Pharmacology

1. Staffs and Students(April, 2008)  

Professor                               Keiichi OHYA

Associate Professor                     Hitoyata SHIMOKAWA

Assistant Professor                     Yukihiko TAMURA

Assistant Professor                     Kazuhiro AOKI

Technologist                            Mariko TAKAHASHI

Secretary                               Chikako KIDO

Graduate Student                        SOYSA Hennadige Niroshani Surangika

                                        Wantida SRIARJ (Developmental Oral Health Science)

                                        ALLES Chrisman Neil Roshan Alexander

                                        Nobuyoshi TOMOMATSU(Maxillofacial Surgery)

                                        Kenichi NAGANO

                                        Hiroyuki NAKACHI(Maxillofacial Surgery)

                                        Naoki HAYASHI(Dentistry for Persons with Disabilities)

                                        Toshimi SATO

2. Purpose of Education

Pharmacology is situated between the basic and clinical sciences and is important for dental students. There is a growing demand on the dental clinicians to know huge knowledge of drugs and how to use them for patients. For these purpose, the first lecture is aimed to teach the scientific aspects of pharmacology and how drugs act on the various body system. The second lecture deals with drugs of medical and dental fields and the last with drugs of special importance of dentistry. Dental students learn the principle of pharmacology through laboratory practice. Following these learning, they must acquire an adequate background for drug use in general practice.

3. Research Subjects

1)Drug effects on the formation mechanism of teeth and bone

2)Pharmacological analysis of bone resorption mechanism

3)Development of inhibitors for bone resorption and their clinical trials

4)Toxicity of heavy metals in mineralized tissue

4. Publications

Original Article

1. Yokota T, Shimokawa H, Shibata S, Itoh K, Baba Y, Ohya K, Ohyama K, Suzuki S. Insulin-like Growth Factor I Regulates Apoptosis in Condylar Cartilage. J Dent Res Vol.87(2), pp159-163, 2008

2. Asagiri M, Hirai T, Kunigami T, Kamano S, Gober H-J, Okamoto K, Nishikawa K, Latz E, Golenbock D.T, Aoki K, Ohya K, Imai Y, Morishita Y, Miyazono K, Kato S, Saftig P, Takayanagi H. Cathepsin K-Dependent Toll-Like Receptor 9 Signaling Revealed in Experimental Arthritis. Science Vol.319, pp.624-627, February 2008

3. Mian MD, Saito H, Alles N, Shimokawa H, Aoki K, Ohya K. Lipopolysaccharide-induced bone resorption is increased in TNF type 2 receptor-deficient mice in vivo. J Bone Miner Metab Vol.26, pp469-477, 2008

4. Yokoyama Y, Damrongrungruang T, Kuroda S, Takano Y, Ohya K, Kasugai S, Kondo H. Comparative Analysis of Gene Expression by cDNA Microarray between Cementoblasts and Periodontal Ligament Cells in the Murine Mandible. J Oral Biosci Vol.50(3), pp183-193, 2008

5. Samee M, Kasugai S, Kondo H, Ohya K, Shimokawa H, Kuroda S. Bone Morphogenetic Protein-2(BMP-2) and Vascular Endothelial Growth Factor (VEGF) Transfection to Human Periosteal Cells Enhances Osteoblast Differentiation and Bone Formation. J Pharmacol Sci Vol.108, pp18-31, 2008