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メディカル統計数理研究部門

生物統計学分野

Department of Biostatistics

生物統計学(Biostatistics)の視点から、医学・歯学・医療にフォーカスしたデータ分析のための方法論を開発し、さらに統計学の応用を通して実践的なM&D領域研究を推進していきます。

メンバー

研究プロジェクト

M&D分野データ分析のための方法論開発

M&D分野のデータ分析のための生物統計学的な方法論の開発を行っています。特に地理・時間情報を利用した空間疫学研究、感染症サーベイランス・モニタリング、複雑かつ精緻でない医療リアルワールドデータ(RWD)分析、多元的なエビデンスやモデルの統合に向けたメタアナリシス、ダイナミックモデリングなどにおける問題解決のための新たな統計的方法の開発とともに、実践的な応用研究、普及に向けたソフトウェアの開発も進めています。

新型インフルエンザ発生時におけるNYC保健局サーベイランスデータ解析

新型インフルエンザ発生時におけるNYC保健局サーベイランスデータ解析

用量反応関係のメタアナリシス(コーヒー摂取量と大腸がんの関係)

用量反応関係のメタアナリシス
(コーヒー摂取量と大腸がんの関係)

実践的なM&D領域研究の推進

医学・歯学・医療分野の専門家と協力し、M&D領域の研究の発展・さらなる向上を目指した共同研究を推進しています。臨床研究・試験、観察研究、基礎実験研究など様々な研究において、研究設計から統計解析まで協業し、実践していきます。さらにデータサイエンスとしての視点から、新たな横断的研究の提案と実践、健診・検査・診療データなど、M&Dデータの有効的な活用研究の推進も目指しています。

最近の主な研究業績

2020

  1. Takahashi K, Takahashi H, Nakaya T, Yasumura S, Ohira T, Ohto H, Ohtsuru A, Midorikawa S, Suzuki S, Shimura H, Yamashita S, Tanigawa K, Kamiya K. Factors influencing the proportion of non-examinees in the Fukushima Health Management Survey for childhood and adolescent thyroid cancer: Results from the baseline survey. J Epidemiol. 2020; 30(7): 301-308.
  2. Takahashi H. Yasumura S, Takahashi K, Ohira T, Ohtsuru A, Midorikawa S, Suzuki S, Shimura H, Ishikawa T, Sakai A, Suzuki S, Yokoya S, Tanigawa K, Ohto H, Kamiya K. Nested matched case control study for the Japan Fukushima Health Management Survey's first full-scale (second-round) thyroid examination. Medicine 2020; 99(27): e20440.
  3. Anzai T, Takahashi K, Watanabe M, Mochizuki M, Murashima A. Adverse event reports in patients taking psychiatric medication during pregnancy from spontaneous reports in Japan and the United States: an approach using latent class analysis. BMC Psychiatry. 2020; 20 (1): 118.
  4. Yasuda Y, Nishikimi M, Nishida K, Takahashi K, Numaguchi A, Higashi M, Matsui S, Matsuda N. Relationship Between Serum Norepinephrine Levels at ICU Admission and the Risk of ICU-Acquired Delirium: Secondary Analysis of the Melatonin Evaluation of Lowered Inflammation of ICU Trial. Crit Care Explor. 2020; 2 (2): e0082
  5. Yoshihara M, Kajiyama H, Tamauchi S, Iyoshi S, Yokoi A, Suzuki S, Kawai M, Nagasaka T, Takahashi K, Matsui S, Kikkawa F. Prognostic impact of pelvic and para-aortic lymphadenectomy on clinically-apparent stage I primary mucinous epithelial ovarian carcinoma: a multi-institutional study with propensity score-weighted analysis. Jpn J Clin Oncol. 2020; 50 (2): 145-151.
  6. Takagi H, Hagiwara D, Handa T, Sugiyama M, Onoue T, Tsunekawa T, Ito Y, Iwama S, Goto M, Suga H, Banno R, Takahashi K, Matsui S, Arima H. Diagnosis of central diabetes insipidus using a vasopressin radioimmunoassay during hypertonic saline infusion. Endocr J. 2020; 67 (3): 267-274.
  7. Ito T, Kubokawa T. Robust estimation of mean squared error matrix of small area estimators in a multivariate Fay-Herriot model. Japanese Journal of Statistics and Data Science 2020; 3: 39-61.
  8. Takagishi M, Esaki N, Takahashi K, Takahashi M. Cytoplasmic dynein functions in planar polarization of basal bodies within ciliated cells. iScience. 2020; 23(6): 101213.
  9. Yoshihara M, Kajiyama H, Tamauchi S, Iyoshi S, Yokoi A, Suzuki S, Kawai M, Nagasaka T, Takahashi K, Matsui S, Kikkawa F. Impact of uterus-preserving surgery on Stage I primary mucinous epithelial ovarian carcinoma: A multi-institutional study with propensity score-weighted analysis. Int J Gyn Obstetrics. 2020; 150(2): 177-183.
  10. Fujii T, Shibata Y, Ban Y, Shitaokoshi A, Takahashi K, Matsui S, Nishiwaki K. A single paravertebral injection via a needle vs. a catheter for the spreading to multiple intercostal levels: a randomized controlled trial. J Anesthesia. 2020; 34: 72-78.
  11. Ishimaru T, Fujino Y, Anzai T, Matsuda S, Tanaka Y. Validity and responsiveness of the Work Functioning Impairment Scale (WFun) in rheumatoid arthritis patients: A multicenter prospective study. Mod Rheumatol. 2020; 30(5): 821-827.
  12. Takahashi K, Shimadzu H. Detecting multiple spatial disease clusters: Information criterion and scan statistic approach. Int J Health Geogr. 2020; 19:33.
  13. Kasugai D, Hirakawa A, Ozaki M, Nishida K, Ikeda T, Takahashi K, Matsui S, Uenishi N. Maximum norepinephrine dosage within 24 hours as an indicator of refractory septic shock: a retrospective study. J Intensive Care Med. 2020. (in press)
  14. Tanaka Y, Kameda H, Saito K, Kaneko Y, Tanaka E, Yasuda S, Tamura N, Fujio K, Fujii T, Kojima T, Anzai T, Hamada C, Fujino Y, Matsuda S, Kohsaka H. Response to tocilizumab and work productivity in patients with rheumatoid arthritis: 2-year follow-up of FIRST ACT-SC study. Mod Rheumatol. 2020. (in press)
  15. Yamauchi T, Takahashi K, Suka M, Sasaki T, Takahashi M, Yoshikawa T, Okoshi H, Umezaki S, Yanagisawa H. Longitudinal association between near-misses/minor injuries and moderate/severe injuries in industrial settings by presence/absence of depressive symptoms in a nationally representative sample of workers in Japan. Occup Environ Med. 2020. (in press)
  16. Isumi A, Doi S, Yamaoka Y, Takahashi K, Fujiwara T (2020). Do suicide rates in children and adolescents change during school closure in Japan? The acute effect of the first wave of COVID-19 pandemic on child and adolescent mental health. Child Abuse Negl. 2020.(in press)
  17. Inose H, Kato T, Nakamura H, Hoshino M, Togawa D, Hirano T, Tokuhashi Y, Ohba T, Haro H, Tsuji T, Sato K, Sasao Y, Takahata M, Otani K, Momoshima S, Takahashi K, Yuasa M, Hirai T, Yoshii T, Okawa A. Predictors for quality of life improvement after acute osteoporotic vertebral fracture: Results of post-hoc analysis of a prospective randomized study. Qual Life Res. 2020. (in press)
  18. Sato R, Hasegawa D, Hamahata N, Narala S, Nishida K, Takahashi K, Sempokuya T, Daoud G. The predictive value of airway occlusion pressure at 100 msec (P0.1) on successful weaning from mechanical ventilation: A systematic review and meta-analysis. J Crit Care. 2020. (in press)
  19. Ito T, Kubokawa T. Empirical best linear unbiased predictors in multivariate nested-error regression models. Commun Stat Theory Methods 2020. (in press)
  20. Otani T, Takahashi K. Flexible scan statistics for detecting spatial disease clusters: the rflexscan R package. J Stat Software. 2020. (in press).
  21. Ito T, Sugasawa S. Improved confidence regions in meta-analysis of diagnostic test accuracy. Comp Stat Data Analysis. 2021; 153 (in press)
  22. Ito T, Kubokawa T. Corrected empirical Bayes confidence region in a multivariate Fay-Herriot model. J Stat Plan Inf. 2021; 211: 12-32. (in press)

2019

  1. Anzai T, Takahashi K, Watanabe M. Adverse reaction reports of neuroleptic malignant syndrome induced by atypical antipsychotic agents in the Japanese Adverse Drug Event Report (JADER) database. Psychiatry Clin. Neurosci.. 2019; 73 (1): 27-33.
  2. Okada E, Takahashi K, Nakamura K, Ukawa S, Takabayashi S, Nakamura M, Sasaki S, Tamakoshi A, Takimoto H. Dietary patterns and abnormal glucose tolerance among Japanese: findings from the National Health and Nutrition Survey, 2012. Public Health Nutr. 2019; 22 (13): 2460-2468.
  3. Liu K, Ogura T, Takahashi K, Nakamura M, Ohtake H, Fujiduka K, Abe E, Oosaki H, Miyazaki S, Suzuki H, Nishikimi M, Komatsu M, Kawarai L, Mato M. A progressive early mobilization program is significantly associated with clinical and economic improvement: a single-center quality comparison study. Crit. Care Med.. 2019; 47 (9): e744-e752.
  4. Yamauchi T, Sasaki T, Takahashi K, Umezaki S, Takahashi M, Yoshikawa T, Suka M, Yanagisawa H. Long working hours, sleep-related problems, and near-misses/injuries in industrial settings using a nationally representative sample of workers in Japan. PLoS ONE. 2019; 14 (7): e0219657.
  5. Kawabata T, Emoto R, Nishino J, Takahashi K, Matsui S. Two-stage analysis for selecting fixed numbers of features in omics association studies. Stat Med. 2019; 38 (16): 2956-2971.
  6. Nishikimi M, Ogura T, Nishida K, Takahashi K, Nakamura M, Matsui S, Matsuda N, Iwami T. External validation of a risk classification at the emergency department of post-cardiac arrest syndrome patients undergoing targeted temperature management. Resuscitation. 2019; 140 135-141.
  7. Nomura K, Hiyama T, Sakuta H, Matsuda T, Lin C, Kobayashi K, Kobayashi K, Kuwaki T, Takahashi K, Matsui S, Noda M. [Na+] increases in body fluids sensed by central Nax induce sympathetically mediated blood pressure elevations via H+-dependent activation of ASIC1a. Neuron. 2019; 101 (1): 60-75.e6.
  8. Fujii T, Shibata Y, Akane A, Aoki W, Sekiguchi A, Takahashi K, Matsui S, Nishiwaki K. A randomised controlled trial of pectoral nerve-2 (PECS 2) block vs. serratus plane block for chronic pain after mastectomy. Anaesthesia. 2019; 74 (12): 1558-1562.
  9. Komori S, Ueno S, Ito Y, Sayo A, Meinert M, Kominami T, Inooka D, Kitagawa M, Nishida K, Takahashi K, Matsui S, Terasaki H. Steeper macular curvature in eyes with non-highly myopic retinitis pigmentosa. Invest. Ophthalmol. Vis. Sci.. 2019; 60 (8): 3135-3141.
  10. Minakata Y, Motegi T, Ueki J, Gon Y, Nakamura S, Anzai T, Hirata K, Ichinose M. Effect of tiotropium/olodaterol on sedentary and active time in patients with COPD: post hoc analysis of the VESUTO study. Int J Chron Obstruct Pulmon Dis. 2019; 14: 1789-1801.
  11. Yoshihara M, Kajiyama H, Tamauchi S, Suzuki S, Takahashi K, Matsui S, Kikkawa F. Prognostic factors and effects of fertility-sparing surgery in woman of reproductive age with ovarian clear-cell carcinoma: a propensity score analysis. Journal of Gynecologic Oncology 2018; 30(6): e102.
  12. Nishida Y, Kawai A, Toguchida J, Ogose A, Ae K, Kunisada T, Matsumoto Y, Matsunobu T, Takahashi K, Nishida K, Ozaki T. Clinical features and treatment outcome of desmoid-type fibromatosis: based on a bone and soft tissue tumor registry in Japan. International Journal of Clinical Oncology 2019; 24: 1498-1505.

2018

  1. 高橋邦彦. 薬剤使用の研究における統計的指標 臨床精神医学. 2018; 47 26-30.
  2. 高橋邦彦(翻訳, 編集委員). 統計科学百科事典. 丸善出版. 2018.
  3. 高橋邦彦(分担執筆). 新版医学統計学ハンドブック. 朝倉書店. 2018.
  4. Takahashi K, Shimadzu H. Multiple-cluster detection test for purely temporal disease clustering: Integration of scan statistics and generalized linear models. PLoS ONE. 2018; 13 (11): e0207821.
  5. Nakaya T, Takahashi K, Takahashi H, Yasumura S, Ohira T, Ohto H, Ohtsuru A, Midorikawa S, Suzuki S, Shimura H, Yamashita S, Tanigawa K, Kamiya K. Spatial analysis of the geographical distribution of thyroid cancer cases from the first-round thyroid ultrasound examination in Fukushima Prefecture. Sci Rep. 2018; 8 (1): 17661.
  6. Kuriki S, Takahashi K, Hara H. Multiplicity adjustment for temporal and spatial scan statistics using Markov property Japanese Journal of Statistics and Data Science. 2018; 1 (1): 191-231.
  7. Igeta M, Takahashi K, Matsui S. Power and sample size calculation incorporating misspecifications of the variance function in comparative clinical trials with over-dispersed count data. Biometrics. 2018; 74 (4): 1459-1467.
  8. Horisaki K, Takahashi K, Ito H, Matsui S. A dose-response meta-analysis of coffee consumption and colorectal cancer risk in the Japanese population: application of a cubic-spline model. J Epidemiol. 2018; 28 (12): 503-509.
  9. Okada E, Takahashi K, Takimoto H, Takabayashi S, Kishi T, Kobayashi T, Nakamura K, Ukawa S, Nakamura M, Sasaki S, Tamakoshi A. Dietary patterns among Japanese adults: findings from the National Health and Nutrition Survey, 2012. Asia Pac J Clin Nutr. 2018; 27 (5): 1120-1130.
  10. Liu K, Ogura T, Takahashi K, Nakamura M, Ohtake H, Fujiduka K, Abe E, Oosaki H, Miyazaki D, Suzuki H, Nishikimi M, Kawarai L, Mato T. The safety of a novel early mobilization protocol conducted by ICU physicians: a prospective observational study. J Intensive Care. 2018; 6 10.
  11. Okumura J, Shindo Y, Takahashi K, Sano M, Sugino Y, Yagi T, Taniguchi H, Saka H, Matsui S, Hasegawa Y. Mortality in patients with community-onset pneumonia at low risk of drug-resistant pathogens: Impact of β-lactam plus macrolide combination therapy. Respirology. 2018; 23 (5): 526-534.
  12. Fukamachi S, Hashiguchi M, Takahashi K, Mochizuki M. Exploratory evaluation of a commercially available Japanese medical record database as an external control for comparative clinical trials in new drug development: Amyotrophic lateral sclerosis Neurology and Clinical Neuroscience. 2018; 6 (4): 94-99.
  13. Matsuhisa T, Takahashi N, Aomatsu M, Takahashi K, Nishino J, Ban N, Stewart W Mercer. How many patients are required to provide a high level of reliability in the Japanese version of the CARE Measure? A secondary analysis. BMC Fam Pract. 2018; 19 (1): 138.
  14. Tanaka Y, Kameda H, Saito K, Kaneko Y, Tanaka E, Yasuda S, Tamura N, Fujio K, Fujii T, Kojima T, Anzai T, Hamada C, Fujino Y, Matsuda S, Kohsaka H. Effect of subcutaneous tocilizumab treatment on work/housework status in biologic-naïve rheumatoid arthritis patients using inverse probability of treatment weighting: FIRST ACT-SC study. Arthritis Res. Ther.. 2018; 20 (1): 151.
  15. Ichinose M, Minakata Y, Motegi T, Ueki J, Gon Y, Seki T, Anzai T, Nakamura S, Hirata K. Efficacy of tiotropium/olodaterol on lung volume, exercise capacity, and physical activity. Int J Chron Obstruct Pulmon Dis. 2018; 13 1407-1419.
  16. 遅野井健, 志岐甲介, 石田真大, 唯保祐介, 安齋達彦, 宮本悠希, 生島一平. 日本人健康成人男性を対象としたエンパグリフロジン・リナグリプチン配合錠のバイオアベイラビリティに対する食事の影響 ランダム化、単回投与、2群クロスオーバー試験 薬理と治療. 2018; 46 (3): 343-353.

連絡先

  • MAIL biostat.dsc@@tmd.ac.jp
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