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Seminar in Beijing held in October, 2010
NSFC A3 Foresight Program 2010 Seminar
-Epigenetic Signatures in Gastric Carcinogenesis-
| Date |
October 17-20, 2010 |
| Venue |
Peking University Cancer Hospital & Institute |
Summary
NSFC A3 Foresight Program 2010 Seminar was held on October 17-20, 2010 at Beijing Cancer Hospital, Beijing, China. This meeting highlighted epigenetic signatures in gastric carcinogenesis via molecular and epidemiological analysis. A total of 42 scientists (16 senior and 26 junior) from 3 nations attended this seminar, and all of the participants talked their current findings by oral presentation. Senior speakers were given 15 minutes for presentation and 5 minutes for discussion, and juniors 7 minutes for presentation and 3 minutes for discussion. There was an enthusiastic discussion in the meeting. It was noted that six young chairpersons (2 persons each from 3 nations) nominated in this meeting presided over their sessions of oral presentation for junior scientists. The enthusiasm of the junior scientists in the oral presentation and discussion in English may brighten the future of epigenetic/genetic/epidemiological analyses in gastric carcinogenesis. Finally, discussion on collaborative researches was held at the end of this meeting. According to the 4 research activities, participants were divided into 4 groups and collaborative researches among 3 nations were further discussed. After the discussion, collaborative research plans were summarized in all the participants. During this seminar, we were able to promote our collaborative researches much among 3 nations.
Program
Oct. 18 (Mon)
| Opening remarks |
Prof. Weicheng You (President of Beijing Cancer Hospital)
Ms. Yinglan Zhang (Senior Official of NSFC, China)
|
Senior Speakers
Chairperson:
Dajun Deng |
Jingde Zhu (Shanghai Jiao-Tong University Cancer Institute, China): DNA methylation analysis for cancer management: Challenges and Opportunities
Yasuhito Yuasa (Tokyo Medical and Dental University, Japan): Comparison of methylation states of blood leukocyte DNA between gastric cancer patients and healthy individuals
DaeHee Kang (Seoul National University College of Medicine, Korea): Differential pattern of DNA methylation in cardia and noncardia gastric cancer
YongSung Kim (Korea Research Institute of Bioscience and Biotechnology): Epigenomic map on gastric cancer and its precancerous lesions
Weicheng You (Peking University Cancer Hospital & Institute, China): Gastric Cancer Prevention in China |
Chairperson:
Woo Ho Kim |
HanKwang Yang (Seoul National University College of Medicine, Korea): Aberrant methylation of the specific CpG island portion regulates cyclooxygenase-2 gene expression in human gastric carcinomas
Dajun Deng (Peking University Cancer Hospital & Institute, China): Chemical differentiation of 5-hydroxymethylcytosine in genomic DNA
Hiroshi Fukamachi (Tokyo Medical and Dental University, Japan): Identification of tumor-initiating cells in human gastric cancers
Weiguo Zhu (Peking University Health Science Center, China): 5-aza-2’-deoxycytidine reactivates gene expression by degrading pRb pocket proteins
Keitaro Matsuo (Aichi Cancer Center Research Institute, Japan): One-carbon metabolism and survival of head and neck cancer |
Chairperson:
Yasuhito Yuasa |
WooHo Kim (Seoul National University College of Medicine, Korea): Epigenetic silencing of glutathione peroxidases in gastric carcinoma
Kaifeng Pan (Peking University Cancer Hospital & Institute): RUNX3 methylation and expression associated with advanced precancerous gastric lesions in a Chinese population
GyeongHoon Kang (Seoul National University College of Medicine, Korea): Comparison of DNA methylation changes and KRAS/BRAF mutations between serrated colorectal polyps and adenomatous colorectal polyps
Yoshimitsu Akiyama (Tokyo Medical and Dental University, Japan): Target gene analysis of GATA4 and GATA5 transcription factors in gastric cancer cells
SeJin Jang (Asan Medical Center, Korea): Methylation of cytosine in CpNpG trinucleotides in the human genome
Mingzhou Guo (Chinese PLA General Hospital, China): SOX17 antagonizes WNT/β-catenin signaling pathway in hepatocellular carcinoma |
Junior Speakers
Chairpersons:
Xi Wang
Baozhen Zhang |
Yutaka Hashimoto (Tokyo Medical and Dental University, Japan): Up-regulation of several miRNAs by treatment with DNA demethylating agent and identification of common target genes in gastric cancer cells
Baozhen Zhang (Peking University Cancer Hospital & Institute, China): p16-specific reactivation by engineered transcription factors through demethylation of CpG island
SoHyun Shin (Seoul National University College of Medicine, Korea): Pharmacological genomic unmasking of DNA hypermethylome in gastric cancer
Ting Ye (Shanghai Jiao-Tong University Ren-Ji Hospital, China): Effect of folic acid supplementation on DNA methylation of specific gene in human PBMC
Aika Hiratsuka (Tokyo Medical and Dental University, Japan): Effect of c-myc siRNA on the growth of gastric cancer cells
Xi Wang (Peking University Health Science Center, China): Histone modification and gene transcriptional regulation
Yasuyuki Shigematsu (National Cancer Center Research Institute, Japan): Current status of our research to identify CpG islands whose DNA methylation status is associated with the presence of lymph node metastases of gastric cancers |
Chairpersons:
MiRang Kim
ChangDo Jee |
ChangDo Jee (Seoul National University College of Medicine, Korea): Genome-wide DNA methylation analysis in human gastric carcinoma
Naoko Hattori (National Cancer Center Research Institute, Japan): Screening of Promoter CpG Islands Methylated in Human Mammary Epithelial Cells
Lian Li (Seoul National University College of Medicine, Korea): Methylation biomarkers using peripheral blood DNA
Huijuan Su (Peking University Cancer Hospital & Institute, China): DNA methylation in circulating leukocytes and gastric cancer tissues
HyangSook Seol (Asan Medical Center, Korea): Primary culture of tumorigenic cells from human gastric, colonic and lung cancers for the identification of epigenetic signature in cancer stem cells
NamHee Jung (Seoul National University College of Medicine, Korea): Identification of specific DNA methylation markers for hepatocellular carcinoma
Shu Shimada (Tokyo Medical and Dental University, Japan): Synergistic tumor suppressor activity of E-cadherin and p53 in a conditional mouse model for metastatic diffuse-type gastric cancer |
Oct. 19 (Tue)
Junior Speakers
Chairpersons:
Isao Oze
Yasuyuki
Shigematsu |
Ayako Mimata (Tokyo Medical and Dental University, Japan): Loss of E-cadherin in parietal cells affects gastric epithelial cell polarity, growth and differentiation, resulting in a pre-malignant condition in mice
Yantao Du (Peking University Cancer Hospital & Institute, China): p16 antisense transcript upregulates expression of p16
Jin Kim (Seoul National University College of Medicine, Korean): Aberrant DNA methylation and tumor suppressive activity of the EBF3 gene in gastric carcinoma
JiEun Yu (Seoul National University College of Medicine, Korean): Expression and Epigenetic regulation of Sulf genes (Sulf-1 and Sulf-2) in human gastric carcinoma
MiRang Kim (Korea Research Institute of Bioscience and Biotechnology): Frequent silencing of popeye domain containing genes, BVES and POPDC3, is associated with promoter hypermethylation in gastric cancer
KwunIll Kim (Korea Research Institute of Bioscience and Biotechnology): Epigenetic regulation of MIR10B targeting MAPRE1 in gastric cancer
TaeSu Han (Seoul National University College of Medicine, Korean): Epigenetic regulation of microRNA expression in gastric cancer
Takeshi Otsubo (Tokyo Medical and Dental University, Japan): MicroRNA-126 inhibits SOX2 expression and consequent changes in expression of SOX2 target genes in gastric cancer cells
Yipeng Du (Peking University Health Science Center, China): PMA reactivates the methylated COX-2 through c-FOS modulated histone modifications
Pichayanoot Rotkrua (Tokyo Medical and Dental University, Japan): MiR-9 down-regulates CDX2 expression in gastric cancer cells
Isao Oze (Aichi Cancer Center Research Institute, Japan): The association between prognosis and IGF2 gene methylation status in patients with gastric cancer
Jie Hong (Shanghai Jiao-Tong University Ren-Ji Hospital, China): Acid-induced p16 hypermethylation contributes to development of esophageal adenocarcinoma via activation of NADPH oxidase NOX5-S, NF-kB and DNMT1 |
Group Discussion on Collaborative Research Themes
| R-1 |
Risk factors of GC accounting for host epigenetic alterations among three nations |
| R-2 |
Investigation of mechanisms of gene-specific silencing of tumor-suppressor genes during gastric carcinogenesis |
| R-3 |
DNA methylome and its applications on subtyping of gastric carcinomas |
| R-4 |
Epigenetic changes in GC stem cells |
Discussions by All the Participants
