Meeting in Nara, Japan held in February, 2012

JSPS A3 Foresight Program 2012 Meeting
-Epigenetic Signatures in Gastric Carcinogenesis-

Date February 17-20, 2012
Venue Hotel Nikko Nara and Hotel Sunroute Nara

Summary

JSPS A3 Foresight Program 2012 Meeting was held on February 17-20, 2012 in Nara, Japan. This meeting highlighted epigenetic signatures in gastric carcinogenesis via molecular and epidemiological analyses. A total of 30 scientists (15 senior and 15 junior) from three nations attended this meeting. Each of 9 junior speakers was given for 15 minutes in presentation and discussion followed on further studies. During this meeting, several new collaborative research plans were proposed, and all of them were strongly supported by participants. Thus we hope that new results will be obtained soon by collaboration of researchers in three nations.

Program

Feb. 18 (Sat)

Opening remarks Yasuhito Yuasa (Tokyo Medical and Dental University)

Presentation by young scientists (I)

Chairperson:
Woo Ho Kim		 Shu Shimada (Tokyo Medical and Dental University): Epigenetic involvement in a mouse model of E-cadherin/p53-deficient diffuse-type gastric cancer
Yasuyuki Shigematsu (National Cancer Center Research Institute): Current status of our research to identify a DNA methylation marker that detects the presence of lymph node metastases of gastric cancers
Isao Oze (Aichi Cancer Center Research institute): The association between dietary folate intake and gastric cancer

Presentation by young scientists (II)

Chairperson:
Yasuhito Yuasa		 Ping Zhang (Peking University Health Science Center): FoxO1 is required for the FoxO3-induced autophagy
Yipeng Du (Peking University Health Science Center): Characterization and prediction of lysine (K)-acethyl-transferase (KAT) specific acethylation sites
Linna Fu (Shanghai Jiao-Tong University): HIF-1α-induced histone demethylase JMJD2B contributes to the malignant phenotype of colorectal cancer cells via an epigenetic mechanism

Presentation by young scientists (III)

Chairperson:
Dajun Deng		 Jeong Mo Bae (Seoul National University): Differential clinicopathological features in microsatellite instability-positive colorectal cancers depending on CIMP
Tae Su Han (Seoul National University): MicroRNA-29c functions as a tumor suppressor by inhibiting ITGB1 in gastric cancer
Mi Rang Kim (Korea Research Institute of Bioscience and Biotechnology): Epigenetic alteration of CDX2 in gastric carcinogenesis

Group discussion (I): Collaborative research and paper submission

R-1 Risk factors of GC accounting for host epigenetic alterations among three nations
R-2 Investigation of mechanisms of gene-specific silencing of tumor-suppressor genes during gastric carcinogenesis
R-3 DNA methylome and its applications on subtyping of gastric carcinomas
R-4 Epigenetic changes in GC stem cells

Feb. 19 (Sun)

Group discussion (II): Extension of the A3 foresight program for next two years

General discussion by all the participants