Meeting in Busan, Korea held in June, 2012

NRF A3 Foresight Program 2012 Meeting
-Epigenetic Signatures in Gastric Carcinogenesis-

Date June 28-July 1, 2012
Venue Seaclound Hotel

Summary

NRF A3 Foresight Program 2012 Meeting was held on June28-July1, 2012 at Seaclound Hotel, Haeundae, Busan, Korea. This meeting highlighted epigenetic signatures in gastric carcinogenesis via molecular and epidemiological analyses. A total of 33 scientists (13 senior and 20 junior) from three nations attended this meeting. Twelve junior speakers presented their results, and senior scientists summarized their progress made in R1-R4 of A3 Program in these 3 years (August 2009 to July 2012). During this meeting, new collaborative research plans were proposed, and were discussed by participants. We thus hope that new collaborations will start soon to obtain good results in this program.

Program

June 29 (Fri)

Opening remarks Woo Ho Kim (Seoul National University)

Presentation by young scientists (I)

Chairperson:
Gyeong Hoon Kang		 Ayuna Sakamoto (Tokyo Medical and Dental University): Functional analysis of Twist1 in diffuse-type gastric cancer cell lines of an E-cadherin/p53-deficient mouse model
Minkyo Song (Seoul National University College of Medicine): Integrative DNA methylation and gene expression analysis in cardia and noncardia gastric cancer
Isao Oze (Aichi Cancer Center Research Institute): Dietary folate intake, MTHFR polymorphisms and gastric cancer risk
Yang Zhang (Beijing Cancer Hospital & Institute): Methylation status of blood leukocyte DNA in gastric cancer and its precancerous lesions

Presentation by young scientists (II)

Chairperson:
Hiroshi Fukamachi		 So-Hyun Shin (Seoul National University College of Medicine): Downregulation of dual-specificity phosphatase 5 in gastric cancer by promoter CpG island hypermethylation and its potential role in carcinogenesis
Ying-Chao Wang (Shanghai Jiao-Tong University School of Medicine): CD24 induces survival and epithelial-mesenchymal transition through a STAT3-dependent mechanism in gastric cancer progression
Keeok Haam (Korea Research Institute of Bioscience and Biotechnology): CDX2 Chip-seq analysis in human gastric cancer AGS cells
Naoko Hattori (National Cancer Center Research Institute): Development of a novel technique to visualize a combination of histone modifications

Presentation by young scientists (III)

Chairperson:
Kaifeng Pan		 Jeong Goo Kim (National Cancer Center Research Institute): Comprehensive analysis of genetic and epigenetic alterations in gastric cancer
Boyan Song (Peking University Health Science Center): MBD4 and SMUG1 are responsible for repair of 5-aza-CdR-induced DNA damage
Zhaojun Liu (Peking University Cancer Hospital and Institute): Reactivation of GFR α1 by demethylation of CpG islands promoting the metastasis of primary gastric carcinomas　
Hyang Sook Seol (Asan Medical Center): Establishment of OncoMouse using primary cultured cancer cells genotyped through OncoMap

June 30 (Fri)

Presentation and discussions by senior scientists

Japanese Reserchers Yasuhito Yuasa (Tokyo Medical and Dental University)
Toshikazu Ushijima (National Cancer Center Research Institute)
Keitaro Matsuo ( Aichi Cancer Center Research Institute)
Yoshimitsu Akiyama (Tokyo Medical and Dental University)
Hiroshi Fukamachi (Tokyo Medical and Dental University)
Chinese Reserachers Dajun Deng (Peking University Cancer Hospital and Institute)
Wei-cheng You (Beijing Cancer Hospital & Institute)
Kai-feng Pan (Beijing Cancer Hospital & Institute)
Korean Researchers Woo Ho Kim (Seoul National University)
Daehee Kang (Seoul National University)
Gyeong Hoon Kang (Seoul National University)
Se Jin Jang (Asan Medical Center)
Han-Kwang Yang (Seoul National University)

General discussion by all the participants