Seminar in Hangzhou, China held in October, 2012

NSFC A3 Foresight Program 2012 Seminar
-Epigenetic Signatures in Gastric Carcinogenesis-

Date October 21-24, 2012
Venue Hangzhou Huagang HNA Resort

Summary

NSFC A3 Foresight Program 2012 Seminar was held on October 21-24, 2012 at Hangzhou Huagang HNA Resort, Hangzhou, China. This meeting highlighted epigenetic signatures in gastric carcinogenesis via molecular and epidemiological analyses. A total of 35 scientists (14 senior and 21 junior) from three nations attended this meeting. Each of 7 senior speakers made a presentation about the summary of A3 Program in the Stage I (August 2009 to July 2012) and the further cooperation in the Stage II (August 2012 to July 2014) for 15 minutes. Each of 14 junior speakers was given for 12 minutes in presentation and discussion followed on further studies. During this meeting, several new collaborative research plans were proposed, and all of them were strongly supported by participants. Thus we hope that new results will be obtained soon by collaboration of researchers in three nations.

Program

Oct. 22 (Mon)

Opening remarks Dajun Deng (Peking University Cancer Hospital and Institute)

Presentation by senior scientists (I)

Theme:
Epigenetics and Epidemiology
Chairperson:
Yasuhito Yuasa		 Wei-Cheng You (Peking University Cancer Hospital and Institute, China): Epigenetic epidemiological studies in a Chinese population
Keitaro Matsuo (Aichi Cancer Center Research Institute, Japan): 2. Epidemiological Studies for gastric cancer exploring epigenetic involvement in Japan
Taichi Shimazu (Research Center for Cancer Prevention and Screening, National Cancer Center, Japan): 3. Association of smoking and fruit and vegetable intake with DNA methylation levels in gastric mucosa of healthy Japanese adults

Presentation by senior scientists (II)

Theme:
Epigenetic Mechanisms and
Cancer Stem Cells
Chairperson:
Woo Ho Kim		 Hiroshi Fukamachi (Tokyo Medical and Dental University, Japan): Summary of tumor-initiating call researchers in the A3 program
Yang Yang (Peking University Health Science Center, China): 5. Mechanistic achievements in epigenetics study

Presentation by senior scientists (III)

Theme:
Epigenetic Signatures of Gastric Cancer
Chairperson:
Dajun Deng		 Gyeong Hoon Kang (Seoul National University College of Medicine, Korea): Summary of DNA methylation-related studies of gastric cancer
Dajun Deng (Peking University Health Science Center, China): Summary of DNA methylation marker researchers on gastric cancer metastasis, and differentiation and adaptation epigenetic networks

Presentation by junior scientists (I)

Theme:
Epidemiology and Epigenetics
Chairperson:
Yang Zhang and Isao Oze		 Seon Young Kim (Korea Research Institute of Bioscience and Biotechnology, Korea): MENT: Methylation and expression database of normal and tumor tissues
Dajun Deng (Peking University Health Science Center, China): Summary of DNA methylation marker researchers on gastric cancer metastasis, and differentiation and adaptation epigenetic networks
Isao Oze (Aichi Cancer Center Research Institute, Japan): 3. Dietary folate intake decreases gastric cancer risk, a case-control study and meta-analysis
Yasuyuki Shigematsu (National Cancer Center Research Institute, Japan): Influence of formalin fixation time on DNA copy number for methylationanalysis

Oct. 23 (Tue)

Presentation by junior scientists (II)

Theme:
Epigenetic Mechanisms and
Cancer Stem Cells
Chairperson:
Jin Kim and Chen Yang		 Chen Yang (Peking University Cancer Hospital and Institute, China): Induction of gastrointestinal tumors by carcinogens in X-ray-irradiated mice not originated from bone marrow-derived cells
Hyang Sook Seol (Asan Medical Center, Korea): Identification of lung cancer stem cells
Changchun Shen (Peking University Health Science Center, China): Set7/9 interacts with and induces methylation of beta-catenin
Jin Kim (Seoul National University College of Medicine, Korea): Wnt antagonist SFRP4 acts as a tumor suppressor gene in gastric carcinomas
Jin-Lin Wang (Shanghai Jiao-Tong University Ren-Ji Hospital, China): Elf3 functions as an oncogene by activating β-catenin in colorectal cancer

Presentation by junior scientists (III)

Theme:
Epigenetic Markers of Cancers
Chairperson:
Shu Shimada and So Hyun Shin		 So Hyun Shin (Seoul National University College of Medicine, Korea): Downregulation of spleen tyrosine kinase in hepatocellular carcinoma by promoter CpG island hypermethylation and its potential role in carcinogenesis
Yan-Tao Du (Peking University Cancer Hospital and Institute, China): miR-663a inhibits metastasis of colon cancers
Shu Shimada (Tokyo Medical and Dental University, Japan): Identification of circulating miRNAs as biomarkers for early detection of diffuse-type gastric cancer using a mouse model
Yukie Yoda (National Cnacer Center Research Institute, Japan): Oncogenic mutations are associated with CpG island methylator phenotype in gastric cancers
Taketo Nishikawaji (Tokyo Medical and Dental University, Japan): Over-expression of SETDB2, a histone methyltransferase, in gastric cancers

General discussion by all the participants