Prof. Don W. Cleveland

Chair of Cellular and Molecular Medicine, Professor of Medicine & Neuroscience, Ludwig Institute for Cancer Research, University of California at San Diego

Dr. Don Cleveland iinitially purified and determined the properties of tau, which accumulates aberrantly in Alzheimer's disease. He uncovered the mechanisms underlying the major genetic forms of Amyotrophic Lateral Sclerosis (ALS) and demonstrated disease to be non-cell autonomous. He has developed gene silencing therapies for ALS and Huntington's diseases. Dr. Cleveland has been elected to the National Academy of Sciences and the American Academy of Arts and Sciences and has won the Wings Over Wall Street MDA Outstanding Scientist and The Sheila Essey Prize from the American Academy of Neurology.

Educational background: Don Cleveland received a B.S. in Physics from New Mexico State University in 1972 and a Ph.D. from Princeton University in Biochemical Sciences in 1977.

Academic history: Postdoctoral fellow at the University of California, San Francisco (1978-1981); Assistant (1981-1985), Associate (1985-1988) and Full (1988-1994) Professor in the Departments of Biological Chemistry and Neuroscience at the Johns Hopkins University School of Medicine; beginning in 1994, Professor of Medicine and Neuroscience, and Head, Laboratory of Cell Biology, The Ludwig Institute for Cancer Research, University of California at San Diego.

Currently, Dr. Cleveland is Associate Editor of the Journal of Cell Biology. His research is supported by the Ludwig Institute for Cancer Research, the NIH, the Muscular Dystrophy Association, and the ALS Association. In December 2008, Dr. Cleveland was elected Chair of the Department of Cellular and Molecular Medicine, University of California at San Diego.

Prof. Cleveland's ISP2012 Lecture Course Abstract:
Understanding ALS: from mechanism to therapy
Prof. Cleveland's ISP2012 Symposium Talk Abstract:
Mechanism and therapy in neurodegenerative disease: ALS and beyond
Prof. Cleveland's UCSD Profile:
Profile | Lab

ISP2012 Speakers