最近の業績

1. Zhou H, Mori S, Kou I, Fuku N, Naka Mieno M, Honma N, Arai T, Sawabe M, Tanaka M, Ikegawa S, Ito H. Association of the formiminotransferase N-terminal sub-domain containing gene and thrombospondin, type 1, domain-containing 7A gene with the prevalence of vertebral fracture in 2427 consecutive autopsy cases. J Hum　Genet. 2013;58:109-112
2. Tanisawa K, Mikami E, Fuku N, Honda Y, Honda S, Ohsawa I, Ito M, Endo S, Ihara K, Ohno K, Kishimoto Y, Ishigami A, Maruyama N, Sawabe M, Iseki H, Okazaki Y, Hasegawa-Ishii S, Takei S, Shimada A, Hosokawa M, Mori M, Higuchi K, Takeda T, Higuchi M, Tanaka M. Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes. BMC Genomics. 2013;14:248
3. Honma N, Mori S, Zhou H, Ikeda S, Mieno MN, Tanaka N, Takubo K, Arai T, Sawabe M, Muramatsu M, Ito H. Association between estrogen receptor-beta dinucleotide repeat polymorphism and incidence of femoral fracture. J Bone Miner Metab. 2013;31:96-101
4. Funabe S, Takao M, Saito Y, Hatsuta H, Sugiyama M, Ito S, Kanemaru K, Sawabe M, Arai T, Mochizuki H, Hattori N, Murayama S. Neuropathologic analysis of Lewy-related alpha-synucleinopathy in olfactory mucosa. Neuropathology. 2013;33:47-58
5. Tanei R, Hasegawa Y, Sawabe M. Abundant immunoglobulin E-positive cells in skin lesions support an allergic etiology of atopic dermatitis in the elderly. J Eur Acad Dermatol Venereol. 2012; DOI: 10.1111/j.1468-3083.2012.04612.x
6. Ko MK, Ikeda S, Mieno-Naka M, Arai T, Zaidi SA, Sato N, Muramatsu M, Sawabe M. Association of COMT gene polymorphisms with systemic atherosclerosis in elderly Japanese. J Atheroscl Thromb. 2012;19:552-558
7. Ishikawa N, Nakamura K, Izumiyama N, Aida J, Sawabe M, Arai T, Kishimoto H, Fujiwara M, Ishii A, Takubo K. Telomere length dynamics in the human pituitary gland: Robust preservation throughout adult life to centenarian age. Age. 2012;34:795-804
8. Ishii T, Hagiwara K, Ikeda S, Arai T, Mieno MN, Kumasaka T, Muramatsu M, Sawabe M, Gemma A, Kida K. Association between genetic variations in surfactant protein D and emphysema, interstitial pneumonia, and lung cancer in a Japanese population. COPD. 2012;9:409-416
9. Aida J, Kobayashi T, Saku T, Yamaguchi M, Shimomura N, Nakamura K, Ishikawa N, Maruyama S, Cheng J, Poon SS, Sawabe M, Arai T, Takubo K. Short telomeres in an oral precancerous lesion: Q-FISH analysis of leukoplakia. J Oral Pathol Med. 2012;41:372-378
10. Sawabe M, Tanaka N, Mieno MN, Ishikawa S, Kayaba K, Nakahara K, Matsushita S. Low lipoprotein(a) concentration is associated with cancer and all-cause deaths: A population-based cohort study (The JMS cohort study). PLoS One. 2012;7(4):e31954.
11. Ishii T, Hagiwara K, Kamio K, Ikeda S, Arai T, Mieno MN, Kumasaka T, Muramatsu M, Sawabe M, Gemma A, Kida K. Involvement of surfactant protein D in emphysema revealed by genetic association study. Eur J Hum Genet. 2012;20(2):230-235.
12. Ikeda S, Tanaka N, Arai T, Chida K, Muramatsu M, Sawabe M. Polymorphisms of LTA, LGALS2, and PSMA6 genes and coronary atherosclerosis: A pathological study of 1503 consecutive autopsy cases. Atherosclerosis. 2012;221(2):458-460.
13. Yamada Y, Nishida T, Ichihara S, Sawabe M, Fuku N, Nishigaki Y, Aoyagi Y, Tanaka M, Fujiwara Y, Yoshida H, Shinkai S, Satoh K, Kato K, Fujimaki T, Yokoi K, Oguri M, Yoshida T, Watanabe S, Nozawa Y, Hasegawa A, Kojima T, Han BG, Ahn Y, Lee M, Shin DJ, Lee JH, Jang Y. Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations. Atherosclerosis. 2011;215(1):145-152.
14. Yamada M, Ishii T, Ikeda S, Naka-Mieno M, Tanaka N, Arai T, Kumasaka T, Gemma A, Kida K, Muramatsu M, Sawabe M. Association of fucosyltransferase 8 (FUT8) polymorphism Thr267Lys with pulmonary emphysema. J Hum Genet. 2011;56(12):857-860.
15. Suzuki M, Liu M, Kurosaki T, Arai T, Sawabe M, Kasuya Y, Kato M, Fujimura T, Fukuhara H, Enomoto Y, Nishimatsu H, Ishikawa A, Kume H, Homma Y, Kitamura T. Association of rs6983561 Polymorphism at 8q24 With Prostate Cancer Mortality in a Japanese Population. Clin Genitourin Cancer. 2011;9:46-52.
16. Sawabe M, Tanaka M, Chida K, Arai T, Nishigaki Y, Fuku N, Mieno MN, Kuchiba A, Tanaka N. Mitochondrial haplogroups A and M7a confer a genetic risk for coronary atherosclerosis in the Japanese elderly: an autopsy study of 1,536 patients. J Atheroscler Thromb. 2011;18(2):166-175.
17. Sawabe M, Hamamatsu A, Chida K, Mieno MN, Ozawa T. Age is a major pathobiological determinant of aortic dilatation: a large autopsy study of community deaths. J Atheroscler Thromb. 2011;18(2):157-165.
18. Otani T, Ikeda S, Lwin H, Arai T, Muramatsu M, Sawabe M. Polymorphisms of the formylpeptide receptor gene (FPR1) and susceptibility to stomach cancer in 1531 consecutive autopsy cases. Biochem Biophys Res Commun. 2011;405(3):356-361.
19. Liu M, Suzuki M, Arai T, Sawabe M, Enomoto Y, Nishimatsu H, Kume H, Homma Y, Kitamura T. A replication study examining three common single-nucleotide polymorphisms and the risk of prostate cancer in a Japanese population. Prostate. 2011;71(10):1023-1032.
20. Ishikawa N, Nakamura KI, Izumiyama N, Aida J, Sawabe M, Arai T, Kishimoto H, Fujiwara M, Ishii A, Takubo K. Telomere length dynamics in the human pituitary gland: robust preservation throughout adult life to centenarian age. Age (Dordr). 2011.
21. Honma N, Arai T, Takubo K, Younes M, Tanaka N, Mieno MN, Tamura K, Ikeda S, Sawabe M, Muramatsu M. Oestrogen receptor-beta CA repeat polymorphism is associated with incidence of colorectal cancer among females. Histopathology. 2011;59(2):216-224.
22. Fukui N, Ikeda Y, Tanaka N, Wake M, Yamaguchi T, Mitomi H, Ishida S, Furukawa H, Hamada Y, Miyamoto Y, Sawabe M, Tashiro T, Katsuragawa Y, Tohma S. alphavbeta5 integrin promotes dedifferentiation of monolayer-cultured articular chondrocytes. Arthritis Rheum. 2011;63(7):1938-1949.
23. Arai T, Sakurai U, Sawabe M, Honma N, Aida J, Takubo K. [Pathologic characteristics of malignant neoplasms occurring in the elderly]. Gan To Kagaku Ryoho. 2011;38(10):1571-1576.
24. Amatya BM, Sawabe M, Arai T, Kumakawa T, Takubo K, Kimula Y, Koike M. Splenic undifferentiated high grade pleomorphic sarcoma (pleomorphic malignant fibrous histiocytoma) of a small size with fatal tumor rupture. J Pathol Nepal. 2011;1(2):151-153.
25. Aida J, Yokoyama A, Izumiyama N, Nakamura K, Ishikawa N, Poon SS, Fujiwara M, Sawabe M, Matsuura M, Arai T, Takubo K. Alcoholics show reduced telomere length in the oesophagus. J Pathol. 2011;223(3):410-416.
26. Aida J, Vieth M, Ell C, May A, Pech O, Hoshihara Y, Kumagai Y, Kawada K, Hishima T, Tateishi Y, Sawabe M, Arai T, Matsuura M, Takubo K. Palisade Vessels as a New Histologic Marker of Esophageal Origin in ER Specimens From Columnar-Lined Esophagus. Am J Surg Pathol. 2011;35(8):1140-1145.
27. Aida J, Kobayashi T, Saku T, Yamaguchi M, Shimomura N, Nakamura KI, Ishikawa N, Maruyama S, Cheng J, Poon SS, Sawabe M, Arai T, Takubo K. Short telomeres in an oral precancerous lesion: Q-FISH analysis of leukoplakia. J Oral Pathol Med. 2011;41(5):372-378.
28. Takubo K, Fujita M, Izumiyama N, Nakamura K, Ishikawa N, Poon SS, Fujiwara M, Sawabe M, Matsuura M, Grabsch H, Arai T, Aida J. Q-FISH analysis of telomere and chromosome instability in the oesophagus with and without squamous cell carcinoma in situ. J Pathol. 2010;221(2):201-209.
29. Takubo K, Aida J, Izumiyama-Shimomura N, Ishikawa N, Sawabe M, Kurabayashi R, Shiraishi H, Arai T, Nakamura K. Changes of telomere length with aging. Geriatr Gerontol Int. 2010;10 Suppl 1:S197-206.
30. Takubo K, Aida J, Izumiyama N, Ishikawa N, Fujiwara M, Poon SS, Kondo H, Kammori M, Matsuura M, Sawabe M, Arai T, Baird DM, Nakamura K. Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence. Mech Ageing Dev. 2010;131(10):614-624.
31. Takahashi M, Kimura Y, Sawabe M, Kitamura K. Modified paraffin-embedding method for the human cochlea that reveals a fine morphology and excellent immunostaining results. Acta Otolaryngol. 2010;130(7):788-792.
32. Smith TJ, Yamamoto K, Kurata M, Yukimori A, Suzuki S, Umeda S, Sugawara E, Kojima Y, Sawabe M, Nakagawa Y, Suzuki K, Crawley JT, Kitagawa M. Differential expression of Toll-like receptors in follicular lymphoma, diffuse large B-cell lymphoma and peripheral T-cell lymphoma. Exp Mol Pathol. 2010;89(3):284-290.
33. Sawabe M. Vascular aging: from molecular mechanism to clinical significance. Geriatr Gerontol Int. 2010;10 Suppl 1:S213-220.
34. Ogiwara Y, Mori S, Iwama M, Sawabe M, Takemoto M, Kanazawa N, Furuta K, Fukuda I, Kondo Y, Kimbara Y, Tamura Y, Chiba Y, Araki A, Yokote K, Maruyama N, Ito H. Hypoglycemia due to ectopic secretion of insulin-like growth factor-I in a patient with an isolated sarcoidosis of the spleen. Endocr J. 2010;57(4):325-330.
35. Katsuragawa Y, Saitoh K, Tanaka N, Wake M, Ikeda Y, Furukawa H, Tohma S, Sawabe M, Ishiyama M, Yagishita S, Suzuki R, Mitomi H, Fukui N. Changes of human menisci in osteoarthritic knee joints. Osteoarthritis Cartilage. 2010;18(9):1133-1143.
36. Fujimoto K, Ikeda S, Arai T, Tanaka N, Kumasaka T, Ishii T, Kida K, Muramatsu M, Sawabe M. Polymorphism of SERPINE2 gene is associated with pulmonary emphysema in consecutive autopsy cases. BMC Med Genet. 2010;11:159.
37. Arai T, Kasahara I, Sawabe M, Honma N, Aida J, Tabubo K. Role of methylation of the hMLH1 gene promoter in the development of gastric and colorectal carcinoma in the elderly. Geriatr Gerontol Int. 2010;10 Suppl 1:S207-212.
38. Akieda-Asai S, Zaima N, Ikegami K, Kahyo T, Yao I, Hatanaka T, Iemura S, Sugiyama R, Yokozeki T, Eishi Y, Koike M, Ikeda K, Chiba T, Yamaza H, Shimokawa I, Song SY, Matsuno A, Mizutani A, Sawabe M, Chao MV, Tanaka M, Kanaho Y, Natsume T, Sugimura H, Date Y, McBurney MW, Guarente L, Setou M. SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals. PLoS One. 2010;5(7):e11755.
39. Aida J, Izumo T, Shimomura N, Nakamura K, Ishikawa N, Matsuura M, Poon SS, Fujiwara M, Sawabe M, Arai T, Takubo K. Telomere lengths in the oral epithelia with and without carcinoma. Eur J Cancer. 2010;46(2):430-438.
40. Adachi T, Saito Y, Hatsuta H, Funabe S, Tokumaru AM, Ishii K, Arai T, Sawabe M, Kanemaru K, Miyashita A, Kuwano R, Nakashima K, Murayama S. Neuropathological asymmetry in argyrophilic grain disease. J Neuropathol Exp Neurol. 2010;69(7):737-744.
41. Yamada Y, Fuku N, Tanaka M, Aoyagi Y, Sawabe M, Metoki N, Yoshida H, Satoh K, Kato K, Watanabe S, Nozawa Y, Hasegawa A, Kojima T. Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study. Atherosclerosis. 2009;207(1):144-149.
42. Tsuda Y, Noguchi T, Mochizuki H, Makino F, Nanjo Y, Sawabe M, Takahashi H. Patients with mild-to-moderate asthma may develop clinically significant chronic obstructive pulmonary disease. Respirology. 2009;14(4):529-536.
43. Takubo K, Vieth M, Aida J, Sawabe M, Kumagai Y, Hoshihara Y, Arai T. Differences in the definitions used for esophageal and gastric diseases in different countries: endoscopic definition of the esophagogastric junction, the precursor of Barrett's adenocarcinoma, the definition of Barrett's esophagus, and histologic criteria for mucosal adenocarcinoma or high-grade dysplasia. Digestion. 2009;80(4):248-257.
44. Takubo K, Aida J, Naomoto Y, Sawabe M, Arai T, Shiraishi H, Matsuura M, Ell C, May A, Pech O, Stolte M, Vieth M. Cardiac rather than intestinal-type background in endoscopic resection specimens of minute Barrett adenocarcinoma. Hum Pathol. 2009;40(1):65-74.
45. Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SE, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, Terry DF, Riva A, Anselmi CV, Malovini A, Kitamoto A, Sawabe M, Arai T, Gondo Y, Steinberg MH, Hirose N, Atzmon G, Ruvkun G, Baldwin CT, Perls TT. RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. PLoS One. 2009;4(12):e8210.
46. Sawabe M, Tanaka N, Nakahara K, Hamamatsu A, Chida K, Arai T, Harada K, Inamatsu T, Ozawa T, Naka MM, Matsushita S. High lipoprotein(a) level promotes both coronary atherosclerosis and myocardial infarction: a path analysis using a large number of autopsy cases. Heart. 2009;95(24):1997-2002.
47. Sawabe M, Arai T, Araki A, Hosoi T, Kuchiba A, Tanaka N, Naito T, Oda K, Ikeda S, Muramatsu M. Smoking confers a MTHFR 677C>T genotype-dependent risk for systemic atherosclerosis: results from a large number of elderly autopsy cases that died in a community-based general geriatric hospital. J Atheroscler Thromb. 2009;16(2):91-104.
48. Liu M, Kurosaki T, Suzuki M, Enomoto Y, Nishimatsu H, Arai T, Sawabe M, Hosoi T, Homma Y, Kitamura T. Significance of common variants on human chromosome 8q24 in relation to the risk of prostate cancer in native Japanese men. BMC Genet. 2009;10:37.
49. Kurosaki T, Suzuki M, Enomoto Y, Arai T, Sawabe M, Hosoi T, Homma Y, Kitamura T. Polymorphism of cytochrome P450 2B6 and prostate cancer risk: a significant association in a Japanese population. Int J Urol. 2009;16(4):364-368.
50. Konstantinou K, Yamamoto K, Ishibashi F, Mizoguchi Y, Kurata M, Nakagawa Y, Suzuki K, Sawabe M, Ohta M, Miyakoshi S, Crawley JT, Kitagawa M. Angiogenic mediators of the angiopoietin system are highly expressed by CD10-positive lymphoma cells in angioimmunoblastic T-cell lymphoma. Br J Haematol. 2009;144(5):696-704.
51. Kato T, Kimura Y, Sawabe M, Masuda Y, Kitamura K. Cervical tuberculous lymphadenitis in the elderly: comparative diagnostic findings. J Laryngol Otol. 2009;123(12):1343-1347.
52. Hoshikawa M, Mochizuki H, Saito M, Noguchi T, Sawabe M, Takahashi H. Contralateral cervicomediastinal lymph node metastases from clinically occult adenocarcinoma of the lung. Clin Lung Cancer. 2009;10(4):249-251.
53. Honma N, Takubo K, Sawabe M, Arai T, Akiyama F, Sakamoto G, Utsumi T, Yoshimura N, Harada N. Alternative use of multiple exons 1 of aromatase gene in cancerous and normal breast tissues from women over the age of 80 years. Breast Cancer Res. 2009;11(4):R48.
54. Hinohara K, Ohtani H, Nakajima T, Sasaoka T, Sawabe M, Lee BS, Ban J, Park JE, Izumi T, Kimura A. Validation of eight genetic risk factors in East Asian populations replicated the association of BRAP with coronary artery disease. J Hum Genet. 2009;54(11):642-646.
55. Hinohara K, Nakajima T, Yasunami M, Houda S, Sasaoka T, Yamamoto K, Lee BS, Shibata H, Tanaka-Takahashi Y, Takahashi M, Arimura T, Sato A, Naruse T, Ban J, Inoko H, Yamada Y, Sawabe M, Park JE, Izumi T, Kimura A. Megakaryoblastic leukemia factor-1 gene in the susceptibility to coronary artery disease. Hum Genet. 2009;126(4):539-547.
56. Hinohara K, Nakajima T, Sasaoka T, Sawabe M, Lee BS, Ban JM, Park JE, Izumi T, Kimura A. Validation of the association between AGTRL1 polymorphism and coronary artery disease in the Japanese and Korean populations. J Hum Genet. 2009;54(9):554-556.
57. Hinohara K, Nakajima T, Sasaoka T, Sawabe M, Lee BS, Ban J, Park JE, Izumi T, Kimura A. Replication studies for the association of PSMA6 polymorphism with coronary artery disease in East Asian populations. J Hum Genet. 2009;54(4):248-251.
58. Fukuda M, Kanou F, Shimada N, Sawabe M, Saito Y, Murayama S, Hashimoto M, Maruyama N, Ishigami A. Elevated levels of 4-hydroxynonenal-histidine Michael adduct in the hippocampi of patients with Alzheimer's disease. Biomed Res. 2009;30(4):227-233.
59. Tamura Y, Adachi J, Chiba Y, Mori S, Takeda K, Kasuya Y, Murayama T, Sawabe M, Sasano H, Araki A, Ito H, Horiuchi T. Primary aldosteronism due to unilateral adrenal microadenoma in an elderly patient: efficacy of selective adrenal venous sampling. Intern Med. 2008;47(1):37-42.
60. Takubo K, Aida J, Sawabe M, Arai T, Kato H, Pech O, Arima M. The normal anatomy around the oesophagogastric junction: a histopathologic view and its correlation with endoscopy. Best Pract Res Clin Gastroenterol. 2008;22(4):569-583.
61. Takei K, Ikeda S, Arai T, Tanaka N, Muramatsu M, Sawabe M. Lymphotoxin-alpha polymorphisms and presence of cancer in 1,536 consecutive autopsy cases. BMC Cancer. 2008;8:235.
62. Sengoku R, Saito Y, Ikemura M, Hatsuta H, Sakiyama Y, Kanemaru K, Arai T, Sawabe M, Tanaka N, Mochizuki H, Inoue K, Murayama S. Incidence and extent of Lewy body-related alpha-synucleinopathy in aging human olfactory bulb. J Neuropathol Exp Neurol. 2008;67(11):1072-1083.
63. Sawabe M, Hamamatsu A, Chida K, Arai T, Harada K, Ozawa T, Tanaka N. Elderly patients with minimal common carotid atherosclerosis not infrequently have severe coronary atherosclerosis and myocardial infarction. Circ J. 2008;72(12):1946-1952.
64. Ikemura M, Saito Y, Sengoku R, Sakiyama Y, Hatsuta H, Kanemaru K, Sawabe M, Arai T, Ito G, Iwatsubo T, Fukayama M, Murayama S. Lewy body pathology involves cutaneous nerves. J Neuropathol Exp Neurol. 2008;67(10):945-953.
65. Hinohara K, Nakajima T, Takahashi M, Hohda S, Sasaoka T, Nakahara K, Chida K, Sawabe M, Arimura T, Sato A, Lee BS, Ban JM, Yasunami M, Park JE, Izumi T, Kimura A. Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in Japanese and Korean populations. J Hum Genet. 2008;53(4):357-359.
66. Harihara S, Nakamura K, Fujiwara M, Arai T, Sawabe M, Takeuchi F, Takubo K. Markedly different clinical features in 2 diabetes mellitus patients with extremely high tissue levels of the mitochondrial DNA A3243G mutation. Gerontology. 2008;54(3):168-172.
67. Fukui N, Miyamoto Y, Nakajima M, Ikeda Y, Hikita A, Furukawa H, Mitomi H, Tanaka N, Katsuragawa Y, Yamamoto S, Sawabe M, Juji T, Mori T, Suzuki R, Ikegawa S. Zonal gene expression of chondrocytes in osteoarthritic cartilage. Arthritis Rheum. 2008;58(12):3843-3853.
68. Fukui N, Ikeda Y, Ohnuki T, Tanaka N, Hikita A, Mitomi H, Mori T, Juji T, Katsuragawa Y, Yamamoto S, Sawabe M, Yamane S, Suzuki R, Sandell LJ, Ochi T. Regional differences in chondrocyte metabolism in osteoarthritis: a detailed analysis by laser capture microdissection. Arthritis Rheum. 2008;58(1):154-163.
69. Fujimoto K, Sawabe M, Sasaki M, Kino K, Arai T. Undiagnosed cirrhosis occurs frequently in the elderly and requires periodic follow ups and medical treatments. Geriatr Gerontol Int. 2008;8(3):198-203.
70. Arai T, Sawabe M, Hosoi T, Tanaka N. Role of DNA repair systems in malignant tumor development in the elderly. Geriatr Gerontol Int. 2008;8(2):65-72.
71. Aida J, Izumiyama-Shimomura N, Nakamura K, Ishikawa N, Poon SS, Kammori M, Sawabe M, Arai T, Matsuura M, Fujiwara M, Kishimoto H, Takubo K. Basal cells have longest telomeres measured by tissue Q-FISH method in lingual epithelium. Exp Gerontol. 2008;43(9):833-839.