スタッフ紹介

准教授

関矢教授関矢 一郎(せきや いちろう)
生年月:1964年9月
大学院医歯学総合研究科 生体支持組織学系専攻
支持分子制御学講座 軟骨再生学分野所属

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経歴

1990年
東京医科歯科大学医学部卒業
2000年
東京医科歯科大学大学院卒業
2000-2002年
Tulane University, Center for Gene Therapy留学
2002年
東京医科歯科大学大学院 運動器外科学 助手
2006年
東京医科歯科大学大学院 軟骨再生学 准教授

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業績

  1. Mochizuki T, Muneta T, Sakaguchi Y, Nimura A, Yokoyama A, Koga H, Sekiya I.
    Higher chondrogenic potential of fibrous synovium- and adipose synovium-derived cells compared with subcutaneous fat-derived cells: distinguishing properties of mesenchymal stem cells in humans.
    Arthritis Rheum. 2006 Mar;54(3):843-53.
  2. Shirasawa S, Sekiya I, Sakaguchi Y, Yagishita K, Ichinose S, Muneta T.
    In vitro chondrogenesis of human synovium-derived mesenchymal stem cells: Optimal condition and comparison with bone marrow-derived cells.
    J Cell Biochem. 2006 Jan 1;97(1):84-97.
  3. Mochizuki T, Muneta T, Nagase T, Shirasawa S, Akita KI, Sekiya I.
    Cadaveric knee observation study for describing anatomic femoral tunnel placement for two-bundle anterior cruciate ligament reconstruction.
    Arthroscopy. 2006 Apr;22(4):356-61.
  4. Muneta T, Koga H, Morito T, Yagishita K, Sekiya I.
    A retrospective study of the midterm outcome of two-bundle anterior cruciate ligament reconstruction using quadrupled semitendinosus tendon in comparison with one-bundle reconstruction.
    Arthroscopy. 2006 Mar;22(3):252-8.
  5. Zhang B, Muneta T, Yagishita K, Sekiya I.
    Substance P immunoreactive fibers of synovial tissue in patients with anterior cruciate ligament injury.
    Knee Surg Sports Traumatol Arthrosc. 2006 Jan 4
  6. Ylostalo J, Smith JR, Pochampally RR, Matz R, Sekiya I, Larson BL, Vuoristo JT, Prockop DJ.
    Use of differentiating adult stem cells (marrow stromal cells) to identify new downstream target genes for transcription factors.
    Stem Cells. 2006 Mar;24(3):642-52. Epub 2006 Jan 26.
  7. Wang J, Asou Y, Sekiya I, Sotome S, Orii H, Shinomiya K.
    Enhancement of tissue engineered bone formation by a low pressure system improving cell seeding and medium perfusion into a porous scaffold.
    Biomaterials. 2006 May;27(13):2738-46.
  8. Nagatomo K, Komaki M, Sekiya I, Sakaguchi Y, Noguchi K, Oda S, Muneta T, Ishikawa I.
    Stem Cell Properties of Human Periodontal Ligament Cells.
    Jounal of Periodontal Research. In press.
  9. Sekiya I, Larson BL, Vuoristo JT, Reger RL, Prockop DJ.
    Comparison of effect of BMP-2, -4, and -6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma.
    Cell Tissue Res. 2005 May;320(2):269-76.
  10. Sakaguchi Y, Sekiya I, Yagishita K, Muneta T.
    Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source.
    Arthritis Rheum. 2005 Aug;52(8):2521-9.
  11. Yagishita K, Sekiya I, Sakaguchi Y, Shinomiya K, Muneta T.
    The effect of hyaluronan on tendon healing in rabbits.
    Arthroscopy. 2005 Nov;21(11):1330-6.
  12. Ichinose S, Tagami M, Muneta T, Sekiya I.
    Morphological examination during in vitro cartilage formation by human mesenchymal stem cells.
    Cell Tissue Res. 2005 Nov;322(2):217-26.
  13. Ichinose S, Yamagata K, Sekiya I, Muneta T, Tagami M.
    Detailed examination of cartilage formation and endochondral ossification using human mesenchymal stem cells.
    Clin Exp Pharmacol Physiol. 2005 Jul;32(7):561-70.
  14. Yokoyama A, Sekiya I, Miyazaki K, Ichinose S, Hata Y, Muneta T.
    In vitro cartilage formation of composites of synovium-derived mesenchymal stem cells with collagen gel.
    Cell Tissue Res. 2005 Nov;322(2):289-98.
  15. Yagishita K, Muneta T, Ogiuchi T, Sekiya I, Shinomiya K.
    Healing potential of meniscal tears without repair in knees with anterior cruciate ligament reconstruction.
    Am J Sports Med. 2004 Dec;32(8):1953-61.
  16. Ichinose S, Muneta T, Sekiya I, Itoh S, Aoki H, Tagami M.
    The study of metal ion release and cytotoxicity in Co-Cr-Mo and Ti-Al-V alloy in total knee prosthesis - scanning electron microscopic observation.
    J Mater Sci Mater Med. 2003 Jan;14(1):79-86.
  17. Sakaguchi Y, Sekiya I, Yagishita K, Ichinose S, Shinomiya K, Muneta T.
    Suspended cells from trabecular bone by collagenase digestion become virtually identical to mesenchymal stem cells obtained from marrow aspirates.
    Blood. 2004 Nov 1;104(9):2728-35.
  18. Asano H, Muneta T, Ikeda H, Yagishita K, Kurihara Y, Sekiya I.
    Arthroscopic evaluation of the articular cartilage after anterior cruciate ligament reconstruction: a short-term prospective study of 105 patients.
    Arthroscopy. 2004 May;20(5):474-81.
  19. Sekiya I, Larson BL, Vuoristo JT, Cui JG, Prockop DJ.
    Adipogenic differentiation of human adult stem cells from bone marrow stroma (MSCs).
    J Bone Miner Res. 2004 Feb;19(2):256-64.
  20. Mochizuki T, Muneta T, Yagishita K, Shinomiya K, Sekiya I.
    Skin sensory change after arthroscopically-assisted anterior cruciate ligament reconstruction using medial hamstring tendons with a vertical incision.
    Knee Surg Sports Traumatol Arthrosc. 2004 May;12(3):198-202.
  21. Sekiya I, Larson BL, Smith JR, Pochampally R, Cui JG, Prockop DJ.
    Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality.
    Stem Cells. 2002;20(6):530-41.
  22. Prockop DJ, Sekiya I, Colter DC.
    Isolation and characterization of rapidly self-renewing stem cells from cultures of human marrow stromal cells.
    Cytotherapy. 2001;3(5):393-6.
  23. Sekiya I, Vuoristo JT, Larson BL, Prockop DJ.
    In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis.
    Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4397-402.
  24. Sekiya I, Koopman P, Tsuji K, Mertin S, Harley V, Yamada Y, Shinomiya K, Niguji A, Noda M.
    Transcriptional suppression of Sox9 expression in chondrocytes by retinoic acid.
    J Cell Biochem. 2001;81(S36):71-78.
  25. Sekiya I, Koopman P, Tsuji K, Mertin S, Harley V, Yamada Y, Shinomiya K, Niguji A, Noda M.
    Transcriptional suppression of Sox9 expression in chondrocytes by retinoic acid.
    J Cell Biochem Suppl. 2001;Suppl 36:71-8.
  26. Colter DC, Sekiya I, Prockop DJ.
    Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells.
    Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7841-5.
  27. Sekiya I, Colter DC, Prockop DJ.
    BMP-6 enhances chondrogenesis in a subpopulation of human marrow stromal cells.
    Biochem Biophys Res Commun. 2001 Jun 8;284(2):411-8.
  28. Sekiya I, Koopman P, Tsuji K, Mertin S, Harley V, Yamada Y, Shinomiya K, Nifuji A, Noda M. R
    Dexamethasone enhances SOX9 expression in chondrocytes.
    J Endocrinol. 2001 Jun;169(3):573-9.
  29. Yamashita T, Sekiya I, Kawaguchi N, Kashimada K, Nifuji A, Nabeshima YI, Noda M.
    Klotho-deficient mice are resistant to bone loss induced by unloading due to sciatic neurectomy.
    J Endocrinol. 2001 Feb;168(2):347-51.
  30. Sekiya I, Tsuji K, Koopman P, Watanabe H, Yamada Y, Shinomiya K, Nifuji A, Noda M.
    SOX9 enhances aggrecan gene promoter/enhancer activity and is up-regulated by retinoic acid in a cartilage-derived cell line, TC6.
    J Biol Chem. 2000 Apr 14;275(15):10738-44.
  31. Muneta T, Yagishita K, Kurihara Y, Sekiya I.
    Intra-articular detachment of the Endobutton more than 18 months after anterior cruciate ligament reconstruction.
    Arthroscopy. 1999 Oct;15(7):775-8.
  32. Muneta T, Sekiya I, Yagishita K, Ogiuchi T, Yamamoto H, Shinomiya K.
    Two-bundle reconstruction of the anterior cruciate ligament using semitendinosus tendon with endobuttons: operative technique and preliminary results.
    Arthroscopy. 1999 Sep;15(6):618-24.
  33. Muneta T, Sekiya I, Ogiuchi T, Yagishita K, Yamamoto H, Shinomiya K.
    Effects of aggressive early rehabilitation on the outcome of anterior cruciate ligament reconstruction with multi-strand semitendinosus tendon.
    Int Orthop. 1998;22(6):352-6.
  34. Muneta T, Sekiya I, Tsuchiya M, Shinomiya K.
    A technique for reconstruction of the medial patellofemoral ligament.
    Clin Orthop Relat Res. 1999 Feb;(359):151-5.
  35. Muneta T, Sekiya I, Ogiuchi T, Yagishita K, Yamamoto H, Shinomiya K.
    Objective factors affecting overall subjective evaluation of recovery after anterior cruciate ligament reconstruction.
    Scand J Med Sci Sports. 1998 Oct;8(5 Pt 1):283-9.
  36. Sekiya I, Muneta T, Ogiuchi T, Yagishita K, Yamamoto H.
    Significance of the single-legged hop test to the anterior cruciate ligament-reconstructed knee in relation to muscle strength and anterior laxity.
    Am J Sports Med. 1998 May-Jun;26(3):384-8.
  37. Muneta T, Ogiuchi T, Sekiya I, Yamamoto H, Shinomiya K.
    Anterior cruciate ligament deficiency accompanied by patellar subluxation treated by reconstruction with lateral retinacular release.
    Arthroscopy. 1998 Apr;14(3):335-9.
  38. Muneta T, Ezura Y, Sekiya I, Yamamoto H.
    Anterior knee laxity and loss of extension after anterior cruciate ligament injury.
    Am J Sports Med. 1996 Sep-Oct;24(5):603-7.

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著書

  1. 関節軟骨の再生医療とそれに関する特許
    ライフサイエンスレポート.2005. No.4
  2. 膝軟骨損傷の診断と治療
    リウマチ科.2005;33(4):373-378.
  3. 和題/骨に大量の幹細胞が存在
    Medical Technology. 2005. 33巻3号.
  4. 骨粗鬆症、骨軟化症
    ベストアプローチ臨床検査ガイド. p377
  5. 化膿性骨髄炎
    ベストアプローチ臨床検査ガイド. p373
  6. 関節軟骨再生 :ソフトナノテクノロジー
    バイオマテリアル革命:2005;12-15.
  7. 骨髄実質由来の幹細胞
    整形外科. 2004.55巻6号 692.
  8. 軟骨の再生医学
    リウマチ科. 2003;30(5):409-417.
  9. 成人骨髄由来幹細胞の増殖と軟骨分化
    整形外科. 2003.. 54(13):p1658.

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著書

  1. 1998. Orthopaedic Research Society, New Investigator Research Award
  2. 2001. Gordon Research Conference Collagen, Oral Presentation
  3. 2002. 日本整形外科学会研究奨励賞
  4. 2002.東京医科歯科大学医科同窓会研究奨励賞
  5. 2002. 東京医科歯科大学整形外科同門会研究奨励賞
  6. 2003.日本軟骨代謝学会評議員

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研究助成金

  1. 平成14年度 交通事故医療研究助成
  2. 平成14年度 整外災害外科学研究助成財団
  3. 平成15年度 中冨健康科学振興財団
  4. 平成16年度 科学研究費基盤C
  5. 平成18年度 科学研究費基盤C

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お問い合わせ

住所
113-8519 東京都文京区湯島1-5-45
TEL
03-3813-6111(大学代表)
E-mail
unki.orj@tmd.ac.jp