研究
【臨床研究】
1）敗血症性ショックの機序解明と治療に関する研究
2）急性肺傷害の治療に関する研究
3）食道癌の治療に関する研究
4）術後急性腎傷害の治療・予防策に関する研究
【基礎研究】
1）肺の虚血・再環流障害の機序解明とその治療・予防策の開発
2）過大一回換気量による肺組織でのサイトカイン遺伝子発現と他臓器障害の機序解明
3) 傷害肺による遠隔臓器傷害の機序・遊離還流肺標本での虚血再還流モデルでの検討
4）エンドトキシンショックモデル犬におけるNO阻害薬の治療効果に関する研究
5）転写因子NF-kB阻害による敗血症性ショックの治療戦略
6）核内酵素ポリ(ADP-リポース)シンセターゼ阻害による敗血症性ショックの治療戦略
【原著論文】
■2008年度
1.Mitaka C, Kudo T, Jibiki M, Sugano N, Inoue Y, Makita K, Imai T, Effects of human atrial natriuretic peptide on renal function in patients undergoing abdominal aortic aneurysm repair, Crit Care Med 2008;36:745-51
2.Haraguchi G, Kosuge H, Maejima Y, Suzuki J, Imai T, Yoshida M, Isobe M, Pioglitazone reduces systematic inflammation and improves mortality in apolipoprotein E knockout mice with sepsis, Intensive Care Med 2008;34:1304-12
3.Katoh I, Sato S, Fukunishi N, Yoshida H, Imai T, Kurata S, Apaf-1-deficient fog mouse cell apoptosis involves hypo-polarization of the mitochondrial inner membrane, ATP depletion and citrate accumulation. Cell Res 2008;18:1210-1219
4.Zhu C, Bilali A, Georgieva GS, Kurata S, Mitaka C, Imai T, Salvage of nonischemic control lung from injury by unilateral ischemic lung with apocynin, a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor, in isolated perfused rat lung. Translational Research 2008;152:273-282
5.Mitaka C, Kudo T, Jibiki M, Sugano N, Inoue Y, Makita K, Imai T. Effects of human atrial natriuretic peptide on renal function in patients undergoing abdominal aortic aneurysm repair. Crit Care Med 2008;36:745-751
6.Nakajima Y, Suzuki T, Haruki S, Ogiya K, Kawada K, Nishikage T, Nagai K, Kawano T, A pilot trial of docetaxel and nedaplatin in cisplatin-pretreated relapsed or refractory esophageal squamous cell cancer. Hepato-Gastroenterology 2008; 55(86-87) :1631-1635
7.Kawano T, Haruki S, Ogiya K, Kawada K, Nakajima Y, Nishikage T, Kojima K, Nagai K, Kawachi H, Reliability of endoscopic esophageal mucosectomy using TxHood, a multipurpose treatment hood. Surg Endosc 2008;22(11):2466-2469
8.Ogiya K, Kawano T, Ito E, Nakajima Y, Kawada K, Nishikage T, Nagai K, Lower esophageal palisade vessels and the definition of Barrett's esophagus. Dis Esophagus 2008;21(7):645-649
9.Wanajo A, Sasaki A, Nagasaki H, Shimada S, Otsubo T, Owaki S, Shimizu Y, Eishi Y, Kojima K, Nakajima Y, Kawano T, Yuasa Y, Akiyama Y, Methylation of the calcium channel-related gene, CACNA2D3, is frequent and a poor prognostic factor in gastric cancer. Gastroenterology 2008;135(2)580-590
■2007年度
1.Georgieva GS, Kurata S, Ikeda S, Eishi Y, Mitaka C, Imai T, Nonischemic lung injury by mediators from unilateral ischemic reperfused lung: Ameliorating effect of tumor necrosis factor-a-converting enzyme inhibitor, Shock 2007;27:84-90
2.Mitaka C, Yokoyama K, Imai T. Nitric oxide production is more prominent in off-pump than in on-pump coronary artery bypass surgery. Anaesth Intensive Care. 2007;38:505-509,
3.Kawada K, Kawano T, Nagai K, Nishikage T, Nakajima Y, Tokairin Y, Ogiya K, Tanaka K, Iwai T. Local injection of interferon beta in malignant melanoma of the esophagus as ajuvant of systemic pre-and postoperative DAV chemotherapy: case report with 7 years of long-term survival. Gastrointestinal Endoscopy. 2007;66: 408-410
4.Kawada K, Kawano T, Momma K, Fujiwada J, Nagai K, Nishikage T, Nakajima Y, Ogiya K, Tanaka K, Haruki S, Iwai T. New argon plasma coagulation method for superficial esophageal carcinomas: Argon plasma coagulation-subepithelial ablation. Digestive Endoscopy. 2007;19: 147-152,
■2006年度
1.Georgieva GS, Kurata S, Ikeda S, Teng S, Katoh I, Eishi Y, Mitaka C, Imai T, Prevention of ischemia reperfusion injury by positive pulmonary venous pressure in isolated rat lung. Shock 2006;25:66-72
■2005年度
1.Mitaka C, Hirata Y, Narumi Y, Yokoyama K, Makita K, Katsuyama K, Imai T, Blockade of nuclear factor-kB activation prevents hypodynamic shock and gastric hypoperfusion induced by endotoxin in anesthetized dogs. Intensive Care Med 2005;31:718-723
2.Mitaka C. Clinical laboratory differentiation of infectious versus non-infectious systemic inflammatory response sundrome. Clin Chim Acta 2005;351:17-29
■2004年度
1.Teng S, Kurata S, Katoh I, Georgieva GS, Nosaka T, Mitaka C, Imai T. Cytokine mRNA expression in unilateral ischemic-reperfused rat lung with salt solution supplemented with low-endotoxin or standard bovine serum albumin. Am J Physiol Lung Cell Mol Physiol 2004;286:L137-L142
2.Onai Y, Suzuki JI, Kakuta T, Maejima Y, Haraguchi G, Fukasawa H, Mutoh S, Itai A, Isobe M, Inhibition of IkB-phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injury. Cardiovascular Research 2004;63:51-59
3.Kosuge H, Suzuki JI, Kakuta T, Haraguchi G, Koga N, Futamatsu H, Gotoh R, Inobe M, Isobe M, Attenuation of graft arterial disease by manipulation of the LIGHT pathway, Arterioscler Thromb Vasc Biol 2004;24:1409-1415
4.Koga N, Suzuki JI, Kosuge H, Haraguchi G, Onai Y, Futamatsu H, Maejima Y, Gotoh R, Saiki H, Tsushima F, Azuma M, Isobe M, Blockade of the interaction between PD-1 and PD-L1 accelerates graft arterial disease in cardiac allograft. Arterioscler Thromb Vasc Biol 2004;24:2057-2062
■2003年度
1.Mitaka C, Hirata Y, Yokoyama K, Wakimoto H, Hirokawa M, Nosaka T, Imai T, Relationship of circulating nitrite/nitrate levels to severity and multiple organ dysfunction syndrome in systemic inflammatory response syndrome. Shock 2003;19:305-309
2.Mitaka C, Hirata Y, Habuka K, Narumi Y, Yokoyama K, Makita K, Imai T, Atrial natriuretic peptide infusion improves ischemic renal failure after suprarenal abdominal aortic cross-clamping in dogs. Crit Care Med 2003;31:2205-2210
3.Nosaka T, Teramoto K, Tanaka Y, Igari T, Takamatsu S, Kawamura T, Inoue Y, Goseki N, Arii S, Iwai T, Inomata Y, Tanaka K, Varicose bleeding after liver transplantation in a patient with severe portosystemic shunts. Journal of Gastroenterology 2003;38(8):700-703
5.Takei T, Saegusa H, Zong S, Murakoshi T, Makita K, Tanabe T, Anesthetic Sensitivities to Propofol and Halothane in Mice Lacking the R-type Ca2+ Channel. Anesth Analg 2003;97: 96-103.
6.Takei T, Saegusa H, Zong S, Murakoshi T, Makita K, Tanabe T. Increased sensitivity to halothane but decreased sensitivity to propofol in mice lacking the N-type Ca2+ channel. Neurosci Lett 2003;350:41-45.
7.Haraguchi G, Kobayashi Y, Tanaka A, Isobe M, Brown ML, William A, Gianturco SH, PPARαand PPARγactivators suppress the monocyte-macrophage apolipoprotein B48 receptor. Journal of Lipid Research; 2003;44: 1224-1231
8.Kasahara H, Ueyama T, Wakimoto H, Liu MK, Maguire CT, Converso KL, Kang PM, Manning WJ, Lawitts J, Paul DL, Berul CI, Izumo S. Nkx2.5 homeoprotein regulates expression of gap junction protein connexin 43 and sarcomere organization in postnatal cardiomyocytes. J Mol Cell Cardiol 2003;35:243-256
9.Tanaka M, Berul CI, Ishii M, Jay PY, Wakimoto H, Douglas P, Yamasaki N, Kawamoto T, Gehrmann J, Maguire CT, Schinke M, Seidman CE, Seidman JG, Kurachi Y, Izumo S. A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5. Cold Spring Harb Symp Quant Biol. 2002;67:317-25.
10.Maguire CT, Wakimoto H, Patel VV, Hammer PE, Gauvreau K, Berul CI. Implications of Ventricular Arrhythmia Vulnerability During Murine Electrophysiology Studies. Physiol Genomics. 2003 ;15(1):84-91
11.Donoghue M, Wakimoto H, Maguire CT, Acton S, Hales P, Stagliano N, Fairchild-Huntress V, Xu J, Lorenz JN, Kadambi V, Berul CI, Breitbart RE. Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins. J Mol Cell Cardiol. 2003 ;35(9):1043-53.
12.Wakimoto H, Kasahara H, Maguire CT, Moskowitz IP, Izumo S, Berul CI. Cardiac electrophysiological phenotypes in postnatal expression of Nkx2.5 transgenic mice. Genesis 2003 ;37(3):144-50
■2002年度
1.Imai T, Sekiguchi T, Nagai Y, Morimoto T, Nosaka T, Mitaka C, Makita K, Sunamori M, Continuous monitoring of gastric intraluminal carbon dioxide pressure, cardiac output, and end-tidal carbon dioxide pressure in the perioperative period in patients receiving cardiovascular surgery using cardiopulmonary bypass. Crit Care Med 2002;30:44-51
2.Mitaka C, Hirata Y, Habuka K, Narumi Y, Yokoyama K, Makita K, Imai T, Atrial natriuretic peptide improves pulmonary gas exchange by reducing extravascular lung water in canine model with oleic acid induced pulmonary edema. Crit Care Med 2002;30:1570-1575
3.Mitaka C, Yokoyama K, Morimoto T, Nosaka T, Sunamori M, Imai T, An increase in urinary nitrite/nitrate excretion is associated with the hyperdynamic state after cardiovascular surgery. Intensive Care Med 2002;28:1103-1109
4.Hirokawa M, Iwai T, Inoue Y, Sato S, Surgical Approach to Popliteal Vein Entrapment Causing Symptoms. Phlebology 2002;17:103-107
5.Wakimoto H, Maguire CT, Sherwood MC, Vargas MM, Sarkar PS, Han J, Reddy S, Berul Cl. Characterization of cardiac conduction system abnormalities in mice with targeted disruption of six5 gene. J Interv Card Electrophysiol 2002;7:127-135
6.Wakimoto H, Kasahara H, Maguire CT,Izumo S, Berul Cl. Developmentally modulated cardiac conduction failure in transgenic mice with fetal or postnatal overexpression of DNA nonbinding mutant Nkx2.5. J Cardiovasc Electropysiol 2002;13:682-688
■2001年度
1.Mitaka C, Hirata Y, Yokoyama K, Imai T. L-canavanine, a selective inhibitor of inducible NO synthase, increases plasma endothelin-1 concentrations in dogs with endotoxic shock. J Crit Care 2001;16;17-23
2.Mitaka C, Hirata Y, Yokoyama K, Makita K, Imai T. A selective inhibitor for inducible nitric oxide synthase improves hypotension and lactic acidosis in canine endotoxic shock. Crit Care Med 2001;29:2156-2161
■2000年度
1.Imai T, Mitaka C, Nosaka T, Koike A, Ohki S, Isa K, Kunimoto F, Accuracy and repeatability of blood volume measurement by pulse dye densitometry compared to the conventional method using 51Cr-labeled red blood cells. Intensive Care Med 2000;26:1343-1349
2.Mitaka C, Hirata Y, Masaki Y, Takei T, Yokoyamam K, Imai T, S-methylisothiourea sulfate improves renal, but not hepatic dysfunction in canine endotoxic shock model. Intensive Care Med 2000;26:117-124
■1999年度
1.Kano H, Koike A, Yajima T, Koyama Y, Marumo F, Hiroe M, Mechanism of overshoot in cardiac function during recovery from submaximal exercise in man. Chest 1999;116:868-873
2.Sato A, Koike A, Koyama Y, Yajima T, Marumo F, Hiroe M. Effects of posture on left ventricular diastolic filling during exercise. Med Sci Sports Exerc 1999;31:1564-1569
3.Shimizu N, Koike A, Koyama Y, Kobayashi K, Marumo F, Hiroe M. Kinetics of pulmonary gas exchange during and while recovering from exercise in patients after anterior myocardial infarction. Jpn Circ J 1999;63:459-466
4.Nosaka T, Bowers JL, Cay O, Clouse ME, Biliary complications after orthotopic liver transplantation in rats. Surgery Today 1999;29:963-965
5.Mitaka C, Hirata Y, Yokoyama K, Nagura T, Tsunoda Y, Amaha K, Improvement of renal dysfunction in dogs with endotoxemia by a nonselective endothelin receptor antagonist. Crit Care Med 1999;27:146-153
■1998年度
1.Imai T, Takahashi K, Masuo F, Goto F, Anaesthesia affects outcome of sepsis in mice. Can J Anaesth 1998;45:360-366
2.Imai T, Takahashi K, Goto F, Morishita Y, Measurement of blood concentratin of indocyanine green by pulse dye densitometry -comparison with the conventinal spectrophotometric method- Journal of Clinical Monitoring & Computing 1998;14:477-484
3.Koike A,Hiroe M, Marumo F. Delayed kinetics of oxygen uptake during recovery after exercise in cardiac patients. Med Sci Sports Exerc 1998;30:185-189
4.Koike A, Yajima T, Koyama Y, Shimizu N, Kano H, Kobayashi K, Taniguchi K, Marumo F, Hiroe M, Effects of isosorbide dinitrate on oxygen uptake kinetics in cardiac patients. Med Sci Sports Exerc 1998;30:190-194
5.Mitaka C, Hirata Y, Yokoyama K, Nagura T, Tsunoda Y, A maha K. Pathologic role of endothelin-1 in septic shock. J Cardiovasc Pharmacol 1998;31(Suppl, I):S233-S235
6.Mitaka C, Hirata Y, Nagura T, Tsunoda Y, Amaha K. Beneficial effect of atrial natriuretic peptide on pulmonary gas exchange in patients with acute lung injury. Chest 1998;114:223-228
7.Yoshikawa T, Shiga T, Saito S, Morita T, Imai T, Goto F, Platelet-activating factor receptor antagonist attenuates endotoxin-induced vascular hyporeactivity in the pithed rat. European Journal of Pharmacology 1998;342:241-245