Publications

2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999

2011

  1. D’Haens GR, Panaccione R, Higgins PD, Vermeire S, Gassull M, Chowers Y, Hanauer SB, Herfarth H, Hommes DW, Kamm M, L?fberg R, Quary A, Sands B, Sood A, Watermayer G, Lashner B, L?mann M, Plevy S, Reinisch W, Schreiber S, Siegel C, Targan S, Watanabe M, Feagan B, Sandborn WJ, Colombel JF, Travis S: The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD With the European Crohn’s and Colitis Organization: When to Start, When to Stop, Which Drug to Choose, and How to Predict Response?
    Am J Gastroenterol. 106(2):199-212,2011. [PubMed]
  2. Hyun SB, Kitazume Y, Nagahori M, Akira T, Fujii T, Tsuchiya K, Suzuki S, Okada E, Araki A, Naganuma M, Watanabe M: MR enterocolonography is useful for simultaneous evaluation of small and large intestinal lesions in Crohn's disease.
    Inflam Bowel Dis.17(5):1063-72,2011.[PubMed]
  3. Iwasaki M, Tsuchiya K, Okamoto R, Zheng X, Kano Y, Okamoto E, Okada E, Araki A, Suzuki S, Sakamoto N, Kitagaki K, Akashi T, Eishi Y, Nakamura T, Watanabe M: Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf4.
    J Gastroenterol. 46(2):191-202,2011.[PubMed]
  4. Kurosaki M, Sakamoto N, Iwasaki M, Sakamoto M, Suzuki Y, Hiramatu N, Sugauchi F, Yatsuhashi H, Izumi N: Pretreatment prediction of response to peginterferon plus ribavirin therapy in genotype 1 chronic hepatitis C using data mining analysis.
    J Gastroenterol. 46(3):401-9,2011. [PubMed]
  5. Kurosaki M, Tanaka Y, Nishida N, Sakamoto N, Enomoto N, Honda M, Sugiyama M, Matsuura K, Sugauchi F, Asahina Y, Nakagawa M, Watanabe M, Sakamoto M, Maekawa S, Sakai A, Kaneko S, Ito K, Masaki N, Tokunaga K, Izumi N, Mizokami M: Pre-treatment prediction of response to pegylated-interferon plus ribavirin for chronic hepatitis C using genetic polymorphism in IL28B and viral factors.
    J Hepatol.54(3):439-48,2011.[PubMed]
  6. Naganuma M, Watanabe M, Hibi T: Safety and usefulness of balloon endoscopy in Crohn's disease patients with postoperative ileal lesions.
    J Crohn's Colitis. 5(1):73-4,2011.[PubMed]
  7. Yamamoto M, Sakamoto N, Nakamura T, Itsui Y, Nakagawa M, Nishimura-Sakurai Y, Kakinuma S, Azuma S, Kato T, Wakita T, Watanabe M: Studies on virus kinetics using infectious fluorescence-tagged hepatitis C virus cell culture.
    Hepatology Research. 41(3):258-69,2011.[PubMed]
  8. Zheng X, Tsuchiya K, Okamoto R, Iwasaki M, Kano Y, Sakamoto N, Nakamura T, Watanabe M: Supression of Hath1 gene expression directly regulated by Hes1 via Notch signaling is associated with goblet cell depletion in ulcerative colitis.
    Inflammatory Bowel Diseases. (in press),2011.[PubMed]

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2010

  1. Akiyama J, Okamoto R, Iwasaki M, Zheng X, Yui S, Tsuchiya K, Nakamura T, Watanabe M： Delta-like 1 expression promotes goblet cell differentiation in Notch-inactivated human colonic epithelial cells.
    Biochemical and Biophysical Research Communications. 393:662-667, 2010.[PubMed]
  2. Bernard D, Prasanth KV, Tripathi V, Colasse S, Nakamura T, Xuan Z, Zhang MQ, Sedel F, Jourdren L, Coulpier F, Triller A, Spector DL, Bessis A: A long nuclear retained non-coding RNA regulates synaptogenesis by modulating gene expression.
    EMBO J. 29:3082-3093, 2010.[PubMed]
  3. Ishige T, Tomomasa T, Takebayashi T, Asakura K, Watanabe M, Suzuki T, Miyazawa R, Arakawa H: Inflammatory bowel disease in children: epidemiological analysis of the nationwide IBD registry in Japan.
    J Gastroenterol. 45:911-917, 2010.[PubMed]
  4. Kameyama K, Nemoto Y, Kanai T, Shinohara T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Totsuka T, Hibi T, Watanabe M: IL-2 is positively involved in the development of colitogenic CD4(+) IL-7Ralpha (high) memory T cells in chronic colitis
    Eur J Immunol. 40:2423-2436, 2010.[PubMed]
  5. Karakama Y, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Nishimura-Sakurai Y, Kakinuma S, Oooka M, Azuma S, Tsuchiya K, Onogi H, Hagiwara M, Watanabe M: Inhibition of Hepatitis C Virus Replication by a Specific Inhibitor of Serine-Arginine-Rich Protein Kinase.
    Antimicrobial Agents and Chemotherapy. 54:3179- 3186, 2010.[PubMed]
  6. Kim KJ, KIm KH, Kim HY, Cho HK, Sakamoto N, Cheong JH: Curecumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway
    FEBS Letter. 584:707-712, 2010.[PubMed]
  7. Mishima K, Sakamoto N, Sekine-Osajima Y, Nakagawa M, Itsui Y, Azuma S, Kakinuma S, Kiyohashi K, Kitazume A, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Wakita T, Watanabe M: Cell culture and in-vivo analyses of plaque-derived cytopathic hepatitis C virus mutants.
    Virology. 405:361-369, 2010.[PubMed]
  8. Mizui T, Yamashita S, Tanida I, Takashima M, Takei Y, Ueno T, Sakamoto N, Ikejima K, Kitamura T, Enomoto N, Sakai T, Kominami E, Watanabe S: Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagy.
    J Gastroenterol. 45:195-203, 2010.[PubMed]
  9. Nagahori M, Hyun SB, Totsuka T, Okamoto R, Kuwahara E, Takebayashi T, Naganuma M, Watanabe M: Prevalence of metabolic syndrome is comparable between inflammatory bowel disease patients and the general population.
    J Gastroenterol. 45:1008-1013, 2010.[PubMed]
  10. Naganuma M, Ichikawa H, Inoue N, Kobayashi T, Okamoto S, Hisamatsu T, Kanai T, Ogata H, Iwao Y, Hibi T: Novel endoscopic activity index is useful for choosing treatment in severe active ulcerative colitis patients.
    J Gastroenterol. 45:936-943, 2010.[PubMed]
  11. Nakagawa M, Sakamoto N, Ueyama M, Mogushi K, Nagaie S, Itsui Y, Azuma S, Kakinuma S, Tanaka H, Enomoto N, Watanabe M: Mutations in the interferon sensitivity determinig region and virological response to combination therapy with pegylated-interferon alpha 2b plus ribavirin in patients with chronic hepatitis C-1b infection.
    J Gastroenterol. 45:656-665, 2010.[PubMed]
  12. Nishimura-Sakurai Y, Sakamoto N, Mogushi K, Nagaie S, Nakagawa M, Itsui Y, Sekine-Osajima Y, Tasaka-Fujita M, Onuki-Karakama Y, Suda G, Mishima K, Yamamoto M, Ueyama M, Funaoka Y, Watanabe T, Chen CH, Kakinuma S, Tsuchiya K, Tanaka H, Enomoto N, Watanabe M: Comparison of HCV-associated gene expression and cell signaling pathways in cells with or without HCV replicon and in replicon-cured cells.
    J Gastroentorol. 45:523-536, 2010.[PubMed]
  13. Prasanth KV, Camiolo M, Chan G, Tripathi V, Denis L, Nakamura T, Hubner M, Spector DL: Nuclear organization and dynamics of 7SK RNA in regulating gene expression.
    Mol Biol Cell. 21(23):4184-4196, 2010.[PubMed]
  14. Sakamoto N, Tanaka Y, Nakagawa M, Yatsuhashi H, Nishiguchi S, Enomoto N, Azuma S, Nishimura-Sakurai Y, Kakinuma S, Nishida N, Tokunaga K, Honda M, Ito K, Mizokami M, Watanabe M: ITPA gene variant protects against anemia induced by pegylated interferon-alfa and ribavirin therapy for Japanese patients with chronic hepatitis C.
    Hepatology Research. 40(11):1063-1071, 2010.[PubMed]
  15. Sato A, Naganuma M, Asakura K, Nishiwaki Y, Yajima T, Hisamatsu T, Iwao Y, Takebayashi T, Watanabe M, Hibi T: Conception outcomes and opinions about pregnancy for men with inflammatory bowel disease.
    Journal and Crohn's and Colitis. 4:183-188, 2010.[PubMed]
  16. Shinohara S, Nemoto Y, Kanai T, Kameyama K, Okamoto R, Tsuchiya K, Nakamura T, Totsuka T, Ikuta K, Watanabe M: Upregulated IL-7R a expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis.
    J Immunol. 186(4):2623-2632, 2010.[PubMed]
  17. Suda G, Sakamoto N, Itsui Y, Nakagawa M, Mishima K, Onuki-Karakama Y, Yamamoto M, Funaoka Y, Watanabe T, Kiyohashi K, Nitta S, Azuma S, Kakinuma S, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Watanabe M: IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones.
    Virology. 407:80-90, 2010.[PubMed]

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2009

  1. Itsui Y, Sakamoto N, Kakinuma S, Nakagawa M, Sekine-Osajima Y, Tasaka-Fujita M, Nishimura-Sakurai Y, Suda G, Karakama Y, Mishima K, Yamamoto M, Watanabe T, Ueyama M, Funaoka Y, Azuma S, Watanabe M:Antiviral effects of the interferon-induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B protein.
    Hepatology . 50: 1727-37, 2009.[PubMed]
  2. Sekine-Osajima Y, Sakamoto N, Nakagawa M, Itsui Y, Tasaka M, Nishimura-Sakurai Y, Chen CH, Suda G, Mishima K, Onuki Y, Yamamoto M, Maekawa S, Enomoto N, Kanai T, Tsuchiya K, Watanabe M: Two flavonoids extracts from a herb, Glycyrrhizae radix, inhibit in-vitro hepatitis C virus replication.
    Hepatology Res. 39: 60-69, 2009.[PubMed]
  3. Takazoe M, Matsui T, Motoya S, Matsumoto T, Hibi T, Watanabe M: Sargramostim in patients with Crohn's disease: results of a phase 1-2 study.
    J Gastroenterol. 44:535-543,2009.[PubMed]
  4. Totsuka T, Kanai T, Nemoto Y, Tomita T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Akiba H, Okumura K, Yagita H, Watanabe M: RANK-RANKL signaling pathway Is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis.
    J Immunol.182: 6079-6087, 2009.[PubMed]
  5. Kakinuma S, Ohta H, Kamiya A, Yamazaki Y, Oikawa T, Okada K, Nakauchi H: Analyses of cell surface molecules on hepatic stem/progennitor cells in mouse fetal liver.
    J Hepatol. 51:127-138,2009.[PubMed]
  6. Kakinuma S, Nakauchi H, Watanabe M: Hepatic stem/progenitor cells and stem cell transplantation for the treatment of liver disease.
    J Gastroenterol. 44:167-172,2009.[PubMed]
  7. Oikawa T, Kamiya A, Kakinuma S, Zeniya M, Nishinakamura R, Tajiri H, Nakauchi H: Sall4 regulates cell fate decision of fetal hepatic stem/progenitor cells.
    Gastroenterology. 136:1000-1011, 2009.[PubMed]
  8. Wang SY, Tseng CP, Tsai KC, Lin CF, Wen CY, Tsay HS, Sakamoto N, Tseng CH, Cheng JC: Bioactivity-guided screening identifies pheophytin a as a potent anti-hepatitis C virus compound from Lonicera hypoglauca Miq.
    Biochem Biophys Res Commun. 385:230-235, 2009.[PubMed]
  9. Chatterji U, Bobardt M, Selvarajah S, Yang F, Tang H, Sakamoto N, Vuagniaux G, Parkinson T, Gallay P: The isomerase active site of cyclophilin a is critical for hepatitis C virus replication.
    J Biol Chem. 284:16998-17005, 2009.[PubMed]
  10. Araki A, Tsuchiya K, Okada E, Suzuki S, Oshima S, Yoshioka S, Yoshioka A, Kanai T, Watanabe M: Single-operator double-balloon endoscopy (DBE) is as effective as dual-operator DBE.
    J Gastroenterol Hepatol. 24:770-775, 2009.[PubMed]

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2008

  1. Fujii F, Kanai T, Tomita T, Nemoto Y, Totsuka T, Sakamoto N, Nakamura T, Tsuchiya K, Okamoto R, Watanabe M:FTY720 suppresses the development of colitis in lymphoid-null mice by modulating the trafficking of colitogenic CD4+ T cells in bone marrow.
    Eur J Immunol.38:3290-3303, 2008.[PubMed]
  2. Ohashi K, Sakamoto N, Watanabe M, Mizushima H, Tanaka H:Development of a telediagnosis endocsopy system over secure internet.
    Methods Inf Med. 47(2):157-166, 2008.[PubMed]
  3. Hino K, Tsuchiya K, Fukao T, Kiga K, Okamoto R, Kanai T, Watanabe M:Inducible expression of microRNA-194 is regulated by HNF-1 during intestinal epithelial cell differentiation.
    RNA. 14(7): 1433-1442, 2008.[PubMed]
  4. Yoshioka A, Okamoto R, Oshima S, Akiyama J, Tsuchiya K, Nakamura T, Kanai T, Watanabe M:Flagellin stimulation suppresses IL-7 secretion of intestinal epithelial cells.
    Cytokine. 44:57-64, 2008.[PubMed]
  5. Nanmoku K, Imaizumi R, Tojimbara T, Nakajima I, Fuchinoue S, Sakamoto N, Watanabe M,Teraoka S:Effects of immunosuppressants on the progression of hepatitis C in hepatitis C virus-positive renal transplantation and the usefulness of interferon therapy.　
    Transplant Proc.40(7):2382-2385, 2008.[PubMed]
  6. Araki A, Tsuchiya K, Okada E, Suzuki S, Oshima S, Okamoto R, Kanai T, Watanabe M:Single-operator method for double-balloon endoscopy: a pilot study.
    Endoscopy.40(11):936-938, 2008.[PubMed]
  7. Murayama M, Okamoto R, Tsuchiya K, Akiyama J ,Nakamura T, Sakamoto N, Kanai T, Watanabe M:Musashi-1 suppresses expression of Paneth cell specific genes in human intestinal epithelial cells.
    J Gastroenterol . (in press), 2008,
  8. Sawada T, Nishiyama C, Kishi T, Sasazuki T, Komazawa-Sakon S, Xue X, Piao JH, Ogata H, Nakayama JI, Taki T, Hayashi Y, Watanabe M, Yagita H, Okumura K, Nakano H:Fusion of One twenty-two to BSAC (Basic, SAP, and coiled-coil domain) results in aberrant upregulation of transcriptional activity.
    J Biol Chem . 283:26820-26828, 2008.[PubMed]
  9. Tomita T, Kanai T, Nemoto Y, Fujii T, Okamoto R, Tsuchiya K, Nakamura T,Sakamoto N, Totsuka T, Watanabe M:Colitogenic CD4+ effector-memory Tcells actively recirculate in chronic colitic mice.
    Inflam Bowel Dis. 14(12):1630-1640, 2008.[PubMed]
  10. Tomita T, Kanai T, Fujii T, Nemoto Y, Okamoto R, Tsuchiya K, Totsuka T,Sakamoto N, Watanabe M: Continuous generation of colitogenic CD4+ Tcells in persistent colitis.
    Eur. J. Immunol. 38:1264-1274, 2008.[PubMed]
  11. Tomita T, Kanai T, Fujii T, Nemoto Y, Okamoto R, Tsuchiya K, Totsuka T, Sakamoto N, Akira S, Watanabe M: MyD88-dependent pathway in T Cells directly modulates the expansion of colitogenic CD4+ T Cells in chronic colitis.
    J Immunol. 180: 5291-5299, 2008.[PubMed]
  12. Totsuka T, Kanai T, Nemoto Y, Tomita T, Tsuchiya K, Sakamoto N, Okamoto R, Watanabe M: Immunosenescent colitogenic CD4+ T cells convert to regulatory cells and suppress colitis.
    Eur J Immunol. 38: 1275-1286, 2008.[PubMed]
  13. Tomita T, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Sakamoto N, Watanabe M: Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis.
    J Immunol. 180: 383-390, 2008.[PubMed]

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2007

  1. Ito Y, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Sakamoto N, Watanabe M: Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis.
    Am J Physiol GI & Liver. 294: G199-207, 2007.[PubMed]
  2. Sekine-Osajima Y, Sakamoto N, Nakagawa M, Itusi Y, Tasaka M, Nishimura-Sakurai Y, Wakita T, Enomoto N, Watanabe M: Development of plaque assays for hepatitis C virus and isolation of mutants with enhanced cytopathogenicity and replication capacity.
    Virology . 371: 71-85, 2007.[PubMed]
  3. Tasaka M, Sakamoto N, Itakura Y, Nakagawa M, Itusi Y, Sekine-Osajima Y, Nishimura-Sakurai Y, Chen CH, Yoneyama M, Fujita T, Wakita T, Maekawa S, Enomoto N, Watanabe M: HCV nonstructural proteins responsible for suppression of RIG-I / Cardif -induced interferon response.
    J Gen Virol. 88: 3323-3333, 2007.[PubMed]
  4. Sakamoto N, Tanabe Y, Yokota T, Saito K, Sekine-Osajima Y, Nakagawa M, Itsui Y, Tasaka M, Sakurai Y, Chen CH, Yano M, Ohkoshi S, Aoyagi Y, Maekawa S, Enomoto N, Kohara M, Watanabe M: Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA.
    J Gastro Hepatol. 23(9):1437-47, 2007. [PubMed]
  5. Sakamoto N, Yoshimura M, Kimura T, Toyama K, Sekine-Osajima Y, Watanabe M, Muramatsu M: Bone morphogenetic protein-7 and interferon-alpha synergistically suppress hepatitis C virus replicon.
    Biochem Biophys Res Commun. 357: 467-473, 2007.[PubMed]
  6. Makita S, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Yamamoto M, Kiyono H, Watanabe M: Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation.
    J Immunol. 178: 4937-4946, 2007.[PubMed]
  7. Totsuka T, Kanai T, Nemoto Y, Makita S, Okamoto R, Tsuchiya K, Watanabe M: IL-7 is essential for the development and the persistence of chronic colitis.
    J Immunol. 178: 4737-4748, 2007.[PubMed]
  8. Kanai T, Makita S, Kawamura T, Nemoto Y, Kubota D, Nagayama K, Totsuka T, Watanabe M: Extracorporeal elimination of TNF-a producing CD14dullCD16+ monocytes in leukocytapheresis therapy for ulcerative colitis.
    Inflam Bowel Dis. 13: 284-290, 2007.[PubMed]
  9. Kakinuma S, Asahina K, Okamura K, Teramoto K, Tateno C, Yoshizato K, Tanaka Y, Yasumizu T, Sakamoto N, Watanabe M, Teraoka H: Human cord blood cells transplanted into chronically damaged liver exhibit similar characteristics to functional hepatocytes.
    Transplant Proc. 39: 240-243, 2007.[PubMed]
  10. Nemoto Y, Kanai T, Makita S, Okamoto R, Totsuka T, Takeda K, Watanabe M: Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis.
    Gastroenterology. 132: 176-189, 2007.[PubMed]
  11. Tsuchiya K, Nakamura T, Okamoto R, Kanai T, Watanabe M: Reciprocal targeting of Hath1 and b-catenin by Wnt- glycogen synthase　kinase 3 b in colonocyte differentiation and proliferation.
    Gastroenterology. 132: 208-220, 2007.[PubMed]

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2006

  1. Kanai T, Kawamura T, Dohi T, Makita S, Nemoto Y, Totsuka T, Watanabe M: Th1/Th2-mediated colitis induced by adoptive transfer of CD4+CD45RBhigh T lymphocytes into nude mice.
    Inflamm Bowel Dis. 12: 89-99, 2006.[PubMed]
  2. Koyama T, Sakamoto N, Tanabe Y, Nakagawa M, Itsui Y, Takeda Y, Kakinuma S, Sekine Y, Maekawa S, Yanai Y, Kurimoto M, Watanabe M: Divergent activities of interferon-alpha subtypes against intracellular hepatitis C virus replication.
    Hepatology Res.     34: 41-49, 2006.[PubMed]
  3. Kanai T, Tanimoto K, Nemoto Y, Fujii R, Makita S, Totsuka T, Watanabe M: Naturally arising CD4+CD25+, regulatory T cells suppress the expansion of colitogenic CD4+CD44highCD62L-effector-memory T cells.
    Am J Physiol. 290: G1051-1058, 2006.[PubMed]
  4. Kanai T, Hibi T, Watanabe M: The logics of leucocytapheresis as a natural biological therapy for inflammatory bowel disease.
    Expert Opin Biol Ther. 6: 453-466, 2006.[PubMed]
  5. Kanai T, Watanabe M: Do fatty acids influence functions of intestinal dendritic cells?
    J Gastroenterol. 41: 288-289, 2006.
  6. Kohashi T, Maekawa S, Sakamoto N, Watanabe H, Tanabe Y, Chen CH, Nakagawa M, Kakinuma S, Kurosaki M, Itsui Y, Koyama T, Takeda Y, Sekine Y, Enomoto N, Watanabe M: Site-specific mutation of the interferon sensitivity-determining region (ISDR) modulates hepatitis C virus replication.
    J Viral Hepatitis. 13: 582-590, 2006. [PubMed]
  7. Okamoto R, Matsumoto T, Watanabe M: Regeneration of the intestinal epithelia: Regulation of bone marrow-derived epithelial cell differentiation towards secretory lineage cells.
    Human Cell. 19: 71-75, 2006. [PubMed]
  8. Kanai T, Uraushihara K, Totsuka T, Nemoto Y, Fujii R, kawamura T, Makita S, Yagita H, Okumura K, Watanabe M: Ameliorating effect of saporin-conjugated anti-CD11b monoclonal antibody in a murine T-cell-mediated chronic colitis.
    J Gastroent Hepatol. 21: 1136-1142, 2006.[PubMed]
  9. Fujii R, Kanai T, Nemoto Y, Makita S, Oshima S, Okamoto R, Tsuchiya K, Totsuka T, Watanabe M: FTY720 suppresses CD4+CD44highCD62L- effector memory T cell-mediated colitis.
    Am J Physiol. 291: G267-G274, 2006.[PubMed]
  10. Itsui Y, Sakamoto N, Kurosaki M, Kanzawa N, Tanabe Y, Koyama T, Takeda Y, Nakagawa M, Kakinuma S, Sekine Y, Maekawa S, Enomoto N, Watanabe M: Expressional screening of interferon-stimulated genes for antiviral activity against hepatitis C virus replication.
    J Viral Hepatitis. 13: 690-700, 2006.[PubMed]
  11. Yamashiro T, Sakamoto N, Kurosaki M, Kanazawa N, Tanabe Y, Nakagawa M, Chen CH, Itsui Y, Koyama T, Takeda Y, Maekawa S, Enomoto N, Sakugawa H, Watanabe M: Negative regulation of intracellular hepatitis C virus replication by interferon regulatory factor-3.
    J Gastroenterol.41:750-757, 2006. [PubMed]

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2005

  1. Araki A, Kanai T, Ishikura T, Makita S, Uraushihara K, Iiyama R, Totsuka T, Takeda K, Akira S, Watanabe M: MyD88 deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis.
    J Gastroenterol. 40: 16-23, 2005.[PubMed]
  2. Kanai T, Watanabe M: Clinical application of human CD4+,CD25+ regulatory T cells for the treatment of inflammatory bowel diseases.
    Expert Opin Biol Ther. 5: 451-462, 2005.[PubMed]
  3. Okada E, Yamazaki M, Tanabe M, Takeuchi T, Nanno M, Oshima S, Okamoto R, Tsuchiya K, Nakamura T, Kanai T, Hibi T, Watanabe M: IL-7 exacerbates chronic colitis with expansion of memory IL-7Rhigh CD4+ mucosal T cells in mice.
    Am J Physiol. 288: G745-G754, 2005.[PubMed]
  4. Nagayama K, Watanabe M: IP10 released by colonic subepithelial myofibroblasts: by which stimuli and which tissue?
    J Gastroenterol. 40: 551-552, 2005.[PubMed]
  5. Matsumoto T, Okamoto R, Yajima T, Mori T, Okamoto S, Ikeda Y, Mukai M, Yamazaki M, Oshima S, Tsuchiya K, Nakamura T, Kanai T, Okano H, Inazawa J, Hibi T, Watanabe M: Increase of bone marrow-derived secretory lineage epithelial cells during regeneration in the human intestine.
    Gastroenterology. 128: 1851-1867, 2005.[PubMed]
  6. Namiki S, Nakamura T, Oshima S, Yamazaki M, Sekine Y, Tsuchiya K, Okamoto R, Kanai T, Watanabe M: IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome.
    FEBS Lett. 579: 2781-2787, 2005.[PubMed]
  7. Totsuka T, Kanai T, Makita S, Fujii R, Nemoto Y, Oshima S, Okamoto R, Koyanagi A, Akiba H, Okumura K, Yagita H, Watanabe M: Regulation of murine chronic colitis by CD4+CD25- programmed death-1+ T cells.
    Eur J Immunol. 18: 1773-1785, 2005.[PubMed]
  8. Tahara T, Inoue N, Hisamatsu T, Kashiwagi K, Takaishi H, Kanai T, Watanabe M, Ishii H, Hibi T: Clinical significance of microsatellite instability in the inflamed mucosa for the prediction of colonic neoplasms in patients with ulcerative colitis.
    J Gastroenterol Hepatol. 20: 710-715, 2005.[PubMed]
  9. Chen CH, Nagayama K, Enomoto N, Miyasaka Y, Kurosaki M, Sakamoto N, Maekawa S, Kakinuma S, Ikeda T, Izumi N, Sato C, Watanabe M: Enhancement of Mitochondrial Gene Expression in the Liver of Primary Biliary Cirrhosis.
    Hepatology Res. 31: 24-30, 2005.[PubMed]
  10. Tanabe Y, Nagayama K, Enomoto N, Izumi N, Tazawa J, Sato C, Watanabe M: Characteristic sequence changes of hepatitis C virus genotype 2b associated with sustained biochemical response to IFN therapy.
    J Viral Hepatitis. 12: 251-261, 2005.[PubMed]
  11. Nagayama K, Watanabe M: Colitis and colony-stimulating factors (CSFs): is stimulation of innate immunity through CSFs really effective for the treatment of chronic colitis?
    J Gastroenterol. 40: 857-858, 2005.[PubMed]
  12. Okamoto R, Watanabe M: Cellular and molecular mechanisms of epithelial repair in IBD.
    Dig Dis Sci. 50: S34- S38, 2005.[PubMed]
  13. Nakagawa M, Sakamoto N, Tanabe Y, Koyama T, Itsui Y, Takeda Y, Chen CH, Kakinuma S, Oooka S, Maekawa S, Enomoto N, Watanabe M: Suppression of hepatitis C virus replication by cyclosporin A is mediated by blockade of cyclophilins.
    Gastroenterology. 129: 1031-1041, 2005.[PubMed]
  14. Hamano K, Sakamoto N, Enomoto N, Izumi N, Asahina Y, Kurosaki M, Ueda E, Tanabe Y, Maekawa S, Itakura J, Watanabe H, Kakinuma S, Watanabe M: Mutations in the NS5B region of the hepatitis C virus genome correlate with clinical outcomes of interferon-alpha plus ribavirin combination therapy.
    J Gastroenterol Hepatol. 20: 1401-1409, 2005.[PubMed]
  15. Itakura J, Nagayama K, Enomoto N, Hamano K, Sakamoto N, Fanning LJ, Kenny-Walsh E, Shanahan F, Watanabe M: Viral load change and sequential evolution of entire hepatitis C virus genome in Irish recipients of single source-contaminated anti-D immunoglobulin.
    J Viral Hepatitis. 12: 594-603, 2005.[PubMed]
  16. Matsukawa H, Kanai T, Naganuma M, Kamada N, Hisamatsu T, Takaishi H, Ogata H, Mukai M, Ishii H, Mimori T, Watanabe M, Hibi T: A novel apoptosis-inducing monoclonal antibody (anti-LHK) for a cell surface antigen on colon cancer cells.
    J Gastroenterol. 40: 945-955, 2005.[PubMed]

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2004

  1. Okamoto R, Watanabe M: Molecular and clinical basis for the regeneration of human gastrointestinal epithelia.
    J Gastroenterol 39: 1-6, 2004. [PubMed]
  2. Sato T, Kanai T, Watanabe M, Sakuraba A, Okamoto S, Nakai T, Okazawa A, Inoue N, Totsuka T, Yamazaki M, Kroczek RA, Fukushima T, Ishii H, Hibi T: Hyperexpression of inducible costimulator and Its contribution on lamina propria T cells in inflammatory bowel disease.
    Gastroenterology. 126: 829-839, 2004. [PubMed]
  3. Nakagawa M, Sakamoto N, Enomoto N, Tanabe Y, Kanazawa N, Koyama T, Kurosaki M, Maekawa S, Yamashiro T, Chen CH, Itsui Y, Kakinuma S, Watanabe M: Specific inhibition of hepatitis C virus replication by cyclosporin A.
    Biochem Biophys Res Com. 313: 42-47, 2004. [PubMed]
  4. Ishii K, Kanai T, Totsuka T, Uraushihara K, Ishikura T, Yamazaki M, Okamoto R, Araki A, Miyata T, Tezuka K, Nakamura T, Watanabe M : Hyperexpression of inducible costimulator (ICOS) on lamina propria mononuclear cells in rat dextran sulfate sodium (DSS) colitis.
    J Gastroenterol Hepatol. 19: 174-181, 2004. [PubMed]
  5. Takenawa H, Kurosaki M, Enomoto N, Miyasaka Y, Kanazawa N, Sakamoto N, Ikeda T, Izumi N, Sato C, Watanabe M: Differential gene-expression profiles associated with gastric adenoma.
    Br J Cancer. 90: 216-223, 2004. [PubMed]
  6. Yamashiro T, Nagayama K, Enomoto N, Watanabe H, Miyagi T, Nakasone H, Sakugawa H, Watanabe M: Quantitation of the level of hepatitis delta virus RNA in serum, by real-time polymerase chain reaction－and its possible correlation with the clinical stage of liver disease.
    J Infect Dis. 189: 1151-1157, 2004. [PubMed]
  7. Kawamura T, Kanai T, Dohi T, Uraushihara K, Totsuka T, Iiyama R, Taneda C, Yamazaki M, Nakamura T, Higuchi T, Aiba Y, Tsubata T, Watanabe M: Ectopic CD40 ligand expression on B cell triggers intestinal inflammation.
    J Immunol. 172: 6388-6397, 2004. [PubMed]
  8. Tanabe Y, Sakamoto N, Enomoto N, Kurosaski M, Ueda E, Maekawa S, Yamashiro T, Nakagawa M, Chen CH, Kanazawa N, Kakinuma S, Watanabe M: Synergistic inhibition of intracellular hepatitis C virus replication by combination of ribavirin and interferon-alpha.
    J Infect Dis. 189: 1129-1139, 2004. [PubMed]
  9. Oshima S, Nakamura T, Namiki S, Okada E, Tsuchiya K, Okamoto R, Yamazaki M, Yokota T, Aida M, Yamaguchi Y, Kanai T, Handa H, Watanabe M: Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells.
    Mol Cell Biol. 24: 6298-6310, 2004. [PubMed]
  10. Makita S, Kanai T, Oshima S, Uraushihara K, Totsuka T, Iiyama R, Sawada T, Nakamura T, Koganei K, Fukushima T, Watanabe M: CD4+,CD25bright T cells in human intestinal lamina propria as regulatory cells.
    J Immunol. 173: 3119-3130, 2004. [PubMed]

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2003

  1. Totsuka T, Kanai T, Iiyama R, Uraushihara K, Yamazaki M, Okamoto R, Hibi T, Tezuka K, Azuma M, Akiba H, Yagita H, Okumura K, Watanabe M: Ameliorating effect of anti-inducible co-stimulator monoclonal antibody in a murine model of chronic colitis.
    Gastroenterology.　124：410-421, 2003. [PubMed]
  2. Kakinuma S, Tanaka Y, Chinzei R, Watanabe M, Shimizu-Saito K, Hara Y, Teramoto K, Arii S, Sato C, Takase K, Yasumizu T, Teraoka H: Human umbilical cord blood as a source of transplantable hepatic progenitor cells. Stem Cells. 21:217-227, 2003. [PubMed]
  3. Watanabe M, Yamazaki M, Kanai T: Mucosal T Cells as a target for treatment of IBD.
    J Gastroenterol. 38 : 48-50, 2003.[PubMed]
  4. Tsuchiya K, Kawano Y, Kojima T, Nagata K, Takao T, Okada M, Shinohara H, Maki K, Toyama-Sorimachi N, Miyasaka N, Watanabe M, Karasuyama H: Molecular cloning and characterization of TPP36 and its isoform TPP32, novel substrates of Abl tyrosine kinase.
    FEBS Lett. 537 : 203-209, 2003. [PubMed]
  5. Totsuka T, Kanai T, Uraushihara K, Iiyama R, Yamazaki M, Akiba H, Yagita H, Okumura K, Watanabe M: Therapeutic effect of anti-OX40L and anti-TNF-a MAbs in a murine model of chronic colitis.
    Am J Physiol. 284: G595-G603, 2003. [PubMed]
  6. Watanabe H, Nagayama K, Enomoto N, Itakura J, Tanabe Y, Hamano K, Izumi N, Sato C,　Watanabe M: Sequence elements correlated with circulating viral load in genotype 1b hepatitis C virus infection.
    Virology. 311 : 376-383, 2003. [PubMed]
  7. Iiyama R, Kanai T, Uraushihara K, Totsuka T, Nakamura T, Miyata T, Yagita H, Tezuka K, Watanabe M: The role of Inducible Co-stimulator (ICOS)/B7 related protein-1 (B7RP-1) interaction in the germinal center formation in Peyer's patches.
    Immunol Lett. 88: 63-70, 2003. [PubMed]
  8. Sakamoto S, Yokota T, Enomoto N, Tanabe Y, Miyagishi M, Maekawa S, Ye L, Kurosaki M, Taira K, Watanabe M, Mizusawa H: Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived siRNAs.
    EMBO Reports. 4: 1-7, 2003. [PubMed]
  9. Ishikura T, Kanai T, Uraushihara K, Iiyama R, Makita S, Totsuka T, Yamazaki M, Sawada T, Nakamura T, Miyata T, Kitahora T, Hibi T, Hoshino T, Watanabe M: IL-18 overproduction exacerbates the development of colitis with markedly infiltrated macrophages in IL-18 transgenic mice.
    J Gastroenterol Hepatol. 18 : 960-969, 2003. [PubMed]
  10. Watanabe M, Yamazaki M, Okamoto R, Ohoka S, Araki A, Nakamura T, Kanai K: Therapeutic approaches to chronic intestinal inflammation by specific targeting of mucosal IL-7/IL-7R signal pathway.
    Current Drug Targets-Inflammation & Allergy. 2: 119-123, 2003. [PubMed]
  11. Kanai T, Uraushihara K, Totsuka T, Okazawa A, Hibi T, Oshima S, Miyata T, Nakamura T, Watanabe M: Macrophage-derived IL-18 targeting for the treatment of Crohns disease.
    Current Drug Targets-Inflammation & Allergy. 2: 131-136, 2003. [PubMed]
  12. Okamoto R, Watanabe M: Prospects for regeneration of gastrointestinal epithelia using bone-marrow cells.
    Trends Mol Med. 9: 286-290, 2003. [PubMed]
  13. Uraushihara K, Kanai T, Ko K, Totsuka T, Makita S, Iiyama R, Nakamura T, Watanabe M: Regulation of murine inflammatory bowel disease by CD25+ and CD25-CD4+ glucocorticoid-induced TNF receptor family-related gene+ regulatory T cells.
    J Immunol.     171: 708-716, 2003. [PubMed]
  14. Ezaki T, Watanabe M, Inoue N, Kanai T, Ogata H, Iwao Y, Ishii H, Hibi T: A specific genetic alteration on chromosome 6 in ulcerative colitis-associated colorectal cancers.
    Cancer Res. 63: 3747-3749, 2003. [PubMed]
  15. Yamazaki M, Yajima T, Tanabe M, Fukui K, Okada E, Okamoto R, Oshima S, Nakamura T, Kanai T, Uehira M, Takeuchi T, Ishikawa H, Hibi T, Watanabe M: Mucosal T cells expressing high levels of IL-7 receptor are potential targets for treatment of chronic colitis.　
    J Immunol. 171: 1556-1563, 2003. [PubMed]
  16. Ota T, Amagai M, Watanabe M, Nishikawa T: No involvement of IgG autoantibodies against extracellular domains of desmoglein 2 in paraneoplastic pemphigus or inflammatory bowel diseases.　
    J Dermatol Sci. 32: 137-141, 2003. [PubMed]
  17. Kanai T, Totsuka T, Uraushihara K, Makita S, Nakamura T, Koganei K, Fukushima T, Akiba H, Yagita H, Okumura K, Machida U, Iwai H, Azuma M, Chen L, Watanabe M: Blockade of B7-H1 suppresses the development of chronic intestinal inflammation.
    J Immunol. 171: 4156-4163, 2003.[PubMed]

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2002

  1. Kobayashi K, Ogata H, Morikawa M, IIjima S, Harada N, Yoshida T, Brown WR, Inoue N, Hamada Y, Ishii H, Watanabe M, Hibi T: Distribution and partial characterization of IgG Fc binding protein in various mucin-producing cells and body fluids.
    Gut 51: 169-176, 2002. [PubMed]
  2. Naganuma M, Watanabe M, Kanai T, Iwao Y, Mukai M, Ishikawa H, Ishii H, Hibi T: Unique structures with T lymphocyte aggregates in ileal villi of Crohn's disease.
    Am J Gastroenterol 97: 1741-1747, 2002. [PubMed]
  3. Chinzei R, Tanaka Y, Shimuzu-Saito K, Hara Y, Kakinuma S, Watanabe M, Teramoto K, Arii S, Takase K, Sato C, Terada N, Teraoka H：Embryoid-body cells derived from a mouse embryonic stem cell line show differentiation into functional hepatocytes.
    Hepatology 36:22-29,2002. [PubMed]
  4. Sasazuki T, Sawada T, Sakon S, Kitamura T, Kishi T, Okazaki T, Katano M, Tanaka M, Watanabe M, Yagita H, Okumura K, Nakano N: Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death.
    J Biol Chem 277: 28853-28860, 2002. [PubMed]
  5. Ono K, Tanaka Y, Kusano F, Kakinuma S, Ishidate K, Watanabe M, Marumo F, Sato C:Fas-ligand and perforin expression in infiltrating cytotoxic T lymphocytes in the liver of chronic hepatitis C.
    Hepatol Res.23:153-162, 2002. [PubMed]
  6. Kanazawa N, Izumi N, Tsuchiya K, Sakurai K, Hamano K, Itakura J, Asahina Y, Noguchi O, Uchihara M, Miyake S, Miyakawa N, Kawachi Y, Shiotsu H, Taki K, Himeno Y, Enomoto N, Watanabe M, Sakai T: A case of primary leiomyoma of the liver in a patient without evidence of immunosuppression.
    Hepatol Res 24:80-88, 2002. [PubMed]
  7. Kanai T, Iiyama R, Ishikura T, Uraushihara K, Totsuka T, Yamazaki M, Nakamura T, Watanabe M: Role of the innate immune system in the development of chronic colitis.
    J Gastroenterol. 37: 38-42, 2002. [PubMed]
  8. Kanai T, Totsuka T, Tezuka K, Watanabe M: ICOS costimulation in inflammatory bowel disease.
    J Gastroenterol. 37: 78-81, 2002. [PubMed]
  9. Okamoto R, Yajima T, Yamazaki M, Kanai T, Mukai M, Okamoto S, Ikeda Y, Hibi T, Inazawa J, Watanabe M: Damaged epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract.
    Nature Med 8: 1011-1017, 2002. [PubMed]
  10. Okazawa A, Kanai T, Watanabe M, Yamazaki M, Inoue N, Ikeda M, Kurimoto M, Ishii H, Hibi T: Th1-mediated intestinal inflammation in Crohn's disease may be induced by activation of lamina propria lymphocytes through synergistic stimulation of interleukin-12 and interleukin-18 without T cell receptor engagement.
    Am J Gastroenterol. 97: 3108-3117, 2002.[PubMed]

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2001

  1. Kanai T, Watanabe M, Okazawa A, Sato T, Yamazaki M, Okamoto S, Ishii H, Totsuka T, Iiyama R, Okamoto R, Ikeda M, Kurimoto M, Takeda K, Akira S, Hibi T.
    Macrophage-derived IL-18 mediated intestinal inflammation in the murine model of Crohn's disease.
    Gastroenterology. 2001;121 : 875-888. [PubMed]
  2. Horiuchi T, Ohkusa T, Watanabe M, Kobayashi D, Miwa H, Eishi Y.
    Helicobacter pylori DNA in drinking water in Japan.
    Microbiol Immunol. 2001; 45 : 515-519. [PubMed]
  3. Sawada T, Yoshida M, Yasukouchi Y, Watanabe M, Numano F.
    Colon cancer cell adhesion to endothelial E-selectin inhibits detachment of endothelial cells through activation of beta(1)-integrin.
    Biochem Biophys Res Commun. 2001; 286 : 20-27. [PubMed]
  4. Watanabe H, Enomoto N, Nagayama K, Izumi N, Marumo F, Sato C, Watanabe M.
    Number and Position of Mutations in the Interferon (IFN) Sensitivity-Determining Region of the Gene for Nonstructural Protein 5A Correlate with IFN Efficacy in Hepatitis C Virus Genotype 1b Infection.
    J Infect Dis. 2001; 183 : 1195-1203.[PubMed]
  5. Nagayama K, Enomoto N, Miyasaka Y, Kurosaki M,Chen CH, Sakamoto N, Nakagawa M, Sato C, Tazawa J,Ikeda T, Izumi N, Watanabe M.
    Overexpression of interferon gamma-inducible protein 10 in the liver of patients with type I autoimmune hepatitis identified by suppression subtractive hybridization.
    Am J Gastroenterol. 2001; 96 : 2211-2217. [PubMed]
  6. Nomura T, Araki A, Chuganji Y, Momoi M, Ohkusa T, Watanabe M.
    Influence of climatic factors in the incidence of upper gastrointestinal bleeding.
    J Gastroent Hepatol. 2001;16 : 619-623. [PubMed]
  7. Miyasaka Y, Enomoto N, Nagayama K, Izumi N, Marumo F, Watanabe M, Sato C.
    Analysis of differentially expressed genes in human hepatocellular carcinoma using suppression subtractive hybridization.
    Br J Cancer. 2001; 85 : 228-234. [PubMed]
  8. Inoue N, Watanabe M, Sato T, Okazawa A, Yamazaki M, Kanai T, Ogata H, Iwao Y, Ishii H, Hibi.
    Restricted VH gene usage in lamina propria B cells that produced anticolon antibody from patients with ulcerative colitis.
    Gastroenterology. 2001;121 :15-23. [PubMed]
  9. Ohbayashi H, Tanaka Y, Ohoka S, Chinzei R, Kahinuma S, Goto M, Watanabe M, Marumo F, Sato C.
    TTV is shown in the liver by in situ hybridization with a PCR-generated probe from the serum TTV-DNA.
    J Gastroenterol Hepatol. 2001;16 : 424-428. [PubMed]
  10. Ohkusa T, Fujiki K, Takashimizu I, Kumagai J, Tanizawa T, Eishi Y, Yokoyama T, Watanabe M.
    Improvement in atrophic gastritis and intestinal metaplasia in patients from whom Helicobacter pylori was eradicated.
    Ann Int Med. 2001; 134 : 380-386. [PubMed]
  11. Kanai, T, Watanabe M, Okazawa A, Sato T, Hibi T.
    IL-18 and Crohn's disease.
    Digestion. 2001; 63 : 37-42. [PubMed]
  12. Yoshida M, Sawada T, Ishii H, Gerszten E Robert, Rosenzweig Anthony, Gimbrone A Michael, Yasukochi Y, Numano F.
    HMG-CoA reductase inhibitor modulates monocyte-endothelial cell interaction under physiological flow conditions in vitro Involvement of Rho GTPase-dependent mechanism.
    Arterioscler Thromb Vasc Biol. 2001: 1165-1171.[PubMed]
  13. Miyasaka K, Masuda M, Kanai S, Ohta M, Suzuki S, Tateishi K, Funakoshi A.
    Inhibitory effect of somatostatin on cholecystokinin release is independent of luminal cholecystokinin-releasing factor content in conscious rats.
    Pancreas. 2001; 23: 414-420. [PubMed]
  14. Miura T, Ouchida R, Yoshikawa N, Okamoto K, Makino Y, Nakamura T, Tanaka H.
    Functional modulation of the giucocorticoid receptor and suppression of NF-kappaB-dependent transcription by ursodeoxycholic acid.
    J Biol Chem. 2001; 276: 47371-47378. [PubMed]
  15. Nakamura T, Ouchida R, Kodama T, Kawashima T, Watanabe S, Kitamura T, Morimoto C, Tanaka H.
    Cytokine receptor common beta subunit-mediated STAT5 activation confers NF-kappaB activation through I-kappaB-independent mechanism in murine proB cell line Ba/F3 cells.
    J Biol Chem. 2001; 227: 6254-6265. [PubMed]
  16. Nagayama K, Enomoto N, Izumi N, Kurosai M, Miyasaka Y, Watanabe H, Itakura J, Chen CH, Tazawa J, Hoshino Y, Ikeda T, Marumo F, Sato C.
    Sequences in the US5A protein of hepatitis C virus and the serum alanine aminotransferase response to interferon therapy in Japanese patients.
    Gut. 2001; 48: 830-835. [PubMed]
  17. Izumi N, Asahina Y, Noguchi O, Uchihara M, Kanazawa N, Itakura J, Himeno Y, Miyake S, Sakai T, Enomoto N.
    Risk factors for distant recurrence of hepatocellular carcinoma in the liver after comlete coagulation by microwave or radiofrequency ablation.
    Cancer. 2001; 91: 949-956. [PubMed]
  18. Tazawa J, Maeda M, Sakai Y, Yamane M, Ohbayashi H, Kakinuma S, Miyasaka Y, Nagayama K, Enomoto N, Sato C.
    Radiation therapy in combination with transcatheter arterial chemoembolization for hepatocellular carcinoma with extensive portal vein involvement.
    J Gastroenterol Hepatol. 2001;16 : 660-665. [PubMed]
  19. Yamashita Y, Koga M, Takeda Y, Enomoto N, Uchida S, Hashimoto K, Yamano S, Dohi K, Marumo F, Sasaki S.
    Two sporadic cases of Liddle's syndrome caused by denovo ENaC mutations.
    Am J kidney Dis. 2001; 37: 499-504.[PubMed]

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2000

  1. Suzuki K, Oida T, Hamada H, Hitotsumatsu O, Watanabe M, Hibi T, Yamamoto H, Kubota E, Kaminogawa S, Ishikawa H. Gut cryptopatches: Direct evidence of extrathymic anatomical sites for intestinal T lymphoiesis.
    Immunitiy. 2000;13: 691-702.[PubMed]
  2. Kanai T, Watanabe M, Nakamaru K, Okazawa A, Okamoto M, Naganuma M, Ishii H, Ikeda M, Kurimoto M, Hibi T.
    IL-18 is a potent proliferative factor for intestinal mucosal lymphocytes in Crohn's disease.
    Gastroenterology. 2000;119:1514-1523.[PubMed]
  3. Nagayama K, Kurosaki M, Enomoto N, Miyasaka Y, Marumo F, Sato C.　Characteristics of hepatitis C viral genome associated with disease progression.
    Hepatology. 2000; 31: 745-750.[PubMed]
  4. Yu S-H, Nagayama K, Enomoto N, Izumi N, Marumo F, Sato C. Intrahepatic mRNA expression of interferon ? inducible antiviral genes in liver disease: PKR overexpressionand RNase L inhibitor suppression in chronic hepatitis C.
    Hepatology. 2000; 32: 1089 -1095.[PubMed]
  5. Kanai T, Watanabe M, Hayashi A, Nakazawa A, Yajima T, Okazawa A, Yamazaki M, Ishii H, Hibi T. Regulatory effect of interleukin-4 and interleukin-13 in colon cancer cell adhesion.
    Br J Cancer. 2000; 82: 1717-1723.[PubMed]
  6. Kashiwagi K, Watanabe M, Ezaki T, Kanai T, Ishii H, Mukai M, Hibi T. Clinical usefulnessof microsatellite instability for the prediction of gastric adenoma or adenocarcinoma inpatients with chronic gastritis.
    Br J Cancer. 2000;82:1814-1818.[PubMed]
  7. Ohkusa T, Fujiki K, Takashimizu I, Kumagai J, Tanizawa T, Eishi Y. 　Endoscopic and histological comparison of nonulcer dyspepsia with and without Helicobacter pylori infectionevaluated by the modified Sydney system.
    Am J Gastroenterol. 2000;95: 2195-2199.[PubMed]
  8. Naganuma M, Iwao Y, Inoue N, Hisamatsu T, Imaeda H, Ishii H, Kanai T, Watanabe M, Hibi T. 　Analysis of Clinical Course and Long-Term Prognosis of Surgical and NonsurgicalPtients with Intestinal Behcet's Disease.
    Am J Gastroenterol. 2000;95: 2848 - 2851.[PubMed]
  9. Matsui A, Ikeda T, Enomoto K, Nakashima H, Omae K, Watanabe M, Hibi T, Kitajima M.Progression of human breast cancers to the metastatic state is linked to genotypes ofcatechol-o-methyltransferase. 　
    Cancer Let. 2000;150: 23- 31.[PubMed]
  10. Matsui A, Ikeda T, Enomoto K, Hosoda K, Nakashima H, Omae K, Watanabe M, Hibi T, Kitajima M.　Increased formation of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine,in human breast cancer tissue and its relationship to GSTP1 and COMT genotype. 　
    Cancer Let. 2000;151: 87-95.[PubMed]
  11. Nomura T, Boku N, Ohtsu A, Muto M, Matsumoto S, Tajiri H, Yoshida S.　Recurrence after endoscopic mucosal resection for superficial esophageal cancer. 　
    Endoscopy. 2000;32: 277-280. [PubMed]
  12. Tamura M, Tanaka A, Kobayashi Y, Nihei Z, Numano F.　Expression of Apolipoprotein B-100 in Isolated Human Small Intestine Epithelium. 　
    Horm Metab Res. 2000;32: 350-354. [PubMed]
  13. Takaishi H, Ohara S, Hotta K, Yajima T, Kanai T, Inoue N, Iwao Y, Watanabe M, Ishii H,Hibi T.　Circulating autoantibodies against purified colonic mucin in ulcerative colitis.
    J Gastroenterol. 　2000;35: 20-27. [PubMed]
  14. Iwai M, Harada Y, Muramatsu A, Tanaka S, Mori T, Okanoue T, Katoh F, Ohkusa T,Kashima K.　Development of gap junctional channels and intercellular communication in ratliver during ontogenesis. 　
    J Hepatol. 2000; 32:11-18. [PubMed]
  15. Hisamatsu T, Watanabe M.　Editorial Tracrolimus(FK506), a novel immuno suppressivedrug for inflammatory bowel disease?
    J Gastroenterol. 2000: 655-657. [PubMed]
  16. Maekawa S, Enomoto N, Kurosaki M, Nagayama K, Sato C, Marumo F: Genetic changes of interferon sensitivity determining region of hepatitis C virus during the natural course ofchronic hepatitis C. 　
    J Med Virol. 2000;61: 303-310. [PubMed]
  17. Kanai S, Masuda M, Suzuki S, Ohta M, Yoshida Y, Funakoshi A, Miyasaka K. Inhibitory effect of central calcitonin-gene related peptide(CGRP) onpancreatic secretion in conscious rats.
    Jpn J Physiol. 2000; 50: 243-248.[PubMed]
  18. Kusano F, Tanaka Y, Marumo F, Sato C.　The expression of C-C chemokines is associated with portal and periportal inflammation in the liver of patients with chronic hepatitis C.
    LabInvest. 2000;80: 415- 422.[PubMed]
  19. Ohbayashi H, Tanaka Y, Ohoka S, Kusano F, Goto M, Marumo F, Sato C.　The presence of hepatitis G virus (GB Virus C) is shown in the liver by in situ polymerase chain reaction.
    Liver. 2000;20: 421-423.[PubMed]
  20. Uchida S, Tanaka Y, Ito H, Satioh-Ohara F, Yokoyama KK, Sasaki S, Marumo F. Transcriptional regulation of the CLC-K1 promoter by MAZ and KKLF, a novel Kruppel-like zinc finger repressor.
    Mol Cell Biol. 2000;20: 7319-7331. [PubMed]
  21. Suzuki S, Miyasaka K, Jimi A, Funakoshi A.　Induction of acute pancreatitis by cerulein in human IL-6 gene transgenic mice.
    Pancreas. 2000;21 : 86- 92. [PubMed]
  22. Suzuki S, Kanai S, Miyasaka K, Jimi A, Funakoshi A.　Regulation of pancreatic secretion by vagal nerve during short-term duct occlusion in conscious rats. 　
    Pancreas. 2000;20: 94- 101. [PubMed]
  23. Kawanami T, Funakoshi A, Suzuki S, Kanai S, Sato Y, Miyasaka K.　Oral administration of synthetic trypsin inhibitor increases pancreatic duct function in CCK-A receptor-deficient rat.
    Pancreas. 2000;20: 394-400. [PubMed]
  24. Tatsumi M, Kishii Y, Miyata T, Numano F.　Transforming growth factor-b 1 restores antiplatelet function of endothelial cells exposed to anozia-reoxygenation injury.
    Thromb Res. 2000;98: 451-459. [PubMed]
  25. Nagayama K, Kurosaki M, Enomoto N, Miyasaka Y, Marumo F, Sato C. Characteristics of hepatitis C viral genome associated with disease progression.
    Hepatology. 2000; 31(3):745-50. [PubMed]

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~1999

  1. Kohyama M, Nanno M, Kawaguchi-Miyashita M, Shimada S, Watanabe M, Hibi T, Kaminogawa S, Ishikawa H.　Cytolytic and IFN-gamma-producing activities of gamma delta T cells in the mouse intestinal epithelium are T cell receptor-beta-chain dependent.
    Proc Natl Acad Sci USA. 1999; 96(13): 7451-5. [PubMed]
  2. Shirai M, Arichi T, Chen M, Masaki T, Nishioka M, Ikeda K, Takahashi H, Enomoto N, Saito T, Major ME, Nakazawa T, Akatsuka T, Feinstone SM, Berzofsky JA. T cell recognitionb of hypervariable region-1 from hepatitis C virus envelope protein with multiple class II MHC molecules in mice and humans: preferential help for induction of antibodies to the hypervariable region.
    J Immunol. 1999; 162(1): 568-76. [PubMed]
  3. Hisamatsu T, Watanabe M, Ogata H, Ezaki T, Hozawa S, Ishii H, Kanai T, Hibi T. Interferon-inducible gene family 1-8U expression in colitis-associated colon cancer and severely inflamed mucosa in ulcerative colitis.
    Cancer Res. 1999; 59(23): 5927-31. [PubMed]
  4. Nakazawa A, Watanabe M, Kanai T, Yajima T, Yamazaki M, Ogata H, Ishii H, Azuma M, Hibi T. 　Functional expression of costimulatory molecule CD86 on epithelial cells in the inflamed colonic mucosa.
    Gastroenterology. 1999; 117(3): 536-45. [PubMed]
  5. Murakami T, Enomoto N, Kurosaki M, Izumi N, Marumo F, Sato C. Mutations in nonstructural protein 5A gene and response to interferon in hepatitis C virus genotype 2 infection.
    Hepatology. 1999; 30(4): 1045-53. [PubMed]
  6. Watanabe M, Ueno Y, Yajima T, Okamoto S, Hayashi T, Yamazaki M, Iwao Y, Ishii H, Habu S, Uehira M, Nishimoto H, Ishikawa H, Hata J, Hibi T. 　Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosa.
    J Exp Med. 1998; 187(3): 389-402. [PubMed]
  7. Fukuma T, Enomoto N, Marumo F, Sato C. Mutations in the interferon-sensitivity determining region of hepatitis C virus and transcriptional activity of the nonstructural region 5A protein.
    Hepatology. 1998; 28(4): 1147-53. [PubMed]
  8. Ohkusa T, Takashimizu I, Fujiki K, Suzuki S, Shimoi K, Horiuchi T, Sakurazawa T, Ariake K, Ishii K, Kumagai J, Tanizawa T. 　Disappearance of hyperplastic polyps in the stomach after adication of Helicobacter pylori. A randomized, clinical trial.
    Ann Intern Med. 1998; 129(9): 712-5. [PubMed]
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