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業績集

2010年

  • Tateno T., Kato M., Tani Y., Yoshimoto T., Oki Y., Hirata Y.: Processing of high molecular weight form ACTH in human ACTH-secreting tumor cell line (DMS-79) after transfection of prohormone convertase 1/3 gene. J. Endocrinol. Invest. 33: 113-117, 2010
  • Sakurada M., Yoshimoto T., Sekizawa N., Hirono Y., Suzuki N., Hirata Y.: Vasculoprotective effect of cilostazol in aldosterone-induced hypertensive rats. Hypertens. Res. 33: 229-235, 2010
  • Akaza I., Yoshimoto T., Tsuchiya K., Hirata Y.: Endothelial dysfunction associated with hypercortisolism is reversible in Cushing’s syndrome. Endocr. J. 57: 245-252, 2010
  • Yamazaki Y., Kamei Y., Sugita S., Akaike F., Kanai S., Miura S., Hirata Y., Troen B.R., Kitamura T., Nishino I., Suganami T., Ezaki I., Ogawa Y.: The cathepsin-L gene is a direct target of FOXO1 in skeletal muscle. Biochem. J. 427: 171-178, 2010
  • Ito T., Sasano H., Tanaka M., Osamura R.Y., Sakai I., Kimura W., Takano K., Obara T., Ishibashi M., Nakao K., Doi R., Shimatsu A., Nishida T., Komoto I., Hirata Y., Nakamura K., Igarashi H., Jensen RT., Wiedermann B., Imamura M.: Epidemiological study of gastroenteropancreactic neuroendocrine tumors in Japan. J. Gastroenterol. 45: 234-243, 2010
  • Sakihara S., Kageyama K., Oki Y., Doi M., Iwasaki Y., Takayasu S., Moriyama T., Terui K., Nigawara T., Hirata Y., Hashimoto K., Suda T.: Evaluation of plasma, salivary, and urinary cortisol levels for diagnosis of Cushing’s syndrome. Endocr. J. 57: 331-337, 2010
  • Wago T., Yoshimoto T., Akaza I., Tsuchiya K., Izumiyama H., Doi M., Hirata Y.: Improvement of endothelial function in patients with hypertension and type 2 diabetes after treatment with telmisartan. Hypertens. Res. 33: 802-807, 2010
  • Sugiyama T., Kouyama R., Tani Y., Izumiyama H., Akashi T., Kishimoto S., Arii S., Hirata Y.: Giant malignant insulinoma from non-functioning pancreatic tumor over a long period of time. Intern. Med.49: 1573-1579, 2010
  • Ikebukuro M., Akaza I., Yoshimoto T., Tsuchiya K., Hirata Y.: Correlation between endothelial dysfunction and hypercalcemia in patients with primary hyperparathyroiis. Jpn. J. Clin. Physiol. 40: 75-81, 2010
  • Tani Y., Sugiyama T., Hirooka S., Izumiyama H., Hirata Y.: Ectopic ACTH syndrome caused by bronchial carcinoid tumor indistinguishable from Cushing’s disease. Endocr. J. 57: 677-684, 2010
  • Tani Y., Inoshita N., Sugiyama T., Kato M., Yamada S., Shichiri M., Hirata Y.: Upregulation of p16INK4a and suppression of cyclin D1 gene expression in ACTH-secreting pituitary adenoma. Eur. J. Endocrinol. 163: 523-529, 2010
  • Sugiyama M., Sugiyama T., Yamaguchi M., Izumiyama H., Yoshimoto T., Kishino M., Akashi T., Hirata Y.: Successful localization of ectopic ACTH-secreting bronchial carcinoid by selective pulmonary artery sampling. Endocr. J. 57: 959-964, 2010
  • Gotyo N., Hiyama M., Adachi J., Watanabe T., Hirata Y.: Respiratory failure with myxedema ascites in a patient with idiopathic myxedema. Intern. Med. 49: 1991-1996, 2010
  • Sekizawa N., Yoshimoto T., Izumiyama H., Hirata Y.: District uptake of 18F-flurodeoxyglucose by brown adipose tissue in catecholamine-secreting tumor. Intern. Med. 49: 2363, 2010
  • Doi. M., Sugiyama T., Izumiyama H., Yoshimoto T., Hirata Y.: Clinical features and management of ectopic ACTH syndrome at a single institute in Japan. Endocr. J. 57: 1061-1069, 2010
  • Hayakawa E., Yoshimoto T., Hiraishi K., Kato M., Izumiyama H., Sasano H., Hirata Y.: A rare case of ACTH-independent macronodular adrenal hyperplasia associated with aldosterone-producing adenoma. Intern. Med. (in press)

2009年

  • Oki Y, Hashimoto K, Hirata Y, Iwasaki Y, Nigawara T, Doi M, Sakihara S, Kageyama K, Suda T. Development and validation of a 0.5 mg dexamethasone suppression test as an initial screening test for the diagnosis of ACTH-dependent Cushing's syndrome. Endocr J 2009;56:897-894.
  • Sekizawa N, Hayakawa E, Tsuchiya K, Yoshimoto T, Akashi T, Fujii T, Yamada S, Hirata Y: Acromegaly associated with multiple tumors. Intern Med 2009;481:273-1278.
  • Akaza I, Tsuchiya K, Akaza M, Sugiyama T, Izumiyama H, Doi M, Yoshimoto T, Hirata Y: Improvement of congestive heart failure after octreotide and transsphenoidal surgery in a patient with acromegaly. Intern Med 2009;48:697-700.
  • Sugiyama T, Levy BD, Michel T Tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells. J Biol Chem 2009;284:12691-700.
  • Ikeda M, Kawata A, Nishikawa M, Tateishi Y, Yamaguchi M, Nakagawa K, Hirabayashi S, Bao Y, Hidaka S, Hirata Y, Hata Y. Hippo pathway-dependent and-independent roles of RASSF6. Sci Signal 2009;2:ra59.
  • Gotyo N, Kida M, Horiuchi T, Hirata Y. Torsade de Pointes associated with recurrent ampulla cardiomyopathy in a patient with idiopathic ACTH deficiency. Endocr. J 2009;56:807-815.
  • Nakayama C, Shichiri M, Sato K, Hirata Y. Expression of prosalusin in human neuroblastoma cells. Peptides 2009;30:1362-1367.
  • Tsuchiya K, Akaza I, Yoshimoto T, Hirata Y. Pioglitazone improves endothelial function with increased adiponectin and high-density lipoprotein cholesterol levels in type 2 diabetes. Endocr J 2009;56:691-698.
  • Tsuchiya K, Yoshimoto T, Hirata Y. Endothelial dysfunction is related to aldosterone excess and raised blood pressure. Endocr J 2009;56:553-559.
  • Tateno T, Kato M, Tani Y, Oyama K, Yamada S, Hirata Y. Differential expression of somatostatin and dopamine receptor subtype genes in adrenocorticotropin (ACTH)-secreting pituitary tumors and silent corticotroph adenomas. Endocr J 2009;56:579-584.
  • Katagiri S, Nitta H, Nagasawa T, Uchimura I, Izumiyama H, Inagaki K, Kikuchi T, Noguchi T, Kanazawa M, Matsuo A, Chiba H, Nakamura N, Kanamura N, Inoue S, Ishikawa I, Izumi Y. Multi-center intervention study on glycohemoglobin (HbA1c) and serum, high-sensitivity CRP (hs-CRP) after local antiinfectious periodontal treatment in type 2 diabetic patients with periodontal disease. Diabetes Res Clin Pract 2009;83:308-315.
  • Sato K, Sato T, Susumu T, Koyama T, Shichiri M. Presence of immunoreactive salusin-beta in human plasma and urine. Regul Pept. 2009;158:63-67.
  • Fukai N, Kenagy RD, Chen L, Gao L, Daum G, Clowes AW. Syndecan-1: an inhibitor of arterial smooth muscle cell growth and intimal hyperplasia. Arterioscler Thromb Vasc Biol. 2009;29:1356-1362.

東京医科歯科大学大学院・分子内分泌内科学(内分泌・代謝内科)
〒113-8519 東京都文京区湯島1-5-45
E-mail:dept.cme@tmd.ac.jp

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