JAPANESE

RESEARCH

1. Bio-functionalization of metals with electrochemical surface modification

Bio-functionalization of metals is investigated with surface treatment techniques such as molecule immobilization and anodic oxidation. These surface treatments make it possible to inhibit protein adsorption, platelet adhesion and biofilm formation, and to enhance wear resistance and hard-tissue compatibility.

Biofunctionalization of metal surface by immobilization of Poly(ethylene glycol)
Biofunctionalization of metal surface by immobilization of Poly(ethylene glycol)
Improvement of bioactivity of bioinert metallic materials by anodic oxidation technique
Improvement of bioactivity of bioinert metallic
materials by anodic oxidation technique

2. Development of novel alloys and porous composites for biomedical applications

Novel alloy systems for biomedical applications are designed from the viewpoints of mechanical properties and biocompatibility. Co-Cr-Mo alloys having high strength and ductility for dental applications are developed. The porous alloys having low Young’s modulus are obtained with selective laser melting technique.

Fabrication of novel metallic materials Fabrication of novel metallic materials
Fabrication of novel metallic materials
Test specimens with porous structure fabricated by additive manufacturing technique
Test specimens with porous structure fabricated by additive manufacturing technique

3. Development of Zr-based alloys for minimizing MRI artifacts

Zr-based alloys with low magnetic susceptibility, high strength and corrosion resistance are investigated for minimizing MRI artifacts by controlling their microstructure and constituent phase for aneurysm clips, artificial joints, and dental implants, etc.

cerebral aneurysm clip
cerebral aneurysm clip
orthodontic appliances
orthodontic appliances
Magnetic susceptibility of common metallic biomaterials and Zr alloys
Magnetic susceptibility of common metallic biomaterials and Zr alloys

4. Effort to minimalize metal allergy

Countermeasure techniques for metal ion release from metallic biomaterials which causes metal allergy are investigated. Novel reagents of patch testing for the detection of sensitization to metal ions are developed.

symptoms of metallic allergy symptoms of metallic allergy
symptoms of metallic allergy