グローバルナビゲーションへ

本文へ

ローカルナビゲーションへ

フッターへ



ホーム  > テニュアトラック研究室 細胞分子医学  > メンバー  > 准教授 : 大石 由美子(Yumiko OISHI)

准教授 : 大石 由美子(Yumiko OISHI)

プロフィール

1998年 群馬大学医学部医学科卒業
2006年 東京大学医学系研究科博士課程卒業

1998-1999年 群馬大学医学部附属病院 研修医(第二内科)
1999-2000年 国立高崎病院 内科研修医
2000-2001年 (財)日本心臓血圧研究振興会附属榊原記念病院 内科研修医
2001-2002年 東京大学大学院医学系研究科循環器内科 医員
2007-2008年 学術振興会特別研究員(PD)
2008-2009年 東京大学大学院医学系研究科循環器内科 特任助教
2009-2013年2月 カリフォルニア大学サンディエゴ校 医学部 細胞分子医学分野 
            Christopher K. Glass研究室 留学
2013年3月~東京医科歯科大学難治疾患研究所 テニュアトラック准教授として現在に至る

内科認定医
循環器内科専門医


●Education
1998 (M.D.) Gunma University
2006 (Ph.D.) The University of Tokyo Graduate School of Medicine

●Professional Experience
1998-1999 Resident (Internal Medicine) Department of Internal Medicine, Gunma University Hospital

1999-2000 Resident (Internal Medicine) Department of Internal Medicine, Takasaki National Hospital

2000-2001 Cardiovascular Resident, Sakakibara Heart Institute, Tokyo

2001-2002 Fellow in Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo

2006-2007 Senior Research Fellow, National Institute of Health and Nutrition

2007-2008 Japan Society for the Promotion of Science (JSPS) Fellow (PD)

2008-2009 Assistant Professor, Translational Systems Biology and Medicine Initiative (TSBMI),
Graduate School of Medicine, The University of Tokyo

2009-Febuary 2013
Postdoctoral researcher, Department of Cellular and Molecular Medicine, School of
Medicine, University of California, San Diego (Laboratory of Dr. Christopher K. Glass)

March 2013 to present
Associate Professor, Department of Cellular and Molecular Medicine, Medical Research
Institute, Tokyo Medical and Dental University, Japan


●Certification
2002 Board Certified Member of the Japanese Society of Internal Medicine
2007 Fellow of the Japanese Circulation Society

PUBLICATIONS

1. Oishi Y, Spann NJ, Link VM, Muse ED, Strid T, Edillor C, Kolar MJ, Matsuzaka T, Hayakawa S, Tao J, Kaikkonen MU, Carlin AF, Lam MT, Manabe I, Shimano H, Saghatelian S, and Glass CK. SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism. Cell Metab (In Press)

2. Hayashi S, Manabe I, Suzuki Y, Relaix F, and Oishi Y. Klf5 regulates muscle differentiation by directly targeting muscle-specific genes in cooperation with MyoD in mice. eLIFE 5. pii: e17462, 2016.

3. Oishi Y and Manabe I. Macrophages in age-related chronic inflammatory diseases. NPJ Aging Mech Dis. doi:10.1038/npjamd.2016.18

4. Hachiya R, Shiihashi T, Shirakawa I, Iwasaki Y, Matsumura Y, Oishi Y, Nakayama Y, Miyamoto Y, Manabe I, Ochi K, Tanaka M, Goda N, Sakai J, Suganami, and Ogawa Y. The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages. Sci Rep 6:28845, 2016.

5. Oishi Y and Manabe I. Integrated regulation of the cellular metabolism and function of immune cells in adipose tissue. Clin Exp Pharmacol Physiol 43:294-303, 2016.

6. Lam MT, Cho H, Lesch HP, Gosselin D, Heinz S, Tanaka-Oishi Y, Benner C, Kaikkonen MU, Kim AS, Kosaka M, Lee CY, Watt A, Grossman TR, Rosenfeld MG, Evans RM, Glass CK. Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription. Nature 498: 511-515, 2013

7. Eguchi K, Manabe I, Oishi-Tanaka Y, Osugi M, Kono N, Ogata F, Yagi N, Ohto U, Kimoto M, Miyake K, Tobe K, Arai H, Kadowaki T, and Nagai R. Saturated fatty acid and TLR signaling link ß cell dysfunction and islet inflammation. Cell Metab 15: 518-533, 2012

8. Oishi-Tanaka Y, Glass CK. A new role for cyclic phosphatidic acid as a PPARgamma antagonist.
Cell Metab 12: 207-208, 2010


9. Oishi Y, Manabe I, Imai Y, Hara K, Horikoshi M, Fujiu K, Tanaka T, Aizawa T, Kadowaki T, Nagai R. Regulatory polymorphism in transcription factor KLF5 at the MEF2 element alters the response to angiotensin II and is associated with human hypertension. FASEB J 24: 1780-1788, 2010

10. Yagi N, Manabe I, Tottori T, Ishihara A, Ogata F, Kim J. H, Fujiu K, Oishi Y, Itaka K, Kato Y, Yamauchi M, Nagai R. A nanoparticle system specifically designed to deliver short interfering RNA inhibits tumor growth in vivo. Cancer Res 69: 6531-8, 2009

11. Oishi Y, Manabe I, Tobe K, Osugi, M, Kubota T, Fujiu K, Maemura K, Kubota N, Kadowaki T, Nagai R. SUMOylation of KLF5 is a molecular switch regulating PPAR-delta-containing transcriptional programs of lipid metabolism. Nat Med 14: 656-666, 2008

12. Nishimura G, Manabe I, Tsushima K, Fujiu K, Oishi Y, Imai Y, Maemura K, Miyagishi M, Higashi Y, Kondoh H, Nagai R. DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation. Dev Cell 11:93-104, 2006

13. Kamei N, Tobe K, Suzuki R, Ohsugi M, Watanabe T, Kubota N, Kumagai K, Sakamoto K, Kobayashi M, Yamauchi T, Ueki K, Oishi Y, Nishimura S, Manabe I, Hashimoto H, Ohnishi Y, Ogata H, Tokuyama K, Tsunoda M, Ide T, Murakami K, Nagai R, Kadowaki T. Overexpression of MCP-1 in adipose tissues causes macrophage recruitment and insulin resistance. J Biol Chem 281: 26602-26614, 2006

14. Fujiu K, Manabe I, Ishihara A, Oishi Y, Iwata H, Nishimura G, Shindo T, Maemura K, Kagechika H, Shudo K, Nagai R. Synthetic retinoid Am80 suppresses smooth muscle phenotypic modulation and in-stent neointima formation by inhibiting KLF5. Circ Res 97: 1132-1141, 2005

15. Oishi Y, Manabe I, Tobe K, Tsushima K, Shindo T, Fujiu K, Nishimura G, Maemura K, Yamauchi T, Kubota N, Suzuki R, Kitamura T, Akira S, Kadowaki T, Nagai R. Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. Cell Metab 1:27-39, 2005