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Home  > Cellular and Molecular Medicine Unit  > welcome to Oishi lab!

welcome to Oishi lab!

Research interest

Cardiovascular disease, as a consequent of the obesity related metabolic syndrome, remains a significant cause of morbidity and mortality in industrialized societies despite major advantages in treatment of hypercholesterolemia and hypertension. A major effort of our laboratory has been to investigate the molecular mechanism of an initiation and progression of metabolic syndrome which leads to the life-threatening cardiovascular diseases from the viewpoint of transcriptional regulation. Because macrophages contribute to all phages of the pathogenesis of atherosclerosis, we have extensively studied the macrophage diversity which respond to various stress within tissue environment. The long term goals of our current study are to elucidate: 1) the mechanism by which cellular homeostasis is regulated through inflammatory response and resolution, and 2) the mechanism by which inflammatory is actively regulated through cellular homeostasis, and 3)mechanism responsible for pathogenesis of metabolic syndrome by disruption of macrophage homeodynamics.