業績

| 2018 | 2017 | 2016 | 2015 | 2014 |2013 |2012 | 2011 | 2010 | 2009 | 2008
| 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999

主要業績

臨床でも研究でも、一流ジャーナル論文が書けます!

15年間で、英文280報!!( うち47報が Impact Factor 6以上 )

掲 載 誌 Impact Factor
Nature Medicine (2報)
27.4
Cell Stem Cell
22.3
Immunity (2報)
21.6
Annals of Internal Medicine
17.8
Gastroenterology (13報)
16.7
Gut (3報)
14.7
Autophagy
11.8
Journal of Hepatology
11.3
Hepatology (7報)
11.1
Genes & Development
10.8
American Journal of Gastroenterology (4報)
10.8
Trends in Mol Medicine
9.5
Cancer Research
9.3
EMBO Reports
9.1
Stem cells
6.5
Journal of Clrohns & Colitis (8報)
6.2
Alimentary Pharmacology & Therapeutics
5.7
Endoscopy (2報)
5.1
Journal of Immunology (14報)
4.9
Molecular and Cellular Biology
4.8
Journal of Gastroenterology
4.8
The Journal of Biological Chemistry
4.6
Inflammatory Bowel Diseases (7報)
4.5
  1. Yui S, Nakamura T, Sato T, Nemoto Y, Mizutani T, Zheng X, Ichinose S, Nagaishi T, Okamoto R, Tuchiya K, Clevers H, Watanabe M: Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell.
    Nat Med
    . 18(4):618-623, 2012[PubMed] (Impact Factor 27.4)
  2. Okamoto R, Yajima T, Yamazaki M, Kanai T, Mukai M, Okamoto S, Ikeda Y, Hibi T, Inazawa J, Watanabe M: Damaged epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract.
    Nat Med. 8: 1011-1017, 2002 [PubMed] (Impact Factor 27.4)
  3. Yui S, Azzolin L, Maimets M, Pedersen MT, Fordham RP, Hansen SL, Larsen HL, Guiu J, Alves M.R.P, Rundsten CF, Johansen JV, Li Y, Madsen CD, Nakamura T, Watanabe M, Nielsen OH, Schweiger PJ, Stefano Piccoloand Kim B. Jensen:YAP/TAZ-dependent reprogramming of colonic epithelium links ECM remodeling to tissue regeneration.
    Cell Stem Cell. 22(1): 35-49, 2018[PubMed] (Impact Factor 22.3)
  4. Fordham RP, Yui S, Hannan NR, Soendergaard C, Madgwick A, Schweiger PJ, Nielsen OH, Vallier L, Pedersen RA, Nakamura T, Watanabe M, Jensen KB: Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury.
    Cell Stem Cell.13(6):734-744,2013[PubMed] (Impact Factor 22.3)
  5. Lassen KG, McKenzie CI, Mari M, Murano T, Begun J, Baxt LA, Goel G, Villablanca EJ, Kuo SY, Huang H, Macia L, Bhan AK, Batten M, Daly MJ, Reggiori F, Mackay CR, Xavier RJ:Genetic Coding Variant in GPR65 Links Lysosomal Dysfunction with Colitis Risk.
    Immunity. 44(6):1392-1405, 2016[PubMed](Impact Factor21.6)
  6. Chen L, Chen Z, Baker K, Halvorsen EM, Cunha AP, Flak MB, Gerber G, Huang YH, Hosomi S, Arthur JC, Dery KJ, Nagaishi T, Beauchemin N, Holmes KV, Ho JWK, Shively JE, Jobin C, Onderdonk AB, Bry L, Weiner HL, Higgins DE, Blumberg RS: The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction.
    Immunity
    . 37(5):930-946, 2012[PubMed](Impact Factor21.6)
  7. Suzuki K, Oida T, Hamada H, Hitotsumatsu O, Watanabe M, Hibi T, Yamamoto H, Kubota E, Kaminogawa S, Ishikawa H: Gut cryptopatches: Direct evidence of extrathymic anatomical sites for intestinal T lymphoiesis.
    Immunitiy. 13: 691-702, 2000. [PubMed] (Impact Factor21.6)
  8. Ohkusa T, Fujiki K, Takashimizu I, Kumagai J, Tanizawa T, Eishi Y, Yokoyama T, Watanabe M.Improvement in atrophic gastritis and intestinal metaplasia in patients from whom Helicobacter pylori was eradicated.
    Ann Int Med. 134 : 380-386, 2001. [PubMed] (Impact Factor17.8)
  9. Naganuma M, Sugimoto S, Mitsuyama K, Kobayashi T, Yoshimura N, Ohi H, Tanaka S, Andoh A, Ohmiya N, Saigusa K, Yamamoto T, Morohoshi Y, Ichikawa H, Matsuoka K, Hisamatsu T, Watanabe K, Mizuno S, Suda W, Hattori M, Fukuda S, Hirayama A, Abe T, Watanabe M, Hibi T, Suzuki Y, Kanai T for the INDIGO Study Group.: Efficacy of indigo naturalis in a multicenter randomized controlled trial of patients with ulcerative colitis.
    Gastroenterology. 154(4): 935-947, 2018. [PubMed] (Impact Factor16.7)
  10. Matsuura K, Sawai H, Ikeo K, Ogawa S, Iio E, Isogawa M, Shimada N, Komori A, Toyoda H, Kumada T, Namisaki T, Yoshiji H, Sakamoto N, Nakagawa M, Asahina Y, Kurosaki M, Izumi N, Enomoto N, Kusakabe A, Kajiwara E, Itoh Y, Ide T, Tamori A, Matsubara M, Kawada N, Shirabe K, Tomita E, Honda M, Kaneko S, Nishina S, Suetsugu A, Hiasa Y, Watanabe H, Genda T, Sakaida I, Nishiguchi S, Takaguchi K, Tanaka E, Sugihara J, Shimada M, Kondo Y, Kawai Y, Kojima K, Nagasaki M, Tokunaga K, Tanaka Y; Japanese Genome-Wide Association Study Group for Viral Hepatitis:Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection.
    Gastroenterology. 152(6): 1383-1394, 2017 . [PubMed] (Impact Factor16.7)
  11. Watanabe T, Ajioka Y, Mitsuyama K, Watanabe K, Hanai H, Nakase H, Kunisaki R, Matsuda K, Iwakiri R, Hida N, Tanaka S, Takeuchi Y, Ohtsuka K, Murakami K, Kobayashi K, Iwao Y, Nagahori M, Iizuka B, Hata K, Igarashi M, Hirata I, Kudo SE, Matsumoto T, Ueno F, Watanabe G, Ikegami M, Ito Y, Oba K, Inoue E, Tomotsugu N, Takebayashi T, Sugihara K, Suzuki Y, Watanabe M, Hibi T:Comparison of Targeted vs Random Biopsies for Surveillance of Ulcerative Colitis-associated Colorectal Cancer.
    Gastroenterology. 151(6):1122-1130, 2016. [PubMed] (Impact Factor16.7)
  12. Yoshimura N, Watanabe M, Motoya S, Tominaga K, Matsuoka K, Iwakiri R, Watanabe K, Hibi T:Safety and Efficacy of AJM300, an Oral Antagonist of α4 Integrin, in Induction Therapy for Patients with Active Ulcerative Colitis.
    Gastroenterology.149(7):1775-1783,2015. [PubMed] (Impact Factor16.7)
  13. Takenaka K, Ohtsuka K, Kitazume Y, Nagahori M, Fujii T, Saito E, Naganuma M, Araki A, Watanabe M:Comparison of Magnetic Resonance and Balloon Enteroscopic Examination of Deep Small Intestine in Patients with Crohn's Disease.
    Gastroenterology
    .147(2):334-342,2014[PubMed](Impact Factor16.7)
  14. Ono Y, Kanai T, Sujino T, Nemoto Y, Kanai Y, Mikami Y, Hayashi A, Matsumoto A, Takaishi H, Ogata H, Matsuoka K, Hisamatsu T, Watanabe M, Hibi T: T-helper 17 and interleukin-17-producing lymphoid tissue inducer-like cells make different contributions to colitis in mice.
    Gastroenterology
    . 143 (5):1288-1297, 2012[PubMed](Impact Factor16.7)
  15. Nemoto Y, Kanai T, Shinohara T, Ito T, Nakamura T, Okamoto R, Tsuchiya K, Lipp M, Eishi Y, Watanabe M: Luminal CD4+ T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation.
    Gastroenterology.
    141(6):2130-2139,2011. [PubMed] (Impact Factor16.7)
  16. Kamiya A, Kakinuma S, Yamazaki Y, Nakauchi H:Enrichment and clonal culture of progenitor cells during mouse postnatal liver development in mice.
    Gastroenterology
    . 137(3):1114-26, 2009. [PubMed] (Impact Factor16.7)
  17. Oikawa T, Kamiya A, Kakinuma S, Zeniya M, Nishinakamura R, Tajiri H, Nakauchi H: Sall4 regulates cell fate decision of fetal hepatic stem/progenitor cells.
    Gastroenterology. 136:1000-1011, 2009. [PubMed] (Impact Factor16.7)
  18. Nemoto Y, Kanai T, Makita S, Okamoto R, Totsuka T, Takeda K, Watanabe M: Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis.
    Gastroenterology. 132: 176-189, 2007. [PubMed] (Impact Factor16.7)
  19. Tsuchiya K, Nakamura T, Okamoto R, Kanai T, Watanabe M: Reciprocal targeting of Hath1 and b-catenin by Wnt- glycogen synthase kinase 3 b in colonocyte differentiation and proliferation.
    Gastroenterology. 132: 208-220, 2007. [PubMed] (Impact Factor16.7)
  20. Nakagawa M, Sakamoto N, Tanabe Y, Koyama T, Itsui Y, Takeda Y, Chen CH, Kakinuma S, Oooka S, Maekawa S, Enomoto N, Watanabe M: Suppression of hepatitis C virus replication by cyclosporin A is mediated by blockade of cyclophilins.
    Gastroenterology.129: 1031-1041, 2005. [PubMed] (Impact Factor16.7)
  21. Matsumoto T, Okamoto R, Yajima T, Mori T, Okamoto S, Ikeda Y, Mukai M, Yamazaki M, Nakamura T, Kanai T, Hibi T, Inazawa J, Watanabe M: Increase of bone marrow-derived secretory lineage epithelial cells during regeneration in the human intestine.
    Gastroenterology. 128: 1851-1867, 2005. [PubMed] (Impact Factor16.7)
  22. Sato T, Kanai T, Watanabe M, Sakuraba A, Okamoto S, Nakai T, Okazawa A, Inoue N, Totsuka T, Yamazaki M, Kroczek RA, Fukushima T, Ishii H, Hibi T: Hyperexpression of inducible costimulator and Its contribution on lamina propria T cells in inflammatory bowel disease.
    Gastroenterology.126: 829-839, 2004. [PubMed] (Impact Factor16.7)
  23. Totsuka T, Kanai T, Iiyama R, Uraushihara K, Yamazaki M, Okamoto R, Hibi T, Tezuka K, Azuma M, Akiba H, Yagita H, Okumura K, Watanabe M: Ameliorating effect of anti-inducible co-stimulator monoclonal antibody in a murine model of chronic colitis.
    Gastroenterology.124 : 410-421, 2003. [PubMed] (Impact Factor16.7)
  24. Kanai T, Watanabe M, Okazawa A, Sato T, Yamazaki M, Okamoto S, Ishii H, Totsuka T, Iiyama R, Okamoto R, Ikeda M, Kurimoto M, Takeda K, Akira S, Hibi T:Macrophage-derived IL-18 mediated intestinal inflammation in the murine model of Crohn's disease.
    Gastroenterology. 121 : 875-888, 2001. [PubMed] (Impact Factor16.7)
  25. Kanai T, Watanabe M, Nakamaru K, Okazawa A, Okamoto M, Naganuma M, Ishii H, Ikeda M, Kurimoto M, Hibi T:IL-18 is a potent proliferative factor for intestinal mucosal lymphocytes in Crohn's disease.
    Gastroenterology. 119:1514-1523, 2000. [PubMed] (Impact Factor16.7)
  26. Li X, Zhao YJ, Dai J, Li XB, Xue HB, Zhang Y, Xiong GS, Ohtsuka K,Gao YJ, Liu Q, Song Y, Fang JY, Ge ZZ: Carbon dioxide insufflation improves the intubation depth and total enteroscopy rate in single-balloon enteroscopy: a randomised, controlled, double-blind trial.
    Gut.63(10)1560-1565, 2014[PubMed](Impact Factor14.7)
  27. Nemoto Y, Kanai T, Takahara M, Oshima S, Nakamura T, Okamoto R, Kiichiro T, Watanabe M: Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4+ memory T cells.
    Gut. 62(8):1142-1152, 2013[PubMed](Impact Factor14.7)
  28. Kobayashi K, Ogata H, Morikawa M, IIjima S, Harada N, Yoshida T, Brown WR, Inoue N, Hamada Y, Ishii H, Watanabe M, Hibi T: Distribution and partial characterization of IgG Fc binding protein in various mucin-producing cells and body fluids.
    Gut. 51: 169-176, 2002. [PubMed](Impact Factor14.7)
  29. Nibe Y, Oshima S, Kobayashi M, Maeyashiki C, Matsuzawa Y, Otsubo K, Matsuda H, Aonuma E, Nemoto Y, Nagaishi T, Okamotoa R, Tsuchiya K, Nakamura T, Nakada S, Watanabe M:Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by p62/SQSTM1.
    Autophagy. 14(2): 347-358, 2018[PubMed](Impact Factor11.8)
  30. Matsuzawa Y, Oshima S, Takahara M, Maeyashiki C, Nemoto Y, Kobayashi M,
    Nibe Y, Nozaki K, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Ma A,
    Watanabe M:TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting
    autophagy.
    Autophagy. 11(7):1052-1062,2015 [PubMed](Epub ahead of print)(Impact Factor11.8)
  31. Nagata H, Nakagawa M, Asahina Y, Sato A, Asano Y, Tsunoda T, Miyoshi M, Kaneko S, Otani S, Kawai-Kitahata F, Murakawa M, Nitta S, Itsui Y, Azuma S, Kakinuma S, Nouchi T, Sakai H, Tomita M, Watanabe M; Ochanomizu Liver Conference Study Group:Effect of interferon-based and -free therapy on early occurrence and recurrence of hepatocellular carcinoma in chronic hepatitis C.
    J Hepatol. 67(5): 933-939, 2017[PubMed](Impact Factor11.3)
  32. Kurosaki M, Hiramatsu N, Sakamoto M, Suzuki Y, Iwasaki M, Tamori A, Matsuura K, Kakinuma S, Sugauchi F, Sakamoto N, Nakagawa M, Yatsuhashi H, Izumi N: Data mining model using simple and readily available factors could identify patients at high risk for hepatocellular carcinoma in chronic hepatitis C.
    J Hepatol.
    56(3):602-608, 2012[PubMed](Impact Factor11.3)
  33. Asahina Y, Tsuchiya K, Nishimura T, Muraoka M, Suzuki Y, Tamaki N, Yasui Y, Hosokawa T, Ueda K, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Nakagawa M, Kakinuma S, Watanabe M, Izumi N: α-fetoprotein levels after interferon therapy and risk of hepatocarcinogenesis in chronic hepatitis C.
    Hepatology. 58(4):1253-1262, 2013 [PubMed](Impact Factor11.1)
  34. Kiyohashi K, Kakinuma S, Kamiya A, Sakamoto N, Nitta S, Yamanaka H, Yoshino K, Fujiki J, Murakawa M, Kusano-Kitazume A, Shimizu H, Okamoto R, Azuma S, Nakagawa M, Asahina Y, Tanimizu N, Kikuchi A, Nakauchi H, Watanabe M: Wnt5a signaling mediates biliary differentiation of fetal hepatic stem/progenitor cells.
    Hepatology
    , 57(6):2502-2513, 2013 [PubMed](Impact Factor11.1)
  35. Nitta S, Sakamoto N, Nakagawa M, Kakinuma S, Mishima K, Kusano-Kitazume A, Kiyohashi K, Murakawa M, Nishimura-Sakurai Y, Azuma S, Tasaka-Fujita M, Asahina Y, Yoneyama M, Fujita T, Watanabe M: Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type-I interferon-dependent innate immunity.
    Hepatology
    . 57(1):46-58, 2013 [PubMed](Impact Factor11.1)
  36. Asahina Y, Tsuchiya K, Muraoka M, Tanaka K, Suzuki Y, Tamaki N, Hoshioka Y, Yasui Y, Katoh T, Hosokawa T, Ueda K, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Nitta S, Sakamoto N, Izumi N: Association of gene expression involving innate immunity and genetic variation in interleukin 28B with antiviral response.
    Hepatology. 55(1):20-29, 2012[PubMed] (Impact Factor11.1)
  37. Itsui Y, Sakamoto N, Kakinuma S, Nakagawa M, Sekine-Osajima Y, Tasaka-Fujita M, Nishimura-Sakurai Y, Suda G, Karakama Y, Mishima K, Yamamoto M, Watanabe T, Ueyama M, Funaoka Y, Azuma S, Watanabe M:Antiviral effects of the interferon-induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B protein.
    Hepatology . 50: 1727-37, 2009. [PubMed](Impact Factor11.1)
  38. Kamiya A, Kakinuma S, Onodera M, Miyajima A, Nakauchi H:Prospero-related homeobox 1 and liver receptor homolog 1 coordinately regulate long-term proliferation of murine fetal hepatoblasts.
    Hepatology
    .48(1):252-64,2008.[PubMed](Impact Factor11.1)
  39. Chinzei R, Tanaka Y, Shimuzu-Saito K, Hara Y, Kakinuma S, Watanabe M, Teramoto K, Arii S, Takase K, Sato C, Terada N, Teraoka H:Embryoid-body cells derived from a mouse embryonic stem cell line show differentiation into functional hepatocytes.
    Hepatology 36:22-29, 2002. [PubMed] (Impact Factor11.1)
  40. Fukuda M, Mizutani T, Mochizuki W, Matsumoto T, Nozaki K, Sakamaki Y,
    Ichinose S, Okada Y, Tanaka T, Watanabe M, Nakamura T: Small intestinal stem
    cell identity is maintained with functional Paneth cells in heterotopically
    grafted epithelium onto the colon.
    Genes Dev. 28(16):1752-1757,2014[PubMed] (Impact Factor 10.8)
  41. Takenaka K, Ohtsuka K, Kitazume Y, Matsuoka K, Nagahori M, Fujii T, Saito E, Kimura M, Fujioka T, Watanabe M:Utility of magnetic resonance enterography for small bowel endoscopic healing in patients with Crohn’s disease.
    Am J Gastroenterol.113(2):283-294, 2018 [PubMed] (Impact Factor 10.8)
  42. D’Haens GR, Panaccione R, Higgins PD, Vermeire S, Gassull M, Chowers Y, Hanauer SB, Herfarth H, Hommes DW, Kamm M, L?fberg R, Quary A, Sands B, Sood A, Watermayer G, Lashner B, L?mann M, Plevy S, Reinisch W, Schreiber S, Siegel C, Targan S, Watanabe M, Feagan B, Sandborn WJ, Colombel JF, Travis S: The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD With the European Crohn’s and Colitis Organization: When to Start, When to Stop, Which Drug to Choose, and How to Predict Response?
    Am J Gastroenterol.106(2):199-212, 2011. [PubMed] (Impact Factor 10.8)
  43. Naganuma M, Watanabe M, Kanai T, Iwao Y, Mukai M, Ishikawa H, Ishii H, Hibi T: Characterization of structures with T-lymphocyte aggregates in ileal villi of Crohn's disease.
    Am J Gastroenterol. 97: 1741-1747, 2002. [PubMed] (Impact Factor 10.8)
  44. Okazawa A, Kanai T, Watanabe M, Yamazaki M, Inoue N, Ikeda M, Kurimoto M, Ishii H, Hibi T: Th1-mediated intestinal inflammation in Crohn's disease may be induced by activation of lamina propria lymphocytes through synergistic stimulation of interleukin-12 and interleukin-18 without T cell receptor engagement.
    Am J Gastroenterol.97: 3108-3117, 2002. [PubMed](Impact Factor 10.8)
  45. Nagayama K, Enomoto N, Miyasaka Y, Kurosaki M,Chen CH, Sakamoto N, Nakagawa M, Sato C, Tazawa J,Ikeda T, Izumi N, Watanabe M.
    Overexpression of interferon gamma-inducible protein 10 in the liver of patients with type I autoimmune hepatitis identified by suppression subtractive hybridization.
    Am J Gastroenterol. 2001; 96 : 2211-2217. [PubMed](Impact Factor 10.8)
  46. Okamoto R, Watanabe M: Prospects for regeneration of gastrointestinal epithelia using bone-marrow cells.
    Trends Mol Med. 9: 286-290, 2003. [PubMed] (Impact Factor9.5)
  47. Oshima H, Nakayama M, HanT, Naoi K, Ju X, Maeda Y, Robine S, Tsuchiya K, Sato T, Sato H, Taketo M, Oshima M:Suppressing TGF-β signaling in regenerating epithelia in an inflammatory microenvironment is sufficient to cause invasive intestinal cancer.
    Cancer Res.75:766-776,2015. [PubMed] (Impact Factor9.3)
  48. Ezaki T, Watanabe M, Inoue N, Kanai T, Ogata H, Iwao Y, Ishii H, Hibi T: A specific genetic alteration on chromosome 6 in ulcerative colitis-associated colorectal cancers.
    Cancer Res. 63: 3747-3749, 2003. [PubMed] (Impact Factor9.3)
  49. Sakamoto S, Yokota T, Enomoto N, Tanabe Y, Miyagishi M, Maekawa S, Ye L, Kurosaki M, Taira K, Watanabe M, Mizusawa H: Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived siRNAs.
    EMBO Reports.. 4: 1-7, 2003. [PubMed] (Impact Factor9.1)
  50. Kakinuma S, Tanaka Y, Chinzei R, Watanabe M, Shimizu-Saito K, Hara Y, Teramoto K, Arii S, Sato C, Takase K, Yasumizu T, Teraoka H:Human umbilical cord blood as a source of transplantable hepatic progenitor cells.
    Stem Cells
    . 21:217-227, 2003.[PubMed](Impact Factor6.5)
  51. Shinzaki S, Matsuoka K, Iijima H, Mizuno S, Serada S, Fujimoto M, Arai N, Koyama N, Morii E, Watanabe M, Hibi T, Kanai T, Takehara T, Naka T:Leucine-rich alpha-2 glycoprotein is a serum biomarker of mucosal healing in ulcerative colitis.
    J Crohns Colitis. 11(1): 84-91, 2017[PubMed](Impact Factor6.2)
  52. Hibiya S, Tsuchiya K, Hayashi R, Fukushima K, Horita N, Watanabe S, Shirasaki T, Nishimura R, Kimura N, Nishimura T, Gotoh N, Oshima S, Okamoto R, Nakamura T, Watanabe M:Long-term inflammation transforms intestinal epithelial cells of colonic organoids.
    J Crohns Colitis. 11(5): 621-630, 2017[PubMed](Impact Factor6.2)
  53. Ogata H, Watanabe M, Matsui T, Hase H, Okayasu M, Tsuchiya T, Shinmura Y, Hibi T:Safety of adalimumab and predictors of adverse events in 1693 Japanese patients with Crohn's disease.
    J Crohns Colitis. 10(9): 1033-1041, 2016[PubMed](Impact Factor6.2)
  54. Matsumoto T, Motoya S, Watanabe K, Hisamatsu T, Nakase H, Yoshimura N, Ishida T, Kato S, Nakagawa T, Esaki M, Nagahori M, Matsui T, Naito Y, Kanai T, Suzuki Y, Nojima M, Watanabe M, Hibi T; DIAMOND study group:Adalimumab Monotherapy and a Combination with Azathioprine for Crohn's Disease: A Prospective, Randomized Trial.
    J Crohns Colitis. 10(11):1259-1266, 2016[PubMed](Impact Factor6.2)
  55. Kobayashi K, Hirai F, Naganuma M, Watanabe K, Ando T, Nakase H, Matsuoka K, Watanabe M: A randomized clinical trial of mesalazine suppository: The usefulness and problems of central review of evaluations of colonic mucosal findings.
    J Crohns Colitis.8(11):1444-1453,2014[PubMed](Impact Factor6.2)
  56. Watanabe M, Hibi T, Mostafa NM, Chao J, Arora V, Camez A, Petersson J, Thakkar R: Long-term safety and efficacy of adalimumab in Japanese patients with moderate to severe Crohn's disease.
    J Crohns Colitis.8(11):1407-1416,2014[PubMed](Impact Factor6.2)
  57. Yokoyama Y, Matsuoka K, Kobayashi T, Sawada K, Fujiyoshi T, Ando T, Ohnishi Y, Ishida T, Oka M, Yamada M, Nakamura T, Ino T, Numata T, Aoki H, Sakou J, Kusada M, Maekawa T, Hibi T: A large-scale, prospective, observational study of leukocytapheresis for ulcerative colitis: treatment outcomes of 847 patients in clinical practice.
    J Crohns Colitis.8(9):981-991 , 2014[PubMed](Impact Factor6.2)
  58. Naganuma M, Fujii T, Kunisaki R, Yoshimura N, Takazoe M, Takeuchi Y, Saito E, Nagahori M, Asakura K, Takebayashi T, Watanabe M: Incidence and characteristics of the 2009 influenza (H1N1) infections in inflammatory bowel disease patients.
    J Crohns Colitis. 7(4):308-318, 2013[PubMed](Impact Factor6.2)
  59. Calabrese E, Zorzi F, Zuzzi S, Ooka S, Onali S, Petruzziello C, Lasinio GJ, Biancone L, Rossi C, Pallone: Development of a numerical index quantitating small bowel damage as detected by ultrasonography in Crohn's disease.
    J Crohns Colitis. 6(8):852-860, 2012[PubMed](Impact Factor6.2)
  60. Watanabe M, Hibi T, Lomax KG, Paulson SK, Chao J, Alam MS, Camez A : Adalimumab for the induction and maintenance of clinical remission in Japanese patients with Crohn's disease.
    J Crohns Colitis. 6(2):160-73, 2012[PubMed](Impact Factor6.2)
  61. Naganuma M, Kunisaki R, Yoshimura N, Nagahori M, Yamamoto H, Kimura H, Sako M, Kawaguchi T, Takazoe M, Yamamoto S, Matsui T, Hibi T, Watanabe M: Conception and pregnancy outcome in women with inflammatory bowel disease: A multicentre study from Japan.
    J Crohns Colitis. 5: 317-323, 2011. [PubMed](Impact Factor6.2)
  62. Watanabe M, Hibi T, Lomax KG, Paulson SK, Chao J, Alam SS, Camez A: Adalimumab for the Induction and Maintenance of Clinical Remission in Japanese Patients With Crohn's Disease.
    J Crohns Colitis. (in press), 2011.[PubMed](Impact Factor6.2)
  63. Nakase H, Motoya S, Matsumoto T, Watanabe K, Hisamatsu T, Yoshimura N, Ishida T, Kato S, Nakagawa T, Esaki M, Nagahori M, Matsui T, Naito Y, Kanai T, Suzuki Y, Nojima M, Watanabe M, Hibi T; DIAMOND study group:Significance of measurement of serum trough level and anti-drug antibody of adalimumab as personalised pharmacokinetics in patients with Crohn's disease: a subanalysis of the DIAMOND trial.
    Aliment Pharmacol Ther. 46(9): 873-882, 2017[PubMed](Impact Factor5.7)
  64. Watanabe M, Nishino H, Sameshima Y, Ota A, Nakamura S, Hibi T: Randomised clinical trial: evaluation of the efficacy of mesalazine (mesalamine) suppositories in patients with ulcerative colitis and active rectal inflammation -a placebo- controlled study.
    Aliment Pharmacol Ther. 38(3):264-273, 2013[PubMed](Impact Factor5.7)
  65. Watanabe D, Kudo SE, Hayashi S, Mori Y, Kodama K, Wakamura K, Miyachi H,Yamamura F, Ohtsuka K, Mikogami T, Kimura S, Fukuchi K, Ikehara N: Endocytoscopy provides an in vivo virtual histopathological diagnosis of Whipple's disease.
    Endoscopy
    . 45(2):143-144, 2013[PubMed](Impact Factor5.1)
  66. Mori Y, Kudo S, Ikehara N, Wakamura K, Wada Y, Kutsukawa M, Misawa M, Kudo T, Kobayashi Y, Miyachi H, Yamamura F, Ohtsuka K, Inoue H, Hamatani S: Comprehensive diagnostic ability of endocytoscopy compared with biopsy for colorectal neoplasms: a prospective randomized noninferiority trial.
    Endoscopy, 45(2):98-105, 2013[PubMed](Impact Factor5.2)
  67. Shinohara S, Nemoto Y, Kanai T, Kameyama K, Okamoto R, Tsuchiya K, Nakamura T, Totsuka T, Ikuta K, Watanabe M: Upregulated IL-7R a expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis.
    J Immunol. 186(4):2623-2632, 2011. [PubMed] (Impact Factor4.9)
  68. Totsuka T, Kanai T, Nemoto Y, Tomita T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Akiba H, Okumura K, Yagita H, Watanabe M: RANK-RANKL signaling pathway Is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis.
    J Immunol.182: 6079-6087, 2009. [PubMed](Impact Factor4.9)
  69. Tomita T, Kanai T, Fujii T, Nemoto Y, Okamoto R, Tsuchiya K, Totsuka T, Sakamoto N, Akira S, Watanabe M: MyD88-dependent pathway in T Cells directly modulates the expansion of colitogenic CD4+ T Cells in chronic colitis.
    J Immunol. 180: 5291-5299, 2008. [PubMed](Impact Factor4.9)
  70. Tomita T, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Sakamoto N, Watanabe M: Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis.
    J Immunol. 180: 383-390, 2008. [PubMed](Impact Factor4.9)
  71. Makita S, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Yamamoto M, Kiyono H, Watanabe M: Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation.
    J Immunol. 178: 4937-4946, 2007. [PubMed](Impact Factor4.9)
  72. Totsuka T, Kanai T, Nemoto Y, Makita S, Okamoto R, Tsuchiya K, Watanabe M: IL-7 is essential for the development and the persistence of chronic colitis.
    J Immunol. 178: 4737-4748, 2007. [PubMed](Impact Factor4.9)
  73. Makita S, Kanai T, Oshima S, Uraushihara K, Totsuka T, Iiyama R, Sawada T, Nakamura T, Koganei K, Fukushima T, Watanabe M: CD4+CD25bright T cells in human intestinal lamina propria as regulatory cells.
    J Immunol. 173: 3119-3130, 2004. [PubMed](Impact Factor4.9)
  74. Kawamura T, Kanai T, Dohi T, Uraushihara K, Totsuka T, Iiyama R, Taneda C, Yamazaki M, Nakamura T, Higuchi T, Aiba Y, Tsubata T, Watanabe M: Ectopic CD40 ligand expression on B cells triggers intestinal inflammation.
    J Immunol. 172: 6388-6397, 2004. [PubMed](Impact Factor4.9)
  75. Kanai T, Totsuka T, Uraushihara K, Makita S, Nakamura T, Koganei K, Fukushima T, Akiba H, Yagita H, Okumura K, Machida U, Iwai H, Azuma M, Chen L, Watanabe M: Blockade of B7-H1 suppresses the development of chronic intestinal inflammation.
    J Immunol. 171: 4156-4163, 2003. [PubMed](Impact Factor4.9)
  76. Yamazaki M, Yajima T, Tanabe M, Fukui K, Okada E, Okamoto R, Oshima S, Nakamura T, Kanai T, Uehira M, Takeuchi T, Ishikawa H, Hibi T, Watanabe M: Mucosal T cells expressing high levels of IL-7 receptor are potential targets for treatment of chronic colitis. 
    J Immunol. 171: 1556-1563, 2003. [PubMed](Impact Factor4.9)
  77. Uraushihara K, Kanai T, Ko K, Totsuka T, Makita S, Iiyama R, Nakamura T, Watanabe M: Regulation of murine inflammatory bowel disease by CD25+ and CD25-CD4+ glucocorticoid-induced TNF receptor family-related gene+ regulatory T cells.
    J Immunol.
    171: 708-716, 2003. [PubMed](Impact Factor4.9)
  78. Nemoto Y, Kanai T, Takahara M, Oshima S, Okamoto R, Tsuchiya K, Matsumoto S, Watanabe M: Th1/Th17-Mediated Interstitial Pneumonia in Chronic Colitis Mice Independent of Intestinal Microbiota.
    J Immunol.190:6616-6625, 2013[PubMed](Impact Factor4.9)
  79. Callahan JA, Hammer GE, Agelides A, Duong BH, Oshima S, North J, Advincula R, Shifrin N, Truong HA, Paw J, Barrera J, DeFranco A, Rosenblum MD, Malynn BA, Ma A: Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells.
    J Immunol. 191(2):535-539, 2013[PubMed](Impact Factor4.9)
  80. Yamaji O, Nagaishi T, Totsuka T, Onizawa M, Suzuki M, Tsuge N, Hasegawa A, Okamoto R, Tsuchiya K, Nakamura T, Arase H, Kanai T, Watanabe M: The development of colitogenic CD4+ T cells is regulated by IL-7 in collaboration with natural killer cell function in a murine model of colitis.
    J Immunol. 188(6):2524-2536, 2012[PubMed](Impact Factor5.1)
  81. Oshima S, Nakamura T, Namiki S, Okada E, Tsuchiya K, Okamoto R, Yamazaki M, Yokota T, Aida M, Yamaguchi Y, Kanai T, Handa H, Watanabe M: Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells.
    Mol Cell Biol. 24: 6298-6310, 2004 [PubMed] (Impact Factor4.8)
  82. Naganuma M, Aoyama N, Tada T, Kobayashi K, Hirai F, Watanabe K, Watanabe M, Hibi T:Complete mucosal healing of distal lesions induced by twice-daily budesonide 2-mg foam promoted clinical remission of mild-to-moderate ulcerative colitis with distal active inflammation: double-blind, randomized study.
    J Gastroenterol. 53(4)494-506, 2018 [PubMed](Impact Factor4.8)
  83. Maekawa S, Sato M, Kuratomi N, Inoue T, Suzuki Y, Tatsumi A, Miura M, Matsuda S, Muraoka M, Nakakuki N, Amemiya F, Takano S, Fukasawa M, Nakayama Y, Yamaguchi T, Sato T, Sakamoto M, Murakawa M, Nakagawa M, Asahina Y, Enomoto N: Association Between Alanine Aminotransferase Elevation And UGT1A1*6 Polymorphisms In Daclatasvir And Asunaprevir Combination Therapy For Chronic Hepatitis C.
    J Gastroenterol. (Epub ahaead of print), 2017 [PubMed](Impact Factor4.8)
  84. Kuwahara E, Murakami Y, Nakamura T, Inoue N, Nagahori M, Matsui T, Watanabe M, Suzuki Y, Nishiwaki Y:Factors associated with exacerbation of newly diagnosed mild ulcerative colitis based on a nationwide registry in Japan.
    J Gastroenterol. 52(2): 185-193, 2017 [PubMed](Impact Factor4.8)
  85. Takenaka K, Ohtsuka K, Kitazume Y, Matsuoka K, Fujii T, Nagahori M, Kimura M, Fujioka T, Araki A, Watanabe M:Magnetic resonance evaluation for small bowel strictures in Crohn's disease: comparison with balloon enteroscopy.
    J Gastroenterol. 52(8):879-888, 2017 [PubMed](Impact Factor4.8)
  86. Tazuma S, Unno M, Igarashi Y, Inui K, Uchiyama K, Kai M, Tsuyuguchi T, Maguchi H, Mori T, Yamaguchi K, Ryozawa S, Nimura Y, Fujita N, Kubota K, Shoda J, Tabata M, Mine T, Sugano K, Watanabe M, Shimosegawa T:Evidence-based clinical practice guidelines for cholelithiasis 2016.
    J Gastroenterol. 52(3): 276-300, 2017 [PubMed](Impact Factor4.8)
  87. Suzuki Y, Motoya S, Hanai H, Hibi T, Nakamura S, Lazar A, Robinson AM, Skup M, Mostafa NM, Huang B, Thakkar R, Watanabe M:Four-year maintenance treatment with adalimumab in Japanese patients with moderately to severely active ulcerative colitis.
    J Gastroenterol.52(9): 1031-1040, 2017 [PubMed](Impact Factor4.8)
  88. Iwakiri K, Kinoshita Y, Habu Y, Oshima T, Manabe N, Fujiwara Y, Nagahara A, Kawamura O, Iwakiri R, Ozawa S, Ashida K, Ohara S, Kashiwagi H, Adachi K, Higuchi K, Miwa H, Fujimoto K, Kusano M, Hoshihara Y, Kawano T, Haruma K, Hongo M, Sugano K, Watanabe M, Shimosegawa T:Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2015.
    J Gastroenterol. 51(8):751-767, 2016 [PubMed](Impact Factor4.8)
  89. Kawai-Kitahata F, Asahina Y, Tanaka S, Kakinuma S, Murakawa M, Nitta S, Watanabe T, Otani S, Taniguchi M, Goto F, Nagata H, Kaneko S, Tasaka-Fujita M, Nishimura-Sakurai Y, Azuma S, Itsui Y, Nakagawa M, Tanabe M, Takano S, Fukasawa M, Sakamoto M, Maekawa S, Enomoto N, Watanabe M:Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features.
    J Gastroenterol
    . 51(5):473-486, 2016 [PubMed](Impact Factor4.8)
  90. Fukui H, Saito H, Ueno Y, Uto H, Obara K, Sakaida I, Shibuya A, Seike M, Nagoshi S, Segawa M, Tsubouchi H, Moriwaki H, Kato A, Hashimoto E, Michitaka K, Murawaki T, Sugano K, Watanabe M, Shimosegawa T:Evidence-based clinical practice guidelines for liver cirrhosis 2015.
    J Gastroenterol. 51(7):629-650, 2016 [PubMed](Impact Factor4.8)
  91. Nozaki K, Mochizuki W, Matsumoto Y, Matsumoto T, Fukuda M, Mizutani T, Watanabe M, Nakamura T: Co-culture with intestinal epithelial organoids allows efficient expansion and motility analysis of intraepithelial lymphocytes.
    J Gastroenterol. 51(3):206-213,2016. [PubMed](Impact Factor4.8)
  92. Ito T, Ishiguro H, Ohara H, Kamisawa T, Sakagami J, Sata N, Takeyama Y, Hirota M, Miyakawa H, Igarashi H, Lee L, Fujiyama T, Hijioka M, Ueda K, Tachibana Y, Sogame Y, Yasuda H, Kato R, Kataoka K, Shiratori K, Sugiyama M, Okazaki K, Kawa S, Tando Y, Kinoshita Y, Watanabe M, Shimosegawa T:Evidence-based clinical practice guidelines for chronic pancreatitis 2015.
    J Gastroenterol. 51(2):85-92,2016. [PubMed](Impact Factor4.8)
  93. Kobayashi T, Suzuki Y, Motoya S, Hirai F, Ogata H, Ito H, Sato N, Ozaki K, Watanabe M, Hibi T:
    First trough level of infliximab at week 2 predicts future outcomes of induction therapy in ulcerative colitis-results from a multicenter prospective randomized controlled trial and its post hoc analysis.
    J Gastroenterol.51(3):241-251,2016. [PubMed](Impact Factor4.8)
  94. Okamoto R, Watanabe M:Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel disease.
    J Gastroenterol.51(1):11-21,2016. [PubMed](Impact Factor4.8)
  95. Fukudo S, Kaneko H, Akiho H, Inamori M, Endo Y, Okumura T, Kanazawa M, Kamiya T, Sato K, Chiba T, Furuta K, Yamato S, Arakawa T, Fujiyama Y, Azuma T, Fujimoto K, Mine T, Miura S, Kinoshita Y, Watanabe M, Sugano K, Shimosegawa T:Evaluation of Kampo medicine in the clinical practice guideline for irritable bowel syndrome.
    J Gastroenterol.50(3):817-818,2015. [PubMed](Impact Factor4.8)
  96. Watanabe M:Recent dramatic evolution of the Journal of Gastroenterology (JG): a note from current Editorial Director and former Editor-in-Chief of JG.
    J Gastroenterol.50(3):249-251,2015. [PubMed](Impact Factor4.8)
  97. Tanaka S, Saitoh Y, Matsuda T, Igarashi M, Matsumoto T, Iwao Y, Suzuki Y, Nishida H, Watanabe T, Sugai T, Sugihara KI, Tsuruta O, Hirata I, Hiwatashi N, Saito H, Watanabe M, Sugano K, Shimosegawa T:Evidence-based clinical practice guidelines for management of colorectal polyps.
    J Gastroenterol. 50:252-260,2015. [PubMed](Impact Factor4.8)
  98. Yoshida M, Kinoshita Y, Watanabe M, Sugano K:JSGE Clinical Practice Guidelines 2014: standards, methods, and process of developing the guidelines.
    J Gastroenterol.50(1):4-10,2015. [PubMed](Impact Factor4.8)
  99. kawa S, Okazaki K, Notohara K, Watanabe M, Shimosegawa T; Study Group for Pancreatitis Complicated with Inflammatory Bowel Disease organized by The Research Committee for Intractable Pancreatic Disease (Chairman: Tooru Shimosegawa) and The Research Committee for Intractable Inflammatory Bowel Disease (Chairman: Mamoru Watanabe), both of which are supported by the Ministry of Health, Labour, and Welfare of Japan:Autoimmune pancreatitis complicated with inflammatory bowel disease and comparative study of type 1 and type 2 autoimmune pancreatitis.
    J Gastroenterol.50(7):815-10,2015. [PubMed](Impact Factor4.8)
  100. Watanabe M:Recent dramatic evolution of the Journal of Gastroenterology (JG): a note from current Editorial Director and former Editor-in-Chief of JG.
    J Gastroenterol. 50(3):249-251,2015. [PubMed](Impact Factor4.8)
  101. Sasazuki T, Sawada T, Sakon S, Kitamura T, Kishi T, Okazaki T, Katano M, Tanaka M, Watanabe M, Yagita H, Okumura K, Nakano N: Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death.
    J Biol Chem 277: 28853-28860, 2002. [PubMed] (Impact Factor4.6)
  102. Kobayashi T, Hishida A, Tanaka H, Nuki Y, Bamba S, Yamada A, Fujii T, Shinzaki S, Yokoyama Y, Yoshida A, Ozeki K, Ashizuka S, Kamata N, Nanjo S, Kakimoto K, Nakamura M, Matsui A, Yamauchi R, Takahashi S, Tomizawa T, Yoshino T, Hibi T:Real-world Experience of Anti-Tumor Necrosis Factor Therapy for Internal Fistulas in Crohn’s disease: A Retrospective Multicenter Cohort Study.
    Inflamm Bowel Dis. 23(12):2245-2251, 2017 [PubMed](Impact Factor4.5)
  103. Calabrese E, Maaser C, Zorzi F, Kannengiesser K, Hanauer SB, Bruining DH, Iacucci M, Maconi G, Novak KL, Panaccione R, Strobel D, Wilson SR, Watanabe M, Pallone F, Ghosh S:Bowel Ultrasonography in the management of Crohn’s disease. A review with recommendations of an international panel of experts.
    Inflamm Bowel Dis. 22(5):1168-1183, 2016 [PubMed](Impact Factor4.5)
  104. Takeshita K, Mizuno S, Mikami Y, Sujino T, Saigusa K, Matsuoka K, Naganuma M, Sato T, Takada T, Tsuji H, Kushiro A, Nomoto K, Kanai T:A Single Species of Clostridium Subcluster XIVa Decreased in Ulcerative Colitis Patients.
    Inflamm Bowel Dis. 22:2802-10, 2016. [PubMed](Impact Factor4.5)
  105. Hayashi R, Tsuchiya K, Fukushima K, Horita N, Hibiya S, Kitagaki K, Negi M, Itoh E, Akashi T, Eishi Y, Okada E, Araki A, Ohtsuka K, Fukuda S, Ohno H, Okamoto R, Nakamura T, Tanaka S, Chayama K, Watanabe M:Reduced Human α-defensin 6 in Noninflamed Jejunal Tissue of Patients with Crohn's Disease.
    Inflamm Bowel Dis. 22(5):1119-1128, 2016[PubMed](Impact Factor4.5)
  106. Takenaka N, Ohtsuka K, Kitazume Y, Nagahori M, Fujii T, Saito E, Fujioka T, Matsuoka K, Naganuma M, Watanabe M:Correlation of the endoscopic and magnetic resonance scoring systems in the deep small intestine in Crohn's disease.
    Inflamm Bowel Dis.21(8):1832-1838,2015[PubMed](Impact Factor4.5)
  107. Suzuki Y, Matsui T, Ito H, Ashida T, Nakamura S, Motoya S, Matsumoto T, Sato N, Ozaki K, Watanabe M, Hibi T:Circulating Interleukin 6 and Albumin, and Infliximab Levels Are Good Predictors of Recovering Efficacy After Dose Escalation Infliximab Therapy in Patients with Loss of Response to Treatment for Crohn's Disease: A Prospective Clinical Trial.
    Inflamm Bowel Dis.21(9):2114-2122,2015.[PubMed](Impact Factor4.5)
  108. Saigusa K, Hisamatsu Classical Th1 Cells Obtain Colitogenicity by Co-existence of RORγt-expressing T Cells in Experimental Colitis.T, Handa T, Sujino T, Mikami Y, Hayashi A, Mizuno S, Takeshita K, Sato T, Matsuoka K, Kanai T: Classical Th1 Cells Obtain Colitogenicity by Co-existence of RORγt-expressing T Cells in Experimental Colitis.
    Inflamm Bowel Dis.20(10):1820-1827, 2014[PubMed](Impact Factor4.5)
  109. Mizuno S, Mikami Y, Kamada N, Handa T, Hayashi A, Sato T, Matsuoka K, Matano M, Ohta Y, Sugita A, Koganei K, Sahara R, Takazoe M, Hisamatsu T, Kanai T: Cross-talk between RORγt+ innate lymphoid cells and intestinal macrophages induces mucosal IL-22 production in Crohn's disease.
    Inflamm Bowel Dis.20(8):1426-1434, 2014[PubMed](Impact Factor4.5)
  110. Watanabe M, Hanai H, Nishino H, Yokoyama T, Terada T, Suzuki Y: Comparison of QD and TID Oral Mesalazine for Maintenance of Remission in Quiescent Ulcerative Colitis: A Double - blind, Double - dummy, Randomized Multicenter Study.
    Inflamm Bowel Dis. 19(8):1681-1690, 2013[PubMed](Impact Factor4.5)
  111. Naganuma M, Nagahori M, Fujii T, Morio J, Saito E, Watanabe M: Poor recall of prior exposure to varicella zoster, rubella, measles, or mumps in patients with IBD.
    Inflamm Bowel Dis. 19(2):418-422, 2013[PubMed](Impact Factor4.5)
  112. Hibi T, Sakuraba A, Watanabe M, Motoya S, Ito H, Motegi K, Kinouchi Y, Takazoe M, Suzuki Y, Matsumoto T, Kawakami K, Matsumoto T, Hirata I, Tanaka S, Ashida T, Matsui T: Retrieval of serum infliximab level by shortening the maintenance infusion interval is correlated with clinical efficacy in Crohn's disease.
    Inflamm Bowel Dis
    . 18(8):1480-1487, 2012[PubMed](Impact Factor4.5)
  113. Watanabe T, Sasaki I, Sugita A, Fukushima K, Futami K, Hibi T, Watanabe M: Interval of less than 5 years between the first and second operation is a risk factor for a third operation for Crohn's disease.
    Inflamm Bowel Dis. 18(1):17-24, 2012[PubMed](Impact Factor4.5)

ページの先頭へ

 

2018年度

  1. Yui S, Azzolin L, Maimets M, Pedersen MT, Fordham RP, Hansen SL, Larsen HL, Guiu J, Alves M.R.P, Rundsten CF, Johansen JV, Li Y, Madsen CD, Nakamura T, Watanabe M, Nielsen OH, Schweiger PJ, Stefano Piccoloand Kim B. Jensen:YAP/TAZ-dependent reprogramming of colonic epithelium links ECM remodeling to tissue regeneration.
    Cell Stem Cell. 22(1): 35-49, 2018
  2. Naganuma M, Sugimoto S, Mitsuyama K, Kobayashi T, Yoshimura N, Ohi H, Tanaka S, Andoh A, Ohmiya N, Saigusa K, Yamamoto T, Morohoshi Y, Ichikawa H, Matsuoka K, Hisamatsu T, Watanabe K, Mizuno S, Suda W, Hattori M, Fukuda S, Hirayama A, Abe T, Watanabe M, Hibi T, Suzuki Y, Kanai T for the INDIGO Study Group.: Efficacy of indigo naturalis in a multicenter randomized controlled trial of patients with ulcerative colitis.
    Gastroenterology.154(4): 935-947, 2018
  3. Takenaka K, Ohtsuka K, Kitazume Y, Matsuoka K, Nagahori M, Fujii T, Saito E, Kimura M, Fujioka T, Watanabe M:Utility of magnetic resonance enterography for small bowel endoscopic healing in patients with Crohn’s disease.
    Am J Gastroenterol.113(2):283-294, 2018
  4. Nibe Y, Oshima S, Kobayashi M, Maeyashiki C, Matsuzawa Y, Otsubo K, Matsuda H, Aonuma E, Nemoto Y, Nagaishi T, Okamotoa R, Tsuchiya K, Nakamura T, Nakada S, Watanabe M:Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by p62/SQSTM1.
    Autophagy.14(2): 347-358, 2018
  5. Naganuma M, Aoyama N, Tada T, Kobayashi K, Hirai F, Watanabe K, Watanabe M, Hibi T:Complete mucosal healing of distal lesions induced by twice-daily budesonide 2-mg foam promoted clinical remission of mild-to-moderate ulcerative colitis with distal active inflammation: double-blind, randomized study.
    J Gastroenterol.53(4)494-506, 2018
  6. Ishibashi F, Shimizu H, Nakata T, Fujii S, Suzuki K, Kawamoto A, Anzai S, Kuno R, Nagata S, Ito G, Murano T, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R:Contribution of ATOH1+ cells to the homeostasis, repair and tumorigenesis of the colonic epithelium.
    Stem Cell Reports. (in press), 2018
  7. Motoya S, Watanabe M, Wallace K, Lazar A, Nishimura Y, Ozawa M, Thakkar R, Robinson A, Singh R, Mostafa N, Suzuki Y, Hibi T:Efficacy and safety of dose escalation to adalimumab 80 mg every other week in Japanese patients with Crohn's disease who lost response to maintenance therapy.
    Inflamm Bowel Dis. (in press), 2018
  8. Fukushima K,  Sugita A, Futami K, Takahashi K, Motoya S, Kimura H, Yoshikawa S, Kinouchi Y, Iijima H, Endo K, Hibi T, Watanabe M, Sasaki I, Suzuki Y, Surical Research Group, the Research Committee of Inflammatory Bowel Disease, the Ministry of Health, Welfare and Labor of Japan:Postoperative therapy with infliximab for Crohn's desease: a 2-year prospective randomizued multicenter study in Japan.
    Surgery Today. (in press), 2018

2017年度

  1. Ishibashi F, Shimizu H, Nakata T, Fujii S, Suzuki K, Kawamoto A, Anzai S, Kuno R, Nagata S, Ito G, Murano T, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R:Contribution of ATOH1+ cells to the homeostasis, repair and tumorigenesis of the colonic epithelium.
    Stem Cell Reports. (in press), 2017
  2. Watanabe K, Matsumoto T, Hisamatsu T, Nakase H, Motoya S, Yoshimura N, Ishida T, Kato S, Nakagawa T, Esaki M, Nagahori M, Matsui T, Naito Y, Kanai T, Suzuki Y, Nojima M, Watanabe M, Hibi T: DIAMOND study group: Clinical and pharmacokinetic factors associated with adalimumab-induced mucosal healing in patients with Crohn's disease.
    Clin Gastroenterol Hepatol. (in press), 2017.
  3. Calabrese E, Kucharzik T, Maaser C, Maconi G, Strobel D, Wilson RS, Zorzi F, Novak LK, Bruining HD, Iacucci M, Watanabe M, Lolli E, Chiaramonte C, Hanauer BS, Panaccione R, Pallone F, Ghosh S, Monteleone G: Real time inter-observer agreement in bowel ultrasonography for diagnostic assessment in patients with Crohn’s diseases: an international multicenter study.
    Inflamm Bowel Dis. (in press), 2017
  4. Watanabe K, Matsumoto T, Hisamatsu T, Nakase H, Motoya S, Yoshimura N, Ishida T, Kato S, Nakagawa T, Esaki M, Nagahori M, Matsui T, Naito Y, Kanai T, Suzuki Y, Nojima M, Watanabe M, Hibi T; DIAMOND study group. Clinical and pharmacokinetic factors associated with adalimumab-induced mucosal healing in patients with Crohn's disease.
    Clin Gastroenterol Hepatol. (Epub ahead of print), 2017
  5. An J, Nagaishi T, Watabe T, Naruse KT, Watanabe M, Kimura A:MKL1 expressed in macrophages contributes to the development of murine colitis.
    Sci Rep. 7(1): 13650, 2017
  6. Park DI, Hisamatsu T, Chen M, Ng SC, Ooi CJ, Wei SC, Banerjee R, Hilmi IN, Jeen YT, Han DS, Kim HJ, Ran Z, Wu K, Qian J, Hu PJ, Matsuoka K, Andoh A, Suzuki Y, Sugano K, Watanabe M, Hibi T, Puri AS, Yang SK:Asian Organization for Crohn's and Colitis and Asia Pacific Association of Gastroenterology consensus on tuberculosis infection in patients with inflammatory bowel disease receiving anti-tumor necrosis factor treatment. Park 1:risk assessment.
    J Gastroenterol Hepatol. (Epub ahead of print), 2017
  7. Park DI, Hisamatsu T, Chen M, Ng SC, Ooi CJ, Wei SC, Banerjee R, Hilmi IN, Jeen YT, Han DS, Kim HJ, Ran Z, Wu K, Qian J, Hu PJ, Matsuoka K, Andoh A, Suzuki Y, Sugano K, Watanabe M, Hibi T, Puri AS, Yang SK:Asian Organization for Crohn's and Colitis and Asia Pacific Association of Gastroenterology consensus on tuberculosis infection in patients with inflammatory bowel disease receiving anti-tumor necrosis factor treatment. Part 2:management.
    J Gastroenterol Hepatol. (Epub ahead of print), 2017
  8. Nakase H, Motoya S, Matsumoto T, Watanabe K, Hisamatsu T, Yoshimura N, Ishida T, Kato S, Nakagawa T, Esaki M, Nagahori M, Matsui T, Naito Y, Kanai T, Suzuki Y, Nojima M, Watanabe M, Hibi T; DIAMOND study group:Significance of measurement of serum trough level and anti-drug antibody of adalimumab as personalised pharmacokinetics in patients with Crohn's disease: a subanalysis of the DIAMOND trial.
    Aliment Pharmacol Ther.46(9): 873-882, 2017
  9. Matsumoto Y, Mochizuki W, Akiyama S, Matsumoto T, Nozaki K, Watanabe M, Nakamura T:Distinct intestinal adaptation for vitamin B12 and bile acid absorption revealed in a new mouse model of massive ileocecal resection.
    Biol Open. 6(9):1364-1374, 2017
  10. Nagata H, Nakagawa M, Asahina Y, Sato A, Asano Y, Tsunoda T, Miyoshi M, Kaneko S, Otani S, Kawai-Kitahata F, Murakawa M, Nitta S, Itsui Y, Azuma S, Kakinuma S, Nouchi T, Sakai H, Tomita M, Watanabe M; Ochanomizu Liver Conference Study Group:Effect of interferon-based and -free therapy on early occurrence and recurrence of hepatocellular carcinoma in chronic hepatitis C.
    J Hepatol. 67(5): 933-939, 2017, 2017
  11. Hibiya S, Tsuchiya K, Hayashi R, Fukushima K, Horita N, Watanabe S, Shirasaki T, Nishimura R, Kimura N, Nishimura T, Gotoh N, Oshima S, Okamoto R, Nakamura T, Watanabe M:Long-term inflammation transforms intestinal epithelial cells of colonic organoids.
    J Crohns Colitis. 11(5): 621-630, 2017
  12. Akiyama S, Fujii T, Matsuoka K, Ebana Y, Negi M, Takenaka K, Nagahori M, Ohtsuka K, Isobe M, Watanabe M:Endoscopic features and genetic background of inflammatory bowel disease complicated with Takayasu arteritis.
    J Gastroenterol Hepatol. 32(5): 1011-1017, 2017
  13. Nagahori M, Kochi S, Hanai H, Yamamoto T, Nakamura S, Omuro S, Watanabe M, Hibi T; OPTIMUM Study Group:Real life results in using 5-ASA for maintaining mild to moderate UC patients in Japan, a multi-center study, OPTIMUM Study.
    BMC Gastroenterol. 17(1):47, 2017
  14. Suzuki Y, Motoya S, Hanai H, Hibi T, Nakamura S, Lazar A, Robinson AM, Skup M, Mostafa NM, Huang B, Thakkar R, Watanabe M:Four-year maintenance treatment with adalimumab in Japanese patients with moderately to severely active ulcerative colitis.
    J Gastroenterol. 52(9): 1031-1040, 2017
  15. Maeyashiki C, Oshima S, Otsubo K, Kobayashi M, Nibe Y, Matsuzawa Y, Onizawa M, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Watanabe M:HADHA, the alpha subunit of the mitochondrial trifunctional protein, is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells.
    Biochem Biophys Res Commun. 484(3): 636-641, 2017
  16. Murakawa M, Asahina Y, Nagata H, Nakagawa M, Kakinuma S, Nitta S, Kawai-Kitahata F, Otani S, Kaneko S, Miyoshi M, Tsunoda T, Asano Y, Sato A, Itsui Y, Azuma S, Nouchi T, Furumoto Y, Asano T, Chuganji Y, Tohda S, Watanabe M:ITPA gene variation and ribavirin-induced anemia in patients with genotype 2 chronic hepatitis C treated with sofosbuvir plus ribavirin.
    Hepatol Res. (Epub ahead of print), 2017
  17. Shinozaki M, Kobayashi K, Kunisaki R, Hisamatsu T, Naganuma M, Takahashi K, Iwao Y, Suzuki Y, Watanabe M, Itabashi M, Torii A, Takazoe M, Sugita A:Surveillance for Dysplasia in Patients with Ulcerative Colitis: Discrepancy between Guidelines and Practice.
    Dig Endosc. 29(5):584-593, 2017
  18. Murakawa M, Asahina Y, Kawai-Kitahata F, Nakagawa M, Nitta S, Otani S, Nagata H, Kaneko S, Asano Y, Tsunoda T, Miyoshi M, Itsui Y, Azuma S, Kakinuma S, Tanaka Y, Iijima S, Tsuchiya K, Izumi K, Tohda S, Watanabe M:Hepatic IFNL4 expression is associated with non-response to interferon-based therapy through the regulation of basal interferon-stimulated gene expression in chronic hepatitis C patients.
    J Med Virol. 89(7): 1241-1247, 2017
  19. Tazuma S, Unno M, Igarashi Y, Inui K, Uchiyama K, Kai M, Tsuyuguchi T, Maguchi H, Mori T, Yamaguchi K, Ryozawa S, Nimura Y, Fujita N, Kubota K, Shoda J, Tabata M, Mine T, Sugano K, Watanabe M, Shimosegawa T:Evidence-based clinical practice guidelines for cholelithiasis 2016.
    J Gastroenterol. 52(3): 276-300, 2017
  20. Nakata T, Shimizu H, Nagata S, Ito G, Fujii S, Suzuki K, Kawamoto A, Ishibashi F, Kuno R, Anzai S, Murano T, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M, Okamoto R:Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors.
    Biochem Biophys Res Commun. 482(4): 1296-1303, 2017
  21. Nakamura T, Watanabe M:Intestinal stem cell transplantation.
    J Gastroenterol. 52(2): 151-157, 2017
  22. Tsuchiya K, Hayashi R, Fukushima K, Hibiya S, Horita N, Negi M, Itoh E, Akashi T, Eishi Y, Motoya S, Takeuchi Y, Kunisaki R, Fukunaga K, Nakamura S, Yoshimura N, Takazoe M, Iizuka B, Suzuki Y, Nagahori M, Watanabe M:Caudal type homeobox 2 expression induced by leukocytapheresis might be associated with mucosal healing in ulcerative colitis.
    J Gastroenterol Hepatol. 32(5):1032-1039, 2017
  23. Takenaka K, Ohtsuka K, Kitazume Y, Matsuoka K, Fujii T, Nagahori M, Kimura M, Fujioka T, Araki A, Watanabe M:Magnetic resonance evaluation for small bowel strictures in Crohn's disease: comparison with balloon enteroscopy.
    J Gastroenterol. 52(8):879-888, 2017
  24. Shinzaki S, Matsuoka K, Iijima H, Mizuno S, Serada S, Fujimoto M, Arai N, Koyama N, Morii E, Watanabe M, Hibi T, Kanai T, Takehara T, Naka T:Leucine-rich alpha-2 glycoprotein is a serum biomarker of mucosal healing in ulcerative colitis.
    J Crohns Colitis. 11(1): 84-91, 2017
  25. Goto F, Kakinuma S, Miyoshi M, Tsunoda T, Kaneko S, Sato A, Asano Y, Otani S, Azuma S, Nagata H, Kawai-Kitahata F, Murakawa M, Nitta S, Itsui Y, Nakagawa M, Asahina Y, Watanabe M:Bone morphogenetic protein-4 modulates proliferation and terminal differentiation of fetal hepatic stem/progenitor cells.
    Hepatol Res. 47(9):941-952, 2017
  26. Fujimoto K, Kinoshita M, Tanaka H, Okuzaki D, Shimada Y, Kayama H, Okumura R, Furuta Y, Narazaki M, Tamura A, Hatakeyama S, Ikawa M, Tsuchiya K, Watanabe M, Kumanogoh A, Tsukita S, Takeda K. Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186.
    Mucosal Immunol. 10(2), 446-59, 2017
  27. Kuwahara E, Murakami Y, Nakamura T, Inoue N, Nagahori M, Matsui T, Watanabe M, Suzuki Y, Nishiwaki Y:Factors associated with exacerbation of newly diagnosed mild ulcerative colitis based on a nationwide registry in Japan.
    J Gastroenterol. 52(2): 185-193, 2017
  28. Nagaishi T, Watanabe M:Paradigm of T cell differentiation in IBD: Crohn's disease and ulcerative colitis.
    Crohn's Disease and Ulcerative Colitis: from Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach. 141-148, 2017
  29. Maekawa S, Sato M, Kuratomi N, Inoue T, Suzuki Y, Tatsumi A, Miura M, Matsuda S, Muraoka M, Nakakuki N, Amemiya F, Takano S, Fukasawa M, Nakayama Y, Yamaguchi T, Sato T, Sakamoto M, Murakawa M, Nakagawa M, Asahina Y, Enomoto N: Association Between Alanine Aminotransferase Elevation And UGT1A1*6 Polymorphisms In Daclatasvir And Asunaprevir Combination Therapy For Chronic Hepatitis C.
    J Gastroenterol. (Epub ahaead of print), 2017
  30. Nagata N, Nakagawa M, Asahina Y:Reply to Imaging Basis of AFP and WFA+M2BP as Indicators of the Risk of HCC after SVR.
    J Hepatol.(Epub ahead of print), 2017
  31. Nomura Y, Yamashita T, Oishi N, Nio K, Hayashi T, Yoshida M, Hayashi T, Hashiba T, Asahina Y, Okada H, Sunagozaka H, Takatori H, Honda M, Kaneko S:De Novo Emergence of Mesenchymal Stem-Like CD105+ Cancer Cells by Cytotoxic Agents in Human Hepatocellular Carcinoma.
    Transl Oncol. 10(2): 184-189, 2017
  32. Matsuura K, Sawai H, Ikeo K, Ogawa S, Iio E, Isogawa M, Shimada N, Komori A, Toyoda H, Kumada T, Namisaki T, Yoshiji H, Sakamoto N, Nakagawa M, Asahina Y, Kurosaki M, Izumi N, Enomoto N, Kusakabe A, Kajiwara E, Itoh Y, Ide T, Tamori A, Matsubara M, Kawada N, Shirabe K, Tomita E, Honda M, Kaneko S, Nishina S, Suetsugu A, Hiasa Y, Watanabe H, Genda T, Sakaida I, Nishiguchi S, Takaguchi K, Tanaka E, Sugihara J, Shimada M, Kondo Y, Kawai Y, Kojima K, Nagasaki M, Tokunaga K, Tanaka Y; Japanese Genome-Wide Association Study Group for Viral Hepatitis:Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection.
    Gastroenterology. 152(6): 1383-1394, 2017
  33. Tamaki N, Kurosaki M, Kusakabe A, Orito E, Joko K, Kojima Y, Kimura H, Uchida Y, Hasebe C, Asahina Y, Izumi N:Hepatitis B Surface Antigen Reduction by Switching from Long-term Nucleoside/nucleotide Analog Administration to Pegylated Interferon.
    J Viral Hepat. 24: 672-678, 2017
  34. Yoneyama T, Arai MA, Akamine R, Koryudzu K, Tsuchiya A, Sadhu SK, Ahmed F, Itoh M, Okamoto R, Ishibashi M:Notch Inhibitors from Calotropis gigantea That Induce Neuronal Differentiation of Neural Stem Cells.
    J Nat Prod. 22;80(9):2453-2461,2017
  35. Mizuno S, Nanki K, Matsuoka K, Saigusa K, Ono K, Arai M, Sugimoto S,Kiyohara H, Nakashima M, Takeshita K, Naganuma M, Suda W, Hattori M, Kanai T:Single fecal microbiota transplantation failed to change intestinal.microbiota and had limited effectiveness against ulcerative colitis in Japanese patients.
    Intest Res. 15:68-74, 2017
  36. Chiba S, Hisamatsu T, Suzuki H, Mori K, Kitazume MT, Shimamura K, Mizuno S,Nakamoto N, Matsuoka K, Naganuma M, Kanai T:Glycolysis regulates LPS-induced cytokine production in M2 polarized human macrophages.
    Immunol Lett. 183:17-23, 2017
  37. Mahlich J, Matsuoka K, Sruamsiri R:Shared Decision Making and Treatment Satisfaction in Japanese Patients with Inflammatory Bowel Disease.
    Dig Dis. (in press), 2017
  38. Mahlich J, Matsuoka K, Nakamura Y, Sruamsiri R:The relationship between socio-demographic factors, health status, treatment type, and employment outcome in patients with inflammatory bowel disease in Japan.
    BMC Public Health. 17(1):623, 2017
  39. Kobayashi T, Hishida A, Tanaka H, Nuki Y, Bamba S, Yamada A, Fujii T, Shinzaki S, Yokoyama Y, Yoshida A, Ozeki K, Ashizuka S, Kamata N, Nanjo S, Kakimoto K, Nakamura M, Matsui A, Yamauchi R, Takahashi S, Tomizawa T, Yoshino T, Hibi T:Real-world Experience of Anti-Tumor Necrosis Factor Therapy for Internal Fistulas in Crohn’s disease: A Retrospective Multicenter Cohort Study.
    Inflamm Bowel Dis. (Epub ahead of print), 2017
  40. Yamada N, Sugiyama R, Nitta S, Murayama A, Kobayashi M, Okuse C, Suzuki M, Yasuda K, Yotsuyanagi H, Moriya K, Koike K, Wakita T, Kato T:Resistance mutations of hepatitis B virus in entecavir-refractory patients.
    Hepatol Commun. 1(1):110-121, 2017
  41. Matsuzawa-Ishimoto Y, Shono Y, Gomez LE, Hubbard-Lucey VM, Cammer M, Neil J, Dewan MZ, Liebermann SR, Lazrak A, Marinis JM, Beal A, Harris PA, Bertin J, Liu C, Ding Y, van den Brink MRM, Cadwell K:Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium.
    J Exp Med. (Epub ahead of print), 2017
  42. Matsuzawa-Ishimoto Y, Hwang S, Cadwell K:Autophagy and Inflammation.
    Annual Review of Immunology. (in press), 2017
  43. Mizutani T, Tsukamoto Y, Clevers H:Oncogene-inducible organoids as a miniature platform to assess cancer characteristics.
    J Cell Biol. 216(6): 1505, 2017
  44. Drost J, van Boxtel R, Blokzijl F, Mizutani T, Sasaki N, Sasselli V, de Ligt J, Behjati S, Grolleman JE, van Wezel T, Nik-Zainal S, Kuiper RP, Cuppen E, Clevers H:Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer.
    Science. eaao3130, 2017
  45. Murakawa M, Asahina Y, Kawai-Kitahata F, Nakagawa M, Nitta S, Otani S, Ngata H, Kaneko S, Asano Y, Tsunoda T, Miyoshi M, Itsui Y, Azuma S, Kakinuma S, Tanaka Y, Iijima S, Tsuchiya K, Izumi K, Tohda S, Watanabe M. Hepatic IFNL4 expression is associated with non-response to interferon-1 based therapy through the regulation of basal interferon-stimulated gene expression in chronic hepatitis C patients.
    J Medical Virology. 89(7),1241-1247 2017

2016年度

  1. Nakata T, Shimizu H, Nagata S, Ito G, Fujii S, Suzuki K, Kawamoto A, Ishibashi F, Kuno R, Anzai S, Murano T, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M, Okamoto R:Data showing proliferation and differentiation of intestinal epithelial cells under targeted depletion of Notch ligands in mouse intestine.
    Data Brief. 10:551-556, 2016
  2. Kobayashi M, Oshima S, Maeyashiki C, Nibe Y, Otsubo K, Matsuzawa Y, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Watanabe M:The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development.
    Sci Rep. 6: 36780, 2016
  3. Fujii S, Suzuki K, Kawamoto A, Ishibashi F, Nakata T, Murano T, Ito G, Shimizu H, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Araki A, Ohtsuka K, Okamoto R, Watanabe M:PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells.
    Sci Rep. 6: 36795, 2016
  4. Kojima T, Tsuchiya K, Ikemizu S, Yoshikawa S, Yamanishi Y, Watanabe M, Karasuyama H:Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R.
    Sci Rep. 6: 36457, 2016
  5. Matsumoto T, Motoya S, Watanabe K, Hisamatsu T, Nakase H, Yoshimura N, Ishida T, Kato S, Nakagawa T, Esaki M, Nagahori M, Matsui T, Naito Y, Kanai T, Suzuki Y, Nojima M, Watanabe M, Hibi T; DIAMOND study group:Adalimumab Monotherapy and a Combination with Azathioprine for Crohn's Disease: A Prospective, Randomized Trial.
    J Crohns Colitis. 10(11):1259-1266, 2016
  6. Watanabe T, Ajioka Y, Mitsuyama K, Watanabe K, Hanai H, Nakase H, Kunisaki R, Matsuda K, Iwakiri R, Hida N, Tanaka S, Takeuchi Y, Ohtsuka K, Murakami K, Kobayashi K, Iwao Y, Nagahori M, Iizuka B, Hata K, Igarashi M, Hirata I, Kudo SE, Matsumoto T, Ueno F, Watanabe G, Ikegami M, Ito Y, Oba K, Inoue E, Tomotsugu N, Takebayashi T, Sugihara K, Suzuki Y, Watanabe M, Hibi T:Comparison of Targeted vs Random Biopsies for Surveillance of Ulcerative Colitis-associated Colorectal Cancer.
    Gastroenterology. 151(6):1122-1130, 2016
  7. Nagata H, Nakagawa M, Nishimura-Sakurai Y, Asano Y, Tsunoda T, Miyoshi M, Kaneko S, Goto F, Otani S, Kawai-Kitahata F, Murakawa M, Nitta S, Itsui Y, Azuma S, Kakinuma S, Tojo N, Tohda S, Asahina Y, Watanabe M; Ochanomizu Liver Conference Study Group:Serial measurement of Wisteria floribunda agglutinin positive Mac-2-binding protein is useful for predicting liver fibrosis and the development of hepatocellular carcinoma in chronic hepatitis C patients treated with IFN-based and IFN-free therapy. Hepatol Int. 10(6):956-964, 2016
  8. Miyoshi M, Kakinuma S, Tanabe Y, Ishii K, Li TC, Wakita T, Tsuura Y, Watanabe H, Asahina Y, Watanabe M, Ikeda T:A Case of Chronic Hepatitis E Infection in a Persistently Immunosuppressed Patient Unable to be Eliminated after Ribavirin Therapy.
    Intern Med. 55(19):2811-2817, 2016
  9. Nitta S, Asahina Y, Matsuda M, Yamada N, Sugiyama R, Masaki T, Suzuki R, Kato N, Watanabe M, Wakita T, Kato T:Effects of Resistance-Associated NS5A Mutations in Hepatitis C Virus on Viral Production and Susceptibility to Antiviral Reagents.
    Sci Rep. 6: 34652, 2016
  10. Matsumoto T, Mochizuki W, Nibe Y, Akiyama S, Matsumoto Y, Nozaki K, Fukuda M, Hayashi A, Mizutani T, Oshima S, Watanabe M, Nakamura T:Retinol promotes in vitro growth of proximal colon organoids through a retinoic acid-independent mechanism.
    PLoS One. 11(8):e162049, 2016
  11. Hosoe N, Watanabe K, Miyazaki T, Shimatani M, Wakamatsu T, Okazaki K, Esaki M, Matsumoto T, Abe T, Kanai T, Ohtsuka K, Watanabe M, Ikeda K, Tajiri H, Ohmiya N, Nakamura M, Goto H, Tsujikawa T, Ogata H:Evaluation of performance of the Omni mode for detecting video capsule endoscopy images: A multicenter randomized controlled trial.
    Endosc Int Open. 4(8):878-882, 2016
  12. Kaneko S, Kakinuma S, Asahina Y, Kamiya A, Miyoshi M, Tsunoda T, Nitta S, Asano Y, Nagata H, Otani S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Nakauchi H, Nishitsuji H, Ujino S, Shimotohno K, Iwamoto M, Watashi K, Wakita T, Watanabe M:Human induced pluripotent stem cell-derived hepatic cell lines as a new model for host interaction with hepatitis B virus.
    Sci. Rep. 6: 29358, 2016
  13. Iwakiri K, Kinoshita Y, Habu Y, Oshima T, Manabe N, Fujiwara Y, Nagahara A, Kawamura O, Iwakiri R, Ozawa S, Ashida K, Ohara S, Kashiwagi H, Adachi K, Higuchi K, Miwa H, Fujimoto K, Kusano M, Hoshihara Y, Kawano T, Haruma K, Hongo M, Sugano K, Watanabe M, Shimosegawa T:Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2015.
    J Gastroenterol. 51(8):751-767, 2016
  14. Okamoto R, Negi M, Tomii S, Eishi Y, Watanabe M:Diagnosis and treatment of microscopic colitis.
    Clin J Gastroenterol. 9(4):169-174, 2016
  15. Fukui H, Saito H, Ueno Y, Uto H, Obara K, Sakaida I, Shibuya A, Seike M, Nagoshi S, Segawa M, Tsubouchi H, Moriwaki H, Kato A, Hashimoto E, Michitaka K, Murawaki T, Sugano K, Watanabe M, Shimosegawa T:Evidence-based clinical practice guidelines for liver cirrhosis 2015.
    J Gastroenterol. 51(7):629-650, 2016
  16. Komoto S, Motoya S, Nishiwaki Y, Matsui T, Kunisaki R, Matsuoka K, Yoshimura N, Kagaya T, Naganuma M, Hida N, Watanabe M, Hibi T, Suzuki Y, Miura S, Hokari R; Japanese study group for pregnant women with IBD:Pregnancy outcome in women with inflammatory bowel disease treated with anti-tumor necrosis factor and/or thiopurine therapy: a multicenter study from Japan.
    Intest Res. 14(2): 139-145, 2016
  17. Ohtsuka K, Takenaka K, Kitazume Y, Fujii T, Matsuoka K, Kimura M, Nagaishi T, Watanabe M:Magnetic resonance enterography for the evaluation of the deep small intestine in Crohn's disease.
    Intest Res. 14(2): 120-126, 2016
  18. Okamoto R, Watanabe M:Investigating cell therapy for inflammatory bowel disease.
    Expert Opin Biol Ther. 16(8): 1015-1023, 2016
  19. Taniguchi M, Tasaka-Fujita M, Nakagawa M, Watanabe T, Kawai-Kitahata F, Otani S, Goto F, Nagata H, Kaneko S, Nitta S, Murakawa M, Nishimura-Sakurai Y, Azuma S, Itsui Y, Mori K, Yagi S, Kakinuma S, Asahina Y, Watanabe M:Evaluation of Interferon Resistance in Newly Established Genotype 1b Hepatitis C Virus Cell Culture System.
    J Clin Transl Hepatol. 4(1):5-11, 2016
  20. Ogata H, Watanabe M, Matsui T, Hase H, Okayasu M, Tsuchiya T, Shinmura Y, Hibi T:Safety of adalimumab and predictors of adverse events in 1693 Japanese patients with Crohn's disease.
    J Crohns Colitis. 10(9): 1033-1041, 2016
  21. Calabrese E, Maaser C, Zorzi F, Kannengiesser K, Hanauer SB, Bruining DH, Iacucci M, Maconi G, Novak KL, Panaccione R, Strobel D, Wilson SR, Watanabe M, Pallone F, Ghosh S:Bowel Ultrasonography in the management of Crohn’s disease. A review with recommendations of an international panel of experts.
    Inflamm Bowel Dis. 22(5):1168-1183, 2016
  22. Hayashi R, Tsuchiya K, Fukushima K, Horita N, Hibiya S, Kitagaki K, Negi M, Itoh E, Akashi T, Eishi Y, Okada E, Araki A, Ohtsuka K, Fukuda S, Ohno H, Okamoto R, Nakamura T, Tanaka S, Chayama K, Watanabe M:Reduced Human α-defensin 6 in Noninflamed Jejunal Tissue of Patients with Crohn's Disease.
    Inflamm Bowel Dis. 22(5):1119-1128, 2016
  23. Nozaki K, Mochizuki W, Matsumoto Y, Matsumoto T, Fukuda M, Mizutani T, Watanabe M, Nakamura T:Co-culture with intestinal epithelial organoids allows efficient expansion and motility analysis of intraepithelial lymphocytes.
    J Gastroenterol. 51(3):206-213, 2016
  24. Nagaishi T, Watabe T, Jose N, Tokai A, Fujii T, Matsuoka K, Nagahori M, Ohtsuka K, Watanabe M:Epithelial Nuclear Factor-x03BA;B Activation in Inflammatory Bowel Diseases and Colitis-Associated Carcinogenesis.
    Digestion. 93(1):40-46, 2016
  25. Asahina Y, Watanabe M:Need for appropriate programs for prevention of hepatitis B infection: lessons from the latest nationwide survey in Japan.
    J Gastroenterol Hepatol. 31(1):12-13, 2016
  26. Ito T, Ishiguro H, Ohara H, Kamisawa T, Sakagami J, Sata N, Takeyama Y, Hirota M, Miyakawa H, Igarashi H, Lee L, Fujiyama T, Hijioka M, Ueda K, Tachibana Y, Sogame Y, Yasuda H, Kato R, Kataoka K, Shiratori K, Sugiyama M, Okazaki K, Kawa S, Tando Y, Kinoshita Y, Watanabe M, Shimosegawa T:Evidence-based clinical practice guidelines for chronic pancreatitis 2015.
    J Gastroenterol. 51(2):85-92, 2016
  27. Otani S, Kakinuma S, Kamiya A, Goto F, Kaneko S, Miyoshi M, Tsunoda T, Asano Y, Kawai-Kitahata F, Nitta S, Nakata T, Okamoto R, Itsui Y, Nakagawa M, Azuma S, Asahina Y, Yamaguchi T, Koshikawa N, Seiki M, Nakauchi H, Watanabe M:Matrix Metalloproteinase-14 Mediates Formation of Bile Ducts and Hepatic Maturation of Fetal Hepatic Progenitor Cells. Biochem Biophys Res Commun. 469(4):1062-1068, 2016
  28. Kawai-Kitahata F, Asahina Y, Tanaka S, Kakinuma S, Murakawa M, Nitta S, Watanabe T, Otani S, Taniguchi M, Goto F, Nagata H, Kaneko S, Tasaka-Fujita M, Nishimura-Sakurai Y, Azuma S, Itsui Y, Nakagawa M, Tanabe M, Takano S, Fukasawa M, Sakamoto M, Maekawa S, Enomoto N, Watanabe M:Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features. J Gastroenterol. 51(5):473-486, 2016
  29. Azuma S, Asahina Y, Nishimura-Sakurai Y, Kakinuma S, Kaneko S, Nagata H, Goto F, Ootani S, Kawai-Kitahata F, Taniguchi M, Murakawa M, Watanabe T, Tasaka-Fujita M, Itsui Y, Nakagawa M, Watanabe M:Efficacy of additional radiofrequency ablation after transcatheter arterial chemoembolization for intermediate hepatocellular carcinoma.
    Hepatol Res. 46(4):312-319, 2016
  30. Kobayashi T, Suzuki Y, Motoya S, Hirai F, Ogata H, Ito H, Sato N, Ozaki K, Watanabe M, Hibi T:First trough level of infliximab at week 2 predicts future outcomes of induction therapy in ulcerative colitis-results from a multicenter prospective randomized controlled trial and its post hoc analysis.
    J Gastroenterol. 51(3):241-251, 2016
  31. Okamoto R, Watanabe M:Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel disease.
    J Gastroenterol. 51(1):11-21,2016
  32. Asahina Y, Izumi N, Hiromitsu K, Kurosaki M, Koike K, Suzuki F, Takikawa H, Tanaka A, Tanaka E, Tanaka Y, Tsubouchi H, Hayashi N, Hiramatsu N, Yotsuyanagi H:JSH Guidelines for the Management of Hepatitis C Virus Infection: A 2016 update for genotype 1 and 2.
    Hepatol Res. 46(2):129-165, 2016
  33. Itakura J, Kurosaki M, Hasebe C, Osaki Y, Joko K, Yagisawa H, Sakita S, Okushin H, Satou T, Hisai H, Abe T, Tsuji K, Tamada T, Kobashi H, Mitsuda A, Ide Y, Ogawa C, Tsuruta S, Takaguchi K, Murakawa M, Asahina Y, Enomoto N, Izumi N:Complex pattern of resistance-associated substitutions of hepatitis C virus after daclatasvir/asunaprevir treatment failure.
    PLoS One. 11(10):165339, 2016
  34. Takada H, Tsuchiya K, Yasui Y, Nakakuki N, Tamaki N, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Asahina Y, Enomoto N, Izumi N:Irregular vascular pattern by contrast-enhanced ultrasonography and high serum Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein level predict poor outcome after successful radiofrequency ablation in patients with early-stage hepatocellular carcinoma.
    Cancer Med. 5(11):3111-3120, 2016
  35. Tsuchiya K:The significance of infectious disease and microbiota in FGID.
    General Medicine. 102(1):23-31, 2016
  36. Naganuma M, Okuda S, Hisamatsu T, Matsuoka K, Mori K, Hosoe N, Nakazato Y, Ogata H, Kanai T:Findings of ulceration and severe stricture on MRE can predict prognosis of Crohn's disease in patients treated with anti-TNF treatment.
    Abdom Radiol (NY). 42:141-51, 2016
  37. Suzuki H, Hisamatsu T, Chiba S, Mori K, Kitazume MT, Shimamura K, Nakamoto N, Matsuoka K, Ebinuma H, Naganuma M, Kanai T: Glycolytic pathway affects differentiation of human monocytes to regulatory macrophages.
    Immunol Lett. 176:18-27, 2016
  38. Arai M, Naganuma M, Sugimoto S, Kiyohara H, Ono K, Mori K, Saigusa K, Nanki K, Mutaguchi M, Mizuno S, Bessho R, Nakazato Y, Hosoe N, Matsuoka K, Inoue N, Ogata H, Iwao Y, Kanai T:The Ulcerative Colitis Endoscopic Index of Severity is Useful to Predict Medium- to Long-Term Prognosis in Ulcerative Colitis Patients with Clinical Remission.
    J Crohns Colitis. 10:1303-9, 2016.
  39. Saigusa K, Matsuoka K, Sugimoto S, Arai M, Kiyohara H, Takeshita K, Mizuno S, Mori K, Nanki K, Takeshita T, Nakazato Y, Yajima T, Naganuma M, Hisamatsu T, Ogata H, Iwao Y, Kanai T:Ulcerative colitis endoscopic index of severity is associated with long-term prognosis in ulcerative colitis patients treated with infliximab.
    Dig Endosc. 28:665-70, 2016.
  40. Naganuma M, Hisamatsu T, Matsuoka K, Kiyohara H, Arai M, Sugimoto S, Mori K, Nanki K, Ohno K, Mutaguchi M, Mizuno S, Bessho R, Nakazato Y, Hosoe N, Inoue N, Iwao Y, Ogata H, Kanai T:Endoscopic Severity Predicts Long-Term Prognosis in Crohn's Disease Patients with Clinical Remission. Digestion. 93:66-71, 2016
  41. Sugimoto S, Naganuma M, Iwao Y, Matsuoka K, Shimoda M, Mikami S, Mizuno S, Nakazato Y, Nanki K, Inoue N, Ogata H, Kanai T:Endoscopic morphological features of ulcerative colitis-associated dysplasia classified according to the SCENIC consensus statement.
    Gastrointest Endosc. 85:639-46, 2016
  42. Takeshita K, Mizuno S, Mikami Y, Sujino T, Saigusa K, Matsuoka K, Naganuma M, Sato T, Takada T, Tsuji H, Kushiro A, Nomoto K, Kanai T:A Single Species of Clostridium Subcluster XIVa Decreased in Ulcerative Colitis Patients.
    Inflamm Bowel Dis. 22:2802-10, 2016.
  43. Klionsky DJ, Oshima S (1536番), et al. 合計2387名:Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
    Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). 12(1):1-222, 2016
  44. Lassen KG, McKenzie CI, Mari M, Murano T, Begun J, Baxt LA, Goel G, Villablanca EJ, Kuo SY, Huang H, Macia L, Bhan AK, Batten M, Daly MJ, Reggiori F, Mackay CR, Xavier RJ:Genetic Coding Variant in GPR65 Links Lysosomal Dysfunction with Colitis Risk.
    Immunity. 44(6):1392-1405, 2016
  45. Kano Y, Cook JD, Lee JE, Ohh M:New structural and functional insight into the regulation of Ras.
    Seminars in Cell & Developmental Biology. 58:70-78, 2016

2015年度

  1. Yoshimura N, Watanabe M, Motoya S, Tominaga K, Matsuoka K, Iwakiri R, Watanabe K, Hibi T:Safety and Efficacy of AJM300, an Oral Antagonist of α4 Integrin, in Induction Therapy for Patients with Active Ulcerative Colitis.
    Gastroenterology.149(7):1775-1783,2015
  2. Okamoto R, Watanabe M:Perspectives for Regenerative Medicine in the Treatment of Inflammatory Bowel Diseases.
    Digestion.92(2):73-77,2015
  3. Suzuki Y, Matsui T, Ito H, Ashida T, Nakamura S, Motoya S, Matsumoto T, Sato N, Ozaki K, Watanabe M, Hibi T:Circulating Interleukin 6 and Albumin, and Infliximab Levels Are Good Predictors of Recovering Efficacy After Dose Escalation Infliximab Therapy in Patients with Loss of Response to Treatment for Crohn's Disease: A Prospective Clinical Trial.
    Inflamm Bowel Dis.21(9):2114-2122,2015
  4. Matsuoka K, Saito E, Fujii T, Takenaka K, Kimura M, Nagahori M, Ohtsuka K, Watanabe M:Tacrolimus for the Treatment of Ulcerative Colitis.
    Intest Res.13(3):219-226,2015
  5. Fukudo S, Kaneko H, Akiho H, Inamori M, Endo Y, Okumura T, Kanazawa M, Kamiya T, Sato K, Chiba T, Furuta K, Yamato S, Arakawa T, Fujiyama Y, Azuma T, Fujimoto K, Mine T, Miura S, Kinoshita Y, Watanabe M, Sugano K, Shimosegawa T:Evaluation of Kampo medicine in the clinical practice guideline for irritable bowel syndrome.
    J Gastroenterol.50(3):817-818,2015
  6. Matsuzawa Y, Oshima S, Takahara M, Maeyashiki C, Nemoto Y, Kobayashi M,
    Nibe Y, Nozaki K, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Ma A,
    Watanabe M:TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting
    autophagy.
    Autophagy.11(7):1052-1062,2015
  7. Takenaka N, Ohtsuka K, Kitazume Y, Nagahori M, Fujii T, Saito E, Fujioka T, Matsuoka K, Naganuma M, Watanabe M:Correlation of the endoscopic and magnetic resonance scoring systems in the deep small intestine in Crohnユs disease.
    Inflamatory bowel disease.21(8):1832-1838,2015
  8. Fukushima K, Tsuchiya K, Kano Y, Horita N, Hibiya S, Hayashi R, Kitagaki K, Negi M, Itoh E, Akashi T, Eishi Y, Oshima S, Nagaishi T, Okamoto R, Nakamura T, Watanabe M:Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line.
    Cancer Sci.106(8):1000-1007,2015
  9. Watanabe M:Recent dramatic evolution of the Journal of Gastroenterology (JG): a note from current Editorial Director and former Editor-in-Chief of JG.
    J Gastroenterol.50(3):249-251,2015
  10. Murakawa M, Asahina Y, Nakagawa M, Sakamoto N, Nitta S, Kusano-Kitazume A, Watanabe T, Kawai-Kitahata F, Otani S, Taniguchi M, Goto F, Nishimura-Sakurai Y, Itsui Y, Azuma S, Kakinuma S, Watanabe M:Impaired induction of IL28B and expression of IFN?4 associated with non-response to interferon-based therapy in chronic hepatitis C.
    J Gastroenterol Hepatol.30(6):1075-1084,2015
  11. Tanaka S, Saitoh Y, Matsuda T, Igarashi M, Matsumoto T, Iwao Y, Suzuki Y, Nishida H, Watanabe T, Sugai T, Sugihara KI, Tsuruta O, Hirata I, Hiwatashi N, Saito H, Watanabe M, Sugano K, Shimosegawa T:Evidence-based clinical practice guidelines for management of colorectal polyps.
    J Gastroenterol. 50:252-260,2015
  12. Asthana AK, Friedman AB, Maconi G, Maaser C, Kucharzik T, Watanabe M, Gibson PR:The failure of gastroenterologists to apply intestinal ultrasound in inflammatory bowel disease in the Asia-Pacific: A need for action.
    J Gastroenterol Hepatol.30(3):446-452,2015
  13. Matsuzawa Y, Osima S, Nibe Y, Kobayashi M, Maeyashiki C, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Watanabe M:RIPK3 regulates p62-LC3 complex formation via the caspase-8-dependent cleavage of p62.
    Biochem Biophys Res Commun.456(1):298-304,2015
  14. Yoshida M, Kinoshita Y, Watanabe M, Sugano K:JSGE Clinical Practice Guidelines 2014: standards, methods, and process of developing the guidelines.
    J Gastroenterol.50(1):4-10,2015
  15. kawa S, Okazaki K, Notohara K, Watanabe M, Shimosegawa T; Study Group for Pancreatitis Complicated with Inflammatory Bowel Disease organized by The Research Committee for Intractable Pancreatic Disease (Chairman: Tooru Shimosegawa) and The Research Committee for Intractable Inflammatory Bowel Disease (Chairman: Mamoru Watanabe), both of which are supported by the Ministry of Health, Labour, and Welfare of Japan:Autoimmune pancreatitis complicated with inflammatory bowel disease and comparative study of type 1 and type 2 autoimmune pancreatitis.
    J Gastroenterol.50(7):815-10,2015
  16. Tasaka-Fujita M, Sugiyama N, Kang W, Masaski T, Murayama A, Yamada N, Sugiyama R, Tsukuda S, Watashi K, Asahina Y, Sakamoto N, Wakita T, Shin EC, Kato T:Amino Acid Polymorphisms in Hepatitis C Virus Core Affect Infectious Virus Production and Major Histocompatibility Complex Class I Molecule Expression.
    Sci Rep.14(5):13994,2015
  17. Tamaki N, Kurosaki M, Higuchi M, Takada H, Nakakuki N, Yasui Y, Suzuki S, Tsuchiya K, Nakanishi H, Itakura J, Takahashi Y, Ogawa S, Tanaka Y, Asahina Y, Izumi N:Genetic Polymorphisms of IL28B and PNPLA3 Are Predictive for HCV Related Rapid Fibrosis Progression and Identify Patients Who Require Urgent Antiviral Treatment with New Regimens.
    PLoS One.10(9):e0137351,2015
  18. Suda G, Yamamoto Y, Nagasaka A, Furuya K, Kudo M, Yoshimichi C, Tsukuda Y, Tsunematsu S, Sato F, Terasita K, Nakai M, Horimoto H, Sho T, Natsuizka M, Ogawa K, Ohnishi S, Chuma M, Fujita Y, Abe R, Taniguchi M, Nakagawa M, Asahina Y, Sakamoto N: Serum granulysin levels as a predictor of serious telaprevir-induced dermatological reactions.
    Hepatol Res.45(8):837-845, 2015
  19. Akiyama S, Kikuchi D, Mitani T, Fujii T, Yamada A, Matsui A, Ogawa O, Iizuka T, Hoteya S, Kaise M:A case of mucinous adenocarcinoma in the setting of chronic colitis associated with intestinal spirochetosis and intestinal stricture.
    Medicine (Baltimore) .94(4):e493,2015
  20. Tsuchiya K:The significance of infectious disease and microbiota in FGID.
    General Medicine.102(1)23-31, 2015
  21. Tsuchiya K:The Effect of TNF-α on the Regulation of Epithelial Function in Inflammatory Bowel Disease.
    Front Gastrointest Res.34:1-8,2015
  22. Oshima H, Nakayama M, HanT, Naoi K, Ju X, Maeda Y, Robine S, Tsuchiya K, Sato T, Sato H, Taketo M, Oshima M:Suppressing TGF-β signaling in regenerating epithelia in an inflammatory microenvironment is sufficient to cause invasive intestinal cancer.
    Cancer Res.75:766-776,2015
  23. Maeda Y, Ohtsuka K, Kudo SE, Wakamura K, Mori Y, Ogata N, Wada Y, Misawa M, Yamauchi A, Hayashi S, Kudo T, Hayashi T, Miyachi H, Yamamura F, Ishida F, Inoue H, Hamatani S:Endocytoscopic narrow-band imaging efficiency for evaluation of inflammatory activity in ulcerative colitis.
    World J Gastroenterol.21(7):2108-2115,2015
  24. Iio E, Matsuura K, Nishida N, Maekawa S, Enomoto N, Nakagawa M, Sakamoto N, Yatsuhashi H, Kurosaki M, Izumi N, Hiasa Y, Masaki N, Ide T, Hino K, Tamori A, Honda M, Kaneko S, Mochida S, Nomura H, Nishiguchi S, Okuse C, Itoh Y, Yoshiji H, Sakaida I, Yamamoto K, Watanabe H, Hige S, Matsumoto A, Tanaka E, Tokunaga K, Tanaka Y:Genome-wide association study identifies a PSMD3 variant associated with neutropenia in interferon-based therapy for chronic hepatitis C.
    Hum Genet. 143(3):279-289,2015
  25. Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Prodhomme T, Duong B, Whang MI, Advincula R , Agelidis A , Barrera J, Wu H, Burlingame A, Malynn BA, Zamvil SS, Ma A:The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis.
    Nat Immunol. 16(6):618-627,2015
  26. Watanabe M:Recent dramatic evolution of the Journal of Gastroenterology (JG): a note from current Editorial Director and former Editor-in-Chief of JG.
    J Gastroenterol. 50(3):249-251,2015
  27. Yoshimura N, Yokoyama Y, Matsuoka K, Takahashi H, Iwakiri R, Yamamoto T, Nakagawa T, Fukuchi T, Motoya S, Kunisaki R, Kato S, Hirai F, Ishiguro Y, Tanida S, Hiraoka S, Mitsuyama K, Ishihara S, Tanaka S, Otaka M, Osada T, Kagaya T, Suzuki Y, Nakase H, Hanai H, Watanabe K, Kashiwagi N, Hibi T:An open-label prospective randomized multicenter study of intensive versus weekly granulocyte and monocyte apheresis in active crohn's disease.
    BMC Gastroenterology. 15(1):163, 2015
  28. Hisamatsu T, Ono N, Imaizumi A, Mori M, Suzuki H, Uo M, Hashimoto M, Naganuma M, Matsuoka K, Mizuno S, Kitazume MT, Yajima T, Ogata H, Iwao Y, Hibi T, Kanai T:Decreased Plasma Histidine Level Predicts Risk of Relapse in Patients with Ulcerative Colitis in Remission.
    PLoS One. 10(10):e0140716, 2015
  29. Hisamatsu T, Ono N, Imaizumi A, Mori M, Suzuki H, Uo M, Hashimoto M, Naganuma M, Matsuoka K, Mizuno S, Kitazume MT, Yajima T, Ogata H, Iwao Y, Hibi T, Kanai T:Computer-Aided Prediction of Long-Term Prognosis of Patients with Ulcerative Colitis after Cytoapheresis Therapy.
    PLoS One. 10(6):e0131197, 2015
  30. Wada Y, Hisamatsu T, Naganuma M, Matsuoka K, Okamoto S, Inoue N, Yajima T, Kouyama K, Iwao Y, Ogata H, Hibi T, Abe T, Kanai T:Risk factors for decreased bone mineral density in inflammatory bowel disease: A cross-sectional study.
    Clinical Nutrition. 34(6):1202-1209, 2015
  31. Duong BH, Onizawa M, Oses-Prieto JA, Advincula R, Burlingame A, Malynn BA, Ma A:A20 restricts ubiquitination of pro-interleukin-1β protein complexes and suppresses NLRP3 inflammasome activity.
    Immunity. 42(1):55-67, 2015
  32. Bunda S, Burrell K, Heir P, Zeng LF, Alamsahebpour A, Kano Y, Raught B, Zhang ZY, Gelareh Zadeh G, Ohh M:Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis.
    Nat Commun. 6:8859, 2015

2014年度

  1. Fukuda M, Mizutani T, Mochizuki W, Matsumoto T, Nozaki K, Sakamaki Y, Ichinose S, Okada Y, Tanaka T, Watanabe M, Nakamura T: Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon.
    Genes Dev. 28(16):1752-1757,2014
  2. Kobayashi K, Hirai F, Naganuma M, Watanabe K, Ando T, Nakase H, Matsuoka K, Watanabe M: A randomized clinical trial of mesalazine suppository: The usefulness and problems of central review of evaluations of colonic mucosal findings.
    J Crohns Colitis. 8(11):1444-1453,2014
  3. Watanabe M, Hibi T, Mostafa NM, Chao J, Arora V, Camez A, Petersson J, Thakkar R: Long-term safety and efficacy of adalimumab in Japanese patients with moderate to severe Crohn's disease.
    J Crohns Colitis. 8(11):1407-1416,2014
  4. Shimizu H, Okamoto R, Ito G, Fujii S, Nakata T, Suzuki K, Murano T, Mizutani T, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M: Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine.
    PeerJ.1:2:e370,2014
  5. Watanabe M: Adult tissue stem cell therapy for gastrointestinal diseases.
    J Gastroenterol Hepatol. (Epub ahead of print)
  6. Suzuki M, Nagaishi T, Yamazaki M, Onizawa M, Watabe T, Sakamaki Y, Ichinose S, Totsuka M, Oshima S, Okamoto R, Shimonaka M, Yagita H, Nakamura T, Watanabe M: Myosin light chain kinase expression induced via tumor necrosis factor receptor 2 signaling in the epithelial cells regulates the development of colitis-associated carcinogenesis.
    PLoS One. 9(2):e88369,2014
  7. Saito E, Nagahori M, Fujii T, Otsuka K, Watanabe M: Efficacy of salvage therapy and its effect on operative outcomes in patients with ulcerative colitis.
    Digestion. 89(1):55-60, 2014
  8. Fujii T, Naganuma M, Kitazume Y, Saito E, Nagahori M, Ohtsuka K, Watanabe M: Advancing magnetic resonance imaging in Crohn's disease.
    Digestion
    . 89(1):24-30, 2014
  9. Suzuki Y, Motoya S, Hanai H, Matsumoto T, Hibi T, Robinson AM, Mostafa NM, Chao J, Arora V, Camez A, Thakkar RB, Watanabe M: Efficacy and safety of adalimumab in Japanese patients with moderately to severely active ulcerative colitis.
    J Gastroenterol. 49(2):283-94,2014
  10. Esaki M, Matsumoto T, Watanabe K, Arakawa T, Naito Y, Matsuura M, Nakase H, Hibi T, Matsumoto T, Nouda S, Higuchi K, Ohmiya N, Goto H, Kurokawa S, Motoya S, Watanabe M.Use of capsule endoscopy in patients with Crohn's disease in Japan: a multicenter survey.
    J Gastroenterol Hepatol. 29(1):96-101,2014
  11. Murano T, Okamoto R, Ito G, Nakata T, Hibiya S, Shimizu H, Fujii S, Kano Y, Mizutani T, Yui S, Akiyama-Morio J, Nemoto Y, Tsuchiya K, Nakamura T, Watanabe M: Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells.
    Biochem Biophys Res Commun. 2014 Jan 17;443(3):840-6,2014
  12. Asahina Y, Tsuchiya K, Nishimura T, Muraoka M, Suzuki Y, Tamaki N, Yasui Y, Hosokawa T, Ueda K, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Nakagawa M, Kakinuma S, Watanabe M, Izumi N: Genetic variation near interleukin 28B and the risk of hepatocellular carcinoma in patients with chronic hepatitis C.
    J Gastroenterol
    . 49(7):1152-1162, 2014
  13. Hibi T, Sakuraba A, Watanabe M, Motoya S, Ito H, Sato N, Yoshinari T, Motegi K, Kinouchi Y, Takazoe M, Suzuki Y, Matsumoto T, Kawakami K, Matsumoto T, Hirata I, Tanaka S, Ashida T, Matsui T: C- reactive protein is an indicator of serum infiximab level in predicting loss of response in patients with Crohn's disease.
    J Gastroenterol
    . 49(2):254-262, 2014
  14. Watanabe K, Sasaki I, Fukushima K, Futami K, Ikeushi H, Sugita A, Nezu R, Mizushima T, Kamoka S, Kusunoki M, Yoshioka K, Funayama Y, Watanabe T, Fujii H, Watanabe M: Long-term Incidence and Characteristics of Intestinal Failure in Crohn's disease: A Japanese Multicenter Study.
    J Gastroenterol. 49(2):231-238, 2014
  15. Hisabe T, Hirai F, Matsui T, Watamabe M: Evaluation of diagnostic criteria for Crohn's disease in Japan.
    J Gastroenterol.49(1):93-99, 2014
  16. Tsuchiya K, Asahina Y, Kurosaki M, Enomoto N, Izumi N: Reply to the letter.
    Liver Transpl.(Epub ahead of print)
  17. Tsuchiya K, Asahina Y, Tamaki N, Yasui Y, Hosokawa T, Ueda K, Nakanishi H, Itakura J, Kurosaki M, Enomoto N, Izumi N: Risk factors for exceeding the Milan criteria after successful radiofrequency ablation in patients with early-stage hepatocellular carcinoma.
    Liver Transpl. 20(3):291-7,2014
  18. Komatsu N, Motosugi U, Maekawa S, Shindo K, Sakamoto M, Sato M, Tatsumi A, Miura M, Amemiya F, Nakayama Y, Inoue T, Fukasawa M, Uetake T, Ohtaka M, Sato T, Asahina Y, Kurosaki M, Izumi N, Ichikawa T, Araki T, Enomoto N: Hepatocellular carcinoma risk assessment using gadoxetic acid-enhanced hepatocyte phase magnetic resonance imaging.
    Hepatol Res.44(13):1339-1346,2014
  19. Nishida N, Sawai H, Kashiwase K, Minami M, Sugiyama M, Seto WK, Yuen MF, Posuwan N, Poovorawan Y, Ahn SH, Han KH, Matsuura K, Tanaka Y, Kurosaki M, Asahina Y, Izumi N, Kang JH, Hige S, Ide T, Yamamoto K, Sakaida I, Murawaki Y, Itoh Y, Tamori A, Orito E, Hiasa Y, Honda M, Kaneko S, Mita E, Suzuki K, Hino K, Tanaka E, Mochida S, Watanabe M, Eguchi Y, Masaki N, Murata K, Korenaga M, Mawatari Y, Ohashi J, Kawashima M, Tokunaga K, Mizokami M: New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia.
    PLoS One.9(2):e86449,2014
  20. Asahina Y, Tsuchiya K, Izumi N.Reply.
    Hepatology. 60(2):764.
  21. Yasui Y, Kudo A, Kurosaki M, Matsuda S, Muraoka M, Tamaki N, Suzuki S, Hosokawa T, Ueda K, Matsunaga K, Nakanishi H, Tsuchiya K, Itakura J,  Takahashi Y, Tanaka S, Asahina Y, Enomoto N, Arii S, Izumi N: Reduced organic anion transporter expression is a risk factor for hepatocellular carcinoma in chronic hepatitis C patients: A propensity score matching study. Oncology. 86(1):53-62, 2014
  22. Tsuchiya K, Asahina Y, Matsuda S, Muraoak M, Nakata T, Suzuki Y, Tamaki N,Yasui Y, Suzuki S, Hosokawa T, Nishimura T, Ueda K, Kuzuya T, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Izumi N: Changes in plasma vascular endothelialgrowth factor at 8 weeks after sorafenib administration as predictors of survival for advanced hepatocellular carcinoma. Cancer. 120(2):229-237, 2014
  23. Tamaki N, Kurosaki M, Matsuda S, Nakata T, Muraoka M, Suzuki Y, Yasui Y, Suzuki S, Hosokawa T, Nishimura T, Ueda K, Tsuchiya K, Nakanishi H, Itakura J, Takahashi Y, Matsunaga K, Taki K, Asahina Y, Izumi N: Prospective comparison of real-time tissue elastography and serum fibrosis markers for the estimation of liver fibrosis in chronic hepatitis C patients.
    Hepatol Res. 44(7):720-727, 2014
  24. Nakanishi H, Kurosaki M, Nakanishi K, Tsuchiya K, Noda T, Tamaki N, Yasui Y, Hosokawa T, Ueda K, Itakura J, Anami K, Asahina Y, Enomoto N, Higuchi T, Izumi N: Impaired brain actvity in cirrhotic patients with minimal hepatic encephalopathy.
    Hepatol Res. 44(3):319-326, 2014
  25. Akiyama S, Izutsu K, Ota Y, Imamura T, Ogawa O, Wake A, Takeuchi K: A case report of histologic transformation of primary follicular lymphoma of the duodenum.
    Medicine (Baltimore).93 (26): e165 , 2014
  26. Yokoyama Y, Matsuoka K, Kobayashi T, Sawada K, Fujiyoshi T, Ando T, Ohnishi Y, Ishida T, Oka M, Yamada M, Nakamura T, Ino T, Numata T, Aoki H, Sakou J, Kusada M, Maekawa T, Hibi T: A large-scale, prospective, observational study of leukocytapheresis for ulcerative colitis: treatment outcomes of 847 patients in clinical practice.
    J Crohns Colitis.8(9):981-991 , 2014
  27. Akiyama S, Imamura T, Koyama R, Tamura T, Koizumi Y, Takeuchi K: Adrenal metastasis and hemorrhage secondary to hepatocellular carcinoma.
    Intern Med.54(12):1513-1517 , 2014
  28. Sasazuki T, Oryoji D, Hisamatsu T, Tsuchiya K, Umeno J, Ueda S, Yamamoto K, Matsumoto T, Watanabe M, Hibi T: Associations of HLA class I alleles in Japanese patients with Crohn's disease.
    Genes Immun.16:54-56 , 2014
  29. Kawa S, Okazaki K, Notohara K, Watanabe M, Shimosegawa T; Study Group for Pancreatitis Complicated with Inflammatory Bowel Disease organized by The Research Committee for Intractable Pancreatic Disease (Chairman: Tooru Shimosegawa) and The Research Committee for Intractable Inflammatory Bowel Disease (Chairman: Mamoru Watanabe), both of which are supported by the Ministry of Health, Labour, and Welfare of Japan:Autoimmune pancreatitis complicated with inflammatory bowel disease and comparative study of type 1 and type 2 autoimmune pancreatitis.
    J Gastroenterol.50(7):805-815 , 2014
  30. Li X, Zhao YJ, Dai J, Li XB, Xue HB, Zhang Y, Xiong GS, Ohtsuka K,Gao YJ, Liu Q, Song Y, Fang JY, Ge ZZ: Carbon dioxide insufflation improves the intubation depth and total enteroscopy rate in single-balloon enteroscopy: a randomised, controlled, double-blind trial.
    Gut.63(10)1560-1565, 2014
  31. Saigusa K, Hisamatsu Classical Th1 Cells Obtain Colitogenicity by Co-existence of RORγt-expressing T Cells in Experimental Colitis.T, Handa T, Sujino T, Mikami Y, Hayashi A, Mizuno S, Takeshita K, Sato T, Matsuoka K, Kanai T: Classical Th1 Cells Obtain Colitogenicity by Co-existence of RORγt-expressing T Cells in Experimental Colitis.
    Inflamm Bowel Dis.20(10):1820-1827, 2014
  32. Mizuno S, Mikami Y, Kamada N, Handa T, Hayashi A, Sato T, Matsuoka K, Matano M, Ohta Y, Sugita A, Koganei K, Sahara R, Takazoe M, Hisamatsu T, Kanai T: Cross-talk between RORγt+ innate lymphoid cells and intestinal macrophages induces mucosal IL-22 production in Crohn's disease.
    Inflamm Bowel Dis.20(8):1426-1434, 2014
  33. Hisamatsu T, Naganuma M, Matsuoka K, Kanai T: Diagnosis and management of intestinal Behcet's disease.
    Clin J Gastroenterol. 7:205-212, 2014
  34. Kanai T, Matsuoka K, Naganuma M, Hayashi A, Hisamatsu T: Diet, microbiota, and inflammatory bowel disease: lessons from Japanese foods.
    Korean J Intern Med.29(4):409-415, 2014
  35. Miyoshi J, Hisamatsu T, Matsuoka K, Naganuma M, Maruyama Y, Yoneno K, Mori K, Kiyohara H, Nanki K, Okamoto S, Yajima T, Iwao Y, Ogata H, Hibi T, Kanai T: Early intervention with adalimumab may contribute to favorable clinical efficacy in patients with Crohn's disease. Digestion.90:130-136, 2014
  36. Kutsukawa M, Kudo S, Ikehara N, Ogawa Y, Wakamura K, Mori Y, Ichimasa K, Misawa M, Kudo T, Wada Y, Hayashi T, Miyachi H, Inoue H, Hamatani S: Efficiency of endocytoscopy in differentiating types of serrated polyps.
    Gastrointestinal Endosc.79(4):648-656, 2014
  37. Kudo S, Mori Y, Wakamura K, Ikehara N, Ichimasa K, Wada Y, Kutsukawa M, Misawa M, Kudo T, Hayashi T, Miyachi H, Inoue H, Hamatani S: Endocytoscopy can provide additional diagnostic ability to magnifying chromoendoscopy for colorectal neoplasms.
    J Gastroenterol Hepatol.29(1):83-90, 2014
  38. Sakuraba A, Iwao Y, Matsuoka K, Naganuma M, Ogata H, Kanai T, Hibi T: Endoscopic and pathologic changes of the upper gastrointestinal tract in Crohn's disease.
    Biomed Res Int. 610767, 2014
  39. Shiguehissa Kawaguti FS, Rizkallah Nahas CS, Sparapan Marques CF, da Costa Martins B, Alves Retes F, Medeiros RS, Hayashi T, Wada Y, de Lima MS, Sato Uemura R, Carlos Nahas SC, Kudo S, Maluf-Filho F: Endoscopic submucosal dissection versus transanal endoscopic microsurgery for the treatment of early rectal cancer.
    Surg Laparosc Endosc Percutan Tech. 28(4):1173-1179, 2014
  40. Matsuoka K, Mizuno S, Hayashi A, Hisamatsu T, Naganuma M, Kanai T: Fecal microbiota transplantation for gastrointestinal diseases.
    Keio J Med. 64(4):69-74, 2014
  41. Fukata N, Okazaki K,Omiya M, Matsushita M, Watanabe M: Hematologic malignancies in the Japanese patients with inflammatory bowel disease.
    J of Gastroenterology.49(9):1299-1306, 2014
  42. Asahina Y, HayashinN, Hiramatsu N, Izumi N, Koike K, Kumada H, Kurosaki M, Oketani M, Suzuki F, Takikawa H, Tanaka A, Tanaka E, Tanaka Y, Tsubouchi H, Yotsuyanagi H: JSH guidelines for the management of hepatitis B virus infection.
    Hepatol Res 44:1-58, 2014
  43. Asahina Y, HayashinN, Hiramatsu N, Izumi N, Koike K, Kumada H, Kurosaki M, Oketani M, Suzuki F, Takikawa H, Tanaka A, Tanaka E, Tanaka Y, Tsubouchi H, Yotsuyanagi H: JSH guidelines for the management of hepatitis B virus infection.
    Hepatol Res44:59-70, 2014
  44. Mikami Y, Mizuno S, Nakamoto N, Hayashi A, Sujino T, Sato T, Kamada N, Matsuoka K, Hisamatsu T, Ebinuma H, Hibi T, Yoshimura A, Kanai T: Macrophages and Dendritic Cells Emerge in the Liver during Intestinal Inflammation and Predispose the Liver to Inflammation.
    PLoS One .2(9):e84619, 2014
  45. Denzer UW, Rösch T, Hoytat B, Abdel-Hamid M, Hebuterne X, Vanbiervielt G, Filippi J, Ogata H, Hosoe N, Ohtsuka K, Ogata N, Ikeda K, Aihara H, Kudo SE, Tajiri H, Treszl A, Wegscheider K, Greff M, Rey JF: Modified bowel preparation regimen for use in second-generation colon capsule endoscopy in patients with ulcerative colitis.
    Dig Endosc. 26(5):665-672, 2014
  46. Usui S, Hosoe N, Matsuoka K, Kobayashi T, Nakano M, Naganuma M, Ishibashi Y, Kimura K, Yoneno K, Kashiwagi K, Hisamatsu T, Inoue N, Serizawa H, Hibi T, Ogata H, Kanai T: Modified bowel preparation regimen for use in second-generation colon capsule endoscopy in patients with ulcerative colitis.
    Dig Endosc. 26(5):665-672, 2014
  47. Nishida N, Sawai H, Kashiwase K, Minami M, Sugiyama M, Seto WK, Yuen MF, Posuwan N, Poovorawan Y, Ahn SH, Han KH, Matsuura K, Tanaka Y, Kurosaki M, Asahina Y, Izumi N, Kang JH, Hige S, Ide T, Yamamoto K, Sakaida I, Murawaki Y, Itoh Y, Tamori A, Orito E, Hiasa Y, Honda M, Kaneko S, Mita E, Suzuki K, Hino K, Tanaka E, Mochida S, Watanabe M, Eguchi Y, Masaki N, Murata K, Korenaga M, Mawatari Y, Ohashi J, Kawashima M, Tokunaga K, Mizokami M: New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia.
    PLoS One9(2):86449, 2014
  48. Ohfuji S, Fukushima W, Watanabe K, Sasaki S, Yamagami H, Nagahori M, Watanabe M, Hirota Y, for the Japnanese Case-Control Study Group for Ulcerative Colitis: Pre-illness isoflavone consumption and disease risk of ulcerative colitis: a multicenter case-control study in Japan.
    PloS One. 9(10):e110270, 2014
  49. Wada Y, Kudo S, Tanaka S, Saito Y, Iishi H, Ikematsu H, Igarashi M, Saitoh Y, Inoue Y, Kobayashi K, Hisabe T, Tsuruta O, Kashida H, Ishikawa H , Sugihara K: Predictive factors for Complications in endoscopic resection of large colorectal lesions: a multicenter prospective study.(Epub ahead of print).
    Surg Endosc.29(5):1216-1222, 2014
  50. Kano Y, Kakinuma S, Goto F, Azuma S, Nishimura-Sakurai Y, Itsui Y, Nakagawa M, Kudo A, Tanabe M, Kirimura S, Amano T, Ito T, Akashi T, Asahina Y, Watanabe M:Primary Hepatic Neuroendocrine Carcinoma with a Cholangiocellular Carcinoma Component in One Nodule. Clinical Journal of Gastroenterology.7:449-454, 2014
  51. Akiyama S, Imamura T, Tamura T, Koizumi Y, Koyama R, Takeuchi K, atanabe G: Recurrent common bile duct stones composed of ursodeoxycholic acid: A report of four cases.
    Intern Med.53:2489-2492, 2014
  52. Yoneno K, Hisamatsu T, Matsuoka K, Okamoto S, Takayama T, Ichikawa R, Sujino T, Miyoshi J, Takabayashi K, Mikami Y, Mizuno S, Wada Y, Yajima T, Naganuma M, Inoue N, Iwao Y, Ogata H, Hasegawa H, Kitagawa Y, Hibi T, Kanai T: Risk and management of intra-abdominal abscess in Crohn's disease treated with infliximab.
    Digestion. 89(3):201-208, 2014
  53. Bunda S, Heir P, Srikumar T, Cook JD, Burrell K, Kano Y, Lee JE, Zadeh G, Raught B, Ohh M: Src promotes GTPase activity of Ras via tyrosine 32 phosphorylation.
    Proc Natl Acad Sci U S A.111(36):3785-3794, 2014
  54. Hisamatsu T, Ueno F, Matsumoto T, Kobayashi K, Koganei K, Kunisaki R, Hirai F, Nagahori M, Matsushita M, Kobayashi K, Kishimoto M, Takeno M, Tanaka M, Inoue N, Hibi T: The 2nd edition of consensus statements for the diagnosis and management of intestinal Behcet's disease: indication of anti-TNFα monoclonal antibodies.
    J Gastroenterol.49(1):156-162, 2014
  55. Matsuoka K, Kanai T: The gut microbiota and inflammatory bowel disease.
    Semin Immunopathol. 37:47-55, 2014
  56. Akiyama S, Ikeda K, Sezaki H, Fukushima T, Sorin Y, Kawamura Y, Saitoh S, Hosaka T, Akuta N, Kobayashi M, Suzuki F, Suzuki Y, Arase Y, Kumada H.Therapeutic effects of short- and intermediate-term tolvaptan administration for refractory ascites in patients with advanced liver cirrhosis.
    Hepatol Res (Epub ahead of print), 2014

2013年度

  1. Ito G, Okamoto R, Murano T, Shimizu H, Fujii S, Nakata T, Mizutani T, Yui S, Akiyama-Morio J, Nemoto Y, Okada E, Araki A, Ohtsuka K, Tsuchiya K, Nakamura T, and Watanabe M: Lineage-specific expression of Bestrophin-2 and Bestrophin-4 in human intestinal epithelial cells.
    PLoS One
    . 8(11): e79693, 2013
  2. Fordham RP, Yui S, Hannan NR, Soendergaard C, Madgwick A, Schweiger PJ, Nielsen OH, Vallier L, Pedersen RA, Nakamura T, Watanabe M, Jensen KB: Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury.
    Cell Stem Cell. 13(6):734-744,(Epub ahead of print), 2013
  3. Takahara M, Nemoto Y, Oshima S, Matsuzawa Y, Kanai T, Okamoto R, Tsuchiya K, Nakamura T, Yamamoto K, Watanabe M: IL-7 promotes long-term in vitro survival of unique long-lived memory subset generated from mucosal effector memory CD4+ T cells in chronic colitis mice. Immunol Lett. 156:82-93, 2013
  4. Fukata N, Okazaki K, Omiya M, Matsushita M, Watanabe M: Hematologic malignancies in the Japanese patients with inflammatory bowel disease.
    J Gastroenterol
    . (Epub ahead of print), 2013
  5. Nemoto Y, Kanai T, Takahara M, Oshima S, Okamoto R, Tsuchiya K, Matsumoto S, Watanabe M: Th1/Th17-Mediated Interstitial Pneumonia in Chronic Colitis Mice Independent of Intestinal Microbiota.
    J Immunol.190:6616-6625, 2013
  6. Watanabe M, Hanai H, Nishino H, Yokoyama T, Terada T, Suzuki Y: Comparison of QD and TID Oral Mesalazine for Maintenance of Remission in Quiescent Ulcerative Colitis: A Double - blind, Double - dummy, Randomized Multicenter Study.
    Inflamm Bowel Dis. 19(8):1681-1690, 2013
  7. Asahina Y, Tsuchiya K, Nishimura T, Muraoka M, Suzuki Y, Tamaki N, Yasui Y, Hosokawa T, Ueda K, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Nakagawa M, Kakinuma S, Watanabe M, Izumi N: α-fetoprotein levels after interferon therapy and risk of hepatocarcinogenesis in chronic hepatitis C.
    Hepatology. 58(4):1253-1262, 2013
  8. Kiyohashi K, Kakinuma S, Kamiya A, Sakamoto N, Nitta S, Yamanaka H, Yoshino K, Fujiki J, Murakawa M, Kusano-Kitazume A, Shimizu H, Okamoto R, Azuma S, Nakagawa M, Asahina Y, Tanimizu N, Kikuchi A, Nakauchi H, Watanabe M: Wnt5a signaling mediates biliary differentiation of fetal hepatic stem/progenitor cells in mice.
    Hepatology. 2013 Jun;57(6):2502-2513.
  9. Okada E, Araki A, Suzuki S, Watanabe H, Ikeda T, Watanabe T, Kurata M, Eishi M, Watanabe M: Histological diagnosis of follicular lymphoma by biopsy of small intestinal normal mucosa. Digestive Endoscopy. 39(5):544-546, 2013
  10. Kano Y, Tsuchiya K, Zheng X, Horita N, Fukushima K, Hibiya S, Yamauchi Y, Nishimura T, Hinohara K, Gotoh N, Suzuki S, Okamoto R, Nakamura T, Watanabe M: The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein. Biochem Biophys Res Commun.1:432(1):175-181,2013
  11. Kurosaki M, Tanaka Y, Nishida N, Sakamoto N, Enomoto N, Matsuura K, Asahina Y, Nakagawa M, Watanabe M, Sakamoto M, Maekawa S, Tokunaga K, Mizokami M, Izumi N: Model incorporating the ITPA genotype identifies patients at high risk of anemia and treatment failure with pegylated-interferon plus ribavirin therapy for chronic hepatitis C.
    J Med Virol
    . 85(3):449-458, 2013
  12. Ohyagi M, Ohkubo T, Yagi Y, Ishibashi S, Akiyama J, Nagahori M, Watanabe M, Yokota T, Mizusawa H: Chronic inflammatory demyelinating polyradiculoneuropathy in a patient with crohn's disease.
    Intern Med. 52(1):125-128, 2013
  13. Nemoto Y, Kanai T, Takahara M, Oshima S, Nakamura T, Okamoto R, Kiichiro T, Watanabe M: Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4+ memory T cells. Gut. 62(8):1142-1152, 2013
  14. Ueno F, Matsui T, Matsumoto T, Matsuoka K, Watanabe M, Hibi T: Evidence-based clinical practice guidelines for Crohn's disease, integrated with formal consensus of experts in Japan.
    J Gastroenterol. 48(1)31-72, 2013
  15. Naganuma M, Kunisaki R, Yoshimura N, Takeuchi Y, Watanabe M: A prospective analysis of the incidence and risk factors for opportunistic infections in patients with inflammatory bowel disease.
    J Gastroenterol. 48(5):595-560, 2013
  16. Nitta S, Sakamoto N, Nakagawa M, Kakinuma S, Mishima K, Kusano-Kitazume A, Kiyohashi K, Murakawa M, Nishimura-Sakurai Y, Azuma S, Tasaka-Fujita M, Asahina Y, Yoneyama M, Fujita T, Watanabe M: Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type I interferon-dependent innate immunity. Hepatology.57(1):46-58,2013
  17. Kuwahara E, Asakura K, Nishiwaki Y, Inoue N, Watanabe M, Hibi T, Takebayashi T: Reply to the letter by A. M. Bianco et al. regarding ''Effects of family history on IBD characteristics in Japanese patients''.
    J Gastroenterol. 48(1):145-146, 2013
  18. Naganuma M, Fujii T, Kunisaki R, Yoshimura N, Takazoe M, Takeuchi Y, Saito E, Nagahori M, Asakura K, Takebayashi T, Watanabe M: Incidence and characteristics of the 2009 influenza (H1N1) infections in inflammatory bowel disease patients.
    J Crohns Colitis
    . 7(4):308-318, 2013
  19. Naganuma M, Nagahori M, Fujii T, Morio J, Saito E, Watanabe M: Poor recall of prior exposure to varicella zoster, rubella, measles, or mumps in patients with IBD.
    Inflamm Bowel Dis. 19(2):418-422, 2013
  20. Tamaki N, Kurosaki M, Tanaka K, Suzuki Y, Hoshioka Y, Kato T, Yasui Y, Hosokawa T, Ueda K, Tsuchiya K, Nakanishi H, Itakura J, Asahina Y, Izumi N: Non-invasive estimation of fibrosis progression overtime using the FIB-4 index in chronic hepatitis C.
    J Viral Hepat
    . 20: 72-76, 2013.
  21. Sato A, Sata M, Ikeda K, Kumada T, Izumi N, Asahina Y, Osaki Y, Chayama K, Kaneko S, Sakai A, Onji M, Hiasa Y, Omura T, Ozeki I, Yokosuka O, Shiina S, Itsubo M, Nishiguchi S, Hirano K, Ide T, Sakisaka S, Yamasaki T, Hidaka I, Tanaka M, Kim SR, Ichida T: Clinical characteristics of patients who developed hepatocellular carcinoma after hepatitis C virus eradication with interferon therapy: current status in Japan.
    Intern Med. 52(24):2701-2706.
  22. Kurosaki M, Tanaka Y, Nishida N, Sakamoto N, Enomoto N, Matsuura K, Asahina Y, Nakagawa M, Watanabe M, Sakamoto M, Maekawa S, Tokunaga K, Mizokami M, Izumi N: Model incorporating the ITPA genotype identifies patients at high risk of anemia and treatment failure with pegylated-interferon plus ribavirin therapy for chronic hepatitis C.
    J Med Virol. 85(3):449-458.
  23. Izumi N, Asahina Y, Kurosaki M, Yamada G, Kawai T, Kajiwara E, Okamura Y, Takeuchi T, Yokosuka O, Kariyama K, Toyoda J, Inao M, Tanaka E, Morikawa H, Adachi K, Katsushima S, Kudo M, Takaguchi K, Hiasa Y, Chayama K, Yatsuhashi H, Oketani M, Kumada H: Inhibition of hepatocellular carcinoma by PegIFNα-2a in patients with chronic hepatitis C: a nationwide multi-center cooperative study.
    J Gastroenterol. 48(3):382-390, 2013
  24. Watanabe D, Kudo SE, Hayashi S, Mori Y, Kodama K, Wakamura K, Miyachi H,Yamamura F, Ohtsuka K, Mikogami T, Kimura S, Fukuchi K, Ikehara N: Endocytoscopy provides an in vivo virtual histopathological diagnosis of Whipple's disease.
    Endoscopy
    . 45(2):143-144, 2013
  25. Watanabe M, Nishino H, Sameshima Y, Ota A, Nakamura S, Hibi T: Randomised clinical trial: evaluation of the efficacy of mesalazine (mesalamine) suppositories in patients with ulcerative colitis and active rectal inflammation -a placebo- controlled study. Aliment Pharmacol Ther. 38(3):264-273, 2013
  26. Asahina Y, Nakagawa M, Kakinuma S, Watanabe M: Polymorphism Near the Interleukin-28B Gene and anti-Hepatitis C viral Response.
    J Clin Transl Hepatol, 1:39-44, 2013
  27. Asahina Y, Hayashi N, Hiramatsu N, Izumi N, Koike K, Kumada H, Oketani M, Suzuki F, Takikawa H, Tanaka A, Tsubouchi H, Yotsuyanagi H: Editors of the Drafting Committee for Hepatitis Managemnt Guidelines: The Japan Society of  Hepatology: Gudelines for the Management of Hepatitis C Virus Infection.
    Hepatol Res. 43(1):1-34, 2013
  28. Nakagawa M, Sakamoto N, Watanabe T, Nishimura-Sakurai Y, Onozuka I, Azuma S, Kakinuma S, Nitta S, Kiyohashi K, Kusano-Kitazume A, Murakawa M, Yoshino K, Itsui Y, Tanaka Y, Mizokami M, Watanabe M, Ochanomizu Liver Conference Study Group: Association of ITPA gene variant and serum ribavirin concentration with blood cells decline in pegylated interferon-alfa plus ribavirin therapy for chronic hepatitis C.
    Hepatol Int
    . 7(1):153-161, 2013.
  29. Okamoto R, Nagahori T, Watanabe M: Perspectives for IBD in Japan.
    AGA Perspectives.
    9(2):18-19 2013
  30. Callahan JA, Hammer GE, Agelides A, Duong BH, Oshima S, North J, Advincula R, Shifrin N, Truong HA, Paw J, Barrera J, DeFranco A, Rosenblum MD, Malynn BA, Ma A: Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells.
    J Immunol. 191(2):535-539, 2013
  31. Kudo S, Sugihara Y, Kida H, Ishida F, Miyachi H, Mori Y, Misawa M, Hisayuki T, Kodama K, Wakamura K, Hayashi T, Wada Y, Hamatani S: Depressed-Type Colonic Lesions and "De Novo" Cancer in Familial Adenomatous Polyposis: A Colonoscopist's Viewpoint. ISRN Gastroenterol. (Epub ahead of print), 2013
  32. Kudo S, Mori Y, Wakamura K, Ikehara N, Ichimasa K, Wada Y, Kutsukawa M, Misawa M, Kudo T, Hayashi T, Miyachi H, Inoue H, Hamatani S: Endocytoscopy can provide additional diagnostic ability to magnifying chromoendoscopy for colorectal neoplasms.
    J Gastroenterol Hepatol.
    (Epub ahead of print) , 2013
  33. Kutsukawa M, Kudo S, Ikehara N, Ogawa Y, Wakamura K, Mori Y, Ichimasa K, Misawa M, Kudo T, Wada Y, Hayashi T, Miyachi H, Inoue H, Hamatani S: Efficiency of endocytoscopy in differentiating types of serrated polyps.
    Gastrointestinal Endosc.
    (Epub ahead of print) , 2013
  34. Misawa M, Kudo S, Wada Y, Nakamura H, Toyoshima N, Hayashi S, Mori Y, Kudo T, Hayashi T, Wakamura K, Miyachi H, Yamamura F, Hamatani S : Magnifying narrow-band imaging of surface patterns for diagnosing colorectal cancer.
    Oncol Rep.
    30(1):350-356, 2013
  35. Mori Y, Kudo S, Ikehara N, Wakamura K, Wada Y, Kutsukawa M, Misawa M, Kudo T, Kobayashi Y, Miyachi H, Yamamura F, Ohtsuka K, Inoue H, Hamatani S: Comprehensive diagnostic ability of endocytoscopy compared with biopsy for colorectal neoplasms: a prospective randomized noninferiority trial.
    Endoscopy, 45(2):98-105, 2013
  36. Shao L, Oshima S, Duong B, Advincula R, Barrera J, Malynn BA, Ma A: A20 restricts wnt signaling in intestinal epithelial cells and suppresses colon carcinogenesis.
    PLoS One. 8(5):e62223, 2013
  37. Toyoda J, Ozeki I, Asahina Y, Izumi N, Takahashi S, Kawakami Y, Chayama K, Kamiya N, Aoki K, Yamada I, Suzuki Y, Suzuki F, Kumada H: Virologic response and safety of 24-week telaprevir alone in Japanese patients infected with hepatitis C virus subtype 1b.
    J Viral Hepat. 20:167-173, 2013

2012年度

  1. Araki A, Suzuki S, Tsuchiya K, Oshima S, Okada E, Watanabe M: Modified single-operator method for double-balloon endoscopy.
    Digestive Endoscopy
    . 24(6):470-474, 2012
  2. Araki A, Tsuchiya K, Oshima S, Okada E, Suzuki S, Morio-Akiyama J, Fujii T, Okamoto R, Watanabe M: Endoscopic ultrasound with double-balloon endoscopy for the diagnosis of inverted Meckel's diverticulum: a case report.
    J Med Case Rep
    . 6(1):328, 2012
  3. Ono Y, Kanai T, Sujino T, Nemoto Y, Kanai Y, Mikami Y, Hayashi A, Matsumoto A, Takaishi H, Ogata H, Matsuoka K, Hisamatsu T, Watanabe M, Hibi T: T-helper 17 and interleukin-17-producing lymphoid tissue inducer-like cells make different contributions to colitis in mice. Gastroenterology. 143 (5):1288-1297, 2012
  4. Fujita K, Naganuma M, Saito E, Suzuki S, Araki A, Negi M, Kawachi H, Watanabe M: Histologically confirmed IgG4-related small intestinal lesions diagnosed via double balloon enteroscopy.
    Dig Dis Sci. 57(12):3303-3308, 2012
  5. Watanabe T, Sasaki I, Sugita A, Fukushima K, Futami K, Hibi T, Watanabe M: Time trend and risk factors for reoperation in Crohn's disease in Japan.
    Hepatogastroenterology. 59(116):1081-1086, 2012
  6. Yui S, Nakamura T, Sato T, Nemoto Y, Mizutani T, Zheng X, Ichinose S, Nagaishi T, Okamoto R, Tuchiya K, Clevers H, Watanabe M: Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell.
    Nat Med
    . 18(4):618-623, 2012
  7. Kuwahara E, Asakura K, Nishiwaki Y, Inoue N, Watanabe M, Hibi T, Takebayashi T: Effects of family history on inflammatory bowel disease characteristics in Japanese patients.
    J Gastroenterol. 47(9):961-968, 2012
  8. Mizutani T, Nakamura T, Morikawa R, Fukuda M, Mochizuki W, Yamauchi Y, Nozaki K, Yui S, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, and Watanabe M: Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultures in vitro.
    Biochem Biophys Res Commun
    . 419(2):238-243, 2012
  9. Yamaji O, Nagaishi T, Totsuka T, Onizawa M, Suzuki M, Tsuge N, Hasegawa A, Okamoto R, Tsuchiya K, Nakamura T, Arase H, Kanai T, Watanabe M: The development of colitogenic CD4+ T cells is regulated by IL-7 in collaboration with natural killer cell function in a murine model of colitis.
    J Immunol. 188(6):2524-2536, 2012
  10. Calabrese E, Zorzi F, Zuzzi S, Ooka S, Onali S, Petruzziello C, Lasinio GJ, Biancone L, Rossi C, Pallone: Development of a numerical index quantitating small bowel damage as detected by ultrasonography in Crohn's disease.
    J Crohns Colitis
    . 6(8):852-860, 2012
  11. Kusano-Kitazume A, Sakamoto N, Okuno Y, Sekine-Osajima Y, Nakagawa M, Kakinuma S, Kiyohashi K, Nitta S, Murakawa M, Azuma S, Nishimura-Sakurai Y, Hagiwara M, Watanabe M: Identification of novel N-(morpholine-4-carbonyloxy) amidine compounds as potent inhibitors against hepatitis C virus replication.
    Antimicrob Agents Chemother
    . 56(3):1315-1323, 2012
  12. Asahina Y, Tsuchiya K, Muraoka M, Tanaka K, Suzuki Y, Tamaki N, Hoshioka Y, Yasui Y, Katoh T, Hosokawa T, Ueda K, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Nitta S, Sakamoto N, Izumi N: Association of gene expression involving innate immunity and genetic variation in interleukin 28B with antiviral response.
    Hepatology. 55(1):20-29, 2012
  13. Watanabe M, Hibi T, Lomax KG, Paulson SK, Chao J, Alam MS, Camez A : Adalimumab for the induction and maintenance of clinical remission in Japanese patients with Crohn's disease. J Crohns Colitis. 6(2):160-73, 2012
  14. Hibi T, Sakuraba A, Watanabe M, Motoya S, Ito H, Motegi K, Kinouchi Y, Takazoe M, Suzuki Y, Matsumoto T, Kawakami K, Matsumoto T, Hirata I, Tanaka S, Ashida T, Matsui T: Retrieval of serum infliximab level by shortening the maintenance infusion interval is correlated with clinical efficacy in Crohn's disease.
    Inflamm Bowel Dis
    . 18(8):1480-1487, 2012
  15. Chen L, Chen Z, Baker K, Halvorsen EM, Cunha AP, Flak MB, Gerber G, Huang YH, Hosomi S, Arthur JC, Dery KJ, Nagaishi T, Beauchemin N, Holmes KV, Ho JWK, Shively JE, Jobin C, Onderdonk AB, Bry L, Weiner HL, Higgins DE, Blumberg RS: The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction. Immunity. 37(5):930-946, 2012
  16. Watanabe T, Sasaki I, Sugita A, Fukushima K, Futami K, Hibi T, Watanabe M: Interval of less than 5 years between the first and second operation is a risk factor for a third operation for Crohn's disease.
    Inflamm Bowel Dis. 18(1):17-24, 2012
  17. Kurosaki M, Hiramatsu N, Sakamoto M, Suzuki Y, Iwasaki M, Tamori A, Matsuura K, Kakinuma S, Sugauchi F, Sakamoto N, Nakagawa M, Yatsuhashi H, Izumi N: Age and total ribavirin dose are independent predictors of relapse after interferon therapy in chronic hepatitis C revealed by data mining analysis.
    Antivir Ther. 17(1):35-43, 2012
  18. Kurosaki M, Hiramatsu N, Sakamoto M, Suzuki Y, Iwasaki M, Tamori A, Matsuura K, Kakinuma S, Sugauchi F, Sakamoto N, Nakagawa M, Yatsuhashi H, Izumi N: Data mining model using simple and readily available factors could identify patients at high risk for hepatocellular carcinoma in chronic hepatitis C.
    J Hepatol.
    56(3):602-608, 2012
  19. Nishida N, Sawai H, Matsuura K, Sugiyama M, Ahn SH, Park JY, Hige S, Kang JH, Suzuki K, Kurosaki M, Asahina Y, Mochida S, Watanabe M, Tanaka E, Honda M, Kaneko S, Orito E, Ttoh Y, Mita E, Tamori A, Murawaki Y, Hiasa Y, Sakaida I, Korenaga M, Hino K, Ide T, Kawashima M, Mawatari Y, Sageshima M, Ogasawara Y, Koide A, Izumi N, Han KH, Tanaka Y, Tokunaga K, Mizokami M: Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean.
    PLoS One. 7(6):e39175, 2012
  20. Ozaka M, Matsumura Y, Ishii H, Omuro Y, Itoi T, Mouri H, Hanada K, Kimura Y, Maetani I, Okabe Y, Tani M, Ikeda T, Hijioka S, Watanabe R, Ooka S, Hirose Y, Suyama M, Egawa N, Sofuni A, Ikari T, Nakajima T: Randomized phase Ⅱstudy of gemcitabine and S-1 combination versus gemcitabine alone in the treatment of unresectable advanced pancreatic cancer (Japan Clinical Cancer Research Oeganization PC-01 study).
    Cancer Chemother Pharmacol. 69:1197-1204, 2012
  21. Ozeki R, Kakinuma S, Asahina K, Simizu-Saito K, Arii S, Tanaka Y, Teraoka H: Hepatic stellate cells mediate differentiation of dendritic cells from monocytes.
    J Med Dent Sci. 59:39-48, 2012
  22. Sakurai K, Nagahara K, Inoue K, Akiyama J, Mabe K, Suzuki J, Habu Y, Araki A, Suzuki T, Satoh K, Nagami H, Harada R, Tano N, Kusaka M, Fujioka Y, Fujimura T, shigeto N, Oumi T, Miwa J, Miwa H, Fujimoto K, Kinoshita Y, Hamura K: Efficacy of omeprazole, famotidine, mosapride and teprenone in patients with upper gastrointestinal symptoms: an omeprazole-controlled randomized study (J-FOCUS)
    BMC Gastroenterology.1(12): 42, 2012
  23. Sawai H, Nishida N, Mbarek H, Matsuda K, Mawatari Y, Yamaoka M, Hige S, Kang JH, Abe K, Mochida S, Watanabe M, Kurosaki M, Asahina Y, Izumi N, Honda M, Kaneko S, Tanaka E, Matsuura K, Itoh Y, Mita E, Korenaga M, Hino K, Murawaki Y, Hiasa Y, Ide T, Ito K, Sugiyama M, Ahn SH, Han KH, Park JY, Yuen MF, Nakamura Y, Tanaka Y, Mizokami M, Tokunaga K: No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations.
    BMC Med Genet
    . 19(13):47, 2012
  24. Tamaki N, Kurosaki M, Tanaka K, Suzuki Y, Hoshioka Y, Kato T, Yasui Y, Hosokawa T, Ueda K, Tsuchiya K, Nakanishi H, Itakura J, Asahina Y, Izumi N: Noninvasive estimation of fibrosis progression overtime using the FIB-4 index in chronic hepatitis CN.
    J Viral Hepat. 20(1):72-76, 2012

2011年度

  1. D’Haens GR, Panaccione R, Higgins PD, Vermeire S, Gassull M, Chowers Y, Hanauer SB, Herfarth H, Hommes DW, Kamm M, L?fberg R, Quary A, Sands B, Sood A, Watermayer G, Lashner B, L?mann M, Plevy S, Reinisch W, Schreiber S, Siegel C, Targan S, Watanabe M, Feagan B, Sandborn WJ, Colombel JF, Travis S: The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD With the European Crohn’s and Colitis Organization: When to Start, When to Stop, Which Drug to Choose, and How to Predict Response?
    Am J Gastroenterol. 106(2):199-212, 2011. [PubMed]
  2. Funaoka Y, Sakamoto N, Nakagawa M, Kakinuma S, Suda G, Watanabe T, Nitta S, Kitazume A, Kiyohashi K, Murakawa M, Azuma S, Tsuchiya K, Watanabe M: Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 91.
    J Virol. 85: 5986-5994, 2011. [PubMed]
  3. Hyun SB, Kitazume Y, Nagahori M, Akira T, Fujii T, Tsuchiya K, Suzuki S, Okada E, Araki A, Naganuma M, Watanabe M: MR enterocolonography is useful for simultaneous evaluation of small and large intestinal lesions in Crohn's disease.
    Inflam Bowel Dis.17(5):1063-72, 2011. [PubMed]
  4. Iwasaki M, Tsuchiya K, Okamoto R, Zheng X, Kano Y, Okamoto E, Okada E, Araki A, Suzuki S, Sakamoto N, Kitagaki K, Akashi T, Eishi Y, Nakamura T, Watanabe M: Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf4.
    J Gastroenterol. 46(2):191-202, 2011. [PubMed]
  5. Kadokura M, Maekawa S, Sueki R, Miura M, Komase K, Shindo H, Amemiya F, Uetake T, Inoue T, Sakamoto M, Nakagawa M, Sakamoto N, Watanabe M, Enomoto N: Analysis of the complete open reading frame of hepatitis C virus in genotype 2a infection reveals critical sites influencing the response to peginterferon and ribavirin therapy. Hepatol Int. (in press), 2011.
  6. Kurosaki M, Sakamoto N, Iwasaki M, Sakamoto M, Suzuki Y, Hiramatu N, Sugauchi F, Yatsuhashi H, Izumi N: Pretreatment prediction of response to peginterferon plus ribavirin therapy in genotype 1 chronic hepatitis C using data mining analysis.
    J Gastroenterol. 46(3):401-9, 2011. [PubMed]
  7. Kurosaki M, Tanaka Y, Nishida N, Sakamoto N, Enomoto N, Honda M, Sugiyama M, Matsuura K, Sugauchi F, Asahina Y, Nakagawa M, Watanabe M, Sakamoto M, Maekawa S, Sakai A, Kaneko S, Ito K, Masaki N, Tokunaga K, Izumi N, Mizokami M: Pre-treatment prediction of response to pegylated-interferon plus ribavirin for chronic hepatitis C using genetic polymorphism in IL28B and viral factors.
    J Hepatol. 54(3):439-48, 2011. [PubMed]
  8. Naganuma M, Kunisaki R, Yoshimura N, Nagahori M, Yamamoto H, Kimura H, Sako M, Kawaguchi T, Takazoe M, Yamamoto S, Matsui T, Hibi T, Watanabe M: Conception and pregnancy outcome in women with inflammatory bowel disease: A multicentre study from Japan.
    J Crohns Colitis.
    5: 317-323, 2011. [PubMed]
  9. Naganuma M, Watanabe M, Hibi T: Safety and usefulness of balloon endoscopy in Crohn's disease patients with postoperative ileal lesions.
    J Crohn's Colitis. 5(1):73-4, 2011. [PubMed]
  10. Nemoto Y, Kanai T, Shinohara T, Ito T, Nakamura T, Okamoto R, Tsuchiya K, Lipp M, Eishi Y, Watanabe M: Luminal CD4+ T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation.
    Gastroenterology.
    (in press), 2011.
  11. Onozuka I, Kakinuma S, Kamiya A, Miyoshi M, Sakamoto N, Kiyohashi K, Watanabe T, Funaoka Y, Ueyama M, Nakagawa M, Koshikawa N, Seiki M, Nakauchi H, Watanabe M: Cholestatic liver fibrosis and toxin-induced fibrosis are exacerbated in matrix metalloproteinase-2 deficient mice.
    Biochem Biophys Res Commun. 406: 134-140, 2011. [PubMed]
  12. Sakamoto N, Nakagawa M, Tanaka Y, Sekine-Osajima Y, Ueyama M, Kurosaki M, Nishida N, Tamori A, Nishimura-Sakurai Y, Itsui Y, Azuma S, Kakinuma S, Hige S, Ito Y, Tanaka E, Hiasa Y, Izumi N, Tokunaga K, Mizokami M, Watanabe M: Association of IL28B polymorphism with response to pegylated-interferon alpha plus ribavirin combination therapy in patients with chronic genotype 2 hepatitis C.
    J Med Virol . 83: 871-878, 2011. [PubMed]
  13. Shinohara T, Nemoto Y, Kanai T, Kameyama K, Okamoto R, Tsuchiya K, Nakamura T, Totsuka T, Ikuta K, Watanabe M: Upregulated IL-7Rα expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis.
    J Immunol. 186:2623-2632, 2011. [PubMed]
  14. Ueyama M, Nakagawa M, Sakamoto N, Onozuka I, Funaoka Y, Watanabe T, Nitta S, Kiyohashi K, Kitazume A, Murakawa M, Nishimura-Sakurai Y, Sekine-Osajima Y, Itsui Y, Azuma S, Kakinuma S, Watanabe M: Serum interleukin-6 levels can predict resistance to treatment of chronic hepatitis C infection with pegylated-interferon alpha 2b plus ribavirin.
    Antiviral Therapy. (in press), 2011.
  15. Watanabe M, Hibi T, Lomax KG, Paulson SK, Chao J, Alam SS, Camez A: Adalimumab for the Induction and Maintenance of Clinical Remission in Japanese Patients With Crohn's Disease.
    J Crohns Colitis
    . (in press), 2011.
  16. Watanabe T, Kobunai T, Ikeuchi H, Yamamoto Y, Matsuda K, Ishihara S, Nozawa K, Iinuma H, Kanazawa T, Tanaka T, Yokoyama T, Konishi T, Eshima K, Ajioka Y, Hibi T, Watanabe M, Muto T, Nagawa H. RUNX3 copy number predicts the development of UC-associated colorectal cancer.
    Int J Oncol. 38: 201-207, 2011. [PubMed]
  17. Yamamoto M, Sakamoto N, Nakamura T, Itsui Y, Nakagawa M, Nishimura-Sakurai Y, Kakinuma S, Azuma S, Kato T, Wakita T, Watanabe M: Studies on virus kinetics using infectious fluorescence-tagged hepatitis C virus cell culture.
    Hepatology Research. 41(3):258-69, 2011. [PubMed]
  18. Zheng X, Tsuchiya K, Okamoto R, Iwasaki M, Kano Y, Sakamoto N, Nakamura T, Watanabe M: Supression of Hath1 gene expression directly regulated by Hes1 via Notch signaling is associated with goblet cell depletion in ulcerative colitis.
    Inflammatory Bowel Diseases. (in press), 2011. [PubMed]

ページの先頭へ

2010年度

  1. Akiyama J, Okamoto R, Iwasaki M, Zheng X, Yui S, Tsuchiya K, Nakamura T, Watanabe M: Delta-like 1 expression promotes goblet cell differentiation in Notch-inactivated human colonic epithelial cells.
    Biochemical and Biophysical Research Communications. 393:662-667, 2010. [PubMed]
  2. Bernard D, Prasanth KV, Tripathi V, Colasse S, Nakamura T, Xuan Z, Zhang MQ, Sedel F, Jourdren L, Coulpier F, Triller A, Spector DL, Bessis A: A long nuclear retained non-coding RNA regulates synaptogenesis by modulating gene expression.
    EMBO J. 29:3082-3093, 2010. [PubMed]
  3. Ishige T, Tomomasa T, Takebayashi T, Asakura K, Watanabe M, Suzuki T, Miyazawa R, Arakawa H: Inflammatory bowel disease in children: epidemiological analysis of the nationwide IBD registry in Japan.
    J Gastroenterol. 45:911-917, 2010. [PubMed]
  4. Kameyama K, Nemoto Y, Kanai T, Shinohara T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Totsuka T, Hibi T, Watanabe M: IL-2 is positively involved in the development of colitogenic CD4(+) IL-7Ralpha (high) memory T cells in chronic colitis
    Eur J Immunol. 40:2423-2436, 2010. [PubMed]
  5. Karakama Y, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Nishimura-Sakurai Y, Kakinuma S, Oooka M, Azuma S, Tsuchiya K, Onogi H, Hagiwara M, Watanabe M: Inhibition of Hepatitis C Virus Replication by a Specific Inhibitor of Serine-Arginine-Rich Protein Kinase.
    Antimicrobial Agents and Chemotherapy. 54:3179- 3186, 2010. [PubMed]
  6. Kim KJ, KIm KH, Kim HY, Cho HK, Sakamoto N, Cheong JH: Curecumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway
    FEBS Letter. 584:707-712, 2010. [PubMed]
  7. Mishima K, Sakamoto N, Sekine-Osajima Y, Nakagawa M, Itsui Y, Azuma S, Kakinuma S, Kiyohashi K, Kitazume A, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Wakita T, Watanabe M: Cell culture and in-vivo analyses of plaque-derived cytopathic hepatitis C virus mutants.
    Virology. 405:361-369, 2010. [PubMed]
  8. Mizui T, Yamashita S, Tanida I, Takashima M, Takei Y, Ueno T, Sakamoto N, Ikejima K, Kitamura T, Enomoto N, Sakai T, Kominami E, Watanabe S: Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagy.
    J Gastroenterol. 45:195-203, 2010. [PubMed]
  9. Nagahori M, Hyun SB, Totsuka T, Okamoto R, Kuwahara E, Takebayashi T, Naganuma M, Watanabe M: Prevalence of metabolic syndrome is comparable between inflammatory bowel disease patients and the general population.
    J Gastroenterol. 45:1008-1013, 2010. [PubMed]
  10. Naganuma M, Ichikawa H, Inoue N, Kobayashi T, Okamoto S, Hisamatsu T, Kanai T, Ogata H, Iwao Y, Hibi T: Novel endoscopic activity index is useful for choosing treatment in severe active ulcerative colitis patients.
    J Gastroenterol. 45:936-943, 2010. [PubMed]
  11. Nakagawa M, Sakamoto N, Ueyama M, Mogushi K, Nagaie S, Itsui Y, Azuma S, Kakinuma S, Tanaka H, Enomoto N, Watanabe M: Mutations in the interferon sensitivity determinig region and virological response to combination therapy with pegylated-interferon alpha 2b plus ribavirin in patients with chronic hepatitis C-1b infection.
    J Gastroenterol. 45:656-665, 2010. [PubMed]
  12. Nishimura-Sakurai Y, Sakamoto N, Mogushi K, Nagaie S, Nakagawa M, Itsui Y, Sekine-Osajima Y, Tasaka-Fujita M, Onuki-Karakama Y, Suda G, Mishima K, Yamamoto M, Ueyama M, Funaoka Y, Watanabe T, Chen CH, Kakinuma S, Tsuchiya K, Tanaka H, Enomoto N, Watanabe M: Comparison of HCV-associated gene expression and cell signaling pathways in cells with or without HCV replicon and in replicon-cured cells.
    J Gastroentorol. 45:523-536, 2010. [PubMed]
  13. Prasanth KV, Camiolo M, Chan G, Tripathi V, Denis L, Nakamura T, Hubner M, Spector DL: Nuclear organization and dynamics of 7SK RNA in regulating gene expression.
    Mol Biol Cell. 21(23):4184-4196, 2010. [PubMed]
  14. Sakamoto N, Tanaka Y, Nakagawa M, Yatsuhashi H, Nishiguchi S, Enomoto N, Azuma S, Nishimura-Sakurai Y, Kakinuma S, Nishida N, Tokunaga K, Honda M, Ito K, Mizokami M, Watanabe M: ITPA gene variant protects against anemia induced by pegylated interferon-alfa and ribavirin therapy for Japanese patients with chronic hepatitis C.
    Hepatology Research. 40(11):1063-1071, 2010. [PubMed]
  15. Sato A, Naganuma M, Asakura K, Nishiwaki Y, Yajima T, Hisamatsu T, Iwao Y, Takebayashi T, Watanabe M, Hibi T: Conception outcomes and opinions about pregnancy for men with inflammatory bowel disease.
    Journal and Crohn's and Colitis. 4:183-188, 2010. [PubMed]
  16. Shinohara S, Nemoto Y, Kanai T, Kameyama K, Okamoto R, Tsuchiya K, Nakamura T, Totsuka T, Ikuta K, Watanabe M: Upregulated IL-7R a expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis.
    J Immunol. 186(4):2623-2632, 2010. [PubMed]
  17. Suda G, Sakamoto N, Itsui Y, Nakagawa M, Mishima K, Onuki-Karakama Y, Yamamoto M, Funaoka Y, Watanabe T, Kiyohashi K, Nitta S, Azuma S, Kakinuma S, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Watanabe M: IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones.
    Virology. 407:80-90, 2010. [PubMed]

ページの先頭へ

2009年度

  1. Itsui Y, Sakamoto N, Kakinuma S, Nakagawa M, Sekine-Osajima Y, Tasaka-Fujita M, Nishimura-Sakurai Y, Suda G, Karakama Y, Mishima K, Yamamoto M, Watanabe T, Ueyama M, Funaoka Y, Azuma S, Watanabe M:Antiviral effects of the interferon-induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B protein.
    Hepatology. 50: 1727-37, 2009. [PubMed]
  2. Sekine-Osajima Y, Sakamoto N, Nakagawa M, Itsui Y, Tasaka M, Nishimura-Sakurai Y, Chen CH, Suda G, Mishima K, Onuki Y, Yamamoto M, Maekawa S, Enomoto N, Kanai T, Tsuchiya K, Watanabe M: Two flavonoids extracts from a herb, Glycyrrhizae radix, inhibit in-vitro hepatitis C virus replication.
    Hepatology Res. 39: 60-69, 2009. [PubMed]
  3. Takazoe M, Matsui T, Motoya S, Matsumoto T, Hibi T, Watanabe M: Sargramostim in patients with Crohn's disease: results of a phase 1-2 study.
    J Gastroenterol. 44:535-543,2009. [PubMed]
  4. Totsuka T, Kanai T, Nemoto Y, Tomita T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Akiba H, Okumura K, Yagita H, Watanabe M: RANK-RANKL signaling pathway Is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis.
    J Immunol.182: 6079-6087, 2009. [PubMed]
  5. Kakinuma S, Ohta H, Kamiya A, Yamazaki Y, Oikawa T, Okada K, Nakauchi H: Analyses of cell surface molecules on hepatic stem/progennitor cells in mouse fetal liver.
    J Hepatol. 51:127-138,2009. [PubMed]
  6. Kakinuma S, Nakauchi H, Watanabe M: Hepatic stem/progenitor cells and stem cell transplantation for the treatment of liver disease.
    J Gastroenterol. 44:167-172,2009. [PubMed]
  7. Oikawa T, Kamiya A, Kakinuma S, Zeniya M, Nishinakamura R, Tajiri H, Nakauchi H: Sall4 regulates cell fate decision of fetal hepatic stem/progenitor cells.
    Gastroenterology. 136:1000-1011, 2009. [PubMed]
  8. Wang SY, Tseng CP, Tsai KC, Lin CF, Wen CY, Tsay HS, Sakamoto N, Tseng CH, Cheng JC: Bioactivity-guided screening identifies pheophytin a as a potent anti-hepatitis C virus compound from Lonicera hypoglauca Miq.
    Biochem Biophys Res Commun. 385:230-235, 2009. [PubMed]
  9. Chatterji U, Bobardt M, Selvarajah S, Yang F, Tang H, Sakamoto N, Vuagniaux G, Parkinson T, Gallay P: The isomerase active site of cyclophilin a is critical for hepatitis C virus replication.
    J Biol Chem. 284:16998-17005, 2009. [PubMed]
  10. Araki A, Tsuchiya K, Okada E, Suzuki S, Oshima S, Yoshioka S, Yoshioka A, Kanai T, Watanabe M: Single-operator double-balloon endoscopy (DBE) is as effective as dual-operator DBE.
    J Gastroenterol Hepatol. 24:770-775, 2009. [PubMed]

ページの先頭へ

2008年度

  1. Fujii F, Kanai T, Tomita T, Nemoto Y, Totsuka T, Sakamoto N, Nakamura T, Tsuchiya K, Okamoto R, Watanabe M:FTY720 suppresses the development of colitis in lymphoid-null mice by modulating the trafficking of colitogenic CD4+ T cells in bone marrow.
    Eur J Immunol.38:3290-3303, 2008. [PubMed]
  2. Ohashi K, Sakamoto N, Watanabe M, Mizushima H, Tanaka H:Development of a telediagnosis endocsopy system over secure internet.
    Methods Inf Med. 47(2):157-166, 2008. [PubMed]
  3. Hino K, Tsuchiya K, Fukao T, Kiga K, Okamoto R, Kanai T, Watanabe M:Inducible expression of microRNA-194 is regulated by HNF-1 during intestinal epithelial cell differentiation.
    RNA. 14(7): 1433-1442, 2008. [PubMed]
  4. Yoshioka A, Okamoto R, Oshima S, Akiyama J, Tsuchiya K, Nakamura T, Kanai T, Watanabe M:Flagellin stimulation suppresses IL-7 secretion of intestinal epithelial cells.
    Cytokine. 44:57-64, 2008. [PubMed]
  5. Nanmoku K, Imaizumi R, Tojimbara T, Nakajima I, Fuchinoue S, Sakamoto N, Watanabe M,Teraoka S:Effects of immunosuppressants on the progression of hepatitis C in hepatitis C virus-positive renal transplantation and the usefulness of interferon therapy. 
    Transplant Proc. 40(7):2382-2385, 2008. [PubMed]
  6. Araki A, Tsuchiya K, Okada E, Suzuki S, Oshima S, Okamoto R, Kanai T, Watanabe M:Single-operator method for double-balloon endoscopy: a pilot study.
    Endoscopy. 40(11):936-938, 2008. [PubMed]
  7. Murayama M, Okamoto R, Tsuchiya K, Akiyama J ,Nakamura T, Sakamoto N, Kanai T, Watanabe M:Musashi-1 suppresses expression of Paneth cell specific genes in human intestinal epithelial cells.
    J Gastroenterol. (in press), 2008,
  8. Sawada T, Nishiyama C, Kishi T, Sasazuki T, Komazawa-Sakon S, Xue X, Piao JH, Ogata H, Nakayama JI, Taki T, Hayashi Y, Watanabe M, Yagita H, Okumura K, Nakano H:Fusion of One twenty-two to BSAC (Basic, SAP, and coiled-coil domain) results in aberrant upregulation of transcriptional activity.
    J Biol Chem . 283:26820-26828, 2008. [PubMed]
  9. Tomita T, Kanai T, Nemoto Y, Fujii T, Okamoto R, Tsuchiya K, Nakamura T,Sakamoto N, Totsuka T, Watanabe M:Colitogenic CD4+ effector-memory Tcells actively recirculate in chronic colitic mice.
    Inflam Bowel Dis. 14(12):1630-1640, 2008. [PubMed]
  10. Tomita T, Kanai T, Fujii T, Nemoto Y, Okamoto R, Tsuchiya K, Totsuka T,Sakamoto N, Watanabe M: Continuous generation of colitogenic CD4+ Tcells in persistent colitis.
    Eur. J. Immunol. 38:1264-1274, 2008. [PubMed]
  11. Tomita T, Kanai T, Fujii T, Nemoto Y, Okamoto R, Tsuchiya K, Totsuka T, Sakamoto N, Akira S, Watanabe M: MyD88-dependent pathway in T Cells directly modulates the expansion of colitogenic CD4+ T Cells in chronic colitis.
    J Immunol. 180: 5291-5299, 2008. [PubMed]
  12. Totsuka T, Kanai T, Nemoto Y, Tomita T, Tsuchiya K, Sakamoto N, Okamoto R, Watanabe M: Immunosenescent colitogenic CD4+ T cells convert to regulatory cells and suppress colitis.
    Eur J Immunol. 38: 1275-1286, 2008. [PubMed]
  13. Tomita T, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Sakamoto N, Watanabe M: Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis.
    J Immunol. 180: 383-390, 2008. [PubMed]

ページの先頭へ

2007年度

  1. Ito Y, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Sakamoto N, Watanabe M: Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis.
    Am J Physiol GI & Liver. 294: G199-207, 2007. [PubMed]
  2. Sekine-Osajima Y, Sakamoto N, Nakagawa M, Itusi Y, Tasaka M, Nishimura-Sakurai Y, Wakita T, Enomoto N, Watanabe M: Development of plaque assays for hepatitis C virus and isolation of mutants with enhanced cytopathogenicity and replication capacity.
    Virology . 371: 71-85, 2007. [PubMed]
  3. Tasaka M, Sakamoto N, Itakura Y, Nakagawa M, Itusi Y, Sekine-Osajima Y, Nishimura-Sakurai Y, Chen CH, Yoneyama M, Fujita T, Wakita T, Maekawa S, Enomoto N, Watanabe M: HCV nonstructural proteins responsible for suppression of RIG-I / Cardif -induced interferon response.
    J Gen Virol. 88: 3323-3333, 2007. [PubMed]
  4. Sakamoto N, Tanabe Y, Yokota T, Saito K, Sekine-Osajima Y, Nakagawa M, Itsui Y, Tasaka M, Sakurai Y, Chen CH, Yano M, Ohkoshi S, Aoyagi Y, Maekawa S, Enomoto N, Kohara M, Watanabe M: Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA.
    J Gastro Hepatol. 23(9):1437-47, 2007. [PubMed]
  5. Sakamoto N, Yoshimura M, Kimura T, Toyama K, Sekine-Osajima Y, Watanabe M, Muramatsu M: Bone morphogenetic protein-7 and interferon-alpha synergistically suppress hepatitis C virus replicon.
    Biochem Biophys Res Commun. 357: 467-473, 2007. [PubMed]
  6. Makita S, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Yamamoto M, Kiyono H, Watanabe M: Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation.
    J Immunol. 178: 4937-4946, 2007. [PubMed]
  7. Totsuka T, Kanai T, Nemoto Y, Makita S, Okamoto R, Tsuchiya K, Watanabe M: IL-7 is essential for the development and the persistence of chronic colitis.
    J Immunol. 178: 4737-4748, 2007. [PubMed]
  8. Kanai T, Makita S, Kawamura T, Nemoto Y, Kubota D, Nagayama K, Totsuka T, Watanabe M: Extracorporeal elimination of TNF-a producing CD14dullCD16+ monocytes in leukocytapheresis therapy for ulcerative colitis.
    Inflam Bowel Dis. 13: 284-290, 2007. [PubMed]
  9. Kakinuma S, Asahina K, Okamura K, Teramoto K, Tateno C, Yoshizato K, Tanaka Y, Yasumizu T, Sakamoto N, Watanabe M, Teraoka H: Human cord blood cells transplanted into chronically damaged liver exhibit similar characteristics to functional hepatocytes.
    Transplant Proc. 39: 240-243, 2007. [PubMed]
  10. Nemoto Y, Kanai T, Makita S, Okamoto R, Totsuka T, Takeda K, Watanabe M: Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis.
    Gastroenterology. 132: 176-189, 2007. [PubMed]
  11. Tsuchiya K, Nakamura T, Okamoto R, Kanai T, Watanabe M: Reciprocal targeting of Hath1 and b-catenin by Wnt- glycogen synthase kinase 3 b in colonocyte differentiation and proliferation.
    Gastroenterology. 132: 208-220, 2007. [PubMed]

ページの先頭へ

2006年度

  1. Kanai T, Kawamura T, Dohi T, Makita S, Nemoto Y, Totsuka T, Watanabe M: Th1/Th2-mediated colitis induced by adoptive transfer of CD4+CD45RBhigh T lymphocytes into nude mice.
    Inflamm Bowel Dis. 12: 89-99, 2006. [PubMed]
  2. Koyama T, Sakamoto N, Tanabe Y, Nakagawa M, Itsui Y, Takeda Y, Kakinuma S, Sekine Y, Maekawa S, Yanai Y, Kurimoto M, Watanabe M: Divergent activities of interferon-alpha subtypes against intracellular hepatitis C virus replication.
    Hepatology Res.
    34: 41-49, 2006. [PubMed]
  3. Kanai T, Tanimoto K, Nemoto Y, Fujii R, Makita S, Totsuka T, Watanabe M: Naturally arising CD4+CD25+, regulatory T cells suppress the expansion of colitogenic CD4+CD44highCD62L-effector-memory T cells.
    Am J Physiol. 290: G1051-1058, 2006. [PubMed]
  4. Kanai T, Hibi T, Watanabe M: The logics of leucocytapheresis as a natural biological therapy for inflammatory bowel disease.
    Expert Opin Biol Ther. 6: 453-466, 2006. [PubMed]
  5. Kanai T, Watanabe M: Do fatty acids influence functions of intestinal dendritic cells?
    J Gastroenterol. 41: 288-289, 2006.
  6. Kohashi T, Maekawa S, Sakamoto N, Watanabe H, Tanabe Y, Chen CH, Nakagawa M, Kakinuma S, Kurosaki M, Itsui Y, Koyama T, Takeda Y, Sekine Y, Enomoto N, Watanabe M: Site-specific mutation of the interferon sensitivity-determining region (ISDR) modulates hepatitis C virus replication.
    J Viral Hepatitis. 13: 582-590, 2006. [PubMed]
  7. Okamoto R, Matsumoto T, Watanabe M: Regeneration of the intestinal epithelia: Regulation of bone marrow-derived epithelial cell differentiation towards secretory lineage cells.
    Human Cell. 19: 71-75, 2006. [PubMed]
  8. Kanai T, Uraushihara K, Totsuka T, Nemoto Y, Fujii R, kawamura T, Makita S, Yagita H, Okumura K, Watanabe M: Ameliorating effect of saporin-conjugated anti-CD11b monoclonal antibody in a murine T-cell-mediated chronic colitis.
    J Gastroent Hepatol. 21: 1136-1142, 2006. [PubMed]
  9. Fujii R, Kanai T, Nemoto Y, Makita S, Oshima S, Okamoto R, Tsuchiya K, Totsuka T, Watanabe M: FTY720 suppresses CD4+CD44highCD62L- effector memory T cell-mediated colitis.
    Am J Physiol. 291: G267-G274, 2006. [PubMed]
  10. Itsui Y, Sakamoto N, Kurosaki M, Kanzawa N, Tanabe Y, Koyama T, Takeda Y, Nakagawa M, Kakinuma S, Sekine Y, Maekawa S, Enomoto N, Watanabe M: Expressional screening of interferon-stimulated genes for antiviral activity against hepatitis C virus replication.
    J Viral Hepatitis. 13: 690-700, 2006. [PubMed]
  11. Yamashiro T, Sakamoto N, Kurosaki M, Kanazawa N, Tanabe Y, Nakagawa M, Chen CH, Itsui Y, Koyama T, Takeda Y, Maekawa S, Enomoto N, Sakugawa H, Watanabe M: Negative regulation of intracellular hepatitis C virus replication by interferon regulatory factor-3.
    J Gastroenterol.41:750-757, 2006. [PubMed]

ページの先頭へ

2005年度

  1. Araki A, Kanai T, Ishikura T, Makita S, Uraushihara K, Iiyama R, Totsuka T, Takeda K, Akira S, Watanabe M: MyD88 deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis.
    J Gastroenterol. 40: 16-23, 2005. [PubMed]
  2. Kanai T, Watanabe M: Clinical application of human CD4+,CD25+ regulatory T cells for the treatment of inflammatory bowel diseases.
    Expert Opin Biol Ther. 5: 451-462, 2005. [PubMed]
  3. Okada E, Yamazaki M, Tanabe M, Takeuchi T, Nanno M, Oshima S, Okamoto R, Tsuchiya K, Nakamura T, Kanai T, Hibi T, Watanabe M: IL-7 exacerbates chronic colitis with expansion of memory IL-7Rhigh CD4+ mucosal T cells in mice.
    Am J Physiol. 288: G745-G754, 2005. [PubMed]
  4. Nagayama K, Watanabe M: IP10 released by colonic subepithelial myofibroblasts: by which stimuli and which tissue?
    J Gastroenterol. 40: 551-552, 2005. [PubMed]
  5. Matsumoto T, Okamoto R, Yajima T, Mori T, Okamoto S, Ikeda Y, Mukai M, Yamazaki M, Oshima S, Tsuchiya K, Nakamura T, Kanai T, Okano H, Inazawa J, Hibi T, Watanabe M: Increase of bone marrow-derived secretory lineage epithelial cells during regeneration in the human intestine.
    Gastroenterology. 128: 1851-1867, 2005. [PubMed]
  6. Namiki S, Nakamura T, Oshima S, Yamazaki M, Sekine Y, Tsuchiya K, Okamoto R, Kanai T, Watanabe M: IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome.
    FEBS Lett. 579: 2781-2787, 2005. [PubMed]
  7. Totsuka T, Kanai T, Makita S, Fujii R, Nemoto Y, Oshima S, Okamoto R, Koyanagi A, Akiba H, Okumura K, Yagita H, Watanabe M: Regulation of murine chronic colitis by CD4+CD25- programmed death-1+ T cells.
    Eur J Immunol. 18: 1773-1785, 2005. [PubMed]
  8. Tahara T, Inoue N, Hisamatsu T, Kashiwagi K, Takaishi H, Kanai T, Watanabe M, Ishii H, Hibi T: Clinical significance of microsatellite instability in the inflamed mucosa for the prediction of colonic neoplasms in patients with ulcerative colitis.
    J Gastroenterol Hepatol. 20: 710-715, 2005. [PubMed]
  9. Chen CH, Nagayama K, Enomoto N, Miyasaka Y, Kurosaki M, Sakamoto N, Maekawa S, Kakinuma S, Ikeda T, Izumi N, Sato C, Watanabe M: Enhancement of Mitochondrial Gene Expression in the Liver of Primary Biliary Cirrhosis.
    Hepatology Res. 31: 24-30, 2005. [PubMed]
  10. Tanabe Y, Nagayama K, Enomoto N, Izumi N, Tazawa J, Sato C, Watanabe M: Characteristic sequence changes of hepatitis C virus genotype 2b associated with sustained biochemical response to IFN therapy.
    J Viral Hepatitis. 12: 251-261, 2005. [PubMed]
  11. Nagayama K, Watanabe M: Colitis and colony-stimulating factors (CSFs): is stimulation of innate immunity through CSFs really effective for the treatment of chronic colitis?
    J Gastroenterol. 40: 857-858, 2005. [PubMed]
  12. Okamoto R, Watanabe M: Cellular and molecular mechanisms of epithelial repair in IBD.
    Dig Dis Sci. 50: S34- S38, 2005. [PubMed]
  13. Nakagawa M, Sakamoto N, Tanabe Y, Koyama T, Itsui Y, Takeda Y, Chen CH, Kakinuma S, Oooka S, Maekawa S, Enomoto N, Watanabe M: Suppression of hepatitis C virus replication by cyclosporin A is mediated by blockade of cyclophilins.
    Gastroenterology. 129: 1031-1041, 2005. [PubMed]
  14. Hamano K, Sakamoto N, Enomoto N, Izumi N, Asahina Y, Kurosaki M, Ueda E, Tanabe Y, Maekawa S, Itakura J, Watanabe H, Kakinuma S, Watanabe M: Mutations in the NS5B region of the hepatitis C virus genome correlate with clinical outcomes of interferon-alpha plus ribavirin combination therapy.
    J Gastroenterol Hepatol. 20: 1401-1409, 2005. [PubMed]
  15. Itakura J, Nagayama K, Enomoto N, Hamano K, Sakamoto N, Fanning LJ, Kenny-Walsh E, Shanahan F, Watanabe M: Viral load change and sequential evolution of entire hepatitis C virus genome in Irish recipients of single source-contaminated anti-D immunoglobulin.
    J Viral Hepatitis. 12: 594-603, 2005. [PubMed]
  16. Matsukawa H, Kanai T, Naganuma M, Kamada N, Hisamatsu T, Takaishi H, Ogata H, Mukai M, Ishii H, Mimori T, Watanabe M, Hibi T: A novel apoptosis-inducing monoclonal antibody (anti-LHK) for a cell surface antigen on colon cancer cells.
    J Gastroenterol. 40: 945-955, 2005. [PubMed]

ページの先頭へ

2004年度

  1. Okamoto R, Watanabe M: Molecular and clinical basis for the regeneration of human gastrointestinal epithelia.
    J Gastroenterol 39: 1-6, 2004. [PubMed]
  2. Sato T, Kanai T, Watanabe M, Sakuraba A, Okamoto S, Nakai T, Okazawa A, Inoue N, Totsuka T, Yamazaki M, Kroczek RA, Fukushima T, Ishii H, Hibi T: Hyperexpression of inducible costimulator and Its contribution on lamina propria T cells in inflammatory bowel disease.
    Gastroenterology. 126: 829-839, 2004. [PubMed]
  3. Nakagawa M, Sakamoto N, Enomoto N, Tanabe Y, Kanazawa N, Koyama T, Kurosaki M, Maekawa S, Yamashiro T, Chen CH, Itsui Y, Kakinuma S, Watanabe M: Specific inhibition of hepatitis C virus replication by cyclosporin A.
    Biochem Biophys Res Com. 313: 42-47, 2004. [PubMed]
  4. Ishii K, Kanai T, Totsuka T, Uraushihara K, Ishikura T, Yamazaki M, Okamoto R, Araki A, Miyata T, Tezuka K, Nakamura T, Watanabe M : Hyperexpression of inducible costimulator (ICOS) on lamina propria mononuclear cells in rat dextran sulfate sodium (DSS) colitis.
    J Gastroenterol Hepatol. 19: 174-181, 2004. [PubMed]
  5. Takenawa H, Kurosaki M, Enomoto N, Miyasaka Y, Kanazawa N, Sakamoto N, Ikeda T, Izumi N, Sato C, Watanabe M: Differential gene-expression profiles associated with gastric adenoma.
    Br J Cancer. 90: 216-223, 2004. [PubMed]
  6. Yamashiro T, Nagayama K, Enomoto N, Watanabe H, Miyagi T, Nakasone H, Sakugawa H, Watanabe M: Quantitation of the level of hepatitis delta virus RNA in serum, by real-time polymerase chain reaction-and its possible correlation with the clinical stage of liver disease.
    J Infect Dis. 189: 1151-1157, 2004. [PubMed]
  7. Kawamura T, Kanai T, Dohi T, Uraushihara K, Totsuka T, Iiyama R, Taneda C, Yamazaki M, Nakamura T, Higuchi T, Aiba Y, Tsubata T, Watanabe M: Ectopic CD40 ligand expression on B cell triggers intestinal inflammation.
    J Immunol. 172: 6388-6397, 2004. [PubMed]
  8. Tanabe Y, Sakamoto N, Enomoto N, Kurosaski M, Ueda E, Maekawa S, Yamashiro T, Nakagawa M, Chen CH, Kanazawa N, Kakinuma S, Watanabe M: Synergistic inhibition of intracellular hepatitis C virus replication by combination of ribavirin and interferon-alpha.
    J Infect Dis. 189: 1129-1139, 2004. [PubMed]
  9. Oshima S, Nakamura T, Namiki S, Okada E, Tsuchiya K, Okamoto R, Yamazaki M, Yokota T, Aida M, Yamaguchi Y, Kanai T, Handa H, Watanabe M: Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells.
    Mol Cell Biol. 24: 6298-6310, 2004. [PubMed]
  10. Makita S, Kanai T, Oshima S, Uraushihara K, Totsuka T, Iiyama R, Sawada T, Nakamura T, Koganei K, Fukushima T, Watanabe M: CD4+,CD25bright T cells in human intestinal lamina propria as regulatory cells.
    J Immunol. 173: 3119-3130, 2004. [PubMed]

ページの先頭へ

2003年度

  1. Totsuka T, Kanai T, Iiyama R, Uraushihara K, Yamazaki M, Okamoto R, Hibi T, Tezuka K, Azuma M, Akiba H, Yagita H, Okumura K, Watanabe M: Ameliorating effect of anti-inducible co-stimulator monoclonal antibody in a murine model of chronic colitis.
    Gastroenterology. 124:410-421, 2003. [PubMed]
  2. Kakinuma S, Tanaka Y, Chinzei R, Watanabe M, Shimizu-Saito K, Hara Y, Teramoto K, Arii S, Sato C, Takase K, Yasumizu T, Teraoka H: Human umbilical cord blood as a source of transplantable hepatic progenitor cells. Stem Cells. 21:217-227, 2003. [PubMed]
  3. Watanabe M, Yamazaki M, Kanai T: Mucosal T Cells as a target for treatment of IBD.
    J Gastroenterol. 38 : 48-50, 2003. [PubMed]
  4. Tsuchiya K, Kawano Y, Kojima T, Nagata K, Takao T, Okada M, Shinohara H, Maki K, Toyama-Sorimachi N, Miyasaka N, Watanabe M, Karasuyama H: Molecular cloning and characterization of TPP36 and its isoform TPP32, novel substrates of Abl tyrosine kinase.
    FEBS Lett. 537 : 203-209, 2003. [PubMed]
  5. Totsuka T, Kanai T, Uraushihara K, Iiyama R, Yamazaki M, Akiba H, Yagita H, Okumura K, Watanabe M: Therapeutic effect of anti-OX40L and anti-TNF-a MAbs in a murine model of chronic colitis.
    Am J Physiol. 284: G595-G603, 2003. [PubMed]
  6. Watanabe H, Nagayama K, Enomoto N, Itakura J, Tanabe Y, Hamano K, Izumi N, Sato C, Watanabe M: Sequence elements correlated with circulating viral load in genotype 1b hepatitis C virus infection.
    Virology. 311 : 376-383, 2003. [PubMed]
  7. Iiyama R, Kanai T, Uraushihara K, Totsuka T, Nakamura T, Miyata T, Yagita H, Tezuka K, Watanabe M: The role of Inducible Co-stimulator (ICOS)/B7 related protein-1 (B7RP-1) interaction in the germinal center formation in Peyer's patches.
    Immunol Lett. 88: 63-70, 2003. [PubMed]
  8. Sakamoto S, Yokota T, Enomoto N, Tanabe Y, Miyagishi M, Maekawa S, Ye L, Kurosaki M, Taira K, Watanabe M, Mizusawa H: Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived siRNAs.
    EMBO Reports. 4: 1-7, 2003. [PubMed]
  9. Ishikura T, Kanai T, Uraushihara K, Iiyama R, Makita S, Totsuka T, Yamazaki M, Sawada T, Nakamura T, Miyata T, Kitahora T, Hibi T, Hoshino T, Watanabe M: IL-18 overproduction exacerbates the development of colitis with markedly infiltrated macrophages in IL-18 transgenic mice.
    J Gastroenterol Hepatol. 18 : 960-969, 2003. [PubMed]
  10. Watanabe M, Yamazaki M, Okamoto R, Ohoka S, Araki A, Nakamura T, Kanai K: Therapeutic approaches to chronic intestinal inflammation by specific targeting of mucosal IL-7/IL-7R signal pathway.
    Current Drug Targets-Inflammation & Allergy. 2: 119-123, 2003. [PubMed]
  11. Kanai T, Uraushihara K, Totsuka T, Okazawa A, Hibi T, Oshima S, Miyata T, Nakamura T, Watanabe M: Macrophage-derived IL-18 targeting for the treatment of Crohns disease.
    Current Drug Targets-Inflammation & Allergy. 2: 131-136, 2003. [PubMed]
  12. Okamoto R, Watanabe M: Prospects for regeneration of gastrointestinal epithelia using bone-marrow cells.
    Trends Mol Med. 9: 286-290, 2003. [PubMed]
  13. Uraushihara K, Kanai T, Ko K, Totsuka T, Makita S, Iiyama R, Nakamura T, Watanabe M: Regulation of murine inflammatory bowel disease by CD25+ and CD25-CD4+ glucocorticoid-induced TNF receptor family-related gene+ regulatory T cells.
    J Immunol.
    171: 708-716, 2003. [PubMed]
  14. Ezaki T, Watanabe M, Inoue N, Kanai T, Ogata H, Iwao Y, Ishii H, Hibi T: A specific genetic alteration on chromosome 6 in ulcerative colitis-associated colorectal cancers.
    Cancer Res. 63: 3747-3749, 2003. [PubMed]
  15. Yamazaki M, Yajima T, Tanabe M, Fukui K, Okada E, Okamoto R, Oshima S, Nakamura T, Kanai T, Uehira M, Takeuchi T, Ishikawa H, Hibi T, Watanabe M: Mucosal T cells expressing high levels of IL-7 receptor are potential targets for treatment of chronic colitis. 
    J Immunol. 171: 1556-1563, 2003. [PubMed]
  16. Ota T, Amagai M, Watanabe M, Nishikawa T: No involvement of IgG autoantibodies against extracellular domains of desmoglein 2 in paraneoplastic pemphigus or inflammatory bowel diseases. 
    J Dermatol Sci. 32: 137-141, 2003. [PubMed]
  17. Kanai T, Totsuka T, Uraushihara K, Makita S, Nakamura T, Koganei K, Fukushima T, Akiba H, Yagita H, Okumura K, Machida U, Iwai H, Azuma M, Chen L, Watanabe M: Blockade of B7-H1 suppresses the development of chronic intestinal inflammation.
    J Immunol. 171: 4156-4163, 2003. [PubMed]
  18. Human umbilical cord blood as a source of transplantable hepatic progenitor cells. Kakinuma S, Tanaka Y, Chinzei R, Watanabe M, Shimizu-Saito K, Hara Y, Teramoto K, Arii S, Sato C, Takase K, Yasumizu T, Teraoka H. Stem Cells. 21:217-227, 2003.[PubMed]

ページの先頭へ

2002年度

  1. Kobayashi K, Ogata H, Morikawa M, IIjima S, Harada N, Yoshida T, Brown WR, Inoue N, Hamada Y, Ishii H, Watanabe M, Hibi T: Distribution and partial characterization of IgG Fc binding protein in various mucin-producing cells and body fluids.
    Gut 51: 169-176, 2002. [PubMed]
  2. Naganuma M, Watanabe M, Kanai T, Iwao Y, Mukai M, Ishikawa H, Ishii H, HibiT:Characterization of structures with T-lymphocyte aggregates in ileal villi of Crohn's disease.
    Am J Gastroenterol 97: 1741-1747, 2002. [PubMed]
  3. Chinzei R, Tanaka Y, Shimuzu-Saito K, Hara Y, Kakinuma S, Watanabe M, Teramoto K, Arii S, Takase K, Sato C, Terada N, Teraoka H:Embryoid-body cells derived from a mouse embryonic stem cell line show differentiation into functional hepatocytes.
    Hepatology 36:22-29,2002. [PubMed]
  4. Sasazuki T, Sawada T, Sakon S, Kitamura T, Kishi T, Okazaki T, Katano M, Tanaka M, Watanabe M, Yagita H, Okumura K, Nakano N: Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death.
    J Biol Chem 277: 28853-28860, 2002. [PubMed]
  5. Ono K, Tanaka Y, Kusano F, Kakinuma S, Ishidate K, Watanabe M, Marumo F, Sato C:Fas-ligand and perforin expression in infiltrating cytotoxic T lymphocytes in the liver of chronic hepatitis C.
    Hepatol Res.23:153-162, 2002. [PubMed]
  6. Kanazawa N, Izumi N, Tsuchiya K, Sakurai K, Hamano K, Itakura J, Asahina Y, Noguchi O, Uchihara M, Miyake S, Miyakawa N, Kawachi Y, Shiotsu H, Taki K, Himeno Y, Enomoto N, Watanabe M, Sakai T: A case of primary leiomyoma of the liver in a patient without evidence of immunosuppression.
    Hepatol Res 24:80-88, 2002. [PubMed]
  7. Kanai T, Iiyama R, Ishikura T, Uraushihara K, Totsuka T, Yamazaki M, Nakamura T, Watanabe M: Role of the innate immune system in the development of chronic colitis.
    J Gastroenterol. 37: 38-42, 2002. [PubMed]
  8. Kanai T, Totsuka T, Tezuka K, Watanabe M: ICOS costimulation in inflammatory bowel disease.
    J Gastroenterol. 37: 78-81, 2002. [PubMed]
  9. Okamoto R, Yajima T, Yamazaki M, Kanai T, Mukai M, Okamoto S, Ikeda Y, Hibi T, Inazawa J, Watanabe M: Damaged epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract.
    Nature Med 8: 1011-1017, 2002. [PubMed]
  10. Okazawa A, Kanai T, Watanabe M, Yamazaki M, Inoue N, Ikeda M, Kurimoto M, Ishii H, Hibi T: Th1-mediated intestinal inflammation in Crohn's disease may be induced by activation of lamina propria lymphocytes through synergistic stimulation of interleukin-12 and interleukin-18 without T cell receptor engagement.
    Am J Gastroenterol. 97: 3108-3117, 2002. [PubMed]

ページの先頭へ

2001年度

  1. Kanai T, Watanabe M, Okazawa A, Sato T, Yamazaki M, Okamoto S, Ishii H, Totsuka T, Iiyama R, Okamoto R, Ikeda M, Kurimoto M, Takeda K, Akira S, Hibi T.
    Macrophage-derived IL-18 mediated intestinal inflammation in the murine model of Crohn's disease.
    Gastroenterology. 2001;121 : 875-888. [PubMed]
  2. Horiuchi T, Ohkusa T, Watanabe M, Kobayashi D, Miwa H, Eishi Y.
    Helicobacter pylori DNA in drinking water in Japan.
    Microbiol Immunol. 2001; 45 : 515-519. [PubMed]
  3. Sawada T, Yoshida M, Yasukouchi Y, Watanabe M, Numano F.
    Colon cancer cell adhesion to endothelial E-selectin inhibits detachment of endothelial cells through activation of beta(1)-integrin.
    Biochem Biophys Res Commun. 2001; 286 : 20-27. [PubMed]
  4. Watanabe H, Enomoto N, Nagayama K, Izumi N, Marumo F, Sato C, Watanabe M.
    Number and Position of Mutations in the Interferon (IFN) Sensitivity-Determining Region of the Gene for Nonstructural Protein 5A Correlate with IFN Efficacy in Hepatitis C Virus Genotype 1b Infection.
    J Infect Dis. 2001; 183 : 1195-1203. [PubMed]
  5. Nagayama K, Enomoto N, Miyasaka Y, Kurosaki M,Chen CH, Sakamoto N, Nakagawa M, Sato C, Tazawa J,Ikeda T, Izumi N, Watanabe M.
    Overexpression of interferon gamma-inducible protein 10 in the liver of patients with type I autoimmune hepatitis identified by suppression subtractive hybridization.
    Am J Gastroenterol. 2001; 96 : 2211-2217. [PubMed]
  6. Nomura T, Araki A, Chuganji Y, Momoi M, Ohkusa T, Watanabe M.
    Influence of climatic factors in the incidence of upper gastrointestinal bleeding.
    J Gastroent Hepatol. 2001;16 : 619-623. [PubMed]
  7. Miyasaka Y, Enomoto N, Nagayama K, Izumi N, Marumo F, Watanabe M, Sato C.
    Analysis of differentially expressed genes in human hepatocellular carcinoma using suppression subtractive hybridization.
    Br J Cancer. 2001; 85 : 228-234. [PubMed]
  8. Inoue N, Watanabe M, Sato T, Okazawa A, Yamazaki M, Kanai T, Ogata H, Iwao Y, Ishii H, Hibi.
    Restricted VH gene usage in lamina propria B cells that produced anticolon antibody from patients with ulcerative colitis.
    Gastroenterology. 2001;121 :15-23. [PubMed]
  9. Ohbayashi H, Tanaka Y, Ohoka S, Chinzei R, Kahinuma S, Goto M, Watanabe M, Marumo F, Sato C.TTV is shown in the liver by in situ hybridization with a PCR-generated probe from the serum TTV-DNA.
    J Gastroenterol Hepatol. 2001;16 : 424-428. [PubMed]
  10. Ohkusa T, Fujiki K, Takashimizu I, Kumagai J, Tanizawa T, Eishi Y, Yokoyama T, Watanabe M.
    Improvement in atrophic gastritis and intestinal metaplasia in patients from whom Helicobacter pylori was eradicated.
    Ann Int Med. 2001; 134 : 380-386. [PubMed]
  11. Kanai, T, Watanabe M, Okazawa A, Sato T, Hibi T.
    IL-18 and Crohn's disease.
    Digestion. 2001; 63 : 37-42. [PubMed]
  12. Yoshida M, Sawada T, Ishii H, Gerszten E Robert, Rosenzweig Anthony, Gimbrone A Michael, Yasukochi Y, Numano F.
    HMG-CoA reductase inhibitor modulates monocyte-endothelial cell interaction under physiological flow conditions in vitro Involvement of Rho GTPase-dependent mechanism.
    Arterioscler Thromb Vasc Biol. 2001: 1165-1171.[PubMed]
  13. Miyasaka K, Masuda M, Kanai S, Ohta M, Suzuki S, Tateishi K, Funakoshi A.
    Inhibitory effect of somatostatin on cholecystokinin release is independent of luminal cholecystokinin-releasing factor content in conscious rats.
    Pancreas. 2001; 23: 414-420. [PubMed]
  14. Miura T, Ouchida R, Yoshikawa N, Okamoto K, Makino Y, Nakamura T, Tanaka H.
    Functional modulation of the giucocorticoid receptor and suppression of NF-kappaB-dependent transcription by ursodeoxycholic acid.
    J Biol Chem. 2001; 276: 47371-47378. [PubMed]
  15. Nakamura T, Ouchida R, Kodama T, Kawashima T, Watanabe S, Kitamura T, Morimoto C, Tanaka H.
    Cytokine receptor common beta subunit-mediated STAT5 activation confers NF-kappaB activation through I-kappaB-independent mechanism in murine proB cell line Ba/F3 cells.
    J Biol Chem. 2001; 227: 6254-6265. [PubMed]
  16. Nagayama K, Enomoto N, Izumi N, Kurosai M, Miyasaka Y, Watanabe H, Itakura J, Chen CH, Tazawa J, Hoshino Y, Ikeda T, Marumo F, Sato C.
    Sequences in the US5A protein of hepatitis C virus and the serum alanine aminotransferase response to interferon therapy in Japanese patients.
    Gut. 2001; 48: 830-835. [PubMed]
  17. Izumi N, Asahina Y, Noguchi O, Uchihara M, Kanazawa N, Itakura J, Himeno Y, Miyake S, Sakai T, Enomoto N.
    Risk factors for distant recurrence of hepatocellular carcinoma in the liver after comlete coagulation by microwave or radiofrequency ablation.
    Cancer. 2001; 91: 949-956. [PubMed]
  18. Tazawa J, Maeda M, Sakai Y, Yamane M, Ohbayashi H, Kakinuma S, Miyasaka Y, Nagayama K, Enomoto N, Sato C.
    Radiation therapy in combination with transcatheter arterial chemoembolization for hepatocellular carcinoma with extensive portal vein involvement.
    J Gastroenterol Hepatol. 2001;16 : 660-665. [PubMed]
  19. Yamashita Y, Koga M, Takeda Y, Enomoto N, Uchida S, Hashimoto K, Yamano S, Dohi K, Marumo F, Sasaki S.
    Two sporadic cases of Liddle's syndrome caused by denovo ENaC mutations.
    Am J kidney Dis. 2001; 37: 499-504. [PubMed]

ページの先頭へ

2000年度

  1. Suzuki K, Oida T, Hamada H, Hitotsumatsu O, Watanabe M, Hibi T, Yamamoto H, Kubota E, Kaminogawa S, Ishikawa H. Gut cryptopatches: Direct evidence of extrathymic anatomical sites for intestinal T lymphoiesis.
    Immunitiy. 2000;13: 691-702. [PubMed]
  2. Kanai T, Watanabe M, Nakamaru K, Okazawa A, Okamoto M, Naganuma M, Ishii H, Ikeda M, Kurimoto M, Hibi T.
    IL-18 is a potent proliferative factor for intestinal mucosal lymphocytes in Crohn's disease.
    Gastroenterology. 2000;119:1514-1523. [PubMed]
  3. Nagayama K, Kurosaki M, Enomoto N, Miyasaka Y, Marumo F, Sato C. Characteristics of hepatitis C viral genome associated with disease progression.
    Hepatology. 2000; 31: 745-750. [PubMed]
  4. Yu S-H, Nagayama K, Enomoto N, Izumi N, Marumo F, Sato C. Intrahepatic mRNA expression of interferon ? inducible antiviral genes in liver disease: PKR overexpressionand RNase L inhibitor suppression in chronic hepatitis C.
    Hepatology. 2000; 32: 1089 -1095. [PubMed]
  5. Kanai T, Watanabe M, Hayashi A, Nakazawa A, Yajima T, Okazawa A, Yamazaki M, Ishii H, Hibi T. Regulatory effect of interleukin-4 and interleukin-13 in colon cancer cell adhesion.
    Br J Cancer. 2000; 82: 1717-1723. [PubMed]
  6. Kashiwagi K, Watanabe M, Ezaki T, Kanai T, Ishii H, Mukai M, Hibi T. Clinical usefulnessof microsatellite instability for the prediction of gastric adenoma or adenocarcinoma inpatients with chronic gastritis.
    Br J Cancer. 2000;82:1814-1818. [PubMed]
  7. Ohkusa T, Fujiki K, Takashimizu I, Kumagai J, Tanizawa T, Eishi Y. Endoscopic and histological comparison of nonulcer dyspepsia with and without Helicobacter pylori infectionevaluated by the modified Sydney system.
    Am J Gastroenterol. 2000;95: 2195-2199. [PubMed]
  8. Naganuma M, Iwao Y, Inoue N, Hisamatsu T, Imaeda H, Ishii H, Kanai T, Watanabe M, Hibi T.  Analysis of Clinical Course and Long-Term Prognosis of Surgical and NonsurgicalPtients with Intestinal Behcet's Disease.
    Am J Gastroenterol. 2000;95: 2848-2851. [PubMed]
  9. Matsui A, Ikeda T, Enomoto K, Nakashima H, Omae K, Watanabe M, Hibi T, Kitajima M. Progression of human breast cancers to the metastatic state is linked to genotypes ofcatechol-o-methyltransferase.
    Cancer Let. 2000;150: 23-31. [PubMed]
  10. Matsui A, Ikeda T, Enomoto K, Hosoda K, Nakashima H, Omae K, Watanabe M, Hibi T, Kitajima M. Increased formation of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine,in human breast cancer tissue and its relationship to GSTP1 and COMT genotype.
    Cancer Let. 2000;151: 87-95. [PubMed]
  11. Nomura T, Boku N, Ohtsu A, Muto M, Matsumoto S, Tajiri H, Yoshida S. Recurrence after endoscopic mucosal resection for superficial esophageal cancer.
    Endoscopy. 2000;32: 277-280. [PubMed]
  12. Tamura M, Tanaka A, Kobayashi Y, Nihei Z, Numano F. Expression of Apolipoprotein B-100 in Isolated Human Small Intestine Epithelium.
    Horm Metab Res. 2000;32: 350-354. [PubMed]
  13. Takaishi H, Ohara S, Hotta K, Yajima T, Kanai T, Inoue N, Iwao Y, Watanabe M, Ishii H,Hibi T. Circulating autoantibodies against purified colonic mucin in ulcerative colitis.
    J Gastroenterol. 2000;35: 20-27. [PubMed]
  14. Iwai M, Harada Y, Muramatsu A, Tanaka S, Mori T, Okanoue T, Katoh F, Ohkusa T,Kashima K. Development of gap junctional channels and intercellular communication in ratliver during ontogenesis.
    J Hepatol. 2000; 32:11-18. [PubMed]
  15. Hisamatsu T, Watanabe M. Editorial Tracrolimus(FK506), a novel immuno suppressivedrug for inflammatory bowel disease?
    J Gastroenterol. 2000: 655-657. [PubMed]
  16. Maekawa S, Enomoto N, Kurosaki M, Nagayama K, Sato C, Marumo F: Genetic changes of interferon sensitivity determining region of hepatitis C virus during the natural course ofchronic hepatitis C.
    J Med Virol. 2000;61: 303-310. [PubMed]
  17. Kanai S, Masuda M, Suzuki S, Ohta M, Yoshida Y, Funakoshi A, Miyasaka K. Inhibitory effect of central calcitonin-gene related peptide(CGRP) onpancreatic secretion in conscious rats.
    Jpn J Physiol. 2000; 50: 243-248. [PubMed]
  18. Kusano F, Tanaka Y, Marumo F, Sato C. The expression of C-C chemokines is associated with portal and periportal inflammation in the liver of patients with chronic hepatitis C.
    LabInvest. 2000;80: 415-422. [PubMed]
  19. Ohbayashi H, Tanaka Y, Ohoka S, Kusano F, Goto M, Marumo F, Sato C. The presence of hepatitis G virus (GB Virus C) is shown in the liver by in situ polymerase chain reaction.
    Liver. 2000;20: 421-423. [PubMed]
  20. Uchida S, Tanaka Y, Ito H, Satioh-Ohara F, Yokoyama KK, Sasaki S, Marumo F. Transcriptional regulation of the CLC-K1 promoter by MAZ and KKLF, a novel Kruppel-like zinc finger repressor.
    Mol Cell Biol. 2000;20: 7319-7331. [PubMed]
  21. Suzuki S, Miyasaka K, Jimi A, Funakoshi A. Induction of acute pancreatitis by cerulein in human IL-6 gene transgenic mice.
    Pancreas. 2000;21 : 86- 92. [PubMed]
  22. Suzuki S, Kanai S, Miyasaka K, Jimi A, Funakoshi A. Regulation of pancreatic secretion by vagal nerve during short-term duct occlusion in conscious rats.  
    Pancreas. 2000;20: 94- 101. [PubMed]
  23. Kawanami T, Funakoshi A, Suzuki S, Kanai S, Sato Y, Miyasaka K. Oral administration of synthetic trypsin inhibitor increases pancreatic duct function in CCK-A receptor-deficient rat.
    Pancreas. 2000;20: 394-400. [PubMed]
  24. Tatsumi M, Kishii Y, Miyata T, Numano F. Transforming growth factor-b 1 restores antiplatelet function of endothelial cells exposed to anozia-reoxygenation injury.
    Thromb Res. 2000;98: 451-459. [PubMed]
  25. Nagayama K, Kurosaki M, Enomoto N, Miyasaka Y, Marumo F, Sato C. Characteristics of hepatitis C viral genome associated with disease progression.
    Hepatology. 2000; 31(3):745-50. [PubMed]

ページの先頭へ

1999年以前

  1. Kohyama M, Nanno M, Kawaguchi-Miyashita M, Shimada S, Watanabe M, Hibi T, Kaminogawa S, Ishikawa H. Cytolytic and IFN-gamma-producing activities of gamma delta T cells in the mouse intestinal epithelium are T cell receptor-beta-chain dependent.
    Proc Natl Acad Sci USA. 1999; 96(13): 7451-5. [PubMed]
  2. Shirai M, Arichi T, Chen M, Masaki T, Nishioka M, Ikeda K, Takahashi H, Enomoto N, Saito T, Major ME, Nakazawa T, Akatsuka T, Feinstone SM, Berzofsky JA. T cell recognitionb of hypervariable region-1 from hepatitis C virus envelope protein with multiple class II MHC molecules in mice and humans: preferential help for induction of antibodies to the hypervariable region.
    J Immunol. 1999; 162(1): 568-76. [PubMed]
  3. Hisamatsu T, Watanabe M, Ogata H, Ezaki T, Hozawa S, Ishii H, Kanai T, Hibi T. Interferon-inducible gene family 1-8U expression in colitis-associated colon cancer and severely inflamed mucosa in ulcerative colitis.
    Cancer Res. 1999; 59(23): 5927-31. [PubMed]
  4. Nakazawa A, Watanabe M, Kanai T, Yajima T, Yamazaki M, Ogata H, Ishii H, Azuma M, Hibi T.  Functional expression of costimulatory molecule CD86 on epithelial cells in the inflamed colonic mucosa.
    Gastroenterology. 1999; 117(3): 536-45. [PubMed]
  5. Murakami T, Enomoto N, Kurosaki M, Izumi N, Marumo F, Sato C. Mutations in nonstructural protein 5A gene and response to interferon in hepatitis C virus genotype 2 infection.
    Hepatology. 1999; 30(4): 1045-53. [PubMed]
  6. Watanabe M, Ueno Y, Yajima T, Okamoto S, Hayashi T, Yamazaki M, Iwao Y, Ishii H, Habu S, Uehira M, Nishimoto H, Ishikawa H, Hata J, Hibi T. Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosa.
    J Exp Med. 1998; 187(3): 389-402. [PubMed]
  7. Fukuma T, Enomoto N, Marumo F, Sato C. Mutations in the interferon-sensitivity determining region of hepatitis C virus and transcriptional activity of the nonstructural region 5A protein.
    Hepatology. 1998; 28(4): 1147-53. [PubMed]
  8. Ohkusa T, Takashimizu I, Fujiki K, Suzuki S, Shimoi K, Horiuchi T, Sakurazawa T, Ariake K, Ishii K, Kumagai J, Tanizawa T. Disappearance of hyperplastic polyps in the stomach after adication of Helicobacter pylori. A randomized, clinical trial.
    Ann Intern Med. 1998; 129(9): 712-5. [PubMed]
  9. Yamamoto C, Enomoto N, Kurosaki M, Yu SH, Tazawa J, Izumi N, Marumo F, Sato C. Nucleotide sequence variations in the internal ribosome entry site of hepatitis C virus-1b: no association with efficacy of interferon therapy or serum HCV-RNA levels.
    Hepatology. 1997; 26(6): 1616-20. [PubMed]
  10. Enomoto N, Sakuma I, Asahina Y, Kurosaki M, Murakami T, Yamamoto C, Ogura Y, Izumi N, Marumo F, Sato C. Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection.
    N Engl J Med. 1996; 334(2): 77-81. [PubMed]
  11. Tamura H, Schild L, Enomoto N, Matsui N, Marumo F, Rossier BC. Liddle disease caused bya missense mutation of beta subunit of the epithelial sodium channel gene.
    J Clin Invest. 1996; 97(7): 1780-4. [PubMed]
  12. Sakamoto N, Wu CH, Wu GY. Intracellular cleavage of hepatitis C virus RNA and inhibition of viral protein translation by hammerhead ribozymes.
    J Clin Invest. 1996; 98(12): 2720-8. [PubMed]
  13. Watanabe M, Ueno Y, Yajima T, Iwao Y, Tsuchiya M, Ishikawa H, Aiso S, Hibi T, Ishii H. Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes.
    J Clin Invest. 1995; 95(6): 2945-53. [PubMed]
  14. Enomoto N, Sakuma I, Asahina Y, Kurosaki M, Murakami T, Yamamoto C, Izumi N, Marumo F, Sato C. Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region.
    J Clin Invest. 1995; 96(1): 224-30. [PubMed]
  15. Watanabe M, Boyson JE, Lord CI, Letvin NL. Chimpanzees immunized with recombinant soluble CD4 develop anti-self CD4 antibody responses with anti-human immunodeficiency virus activity.
    Proc Natl Acad Sci USA. 1992; 89(11): 5103-7. [PubMed]
  16. Hasunuma T, Tsubota H, Watanabe M, Chen ZW, Lord CI, Burkly LC, Daley JF, Letvin NL.
    Regions of the CD4 molecule not involved in virus binding or syncytia formation are required for HIV-1 infection of lymphocytes.
    J Immunol. 1992; 148(6): 1841-6. [PubMed]
  17. Watanabe M, Chen ZW, Tsubota H, Lord CI, Levine CG, Letvin NL. Soluble human CD4 elicits an antibody response in rhesus monkeys that inhibits simian immunodeficiency virus replication.
    Proc Natl Acad Sci USA. 1991; 88(1): 120-4. [PubMed]
  18. Watanabe M, Levine CG, Shen L, Fisher RA, Letvin NL. Immunization of simian immunodeficiency virus-infected rhesus monkeys with soluble human CD4 elicits an antiviral response.
    Proc Natl Acad Sci USA. 1991; 88(11): 4616-20. [PubMed]
  19. Watanabe M, Reimann KA, DeLong PA, Liu T, Fisher RA, Letvin NL. Effect of recombinant soluble CD4 in rhesus monkeys infected with simian immunodeficiency virus of macaques.
    Nature. 1989; 337(6204): 267-70. [PubMed]

ページの先頭へ