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- Mutsuda Y., Miyakoshi T., Horiuchi Y.,
Kameda T., Tozuka M., and *Ohkawa R. Development and
validation of novel automatable assay for
cholesterol efflux capacity. Bioscience Reports. (in
Press).
- Ogino M., Kameda T., Mutsuda Y., Tanaka
H., Takahashi J., Okazaki M., Ai M., and *Ohkawa R.
Development of internal standard for lipoprotein
subclass analysis using dual detection
gel-permeation high-performance liquid
chromatography system. Biosience Reports.
42(6):BSR20220291, 2022. doi: 10.1042/BSR20220291.
- Horiuchi Y., Lai S.J., Kameda T.,
Tozuka M., and *Ohkawa R. Novel cholesterol efflux
assay using immobilized liposome-bound gel beads:
Confirmation and improvement for application in
clinical laboratory. Ann Clin Biochem.
59(2):134-143, 2022. DOI:
10.1177/00045632211054406.73.
- Kameda
T., Horiuchi Y., Shimano S., Yano K., Lai S.J., Ichimura N.,
Tohda S., Kurihara Y., Tozuka M., *Ohkawa, R. Effect of
myeloperoxidase oxidation and N-homocysteinylation of
high-density lipoprotein on endothelial repair function.
Biological Chemistry. 403(3):265-277, 2021. doi:
10.1515/hsz-2021-0247.
- Kobayashi, T., *Kurano, M., Nanya, M., Shimizu,
T., Ohkawa, R., Tozuka, M., and Yatomi, Y. Glycation of HDL
polymerizes Apolipoprotein M and attenuates its capacity to
bind to sphingosine 1-phosphate. Journal of Atherosclerosis
and Thrombosis. 28: 730-741, 2021. doi: 10.5551/jat.55699
-
Yamazaki, A., *Ohkawa, R., Yamagata, Y., Horiuchi, Y., Lai,
S.J., Kameda, T., Ichimura, N., Tohda, S. and Tozuka, M.
Apolipoprotein C-II and C-III preferably transfer to both
high-density lipoprotein (HDL)2 and the larger HDL3
from very low-density lipoprotein (VLDL). Biological
Chemistry. 402(4): 439-449, 2021. doi: 10.1515/hsz-2020-0288
- Shimano S., *Ohkawa, R., Nambu M., Sasaoka M.,
Yamazaki A., Fujii Y., Horiuchi Y., Lai S.J., Kameda T.,
Ichimura N., Fujita K., Tohda S. and Tozuka M. Marked changes
in serum amyloid A distribution and high-density lipoprotein
structure during acute inflammation. Biomed Res Int.
2021:9241259, 2021. doi: 10.1155/2021/9241259. eCollection
2021
- *Iwata, Y., Kitajima, S., Yamahana, J.,
Shimomura, S., Yoneda-Nakagawa, S., Sakai, N., Furuichi, K.,
Ogura, H., Sato, K., Toyama, T., Yamamura, Y., Miyagawa, T.,
Hara, A., Shimizu, M., Ohkawa, R., Kurano, M., Yatomi, Y., and
Wada, T. Higher serum levels of Autotaxin and
Phosphatidylserine-Specific Phospholipase A1 in the Patients
with Lupus Nephritis. International Journal of Rheumatic
Diseases. 24(2): 231-239, 2021. doi: 10.1111/1756-185X.14031
- *Ohkawa, R., Low, H., Mukhamedova, N., Fu, Y.,
Lai, S.J., Sasaoka, M., Hara, A., Yamazaki, A., Kameda, T.,
Horiuchi, Y., Meikle, J.P., Pernes, G., Lancaster, G.I.,
Ditiatkovski, M., Nestel, P., Vaisman, B.L., Sviridov, De.,
Murphy, A.J., Remaley, A.T., *Sviridov, Dm., and Tozuka, M.
Cholesterol transport between red blood cells and lipoproteins
contributes to cholesterol metabolism in blood. J. Lipid Res.
61(12): 1577-1588, 2020. doi:10.1194/jlr.RA120000635
- Low H., Mukhamedova N., Capettini L.D.S.A., Xia
Y., Carmichael I., Cody S.H., Huynh K., Ditiatkovski M.,
Ohkawa R., Bukrinsky M., Meikle P.J., Choi S.H, Field S.,
Miller Y.I., and *Sviridov D. Cholesterol Efflux-Independent
Modification of Lipid Rafts by AIBP (Apolipoprotein A-I
Binding Protein). Arterioscler Thromb Vasc Biol. 40(10):
2346-2359, 2020. doi: 10.1161/ATVBAHA.120.315037
- Horiuchi, Y., Lai S.J., Kameda, T., Tozuka, M., and
*Ohkawa, R. Comparison of a novel cholesterol efflux assay using
immobilized liposome-bound gel beads with the conventional method.
Bioscience Reports. 40 (8) BSR20201495, 2020.
- Mukhamedova, N., Hoang, A., Dragoljevic, D., Dubrovsky,
L., Pushkarsky, T., Low, H., Ditiatkovski, M., Fu, Y., Ohkawa R.,
Meikle, PJ., Horvath, A., Brichacek, B., Miller, YI., Murphy, A.,
Bukrinsky, M., and *Sviridov., D. Exosomes containing HIV protein Nef
reorganize lipid rafts potentiating inflammatory response in bystander
cells. PLOS Pathogens. 15(7):e1007907. doi:
10.1371/journal.ppat.1007907, 2019
- Lai SJ, *Ohkawa, R., Horiuchi Y., Kubota, T., and Tozuka
M. Red Blood Cells Participate in Reverse Cholesterol Transport by
Mediating Cholesterol Efflux of High-density lipoprotein and
Apolipoprotein A-I from THP-1 macrophages. Biological Chemistry.
400(12): 1593-1602, 2019.
- Sato M., *Ohkawa R., Low H., Nishimori M., Okubo S.,
Yoshimoto A., Yano K., Kameda T., Yatomi Y., and Tozuka M. Serum
amyloid A does not affect high-density lipoprotein cholesterol
measurement by a homogeneous assay. Clin Biochem. 63: 97-101, 2019
- Horiuchi Y., *Ohkawa, R., Lai S.J., Yamazaki A., Ikoma
H., Yano K., Kameda T., and Tozuka M. Characterization of the
cholesterol efflux of apolipoprotein E-containing high-density
lipoprotein in THP-1 cells. Biol Chem. 400(2): 209-218, 2019
- Horiuchi Y., *Ohkawa, R., Lai SJ, Shimano S, Hagihara M,
Tohda S, Kameda T, and Tozuka M. Usefulness of apolipoprotein
B-depleted serum in cholesterol efflux capacity assay using
immobilized liposome-bound gel beads Bioscience Reports. 39 (4)
BSR20190213; DOI:10.1042/BSR20190213, 2019
- Mishima Y., Kurano M., Kobayashi T., Nishikawa M., Ohkawa
R., Tozuka M., and *Yatomi Y. Dihydro-sphingosine 1-phosphate
interacts with carrier proteins in a manner distinct from that of
sphingosine 1-phosphate. Bioscience Reports. 38(5). pii: BSR20181288.
doi: 10.1042/BSR20181288, 2018
- Horiuchi Y, Lai SJ, Yamazaki A, Nakamura A, Ohkawa R,
Yano K, Kameda T, Okubo S, Shimano S, Hagihara M, Tohda S, *Tozuka M.
Validation and application of a novel cholesterol efflux assay using
immobilized liposomes as a substitute for cultured cells. Biosci Rep.
2018 Mar 15. pii: BSR20180144. doi: 10.1042/BSR20180144.
- Ohkawa R, Kurano M, Sakai N, Kishimoto T, Nojiri T,
Igarashi K, Hosogaya S, Ozaki Y, Dohi T, Miyauchi K, Daida H, Aoki J,
Okubo S, Ikeda H, Tozuka M, *Yatomi Y. Measurement of plasma choline
in acute coronary syndrome: importance of suitable sampling conditions
for this assay. Sci Rep. 2018 Mar 16;8(1):4725. doi:
10.1038/s41598-018-23009-x.
- Kareinen I, Baumann M, Nguyen SD, Maaninka K, Anisimov A,
Tozuka M, Jauhiainen M, Lee-Rueckert M, *Kovanen PT. Chymase released
from hypoxia-activated cardiac mast cells cleaves human
apolipoproteinA-I at Tyr192 and compromises its cardioprotective
activity. J Lipid Res. 2018 Mar 26. pii: jlr.M077503. doi:
10.1194/jlr.M077503.
- Suzuki L, Hirayama S, Fukui M, Sasaki M, Hiroi S, Ayaori
M, Terai S, Tozuka M, Watada H, *Miida T. Lipoprotein-X in cholestatic
patients causes xanthomas and promotes foam cell formation in human
macrophages. J Clin Lipidol, 11:110-118, 2017. doi:
10.1016/j.jacl.2016.10.013.
- Yano K, *Ohkawa R, Sato M, Yoshimoto A, Ichimura N,
Kameda T, Kubota T, Tozuka M. Cholesterol efflux capacity of
apolipoprotein A-I varies with the extent of differentiation and foam
cell formation of THP-1 cells. J Lipids 2016, 2016/9891316.
- Yoshimoto A, *Ohkawa R, Yano K, Sato M, Ichimura N, Usami
Y, Miyazaki A, Sugano M, Uehara T, Tozuka M. Paraoxonase 1 associated
with high-density lipoprotein transfers to oxidized low-density
lipoprotein depending on the degree of oxidation. Int J Anal Bio-Sci,
4: 99-109, 2016
- Sato M, *Ohkawa R, Yoshimoto A, Yano K, Ichimura N,
Nishimori M, Okubo S,. Yatomi Y, Tozuka M. Effects of serum amyloid A
on the structure and antioxidant ability of high-density lipoprotein.
Biosci Rep 2016. doi: 10.1042/BSR20160075.
- Nagura Y, *Tsuno NH, Kano K, Inoue A, Aoki J, Hirowatari
Y, Kaneko M, Kurano M, Matsuhashi M, Ohkawa R, Tozuka M, Yatomi Y,
Okazaki H. Regulation of the lysophosphatidylserine and sphingosine
1-phosphate levels in autologous whole blood by the pre-strage
leukocyte reduction. Transfus Med 2016, doi: 0.1111/tme.12326
- Ichimura N, Sato M, Yoshi moto A, Yano K, Ohkawa R,
Kasama Takeshi, *Tozuka M, High-density lipoprotein binds to
Mycobacterium avium and affects the infection of THP-1 macropage. J
Lipids 2016, doi.org/10.1155/2016/4353620
- Shukuya K, Ogura S, Tokuhara Y, Okubo S, Yatomi Y, Tozuka
M, *Shimosawa T. Novel round cells in urine sediment and their
clinical implication. Clin Chem Acta 457: 142-149, 2016. doi:
10.1016/j.cca2016.04.017
- Nanya M, Sato M, Tanimoto K, Tozuka M, Mizutani S,
*Takagi M. Dysregulation of the DNA damage response and KMT2A
rearrangement in fetal liver cells. PLOS ONE 2015,
doi:10.1371/journal.pone.0144540
- Kameda T, Ohkawa R, Yano K, Usami Y, Miyazaki A, Matsuda
K, Kawasaki K, Sugano M, Kubota T, *Tozuka M. Effects of
Myeloperoxidase-Induced Oxidation on Anti-Atherogenic Functions of
High-Density Lipoprotein. J Lipids 2015, doi.org/10.1155/2015/592594
- Ohkawa R,Kurano M,Mishima Y,Nojiri T,Tokuhara Y,Kishimoto
T,Nakamura K, Okubo S, Hosogaya S, Ozaki Y, Yokota H, Igarashi K,
Ikeda H, Tozuka M, *Yatomi Y. Possible involvement of sphingomyelin in
the regulation of the plasma sphingosine 1-phosphate level in human
subjects. Clin Biochem 48: 690-697, 2015. doi:
10.1016/j.clinbiochem.2015.03.019.
- Iino J, Osada M, Kurano M, Kaneko M, Ohkawa R, Satoh Y,
Okubo S, Ozaki Y, Tozuka M, Tsuno NH, *Yatomi Y. Platelet-derived
sphingosine 1-phosphate induces migration of Jurkat cells. Lipid
Health Dis 2014, doi:10.1186/1476-511X-13-150
- Miyazaki A, Sagae N, Usami@Y, Sato M, Kameda T, Yoshimoto
A, Ishimine N, Matsuda K, Sugano M, Hara M, Honda H, *Tozuka M.
N-homocysteinylation of apolipoprotein A-I impairs the proteinfs
antioxidant ability but not its cholesterol efflux capacity. Biol Chem
2014, doi: 10.1515/hsz-2013-0262
- Matsuhashi M, *Tsuno NH, Sone S, Mishima Y, Nagura Y,
Watanabe-Okochi N, Ikeda T, Kashiwase K, Fukuda S, Iriyama T, Hyodo H,
Yamashita T, Kamei Y, Arai S, Minami M, Fujii T, Kurokawa M, Tozuka M,
Takahashi K, Santoso S. The role of alloantibodies against human
platelet antigen-15 in multiply platelet transfused patients.
Transfusion 2013 doi: 10.1111/trf.12455
- Matsuhashi M, *Tsuno NH, Ikeda T, Mishima Y,
Watanabe-Okochi N, Santoso S, Tozuka M, Takahashi K. The frequencies
of SLC44A2 alleles among the Japanese population. Tissue Antigens 81:
227-228, 2013
- Ono Y, Kurano M, Ohkawa R, Yokota H, Igarashi K, Aoki J,
Tozuka M, *Yatomi Y. Sphingosine 1-phosphate release from platelets
during clot formation: close correlation between platelet count and
serum sphingosine 1-phosphate concentration. Lipid Health Dis 2013,
12:20. doi:10.1186/1476-511X-12-20
- Usami Y, Kobayashi Y, Kameda T, Miyazaki A, Matsuda K,
Sugano M, Kawasaki K, Kurihara Y, Kasama T, *Tozuka M. Identification
of sites in apolipoprotein A-I susceptible to chymase and
carboxypeptidase A digestion. Biosci Rep 33: 49-56, 2013
- Kameda T, Usami Y, Shimada S, Haraguchi G, Matsuda K,
Sugano M, Kurihara Y, Isobe M, *Tozuka M. Determination of
Myeloperoxidase-induced apoAI-apoAII Heterodimers in High-Density
Lipoprotein. Ann Clin Lab Sci 42: 384-391, 2012
- Matsuhashi M, *Tsuno NH, Kawabata M, Mishima Y, Okochi N,
Santoso S, Tozuka M, Takahashi K. The frequencies of human neutrophil
alloantigens among the Japanese population. Tissue Antigens 80:
336-340, 2012
- Usami Y, Matsuda K, Sugano M, Ishimine N, Kurihara Y,
Sumida T, Yamauchi K, *Tozuka M, Detection of chymase-digested
C-terminally truncated apolipoprotein A-I in normal human serum.
J Immunol Methods 369: 51-58, 2011
- Ishimine N, Usami Y, Nogi S, Sumida T, Kurihara Y,
Matsuda K, Nakamura K, Yamauchi K, Okumura N, *Tozuka M.
Identification of N-homocysteinylated apolipoprotein AI in normal
human serum. Ann Clin Biochem 47: 453-459, 2010