The 5th Asian Epigenomics Meeting & A3 Symposium 2010 in Jeju, Korea

Date June 20-22, 2010
Venue Jeju Heavichi Hotel Grand Ball Room, Korea

Summary

The A3 Foresight Symposium was held together with the 5th Asian Epigenomics Meeting (AEM) on June 20-22, at Jeju Heavichi Hotel Grand Ball Room, Korea. The AEM was designed to build scientific network among 4 nations, i.e., Korea, Japan, China, and Singapore, and this 5th symposium was organized by 2010 AEM organizing committee and Korea Genome Organization. In the joint meeting, A3 Foresight meeting consisted of two programs, as shown below. All the researchers in the A3 Foresight program participated in the AEM. Dr. Woo Ho Kim is the head of A3 Foresight program committee and Dr. Ushijima is the member country coordinator in AEM side. Dr. Yong Sung Kim, Dr. Yuasa and Dr. Ushijima talked their current research findings in the symposia of this joint meeting. The poster sessions consisting of 7 AEM candidates and 7 A3 Foresight young scientists were held on June 20. Next day, there were two A3 concurrent sessions, i.e., “Progress on epigenetics of gastric cancer” and “Recent progress of miRNA mediated mechanisms of breast cancer”, and we have attended the former session. Ten scientists from 3 nations talked their current findings by oral presentation. Finally, discussion of collaborative researches was made at the end of this session.

There was a travel accident by a heavy fog in the Jeju island on June 20 and arrival was delayed, subsequently some schedules of the meeting were changed. Nevertheless, the joint meeting of two A3 Foresights and AEM groups was very fruitful through active discussion for cancer epigenetics/epigenomics. During the meeting, we could obtain a lot of information on “epigenomics” in various cancers. We could also discuss about the epigenetic mechanisms in gastric carcinogenesis in the A3 Foresight meeting, and further discussed on collaborate researches among 3 nations.


Program

Program of the 5th Asian Epigenomics Meeting and A3 symposium 2010

Symposia (June 20) Yong Sung Kim (Korea Research Institute of Bioscience and Biotechnology): MeMAC, MeDIP-seq based methylome analysis of circulating DNA.
Symposia (June 21) Yasuhito Yuasa (Tokyo Medical and Dental University): Epigenetic epidemiology of gastric cancer.
Symposia (June 22) Toshikazu Ushijima (National Cancer Center Research Institute): Induction of aberrant DNA methylation by H. pylori infection-triggered inflammation.

Concurrent session A (A3 Foresight Program)

June 21

Chairperson:
Woo Ho Kim		 Keitaro Matsuo (Aichi Cancer Center Research Institute): Molecular epidemiologic study for stomach cancer: susceptibility and survival.
Yong Sung Kim (Korea Research Institute of Bioscience and Biotechnology): Hypomethylation of CDX2 promoter region in gastric cancers.
Yoshimitsu Akiyama (Tokyo Medical and Dental University): The target gene analyses of GATA4/5 transcription factors in gastric cancers.
Kai-feng Pan (Peking University School of Oncology): Serum microRNAs as potential biomarkers for gastric cancer.
Gyeong Hoon Kang (Seoul National University College of Medicine): The timing of methylation changes in colorectal adenoma-carcinoma sequence.
Woo Ho Kim (Seoul National University College of Medicine): Hypomethylation of MAGE-A in gastric cancer: Implication for cancer vaccine.
Wei-Guo Zhu (Peking University Health Science Center): 5-aza-CdR activates gene expression via degradating pRB.
Dajun Deng (Peking University School of Oncology): DNA methylation signature associated with metastasis of gastric carcinomas.
Jingyung Fang (Shanghai Jiao-Tong University School of Medicine): DNA methylation and cell signal pathway in GI carcinogenesis.
Hiroshi Fukamachi (Tokyo Medical and Dental University): Identification of tumor-initiating cells in human gastric cancers.

Poster session (A3 Foresight Program)

June 20 Hideyuki Takeshima (National Cancer Research Center Institute): The presence of repetitive elements LINE and SINE confers susceptibility to aberrant DNA methylation induction.
Isao Oze (Aichi Cancer Center Research Institute): Comparison between self-report facial flushing after alcohol consumption and ALDH2 Glu504Lys polymorphism for the risk of upper aerodigestive tract cancer in a Japanese population.
Pichayanoot Rotkrua (Tokyo Medical and Dental University): Epigenetic inactivation of the miR-9 genes is involved in gastric carcinogenesis through CDX2 deregulation.
Satoshi Yamashita (National Cancer Research Center Institute): Identification of DNA methylation markers to predict metastasis of esophageal cancer by MeDIP-CpG island microarray analysis.
Seon-Young Kim (Korea Research Institute of Bioscience and Biotechnology): Genome-wide screening of aberrant methylation identifies novel biomarkers in gastric cancer.
Yutaka Hashimoto (Tokyo Medical and Dental University): Epigenetically repressed microRNA miR-181c targets oncogenic K-RAS and NOTCH4 in gastric cancer.
Takeshi Otsubo (Tokyo Medical and Dental University): MicroRNA-126 inhibits SOX2 expression in gastric carcinogenesis.

Photograph of the A3 Foresight Symposium held on June 21, 2010, Jeju, Korea



Photograph of the 5th Asian Epigenomics Meeting & A3 Foresight Symposium held on June 20-22, 2010, Jeju, Korea