[研究内容]
costimulatory moleculeによる寛容誘導機構の解明
[略歴]
- 3 東京大学農学生命科学研究科において上野川修一教授指導のもと腸管免疫応答における研究にて博士を取得
- 6-2003.8 Medical College of Georgia、Institute of Molecular Medicine and GenticsにおいてMakio Iwashima博士のもとPost DocとしてDT40をもちいたgene targeting法を主としてシグナル伝達物質の研究を行う
- 9- 現職
[業績]
原著
1 K. Shida, S. Hachimura, A. Ametani, M. Ishimori, M. Ling, M. Hashiguchi, Y. Ueda, T. Sato, Y. Kumagai, K. Takamizawa, S. Habu, and S. Kaminogawa. Serum IgE response to orally ingested antigen: a novel IgE response model using allergen-specific T cell receptor transgenic mice. J. Allergy Clin. Immunol. 105: 788-795. 2000.
2 M. Hashiguchi, S. Hachimura, A. Ametani, and S. Kaminogawa. Th2 polarization by higher doses of oral administration of antigen. Cytotechnology 33: 237-245. 2000.
3 A. Ozaki, A. Fukushima, K. Fukata, S. Sakamoto, T. Taniguchi, M. Hashiguch, H. Ueno. Genetic background determines sensitivity to the inhibitory function of NO on T cell proliferation and the amounts of NO production mediated through IFN-gamma. Microbiol. Immunol. 46: 555. 2002.
4 T. Nagura, S. Hachimura, M. Hashiguchi, Y. Ueda, T. Kanno, H. Kikuchi, K. Sayama and S. Kaminogawa. Suppressive effect of dietary raffinose on T-helper 2 cell-mediated immunity. Brit. J. Nutr. 88: 421. 2002.
5 A. Sato, M. Hashiguchi, S. Hachimura, and S. Kaminogawa. Murine Peyer's patch dendritic cells prime naive CD4+ T cells to produce interferon-gamma. Cytotechnology 40: 31. 2002.
6 N. Yoshida, S. Hishiyama, M. Yamaguchi, M. Hashiguchi, Y. Miyamoto, S. Kaminogawa, and T. Hisatsune. Decrease in expression of alpha5beta1 integrin during neuronal differentiation of cortical progenitor cells. Exp. Cell Res. 287: 262. 2003.
7 A. Sato, M. Hashiguchi, E. Toda, S. Hachimura, A. Iwasaki, S. Kaminogawa. CD11b+ Peyer's patch dendritic cells secrete IL-6 and induce IgA secretion from naive B cells. J. Immunol. 171: 3684-3690. 2003.
8 M. Hibi, S. Hachimura, T. Somaya, E. Toda, M. Hashiguchi, T. Takayama, K. Sasaki, T. Senga, S. Hashizume and S. Kaminogawa. Splenic dendritic cells from antigen-fed mice induced antigen-specific T cell unresponsiveness in vivo. Cytotechnology 43: 41-48. 2004.
9 F. Kanamaru, P. Youngnak, M. Hashiguchi, T. Nishioka, T. Takahashi, S. Sakaguchi, I. Ishikaha, M. Azuma. Costimulation via Glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells. J. Immunol. 172: 7306-7314. 2004.
10 M. Kuraoka*, M. Hashiguchi*, S. Hachimura, S. Kaminogawa (*Equally contributed). CD4-c-kit-CD3epsilon-IL-2Ralpha+ Peyer's patch cells are a novel cell subset which secrete IL-5 in response to IL-2: implications for their role in IgA production. Eur. J. Immunol. 34: 1920-1929. 2004.
11 K, Iwai, B. R. Lee, M. Hashiguchi, A. Fukushima, M. Iwashima. IkB-alpha-specific transcript regulation by the C-terminal end of c-Rel. FEBS Lett. 579: 141-144. 2005.
日本語総説
- 橋口昌章, 八村敏志, 上野川修一. 腸管におけるIgA産生とパイエル板T細胞のサイトカイン分泌. 臨床免疫. 30: 1524. 1998.
- 八村敏志, 植田祥啓, 橋口昌章, 上野川修一. 抗原の経口投与により誘導されるT細胞: 抗体産生誘導能の弱い「Th2」細胞？臨床免疫. 30: 408. 1998.
- 八村敏志, 後藤真生, 好田正, 橋口昌章, 上野川修一. 腸管免疫応答の特性. 日本農芸化学会誌. 73: 523. 1999.
- 橋口昌章，東みゆき. B7ファミリーと免疫応答の制御. 臨床免疫. 42: 85. 2004.
著書
橋口昌章. 腸管免疫系の構造と機能 バイエル板 pp. 74-86. 食品とからだ. 免疫・アレルギーのしくみ 上野川修一編. 朝倉書店. 2003.
