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News&Topics

2014

Identifying frequent gain-of-function mutations of RHOA in Diffuse-type Gastric Carcinoma

Diffuse-type Gastric Carcinoma, a subtype of gastric carcinoma, is one of the most malignant cancers worldwide as well as in Japan. We, in collaboration with Univ. of Tokyo group, performed exome sequencing for clinical Diffuse-type Gastric Carcinoma, and identified frequent gain-of-function mutations of RHOA gene. RHOA is associated with cell movement and cell growth, and our analyses showed that newly identified mutant RHOA works in a gain-of-function manner. Diffuse-type Gastric Carcinoma cannot be included for therapeutic applications of any known molecular targeted drugs available so far. These results provide us a potential new therapeutic target against Diffuse-type Gastric Carcinoma.

“Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma”
Nature Genetics, 11th May, advanced online publication