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ホーム  > テニュアトラック研究室 細胞分子医学  > メンバー  > 助教:早川 清雄(Sumio HAYAKAWA)

助教:早川 清雄(Sumio HAYAKAWA)

早川清雄 のプロフィール


        2002年3月 静岡県立大学大学院 生活健康科学研究科
                食品栄養科学専攻 博士課程 修了(伊勢村護先生)

2002年4月〜2003年3月 東京大学大学院医学研究科 病因・病理専攻 免疫学講座
                博士研究員(谷口維紹先生)
2003年4月〜2007年7月 近畿大学 医学部 生化学教室 
                助教(宗像浩先生)
2007年8月〜2014年3月 北海道大学 遺伝子病制御研究所 分子生体防御分野 
                助教(高岡晃教先生)
2014年4月〜現在      東京医科歯科大学 難治疾患研究所 細胞分子医学分野

<抱負>
栄養と免疫,特に自然免疫という観点から、炎症慢性化に関わる分子メカニズムを解明し、生活習慣病の予防・治療につながる基盤的研究を大石先生と共に進めていきたいと考えております。

<論文>
Tabuchi M ※, Hayakawa S ※, Honda E, Ooshima K, Itoh T, Yoshida K, Park AM, Higashino H, Isemura M, Munakata H. EGCG suppresses TGF-bete signaling by interacting with TGF-beta type II receptor. World J. Exp. Med., 3, 100-107, 2013 ※ Contributed equally to this work.

Park AM, Hayakawa S, Honda E, Mine Y, Yoshida K, Munakata H. Conditioned media from lung cancer cell line A549 and PC9 inactivate pulmonary fibroblasts by regulating protein phosphorylation. Arch. Biochem. Biophys., 15, 133-41, 2012.

Hayakawa, S., Shiratori, S., Yamato, H., Kameyama, T., Kitatsuji, C., Kashigi, F., Goto, S., Kameoka, S., Fujikura, D., Yamada, T., Mizutani, T., Kazumata, M., Sato, M., Tanaka, J., Asaka, M., Ohba, Y., Miyazaki, T., Imamura, M. and Takaoka, A. ZAPS is a potent stimulator of RIG-I-mediated signaling during antiviral response. Nature Immunology, 12, 37-44, 2011.

Sato, M., Amemiya, K., Hayakawa, S., and Munakata, H. Subcellular localization of human heparanase and its alternative splice variant in COS-7 cells. Cell Biochem. Funct., 26, 676-683, 2008.

Isogai, N., Nakagawa, Y., Suzuki, K., Yamada, R., Asamura, S., Hayakawa, S., and Munakata, H. Cytokine-rich autologous serum system for cartilaginous tissue engineering. Ann. Plast. Surg., 60, 703-709, 2008.

Nakatani, T., Honda, E., Hayakawa, S., Sato, M., Satoh, K., Kudo, M., and Munakata, H. Effects of decorin on the expression of alpha-smooth muscle actin in a human myofibroblast cell line. Mol. Cell. Biochem., 308, 201-207, 2008.

Hagiwara, S., Kudo, M., Nakatani, T., Sakaguchi, Y., Nagashima, M., Fukuta, N., Kimura, M., Hayakawa, S., and Munakata H. Combination therapy with PEG-IFN-alpha and 5-FU inhibits HepG2 tumour cell growth in nude mice by apoptosis of p53. Br. J. Cancer, 97, 1532-1537, 2007.

Kanata, S., Akagi, M., Nishimura, S., Hayakawa, S., Yoshida, K., Sawamura, T., Munakata, H., and Hamanishi, C. Oxidized LDL binding to LOX-1 upregulates VEGF expression in cultured bovine chondrocytes through activation of PPAR-gamma. Biochem. Biophys. Res. Commun., 348, 1003-1010, 2006.

Suzuki, T., Tazoe, H., Taguchi, K., Koyama, Y., Ichikawa, H., Hayakawa, S., Munakata, H., and Isemura, M. DNA microarray analysis of changes in gene expression induced by 1,25-dihydroxyvitamin D3 in human promyelocytic leukemia HL-60 cells. Biomed. Res., 27, 99-109, 2006.

Suzuki, T., Koyama, Y., Hayakawa, S., Munakata, H., and Isemura, M. 1,25-Dihydroxyvitamin D3 suppresses exportin expression in human promyelocytic leukemia HL-60 cells. Biomed. Res., 27, 89-92, 2006.

Hashimoto, K., Fukuda, K., Yamazaki, K., Yamamoto, N., Matsushita, T., Hayakawa, S., Munakata, H., and Hamanishi, C. Hypoxia-induced hyaluronan synthesis by articular chondrocytes: the role of nitric oxide. Inflamm. Res., 55, 72-77, 2006.

Isogai, N., Morotomi, T., Hayakawa, S., Munakata, H., Tabata, Y., Ikada, Y., and Kamiishi, H. Combined chondrocyte-copolymer implantation with slow release of basic fibroblast growth factor for tissue engineering an auricular cartilage construct. J. Biomed. Mater. Res. A., 74, 408-418, 2005.

Suzuki, T., Koyama, Y., Ichikawa, H., Tsushima, K., Abe, K., Hayakawa, S., Kuruto-Niwa, R., Nozawa, R., and Isemura, M. 1,25-Dihydroxyvitamin D3 suppresses gene expression of eukaryotic translation initiation factor 2 in human promyelocytic leukemia HL-60 cells. Cell Struct. Funct., 30, 1-6, 2005.

Ohata, M., Koyama, Y., Suzuki, T., Hayakawa, S., Saeki, K., Nakamura, Y., and Isemura, M. Effects of tea constituents on cell cycle progression of human leukemia U937 cells. Biomed. Res., 26, 1-7, 2005.

Munakata, H., Sun, J.Y., Yoshida, K., Nakatani, T., Honda, E., Hayakawa, S., Furuyama, K., and Hayashi, N. Role of the heme regulatory motif in the heme-mediated inhibition of mitochondrial import of 5-aminolevulinate synthase. J. Biochem., 136, 233-238, 2004.

Nishimura, S., Akagi, M., Yoshida, K., Hayakawa, S., Sawamura, T., Munakata, H., and Hamanishi, C. Oxidized low-density lipoprotein (ox-LDL) binding to lectin-like ox-LDL receptor-1 (LOX-1) in cultured bovine articular chondrocytes increases production of intracellular reactive oxygen species (ROS) resulting in the activation of NF-kappaB. Osteoarthritis and Cartilage, 12, 568-576, 2004.

Takaoka, A., Hayakawa, S., Yanai, H., Stoiber, D., Negishi, H., Kikuchi, H., Sasaki, S., Imai, K., Shibue, T., Honda, K., and Taniguchi, T. Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence. Nature, 424, 516-523, 2003.

Watanabe, M., Ohata, M., Hayakawa, S., Isemura, M., Kumazawa, S., Nakayama, T., Furugori, M., and Kinae, N. Identification of 6-methylsulfinylhexyl isothiocyanate as an apoptosis-inducing component in wasabi. Phytochemistry, 62, 733-739, 2003.

Watanabe, M., Hayakawa, S., Isemura, M., Kumazawa, S., Nakayama, T., Mori, C., and Kawakami, T. Identification of licocoumarone as an apoptosis-inducing component in licorice. Biol. Pharm. Bull., 25, 1388-1390, 2002.

Koyama, Y., Katsuno, Y., Miyoshi, N., Hayakawa, S., Mita, T., Muto, H., Isemura, S., Aoyagi, Y., and Isemura, M. Apoptosis induction by lectin isolated from the mushroom Boletopsis leucomelas in U937 cells. Biosci. Biotechnol. Biochem., 66, 784-789, 2002.

Miyoshi, N., Koyama, Y., Katsuno, Y., Hayakawa, S., Mita, T., Ohta, T., Kaji, K., and Isemura, M. Apoptosis induction associated with cell cycle dysregulation by rice bran agglutinin. J. Biochem., 130, 799-805, 2001.

Hayakawa, S., Saeki, K., Sazuka, M., Suzuki, Y., Shoji, Y., Ohta, T., Kaji, K., You, A., and Isemura, M. Apoptosis induction by epigallocatechin gallate involves its binding to Fas. Biochem. Biophys. Res. Commun., 285, 1102-1106, 2001.

Hayakawa, S., Kimura, T., Saeki, K., Koyama, Y., Aoyagi, Y., Noro, T., Nakamura, Y., and Isemura, M. Apoptosis-inducing activity of high molecular weight fractions of tea extracts. Biosci. Biotechnol. Biochem., 65, 459-462, 2001.

Isemura, M., Saeki, K., Kimura, T., Hayakawa, S., Minami, T., and Sazuka, M. Tea catechins and related polyphenols as anti-cancer agents. Biofactors, 13, 81-85, 2000.

Saeki, K., Hayakawa, S., Noro, T., Miyase, T., Nakamura, Y., Tanji, K., Kumazawa, S., Nakayama, T., and Isemura, M. Apoptosis-inducing activity of galloyl monosaccharides in human histiocytic lymphoma U937 cells. Planta Med., 66, 124-126, 2000.

Saeki, K., Hayakawa, S., Isemura, M., and Miyase, T. Importance of a pyrogallol-type structure in catechin compounds for apoptosis-inducing activity. Phytochemistry, 53, 371-374, 2000.

Isemura, M., Saeki, K., Minami, T., Hayakawa, S., Kimura, T., Shoji, Y., and Sazuka, M. Inhibition of matrix metalloproteinases by tea catechins and related polyphenols. Ann. N. Y. Acad. Sci., 878, 629-631, 1999.