研究

主な研究テーマ

不正咬合の病態生理および
   正常咬合の生物学的意義

 

 

  • 咬合機能低下と歯周組織
  • 咀嚼筋機能低下と顎関節
  • 加齢に伴う顎口腔の形態および機能の変化
  • 咬合と頭頚部および全身との関係
  • 咬合と顎関節症状との関係
  • 咬合・咀嚼の生力学的解析

 
 

歯の移植に関する研究

 


 
  • 移植歯に対する矯正力や咬合による機械的刺激の影響(基礎および臨床研究)

 
 

矯正力に対する
         生物学的反応

 

 

  • 実験的歯の移動における各種タンパク、ホルモンの影響
  • 機械的刺激に対する歯根膜細胞および骨系細胞の反応

 
 
 

矯正治療用材料

 

 

  • 超弾性型チタンニッケル合金角型ワイヤーの改良および臨床応用
  • 強化プラスチックワイヤーの開発
  • MRIにおける金属アーチファクト

 
 
 

味覚

 

 

  • 抜歯と味覚の関連
  • 口呼吸と味覚の関連

 
 
 

気道・呼吸関連 

 


 
 
 
 
 

研究業績

2016
Original Articles

  • Lai WJ, Midorikawa Y, Kanno Z, Takemura H, Suga K, Soga K, Ono T, Uo M. Development and modification of a device for three-dimensional measurement of orthodontic force system: The V-bend system re-visited. Dent Mater J. 2016.12; 35 (6): 908-917. 
  • Hosomichi J, Kuma Y, Oishi S, Nagai H, Maeda H, Usumi-Fujita R, Shimizu Y, Kaneko S, Shitano C, Suzuki J, Yoshida K, Ono T. Intermittent hypoxia causes mandibular growth retardation and macroglossia in growing rats. Am J Orthod Dentofacial Orthop. 2017.02; 151 (2): 363-371.
  • Imai H, Tanaka Y, Nomura N, Doi H, Tsutsumi Y, Ono T, Hanawa T. Magnetic susceptibility, artifact volume in MRI, and tensile properties of swaged Zr-Ag composites for biomedical applications J Mech Behav Biomed Mater. 2017.02; 66 152-158.
  • Uchima Koecklin KH, Hiranuma M, Kato C, Funaki Y, Kataguchi T, Yabushita T, Kokai S, Ono T. Unilateral nasal obstruction during later growth periods affects craniofacial muscles in rats. Front Physiol. 2017.01; 7 (669): 1-10.
  • Ishida Y, Ono T. Nonsurgical treatment of skeletal class II gummy smile adult case using zygomatic temporary anchorage devices and improved superelastic nickel-titanium alloy wires. Am J Orthod Dentofacial Orthop. 2017;
  • 本田康二, 大村進, 藤田紘一, 渋谷直樹, 米満郁男, 島﨑一夫, 村田彰吾, 高須曜, 山下陽介, 岩井俊憲, 小野卓史, 藤内祝. 上下顎同時骨延長術を施行した著しい垂直的上顎劣成長を伴う下顎前突症の1例. 日本顎変形症学会誌. 2016.12; 26 (4): 275-283.
  • Makiguchi M, Funaki Y, Kato C, Okihara H, Ishida T, Yabushita T, Kokai S, Ono T. Effects of increased occlusal vertical dimension on the jaw-opening reflex in adult rats. Arch Oral Biol. 2016.12; 72 39-46.
  • Kita S, Oshima M, Shimazaki K, Iwai T, Omura S, Ono T. Computational fluid dynamic study of nasal respiratory function before and after bimaxillary orthognathic surgery with bone trimming at the inferior edge of the pyriform aperture. J Oral Maxillofac Surg. 2016.11; 74 (11): 2241-2251.
  • Dei A, Miyamoto JJ, Takada JI, Ono T, Moriyama K. Evaluation of blood flow and electromyographic activity in the perioral muscles. Eur J Orthod. 2016.10; 38: 525-531.
  • Oishi S, Shimizu Y, Hosomichi J, Kuma Y, Nagai H, Maeda H, Usumi-Fujita R, Kaneko S, Shibutani N , Suzuki J, Yoshida K, Ono T. Intermittent hypoxia Influences alveolar bone proper microstructure via hypoxia-inducible factor and VEGF expression in periodontal ligaments of growing rats. Front phsyiol. 2016.09; 7 Article 416.
  • 本田康二, 大村進, 藤田紘一, 渋谷直樹, 米満郁男, 島﨑一夫, 村田 彰吾, 高須曜, 山下陽介, 岩井俊憲, 小野卓史, 藤内祝. 横浜市立大学附属市民総合医療センター歯科・口腔外科・矯正歯科における過去16年間の顎変形症治療に関する実態調査 日本顎変形症学会誌. 2016.08; 26 (3): 195-201.
  • 前川南, 簡野瑞誠, 小野卓史, 宇尾基弘. オールプラスチック製歯科矯正用ワイヤーの開発. 日本歯科理工学会誌. 2016.05; 35 (3): 189-192.
  • Arai Y, Aoki K, Shimizu Y, Tabata Y, Ono T, Murali R, Mise-Omata S, Wakabayashi N. Peptide-induced de novo bone formation after tooth extraction prevents alveolar bone loss in a murine tooth extraction model. Eur J Pharmacol. 2016.04;
  • 小海暁, 小野卓史. 根完成歯自家移植と矯正歯科治療のコンビネーション. 口腔病学会雑誌. 2016.03; 83 (1): 42-43. ( 医中誌 )
  • 山田恭平, 大森浩子, 桐本博章, 島﨑一夫, 小野卓史. 下顎側方偏位を伴う顎変形症患者における顎関節症状と下顎頭形態との関連. Orthod Waves-Jpn Ed. 2016.03; 75 (1): 1-7.
  • Abbassy MA, Watari I, Bakry AS, Ono T, Hassan A. Calcitonin and vitamin D3 have high therapeutic potential for improving diabetic mandibular growth. Int J Oral Sci. 2016.03; 8 (1): 39-44.
  • Miyazaki M, Yonemitsu I, Takei M, Kure-Hattori I, Ono T. The imbalance of masticatory muscle activity affects the asymmetric growth of condylar cartilage and subchondral bone in rats. Arch Oral Biol. 2016.03; 63 22-31.
  • Oishi S, Shimizu Y, Hosomichi J, Kuma Y, Nagai H, Maeda H, Usumi-Fujita R, Kaneko S, Shitano C, Suzuki J, Yoshida K, Ono T. Intermittent hypoxia induces disturbances in craniofacial growth and defects in craniofacial morphology. Arch Oral Biol. 2016.01; 61 115-124. ( PubMed )
  • Uesugi S, Yonemitsu I, Kokai S, Takei M, Omura S, Ono T. Features in subjects with the frontal occlusal plane inclined toward the contralateral side of the mandibular deviation. Am J Orthod Dentofacial Orthop. 2016.01; 149 (1): 46-54.
  • Sakaguchi-Kuma T, Hayashi N, Fujishiro H, Yamaguchi K, Shimazaki K, Ono T, Akita K. An anatomic study of the attachments  on the condylar process of the mandible: muscle bundles from the temporalis. Surg Radiol Anat. 2016;38:461-467.

2015
Original Articles

  • Kokai S, Kanno Z, Koike S, Uesugi S, Takahashi Y, Ono T, Soma K. Retrospective study of 100 autotransplanted teeth with complete root formation and subsequent orthodontic treatment. Am J Orthod Dentofacial Orthop. 2015.12; 148 (6): 982-989.
  • Takada J, Miyamoto JJ, Yokota T, Ono T, Moriyama K. Comparison of the mandibular hinge axis in adult patients with facial asymmetry with and without posterior unilateral  crossbite. Eur J Orthod. 2015;37:22-27.
  • Maekawa M, Kanno Z, Wada T, Hongo T, Doi H, Hanawa T, Ono T, Uo M. Mechanical properties of orthodontic wires made of super engineering plastic.Dent Mat J. 2015;34:114-119.
  • Sawada A, Usui N, Shimazaki K, Taira M, Ono T.The effects of cognitive behavioral therapy on experimental orthodontic pain. Orthod Waves. 2015;74:10-14.
  • Okito A, Nakahama K, Akiyama M, Ono T, Morita I. Involvement of the G-protein-coupled receptor 4 in RANKL expression by osteoblasts in an acidic environment.Biochem Biophys Res Commun. 2015;458:435-440.
  • Abbassy MA, Watari I, Bakry AS, Hamba H, Hasan AH, Tagami J, Ono T. Diabetes detrimental effects on enamel and dentin formation.  J Dent. 2015;43:589-596.
  • Uchima Koecklin KH, Kato C, Funaki Y, Hiranuma M, Ishida T, Fujita K, Yabushita T, Kokai S, Ono T.Effect of unilateral nasal obstruction on tongue protrusion forces in growing rats.J Appl Physiol. 2015;118:1128-1135.Nunthayanon K, Honda E, Shimazaki K, Ohmori H, Inoue-Arai MS, Kurabayashi T, Ono T. Use of an advanced 3-T MRI movie to investigate articulation. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;119:684-694.
  • Nunthayanon K, Honda E, Shimazaki K, Ohmori H, Inoue-Arai MS, Kurabayashi T, Ono T.A pilot study on characterization of articulatory movements during fricative /s/ sound in an anterior open bite subject: a tooth-visualized 3-TMRI movie evaluation.J World Feder Orthod. 2015;4:71-77.
  • 喜田壮馬, 島﨑一夫, 矢島康治, 大村進, 小野卓史, 大島まり . 上下顎移動術前後における鼻呼吸機能の流体解析. 生産研究. 2015.01; 67 (1): 55-58.
  • Nunthayanon K, Honda E, Shimazaki K, Ohmori H, Inoue-Arai MS, Kurabayashi T, Ono T.Differences in velopharyngeal structure during speech among Asians revealed by 3-Tesla magnetic resonance imaging movie mode.BioMed Res International. 2015, 126264, 2015. doi:10.1155/2015/126264.
  • Ishida T, Ikemoto S, Ono T. Nasomaxillary hypoplasia with a congenitally missing tooth treated with Le Fort II osteotomy, autotransplantation and nickel-titanium alloy wire. Am J Orthod Dentofacial Orthop. 2015.09; 148 (3): 479-492.
  • Kato G, Shimizu Y, Sugamori Y, Maeda M, Takahashi M, Tamura Y, Murali R, Ono T, Ohya K, Aoki K. The inhibitory effects of a RANKL-binding peptide on articular and periarticular bone loss in a murine model of collagen-induced arthritis: A bone histomorphometric study. Arthritis Res Ther. 2015.09; 17 251.
  • 桐井絢子、島崎一夫、酒井敬一、小野卓史. 上下顎歯列弓幅径の拡大に伴う舌骨の位置および咽頭気道形態の変化. Orthodontic Waves Jpn Ed. 2015;74:78-85. 
  • Ono R, Watari I, Kubono-Mizumachi M, Ono T.GLP-1R expression in the major salivary glands of rats.J Oral Biosci. 2015;57:200-204.
  • Imamura T, Kanno Z, Imai H, Sugiyama T, Wada T, Yoshida M, Sakama M, Ono T, Honda E, Uo M.  Infiltration of trace metal ions in the oral mucosa of a rat analyzed using SR-XRF, XAFS, and ICP-MS. Dent Mat J. 2015;34:814-821.
  • Kokai S, Fukuyama E, Sato Y, Hsu JC, Takahashi Y, Harada K, Ono T. Comprehensive treatment approach for bilateral cleft lip and palate in an adult with premaxillary osteotomy, tooth autotransplantation, and 2-jaw surgery. Am J Orthod Dentofacial Orthop. 2015.01; 147 (1): 114-126. 

2014
Original Articles

  • Shimazaki K, Otsubo K, Yonemitsu I, Kimizuka S, Omura S, Ono T. Severe unilateral scissor bite and bimaxillary protrusion treated by horse-shoe Le Fort I osteotomy combined with mid-alveolar osteotomy. Angle Orthod. 2014; 84(2); 374-379
  • Kawakubo N, Miyamoto JJ, Katsuyama N, Ono T, Honda E, Kurabayashi T, Taira M, Moroyama K. Effects of cortical activations on enhancement of handgrip force during teeth clenching: An fMRI study. Neurosci Res. 2014;79:67-75.
  • Shimizu Y, Yonemitsu I, Ono T. Facilitating mandibular horizontal growth in a Class II high-angle case with modified functional appliance. J World Fed Orthod. 2014; 3; e27-39
  • Funaki Y, Hiranuma M, Shibata M, Kokai S, Ono T. Effects of nasal obstruction on maturation of the jaw-opening reflex in growing rats. Arch Oral Biol. 2014; 59(5); 530-538
  • 上杉俊輔、米満郁男、小海暁、大村進、小野卓史.上顎咬合平面の傾斜と下顎側方偏位方向が相反する顔面非対称患者の形態学的特徴.顎変形誌. 2014;24:27-36.
  • 渡一平、パイワッタナヌパン・ジュティポーン、許瑞瑾、井上カタジナアンナ、青山絵美奈、小野卓史.妊娠中の耐糖能低下が母体の口腔内および新生児の頭蓋顎顔面成長発育に与える影響.女性健康科学研究会誌. 2014;3:57-62.
  • Privatananupunt J, Watari I, Podyma-Inoue KA, Kubono M, Ono T. Expression of glucose-dependent insulinotropic polypeptide and its receptor in the rat major salivary glands. Acta Histochemica. 2014; 116(4); 545-550
  • Okihara H, Ito J, Kokai S, Ishida T, Hiranuma M, Kato C, Yabushita T, Ishida K, Ono T, Michikawa M. Liquid diet induces memory impairment accompanied by a decreased number of hippocampal neurons in mice. J Neurosci Res. 2014; 92(8); 1010-1017
  • Aoyama E, Watari I, Podyma-Inoue KA, Yanagishita M, Ono T. Expression of glucagon-like peptide-1 receptor and glucose dependent insulinotropic polypeptide receptor is regulated by the glucose concentration in mouse osteoblastic MC3T3-E1 cells. Int J Mol Med. 2014.08; 34(2); 475-482
  • Kuma Y, Usumi-Fujita R, Hosomichi J, Oishi S, Maeda H, Nagai H, Shimizu Y, Kaneko S, Shitano C, Suzuki J, Yoshida K, Ono T. Impairment of nasal airway under intermittent hypoxia during growth period in rats. Arch Oral Biol. 2014; 59(11); 1139-1145
  • Ikeda Y, Yonemitsu I, Takei M, Shibata S, Ono T. Mechanical loading leads to osteoarthritis-like changes in the hypofunctional temporomandibular joint in rats. Arch Oral Biol. 2014; 59(12); 1368-1376
  • Ishida T, Ono T. Asymmetric severe skeletal Class II division 1 patient with temporo- mandibular joint disorder treated with zygomatic anchorage devices and Ni-Ti alloy wires. Angle Orthod. 2014; 84(5); 919-930
  • Kawabe A, Nakagawa I, Kanno Z, Tsutsumi Y, Hanawa T, Ono T. Evaluation of biofilm formation in the presence of saliva on poly (ethylene glycol) deposited titanium. Dent Mater J. 2014; 33(5); 638-647
  • Shimizu Y, Hosomichi J, Nakamura S, Ono T. Micro-computed tomography analysis of changes in the periodontal ligament and alveolar bone proper induced by occlusal hypofunction of rat molars. Korean J Orthod. 2014; 44(5); 263-267
  • Hsu JC, Watari I, Ono R, Privatananupunt J, Mizumachi-Kubono M, Honda K, Ishida Y, Ono T. Degeneration of fungiform and circumvallate papillae following molar extraction in rats. Acta Odontol Scand. 2014; 72(8); 880-886
  • Yoon HS, Ishida T, Ono T. Influences of lymphoid tissues on facial pattern. J World Fed Orthod. 2014; 3(4); 163-168

2013
Original Articles

  • Usumi-Fujita R, Hosomichi J, Ono N, Shibutani N, Kaneko S, Shimizu Y, Ono T: Occlusal hypofunction causes periodontal atrophy and VEGF/VEGFR inhibition in tooth movement. Angle Orthod 83:48-56, 2013.
  • Shindoi JM, Matsumoto Y, Sato Y, Ono T, Harada K: Soft tissue cephalometric norms for orthognathic and cosmetic surgery. J Oral Maxillofac Surg 71:e24-30, 2013.
  • Hikita R, Miyamoto JJ, Ono T, Honda E, Kurabayashi T, Moriyama K.Activation patterns in the auditory association area involved in glottal stop perception. J Oral Biosci. 2013;55:34-39.
  • Kapila S, Park Y, Ahmad N, Hosomichi J, Hayami T, Tacon C: Mechanisms for Relaxin’s Modulation of MMPs and Matrix Loss in Fibrocartilages. Ital J Anat Embryol 118:62-65, 2013.
  • Ohmori H, Ono T: Unilateral scissors bite treated with a removable plate that incorporates a Ti-Ni wire. Orthodontics 14:e222-e226, 2013.
  • Koike S, Sujino T, Ohmori H, Shimazaki K, Fukuyama E, Kanai T, Hibi T, Ono T: Gastric emptying rate in subjects with malocclusion examined by [13C] breath test. J Oral Rehabil 40:574-81, 2013.
  • Shimizu Y, Ishida T, Hosomichi J, Kaneko S, Hatano K, Ono T: Soft diet causes greater alveolar osteopenia in the mandible than in the maxilla. Arch Oral Biol 58:907-11, 2013.
  • Imai H, Tanaka Y, Nomura N, Tsutsumi Y, Doi H, Kanno Z, Ohno K, Ono T, Hanawa T: Three-dimensional quantification of susceptibility artifacts from various metals in magnetic resonance images.ActaBiomater 9:8433-9, 2013.
  • Ishida T, Yabushita T, Ono T: Functional reversibility of temporomandibular joint mechanoreceptors.Arch Oral Biol 58:1078-83, 2013.
  • Hiranuma M, Kokai S, Fujita K, Ishida T, Shibata M, Naito S, Yabushita T, Ono T: Effects of a liquid diet on the response properties of temporomandibular joint nociceptive neurons in the trigeminal subnucleus caudalis of growing rats. Orthod Craniofac Res 16:214-22, 2013.
  • Ishida T, Yoon HS, Ono T: Asymmetrical distalization of maxillary molars with zygomatic anchorage, improved superelastic nickel-titanium alloy wires, and open-coil springs. Am J Orthod Dentofacial Orthop 144:583-93, 2013.
  • 大森浩子、桐本博章、小野卓史. 成人女性不正咬合患者における顎関節症状と顎顔面形態および早期接触の関連性. Orthodontic Waves Jpn Ed. 2013;72:121-5.
  • 内藤聡美、金香佐和、小海暁、酒井敬一、金島貴子、小野卓史.東京医科歯科大学咬合機能矯正学分野における過去15年間の顎矯正手術症例の調査.顎変形誌. 2013;23:191-7.
  • Shitano C, Baba O, Kaneko S, Hosomichi J, Shimizu Y, Shibutani N, Usumi R, Takano Y, Ono T: Alveolar bone loss induced by the orthodontic tooth movement under hypofunctional conditions in rats. Orthod Waves 72:148-55, 2013.

 Review Articles

  • Abbassy MA, Watari I, Bakry AS, Ono T: Chapter 16, The effect of type 1 Diabetes Mellitus on the dento-craniofacial complex. Type 1 Diabetes, ISBN 978-953-51-1017-0, Ed. Escher AP, Li A, pp401-30, In Tech, 2013.

2012
Original Articles

  • Kato C, Fujita K, Naito S, Shibata M, Ishida T, Kokai S, Yabushita T, Ono T: Increased occlusal vertical dimension induces cortical plasticity in the rat face primary motor cortex. Behav Brain Res 228: 254-260, 2012.
  • Ng IW, Ono T, Inoue-Arai MS, Honda E, Kurabayashi T, Moriyama K: Differential articulatory movements during Japanese /s/ and /t/ as revealed by MR image sequences with tooth visualization. Arch Oral Biol 57: 749-59, 2012.
  • Abbassy MA, Horiuchi M, Harouny NME, Kanno Z, Ono T: Comparative cephalometric study of Class I malocclusion in Egyptian and Japanese adult females. Orthod Waves 71: 59-65, 2012.
  • Mizumachi-Kubono M, Watari I, Ishida Y, Ono T: Reduced mechanical stress on the periodontium influences AQP5 expression and distribution in the rat submandibular salivary gland. Arch Oral Biol 57: 877-883, 2012.
  • Kure-Hattori I, Watari I, Takei M, Ishida Y, Yonemitsu I, Ono T: Effect of functional shift of the mandible on lubrication of the temporomandibular joint. Arch Oral Biol 57: 987-994, 2012.
  • Sakamoto-Ozaki K, Matsumoto Y, Kanno Z, Iida J, Soma K: Development of a surgical procedure for biointegration of a newly designed orthodontic onplant. Orthodontics 13: 216-225, 2012.
  • Ohmori H, Kirimoto H, Ono T: Comparison of the physiological properties of human periodontal-masseteric reflex evoked by incisor and canine stimulation. Front Physiol 3: 233, 2012.
  • Ono T: Orale Dysfunktionen in der kieferorthopädischen Praxis: der Anteil des peripheren und des zentralen Nervensystems auf die Lage der Zunge bei Mundatmung. Inf Orthod Kieferorthop 44: 293-301, 2012.
  • 酒井敬一、島崎一夫、小海暁、福山英治、小野卓史. 骨格性下顎前突症患者に対する異なる外科手術法が上気道形態に与える影響. 顎変形誌. 2012;22:239-43.

Review Articles

  • Ono T. Tongue and upper airway function in subjects with and without obstructive sleep apnea. Jpn Dent Sci Rev 48: 71-80, 2012.