Principal Investigator: Yoshio MIKI, MD, PhD (Professor, Medical Research Institute)
"A path-signaling biology research program" was initiated with the Special Funds for Education and Research of the Ministry of Education, Culture, Sports, Science and Technology. In this project, we define the signal abnormality in the body which is the beginning of pathological states as "pathogenic signaling" and it is abbreviated to pathsignaling. We promote a disease signal research for conquering intractable diseases in medical science.
We use nervous, cardiovascular and locomotory diseases and cancers as models, and consolidate the basic and clinical research groups of TMDU and develop the biomedical science (path-signaling biology) based on the information of genome, transcriptome and phosphoproteome to elucidate a disease process (the molecular mechanism from normal state of cells and tissues to abnormal state, and further to onset of disease in a systemic manner ).
We set up the new mass spectrometry with high performance, and collect information of phosphoproteins,and aim at the new disease understanding based on phosphoproteomics. This analysis system is installed in Advanced Technology Laboratory of Medical Research Institute and it is planned to have use for researchers of TMDU by employing a full-time engineer. In addition, we combine an intermolecular interaction analyzer with MS. It's very important for signal transduction research to observe changes comprehensively in binding-proteins due to a structural change,
In this program, we establish the experimental basis for biomedical science and the system to use this basis for researchers of TMDU. Using this system, the researchers may develop the biomedical study based on the signal information.
