Molecular Pathophysiology
Department of Moleculo-genetic Sciences, Division of Biomedical Laboratory Sciences
Graduate School of Health Care Sciences, Tokyo Medical and Dental University

[Japanese Page]

Staff

Professor
Toichiro Takizawa M.D., Ph.D.　(Leave of absence)

Associate Prof.
Jiro Kumagai M.D., Ph.D.

Instructor
Shoko Yoshida M.T., Ph.D.

Education

Undergraduate / Graduate Course
In this course, students learn the pathological findings of various diseases for understanding of their etiology and pathogenesis on macroscopical, histological, cellular and molecular levels. Moreover, this course prepares to be able to develop or improve pathological laboratory theories and methods for the diagnosis, therapy and assessing prognosis in various diseases.

Research

  1. Relationships between chronic prostatitis and prostatic carcinogenesis; bacteriological and pathological approach.
  2. Study of the pathogenesis of Helicobacter pylori gastritis; histological and ultrastructural analysis of intramucosal distribution of the bacteria.
  3. Clinicopathological study of the "serrated lesions" of colorectum; an attempt to establish the objective criteria for histopathological discrimination between neoplastic and non-neoplastic lesions.
  4. Analysis of the genetic change in early esophageal cancer; an attempt to establish the objective criteria for histopathological diagnosis.
  5. Study of the transposition of Bcl-6 gene in malignant lymphoma, by analysis of transposition pattern and of genetic changes in partner genes.
Publications
  1. Ohtsuka Y, Kawakami S, Fujii Y, Koga F, Saito K, Ando N, Takizawa T, Kageyama Y, Kihara K: Loss of uroplakin III expression is associated with a poor prognosis in patients with urothelial carcinoma of the upper urinary tract. BJU International 97:1322-1326, 2006.
  2. Kawamura-Saito M, Yamazaki Y, Kaneko K, Kawaguchi N, Kanda H, Mukai H, Gotoh T, Motoi T, Fukayama M, Aburatani H, Takizawa T, Nakamura T: Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation. Hum Mol Genet 15: 2125 - 2137, 2006.
  3. Ohta A, Yang SS, Rai T, Chiga M, Sasaki S, Uchida S: Overexpression of human WNK1 increases paracellular chloride permeability and phosphorylation of claudin-4 in MDCKII cells. Biochem Biophys Res Commun 349: 804-808, 2006.
  4. Kobayashi M, Kawachi H, Takizawa T, Uchida K, Sekine M, Kumagai J, Momma K, Nemoto T, Akashi T, Funata N, Eishi Y, Koike M: p53 Mutation analysis of low-grade dysplasia and high-grade dysplasia/carcinoma in situ of the esophagus using laser capture microdissection. Oncology 71: 237-245, published online 2007.
  5. Jin G, Yamazaki Y, Takuwa M, Takahara T, Kaneko K, Kuwata T, Miyata S, Nakamura T: Trib1 and Evi1 cooperate with Hoxa and Meis1 in myeloid leukemogenesis. Blood 109: 3998-4005, 2007.
  6. Ito T, Tsutsumi T, Ohno K, Takizawa T, Kitamura K: Intracranial angiosarcoma arising from a schwannoma. J Laryngol Otol 121: 68-71, 2007.
  7. Urushibara M, Kageyama Y, Akashi T, Otsuka Y, Takizawa T, Koike M, Kihara K: HSP60 may predict good pathological response to neoadjuvant chemoradiotherapy in bladder cancer. Jpn J Clin Oncol 37: 56-61, 2007.
  8. Shimizu S, Kumagai J, Eishi Y, Uehara T, Kawakami S, Takizawa T, Koike M: Frequency and number of neuroendocrine tumor cells in prostate cancer: no difference between radical prostatectomy specimens from patients with and without neoadjuvant hormonal therapy. Prostate 67: 645-652, 2007.
  9. Yang SS, Morimoto T, Rai T, Chiga M, Sohara E, Ohno M, Uchida K, Lin SH, Moriguchi T, Shibuya H, Kondo Y, Sasaki S, Uchida S: Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. Cell Metab 5: 331-344, 2007.
  10. Chiga M, Rai T, Yang SS, Ohta A, Takizawa T, Sasaki S, Uchida S: Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone. Kidney Int 74:1403-1409, 2008.
  11. Tamahashi U, Kumagai J, Takizawa T, Sekine M, Eishi Y: Expression and intracellular localization of matrix metalloproteinases in intraductal papillary mucinous neoplasms of the pancreas. Virchows Arch 453:79-87, 2008.

[Graduate School of Health Care Sciences]
[Tokyo Medical and Dental University]

1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Phone, Fax: +81-3-5803-5370

Last Updated : 15 April 2009