Yasuhiko IWASAKI

Division of Organic Materials STAFF

Yasuhiko IWASAKI, Ph.D.



Born on January 6, 1971 in Tokyo

Education:
1989/04-1993/03
Bachelor of Science, Department of Industrial Chemistry
Nihon University, Tokyo, Japan
1993/04-1995/03
Master of Science, Department of Industrial Chemistry
Nihon University, Tokyo, Japan
1998/04-
Ph.D. Department of Industrial Chemistry
Nihon University, Tokyo, Japan
Title of Ph.D. thesis was "Synthesis of Polymer Having a Phospholipid Polar Group and the Effect of Their Chemical Structure on the Blood Compatibility"

Professional career:
1995/04-1995/09 Lecturer, Tokyo Medical and Dental University
1995/10-1998/06 Assistant Professor, Tokyo Medical and Dental University
1998/07-        Associate Professor, Tokyo Medical and Dental University
2000/06-2000/12 Visiting Scientist, University of Massachusetts

Research fields:
Synthetic polymer science
Biomaterials

Social activities:
The Chemical Society of Japan
The Society of Polymer Science, Japan
The Japanese Society for Biomaterials
The Japanese Society for Dental Materials and Devices
Society for Biomaterials
American Chemical Society

Publications:
1. S.Tanaka, Y.Iwasaki, K.Ishihara, and N.Nakabayashi, "Assessment of adsorption of liposome on a phospholipid polymer surface using a quartz crystal microbarance". Macromol. Rapid Commun., 15, 319-326(1994).

2. Y.Iwasaki, K.Kurita, K.Ishihara, and N.Nakabayashi, "Effect of methylene chain length in phospholipid moiety on blood compatibility of phospholipid polymers". J. Biomater. Sci., Polym. Edn., 6(5), 447-461(1994).

3. Y.Iwasaki, K.Kurita, S.Tanaka, K.Ishihara, and N.Nakabayashi, "Ex vivo blood compatibility of polymers having phospholipid polar group". J. Jpn. Soc. Biomater., 13(2), 62-70 (1995).

4. K.Ishihara, A.Fujiike, Y.Iwasaki, and N.Nakabayashi, "Synthesis of polymer having a phospholipid polar group connected to a poly(oxyethylene) chain and their protein adsorption-resistance properties". J. Polym. Sci. Part A: Polym. Chem., 34(1), 199-205(1996).

5. K.Ishihara, N.Shibata, S.Tanaka, Y.Iwasaki, T.Kurosaki, and N.Nakabayashi, "Improved blood compatibility of segmented polyurethane by polymeric additives having phospholipid polar group. 2. Dispersion state of the polymeric additive and protein adsorption on the surface". J. Biomed. Mater. Res., 32, 401-408(1996).

6. Y.Iwasaki, A.Fujiike, K.Kurita, K.Ishihara, and N.Nakabayashi, "Protein adsorption and platelet adhesion on polymer surfaces having phospholipid polar group connected with oxyethylene chain". J. Biomater. Sci., Polym. Edn., 8(2), 91-102(1996).

7. Y.Iwasaki, K.Kurita, K.Ishihara, and N.Nakabayashi, "Effect of reduced protein adsorption on platelet adhesion at the phospholipid polymer surfaces". J. Biomater. Sci., Polym. Edn., 8(2), 151-163(1996).

8. Y.Iwasaki, A.Mikami, K.Kurita, N.Yui, K.Ishihara, and N.Nakabayashi, "Reduction of surface-induced platelet activation on phospholipid polymer". J. Biomed. Mater. Res., 36(4), 508-515 (1997).

9. K.Ishihara, H.Nomura, T.Mihara, K.Kurita, Y.Iwasaki, and N.Nakabayashi, "Why do phospholipid polymers reduce protein adsorption ?". J. Biomed. Mater. Res., 39(2), 323-330 (1997).

10. Y.Iwasaki, S.Tanaka, M.Hara, K.Ishihara, and N.Nakabayashi, "Stabilization of liposomes attached to polymer surfaces having phosphorylcholine groups". J. Colloid Interface Sci., 192, 432-439 (1997).

11. P.F.Williams III, Y.Iwasaki, K.Ishihara, G.L.Powell, J.A.Gilbert, N.Nakabayashi, and M.LaBerge, "Evaluation of the frictional properties of an elastmer with enhanced lipid-adsorbing ability". Proc. Instn. Mech. Engrs. 211: Prat H, 359-367 (1997).

12. H.Kawano, K.Kurita, Y.Iwasaki, N.Nakabayashi, and K.Ishihara, "Surface grafting of phospholipid polymer on cellulose membrane for improving hemocompatibility". R. P. P. J., 41, 305-308 (1998).

13. T,Saito, N.Kurosawa, M.Watanabe, Y.Iwasaki, and K.Ishihara, "Design of Enzymatic Glucose Sensor by Using Biocompatible Polymeric Mediator". Kobunshi Ronbunshu, 55(4), 200-206 (1998).

14. H.Kawano, K.Kurita, Y.Iwasaki, K.Ishihara, and N.Nakabayashi "Blood Compatibility of Cellulose Hemodialysis Membrane Grafted with VariousPolymers". Kobunshi Ronbunshu, 55(6), 334-343 (1998).

15. Y.Iwasaki, K.Ishihara, N.Nakabayashi, G.Khang, J.H.Jeon, J.W.Lee, and H.B.Lee, "Platelet adhesion on the gradient surfaces grafted with phospholipid polymer". J. Biomater. Sci., Polym. Edn., 9(8), 801-816 (1998).

16. K.Ishihara and Y.Iwasaki, "Reduced protein adsorption on novel phospholipid polymers". J. Biomat. Appln., 13, 111-127 (1998).

17. K.Ishihara, Y.Iwasaki, and N.Nakabayashi, "Novel biomedical polymers for regulating serious biological reaction". Material Science & Engineering C, 6, 253-259 (1998).

18. K.Ishihara, T.Shinozuka, Y.Hanazaki, Y.Iwasaki and N.Nakabayashi, "Improvement of blood compatibility on cellulose hemodialysis membrane. IV. Phospholipid polymer bonded to the membrane surface". J. Biomater. Sci., Polym. Edn., 3, 271-282 (1999).

19. Y.Iwasaki, M.Nakatani, T.Mihara, K.Kurita, K.Ishihara, and N.Nakabayashi, "Competitive adsorption between phospholipid and plasma protein on the phospholipid polymer surface". J. Biomater. Sci., Polym. Edn., 10(5), 513-530 (1999).

20. K.Ishihara, K.Fukumoto, Y.Iwasaki, and N.Nakabayashi, "Modiification of polusulfone with phospholipid polymer for improvement of the blood compatibility. 1. Surface characterization". Biomaterials, 20, 1545-1551 (1999).

21. K.Ishihara, K.Fukumoto, Y.Iwasaki, and N.Nakabayashi, "Modiification of polusulfone with phospholipid polymer for improvement of the blood compatibility. 2. -Protein adsorption and platelet adhesion-". Biomaterials, 20, 1553-1559 (1999).

22. Y.Iwasaki, M.Ijuin, A.Mikami, K.Ishihara, and N.Nakabayashi, "Behavior of blood cells contacted with water-soluble phospholipid polymer". J. Biomed. Mater. Res., 46, 360-367 (1999).

23. Y.Iwasaki, S.Sawada, N.Nakabayashi, G.Khang, H.B.Lee, and K.Ishihara, "The effect of the chemical structure of the phospholipid polymer on fibronectin adsorption and fibroblast adhesion on the gradient phospholipid surface". Biomaterials, 20(22), 2185-2191 (1999).

24. K.Ishihara, E Ishikawa, Y.Iwasaki, and N.Nakakabayashi, "Inhibition of cell adhesion on substrate by coating with 2-methacryloyloxyethyl phosphorylcholine polymers". J. Biomater. Sci. Polymer Edn., 10(10), 1047-1061 (1999)

25. T.Konno, K.Kurita, Y.Iwasaki, N.Nakabayashi, and K.Ishihara, "Poly(L-lactic acid) nanoparticles covered with the phospholipid polymer with excellent biocompatibility". R. P. P. J., 42, 463-466 (1999).

26. K.Ishihara, Y.Iwasaki, and N.Nakabayashi, "Polymeric lipid nanosphere consisting of water-soluble poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate)". Polym. J., 31, 1231-1236 (1999).

27. Y.Iwasaki, K.Ishihara, and N.Nakabayashi, "Synthesis of novel phospholipid polymers by poly condensation". Macromol. Rapid Commun., 21, 287-290 (2000).

28. K.Ishihara, Y.Iwasaki, S.Ebihara, Y.Shindo, and N.Nakabayashi, "Photoinduced graft polymerization of 2-methacryloyioxyethyl phosphorylcholine on polyethylene membrane surface for obtaining blood cell adhesion resistance" Colloids and Suraces B: Biointerfaces, 18, 325-335 (2000).

29. Y.Iwasaki, Y.Aiba, N.Morimoto, N.Nakabayashi, and K.Ishihara, "Semi-interpenetrating polymer networks composed of biocompatible phospholipid polymer and segmented polyurethane". J. Biomed. Mater. Res., 52, 701-708 (2000).

30. S.Sakaki, Y.Iwasaki, N.Nakabayashi, and K.Ishihara, "Novel Synthetic Blocking Reagent Using Water-soluble 2-Methacryloyloxyethyl Phosphorylcholine Copolymer in Immunoassay System". Polym. J., 33(8) 337-341 (2000)

31. K.Ishihara, H.Fujita, T.Yoneyama, and Y.Iwasaki, "Antithrombogenic Polymer Alloy Composed of 2-Methacryloyloxyethyl Phosphorylcholine Polymer and Segmented Polyurethane, ". J. Biomater. Sci., Polymer Edn, 11(11), 1183-1195 (2000).

32. K.Ishihara and Y.Iwasaki, "Biocompatible elastomers composed of segmented polyurethane and 2-methacryloyloxyethyl phosphorylcholine polymer, "Polym. Adv. Technol., 11, 626-634 (2000).

33. T.Hasegawa, Y.Iwasaki, and K.Ishihara, "Preparation of Performance of Protein Adsorption Resistance Asymmetric Porous Membrane by Polysulfone/Phospholipid Polymer Blend". Biomaterials 22(3), 243-251 (2001).

34. T.Konno, K.Kurita, Y.Iwasaki, K.Ishiahra, "Preparation of Blood Compatible Nanoparticles Bearing Phospholipid Polar Group As a Novel Drug Carrier". Biomaterials, 22,1883-1889 (2001).

35. G.Khang, M.K.Choi, J.M.Rhee, S.J.Lee, H.B.Lee, Y.Iwasaki, N.Nakabayashi, and K.Ishihara, "Biocompatibility of Poly(MPC-co-EHMA)/Poly (L-lactide-co-glycolide) Blend". Korea Polym. J., 9(2), 107-115 (2001).

36. Y.Iwasaki, K.Ishihara, and N.Nakabayashi, "Preservation of platelet function on 2-methacryloyloxyethyl phosphorylcholine graft polymer compared to various water-soluble graft polymers". J. Biomed. Mater. Res., 57, 72-78 (2001).

37. K.Ishihara, Y.Iwasaki, C.Nojiri, "Phospholipid Polymer Biomaterials for Making Ventricular Assist Devices". J. Circulatory Support, 1(4), 265-270 (2001).

38. T.Yoneyama, K.Sugihara, K.Ishihara, Y.Iwasaki, N.Nakabayashi, "The Vascular Prosthesis without Pseudointima Prepared by Antithrombogenic Phospholipid Polymer", Biomaterials, 23, 1455-1459 (2002).

39. Y.Iwasaki, N.Shibata, M.Ninomiya, K.Kurita, N.Nakabayashi, and K.Ishihara, "Importance of a biofouling resistant phospholipid polymer to create a heparinized blood compatible surface". J. Biomater. Sci., Polymer Edn, 13(3), 323-336 (2002).

40. T.Hasegawa, Y.Iwasaki, and K.Ishihara, "Preparation of blood compatible hollow fibers from a polymer alloy composed of polysulfone and 2-mrthacryloyloxyethyl phosphorylcholine polymer". J. Biomed. Mater. Res., Applied Biomater., 63, 333-341 (2002).

41. Y.Iwasaki, S.Uchiyama, K.Kurita, N.Morimoto, and N.Nakabayashi, "A nonthrombogenic gas-permeable membrane composed of a phospholipid polymer skin film adhered to a polyethylene porous membrane". Biomaterials, 23, 3421-3427 (2002).

42. Y.Iwasaki, S.Sawada, K.Ishihara, G.Khang, and H.Lee, "Reduction of surface-induced inflamatory reaction on PLGA/MPC polymer blend". Biomaterials, 23, 3897-3903 (2002).

43. R.Ogawa, Y.Iwasaki, K.Ishihara, "Thermal property and processability of elastic polymer alloy composed of segmented polyurethane and phospholipid polymer", J. Biomed. Mater. Res., 62, 214-221 (2002).

44. K.Ishihara, R.Tsujino, M.Hamada, N.Toyoda, and Y.Iwasaki, "Stabilized liposomes with phospholipid polymers and their interaction with blood cells". Colloids and Suraces B: Biointerfaces, 25, 325-333 (2002).

45. N.Morimoto, I.Sato, A.Watanabe, N.Nakabayashi, Y.Iwasaki, and K.Ishihara, "Coating stability and blood compatibility of stainless steel surface modified with phospholipid polymer". Kobunshi Ronbunshu, 59(7), 432-437 (2002).

46. N.Morimoto, Y.Iwasaki, N.Nakabayashi, and K.Ishihara, "Phisical properties and blood compatibility of surface modified segmented polyurethane by semi-interpenetrating polymer networks with a phospholipid polymer". Biomaterals, 23, 4881-4887 (2002).

47. M.Piemjai, K.Miyasaka, Y.Iwasaki, and N.Nakabayashi, "Comparison of microleakage of three acid-base luting cements versus one resin-bonded cement for Class V direct composite inlays". J. Prosthet. Dent., 88, 598-603 (2002).

48. S. Ye, J. Watanabe, Y.Iwasaki, and K.Ishihara, "Novel cellulose acetate membrane blended with phospholipid polymer for hemocompatible filtration system". J. Membrane Sci., 210, 411-421 (2002).

49. K.Ishihara, T.Hasegawa, J.Watanabe, and Y.Iwasaki, "Protein adsorption resistible hollow fiber membranes for blood purification". Artif. Organs, 26(12), 1014-1019 (2002).

50. E.Keh, I.Hayakawa, H.Takahashi, A.Watanabe, Y.Iwasaki, K.Akiyoshi and N.Nakabayashi, Improving a Self-curing Dental Resin by Eliminating Oxygen, Hydroquinone and Water from its Curing Process". Dent. Mater. J., 21(4), 373-382 (2002).

51. Y.Iwasaki, K.Shimakata, N.Morimoto, and K.Kurita, Hydrogel-like elastic membrane consisting of semi-interpenetrating polymer networks based on a phospholipid polymer and segmented polyurethane". J. Polym. Sci. Part A: Polym. Chem., 41, 68-75 (2003).

52. Yamasaki, Y.Imamura, K.Kurita, Y.Iwasaki, N.Nakabayashi, and K.Ishihara, The surface mobility of polymers having phosphorylcholine groups connected with various bridging units and their protein adsorption-resistance properties". Colloids and Suraces B: Biointerfaces, 28, 53-62 (2003).

53. S.Sawada, S.Sakaki, Y.Iwasaki, N.Nakabayashi, and K.Ishihara, "Suppression of inflammatory response from adherent cells on phospholipid polymers". J. Biomed. Mater. Res., 64A, 411-416 (2003).

54. Y.Iwasaki, Y.Tojo, and T.Kurosaki, "Synthesis and characterization of PLLA-based biodegradable polymer having a phospholipid polar group". J. Biomed. Mater. Res., 65A, 164-169 (2003).

55. M.Piemjai, Y.Iwasaki, N.Nakabayashi, "Influence of dentinal polyelectrolytes on dry and wet bonding to conditioned dentin". J. Biomed. Mater. Res., 66A, 789-794 (2003).

56. Y.Iwasaki, S.Komatsu, T.Narita, K.Ishihara, and K.Akiyoshi, Biodegradable phosphorylcholine-hydrogel consist of polyphosphate cross-linking reagents". Macromol. Biosci., 3, 238-242 (2003).

57. T.Ito, Y.Iwasaki, T.Narita, K.Akiyoshi, and K.Ishihara, "Controlled adhesion of human lymphocytes on electrically charged polymer surface having phosphorylcholine moiety". Sci. Tech. Adv. Mater., 4(2), 99-104 (2003).

58. Y.Iwasaki, A.Yamasaki, and K.Ishihara, "Improvement of platelet compatibility of blood filtration devices with a phospholipid polymer having high surface mobility". Biomaterials, 24, 3599-3604 (2003).

59. Y.Iwasaki, N.Nakabayashi, K.Ishihara, "Nonthrombogenic hemodialyzer with MPC copolymer". Advances in Science and Technology (Faenza, Italy), 41(Materials in Clinical Applications VI),161-170 (2003).

60. S.Ye, J.Watanabe, Y.Iwasaki, and K.Ishihara, "Antifouling Blood Purification Membrane Composed of Cellulose Acetate and Phospholipid Polymer". Biomaterials, 24(23), 4143-4152 (2003).

61. Y.Iwasaki, N.Saito, "Chemically adsorption of phosphorylcholine polymers to Ti-supported vinyldimethylsilyl monolayers and reduction of albumin adsorption". Colloids and Suraces B: Biointerfaces, 32, 77-84 (2003).

62. S.P.Ho, N.Nakabayashi, Y.Iwasaki, T.Boland, and M.LaBerge, "Nanofrictional properties of poly(MPC-co-BMA) phospholipid polymer for biomaterials application". Biomaterials, 24, 5121-5129 (2003).

63. Y.Iwasaki, N.Nakabayashi, and K.Ishihara, "In vitro and ex vivo blood compatibility study of 2-methacryloyoxyethyl phosphorylcholine (MPC) polymer-coated hollow fibers". J. Artif. Organs, 6, 260-266 (2003).

64. K.Ishihara, D.Nishiuchi, J.Watanabe, and Y.Iwasaki, Polymer alloy composed polyethylene and phospholipids polymer as green biomaterials". Biomaterials, 25,1115-1122 (2004).

65. W.Iramaneerat, F.Seki, A.Watanabe, H.Mukohyama, Y.Iwasaki, K.Akiyoshi, H.Taniguchi, "Innovative gas injection technique for closed hollow obturator". Int. J. Prothdont., in press (2004).

66. Y.Iwasaki, T.Toida, and N.Nakabayashi, "Improved wet-bonding of MMA-TBB resin to dentin etched by 10% phosphoric acid in the presence of ferric ions". J. Biomed. Mater. Res., in press (2004).

67. N.Morimoto, A.Watanabe, Y.Iwasaki, K.Akiyoshi, and K.Ishihara, "Nano-scale surface modification of a segmented polyurethane with a biocompatible phospholipid polymer". Biomaterials, in press (2004).

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