-224

　18. Ueno T, Toi M, Saji H, Muta M, Bando H, Kuroi K, Koike M, Inadera H, Matsushima K : The role of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis and survival of human breast cancer. Clin Cancer Res 6: 3282-3289, 2000.

　19. Ueno T, Toi M, Koike M, Nakamura S, Tominaga T. Tissue factor expression in breast cancer tissues: its correlation with prognosis and plasma concentration Br J Cancer 83: 164-70, 2000.

　

[Graduate School, School of Medicine]

［TOKYO MEDICAL AND DENTAL UNIVERSITY］