top > Div. of Biomedical Materials > Dept. of Inorganic Biomaterials

  • Div. of Biomedical Materials
  • Div. of Biofunctional Restoration
  • Div. of Medical Devices
  • Div. of Biomolecular Chemistry
  • Medical and Dental Device Technology Incubation Center
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Member

K. Yamashita Prof
M. Nakamura Assoc Prof
N. Horiuchi Assist Prof

Research Theme

  1. Development of Electrovector ceramics
    Some ceramics, such as a hydroxyapatite, are able to be ionically polarized by thermoelectrical treatments. Consequently, the polarized ceramics have large and time-durable induced electrostatic charges on their surfaces. The effects of the induced charges profoundly dominate the proximate few millimeter regions. We named the effects “Electrovector effects” and develop “Electrovector ceramics” defined as ceramics emiting the Electrovector Effects.
  2. Control of electrical space on Electrovector ceramic
    To apply Electrovector ceramics to medical devises, electrical space on Electrovector ceramics should be suitably controlled under the poling process. We are evaluating the poling mechanisms of some bio-ceramics, based on the various disciplines. In particular, we are putting emphasis on the relationship between the origin of electrical space and the crystal structure on the surface of the polarized bio-ceramics. The crystal defect, crystal distortion and fine change of ion composition of Electrovector ceramics polarized under various conditions are systematically investigated.
  3. Manipulation of biological responses by Electrovector ceramics
    The electrostatic energies of the Electrovector effects aforementioned dominate the limited proximate areas and can control reactions locally. Therefore, the Electrovector ceramics can manipulate biological responses in a target space by both of the surface character and the electrostatic energies of the Electrovector ceramics at ion and tissue levels. We have demonstrated that the Electrovector ceramics enhanced protein adsorption, proliferation, adhesion, and differentiation of cultured cells on the ceramics as well as osteoconductivities in vivo by molecular biological and immunological detections.
  4. Development of applicatable devices by ceramic technologies
    We apply the Electrovector ceramics aforementioned to implant systems, such as artificial bones, bone joints, tooth roots, and are developing implantable devices with autograft-like osteoconductivities. We are undergoing improvements of sol-gel method for hydroxyapatite thin film coating and materials for vascular regeneration. We are extending our researches based on ceramic technologies farther, such as a control of oral environment, an improvement of oral esthetics, more effective and precise diagnosis systems for clinical laboratory medicine.

Publications

  1. Nakamura S, Shinohara K, Kieda N, Yamashita K. Polarization Energy Effect of Electrovector Hydroxyapatite on Bonelike Crystal Growth in SBF. Key Eng Mat 309-311: 145-148, 2006.
  2. Itoh S, Nakamura S, Kobayashi T, Shinomiya K, Yamashita K. The Effects of Electrically Polarized Hydroxyapatite on Osteogenic Cell Activity and Bone Formation. Key Eng Mat 309-311: 153-156, 2006.
  3. Kobayashi T, Nakamura S, Yamashita K. Optimum Conditions for Superosteoconductivity of Polarized Hydroxyapatite Ceramics. Key Eng Mat 309-311: 157-160, 2006.
  4. Amaoka E, Vedel E, Nakamura S, Moriyoshi Y, Salonen J, Yamashita K. Effect of Electrical Polarization on the behavior of Bioactive Glass Containing MgO and B2O3 in SBF. Key Eng Mat 309-311: 333-336, 2006.
  5. Sasaki T, Kobayashi M, Nakamura S, Yamashita K. Electrovector Effect of Polarized and Chemically Treated Na2O-CaO-P2O5-SiO2-Al2O3 Bioglasses. Key Eng Mat 309-311: 337-340, 2006.
  6. Kishi S, Okimoto N, Nakamura S, Nishio K, Hashimoto K, Toda Y, Yamashita K. Chemicovector Effect of Nano-Size-Hydroxyapatite Doped YSZ Ceramics on Apatite Formability in SBF. Key Eng Mat 309-311: 589-592, 2006.
  7. Ikeda C, Ueki M, Nakamura S, Kobayashi T, Yamashita K. Electrovector Effect of Polarized Porous Hydroxyapatite Ceramics. Key Eng Mat 309-311: 1043-1046, 2006.
  8. Nakamura M, Sekijima Y, Nakamura S, Niwa K, Kobayashi T, Yamashita K. Immediate Mechanism of the Osteoconductivity of the Polarized Hydroxyapatite. Key Eng. Mat. 309-311: 1413-1416, 2006.
  9. Nakamura S, Konno M, Katayama K, Yamashita K. Chemico-Vector and Mechanochemico-Vector Properties of Polarized Glass-Ceramic Silicophosphate of Narpsio. J Ceram Soc Jpn 114 (1): 67-71, 2006.
  10. Okura T., Monma H., Yamashita K. Superionic Conducting Na5SmSi4O12-type Glass-ceramics: Crystallization, Conduction and Ionic Conductivity. J Euro Ceram Soc 26 (4-5): 619-622, 2006.
  11. Itoh S, Nakamura S, Kobayashi T, Shinomiya K, Yamashita K. Effect of Electrical Polarization of Hydroxyapatite Ceraimcs on New Bone Formation. Calcified Tissue Int 78 (3): 133-142, 2006.
  12. Itoh S, Nakamura S, Kobayashi T, Shinomiya K, Yamashita K. Effect of Electrical Polarization of Hydroxyapatite Ceramics on New Bone Formation. Calcif Tissue Int 78: 133-142, 2006.
  13. Itoh S, Nakamura S, Nakamura M, Shinomiya K, Yamashita K. Enhanced Bone ingrowth into hydroxyapatite with interconnected pores by Electrical Polarization. Biomaterials 27: 5572-5579, 2006.
  14. Nakamura M, Nakamura S, Sekijima Y, Niwa K, Kobayashi T, Yamashita K. Role of Blood Coagulation Components as Intermediators of High Osteoconductivity of Electrically Polarized Hydroxyapatite J Biomed Mater Res A 79(3): 627-634 2006
  15. Nakamura M, Niwa K, Nakamura S, Sekijima Y, Yamashita K. Interaction of A Blood Coagulation Factor on Electrically Polarized Hydroxyapatite Surfaces. J Biomed Mater Res B, in press
  16. Itoh S, Nakamura S, Nakamura M, Shinomiya K, Yamashita K. Enhanced Bone Regeneration by Electrical Polarization of Hydroxyapatite. Artif Organs, 30 (11): 863-869, 2006.
  17. Kobayashi T, Itoh S, Nakamura S, Nakamura M, Shinomiya K, Yamashita K. Enhanced Bone Bonding of Hydroxyapatite-coated Titanium Implants by Electrical Polarization. J. Biomed Mater Res, in press, 2006

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