Biofunctional Informatics
Department of Life Sciences and Bio-informatics, Division of Biomedical Laboratory Sciences,
Graduate School of Health Sciences, Tokyo Medical and Dental University

[Japanese Page]

Staff

Professor
Masato Matsuura M.D., Ph.D.

Senior Lecturer
Tokuhio Kawara M.D., Ph.D.

Instructor
Keiko Hara M.D.

Education

Undergraduate Course
There is a series of lectures and practices on clinical physiological tests in the third school year. Physiological tests of circulation and respiration, electroencephalography, neurophysiological tests, ultrasound tests, MR imaging tests, thermography, equilibrium test, and non-mydriatic retinal camera are contained.
Some students make a study on ECG, MEG, PSG, etc. during the previous term of the forth school year. There is a series of laboratory practices in the latter term of the forth school year. Students observe and practice ECG, exercise test, Holter ECG, respiratory tests, blood gas analysis, and electroencephalography, and electromyography, cardiac and abdominal ultrasound in groups for two weeks.
Graduate Course
Based on physiology, imaging techniques and information technology, students learn how to analyze biomedical function as an organized system from a molecular level to an organ level. Students also learn how to develop and improve non-invasive examinations to measure higher biomedical function.

Research

  1. Neuroimaging Studies of Neuropsychiatry Diseases.
  2. Evaluation of Higher Brain Function using Non-invasive Techniques.
  3. Development of Neuroimaging and Physiological Techniques in Clinical Laboratory Medicine.
  4. Studies of Pulse Wave, Echocardiography, and Miscellaneous Electrocardiographic Technique.
  5. Studies of Meaning and Explanation about Medical Test Data.
Publications
  1. Ito S, Suhara T, Ito H, Yasuno F, Ichimiya T, Takano A, Maehara T, Matsuura M, Okubo Y: Changes in central 5-HT1A receptor binding in mesial temporal epilepsy measured by positron emission tomography with [11C]WAY100635. Epi Res 73: 111-118, 2007
  2. Koeda M, Takahashi H, Yahata N, Matsuura M, Okubo Y, Tanaka H: Neural responses to human voice and hemisphere dominance for lexical-semantic processing. Methods Int Med 2: 247-250, 2007.
  3. Kikuchi T, Nomura M, Tomita H, Kanai K, Konishi T, Yasuda A, Matsuura M, Kato N, Yoshiura K, Niikawa N: Paroxysmal kinesigenic choreoathetosis (PKC): confirmation of linkage to 16p11-q21, but unsuccessful detection of mutations among 157 genes at the PKC-critical region in seven PKC families. J Hum Gen 52: 334-341, 2007.
  4. Ushiyama A, Masuda H, Hirota S, Wake K, Kawai H, Watanabe S, Taki M, Ohkubo C: Biological effect on blood cerebrospinal fluid barrier due to radio frequency electromagnetic fields exposure of the rat brain in vivo. Environmentalist 27(4): 489-492 , 2007
  5. Masuda H, Ushiyama A, Hirota S, Lawlor GF, Ohkubo C: Long-term observation of pial microcirculatory parameters using an implanted cranial window method in the rat. In Vivo. 21(3):471-9, 2007
  6. Masuda H, Ushiyama A, Hirota S, Wake K, Watanabe S, Yamanaka Y, Taki M, Ohkubo C: Effects of acute exposure to a 1439 MHz electromagnetic field on the microcirculatory parameters in rat brain. In Vivo 21(4): 555-562 , 2007.
  7. Masuda H, Ushiyama A, Hirota S, Wake K, Watanabe S, Yamanaka Y, Taki M, Ohkubo C: Effects of subchronic exposure to a 1439 MHz electromagneticField on the microcirculatory parameters in rat brain.In Vivo 21(4): 563-570, 2007.
  8. Takahashi H, Matsuura M, Koeda M, Yahata N, Suhara T, Kato M, Okubo Y : Brain activations during judgments of positive self-conscious emotion and positive basic emotion: pride and joy. Cereb Cortex. Epub ahead of print, 2007
  9. Takahashi H, Kato M, Matsuura M, Koeda M, Yahata N, Suhara T, Okubo Y: Neural correlates of human virtue judgment. Cereb Cortex Epub ahead of print, 2007
  10. Enomoto M, Inoue Y, Namba K, Munezawa T, Matsuura MFClinical characteristics of restless legs syndrome in end-stage renal failure and idiopathic RLS patients. Mov Disord. 2007
  11. Matsukawa Y, Kamei S, Takahashi S, Kojima T, Nagashima M, Matsuura M, Sawada S: Eye movement and random number in NP lupus evaluation. Clin Rheumatol 2007.
  12. Enomoto M, Li L, Aritake S, Nagase Y, Kaji T, Tagaya H, Matsuura M, Kaneita Y, Ohida T, Uchiyama M: Restless legs syndrome and its correlation with other sleep problems in the general adult population of Japan. Sleep Biol Rhythms 4: 153-159, 2006.
  13. Koeda M, Takahashi H, Yahata N, Matsuura M, Asai K, Okubo Y, Tanaka H: Language processing and human voice perception in schizophrenia: A functional magnetic resonance imaging study. Biol Psychiatry 59: 948-957, 2006.
  14. Matsukawa Y, Nagashima S, Kamei S, Tanabe E, Takahashi S, Kojima T, Taira M, Morita K, Matsuura M, Sawada S: Random number generation evaluation in patients with systemic lupus erythematosus indicates a heterogeneous nature of central nervous system vulnerability. Sacd J Rheumatol 35: 295-299, 2006.
  15. Takahashi H, Matsuura M, Yahata N, Koeda M, Suhara T, Okubo Y: Men and women show distinct brain activations during imagery of sexual and emotional infidelity. Neuroimage 32: 1299-1307, 2006.
  16. Matsuura M, Adachi N, Muramatsu R, Kato M, Onuma T, Okubo Y, Oana Y, Hara T: Intellectual disability and psychotic disorders of adult epilepsy. Epilepsia 46 (Suppl.1): 11-14, 2005.
  17. Koyama S, Sasaki Y, Tootell RBH, Andersen GJ, Matsuura M, Watanabe T: Separate processing of different global motion structures in visual cortex revealed by fMRI. Curr Biol 15: 2027-2032, 2005.
  18. Kamei S, Oga K, Matsuura M, Tanaka N, Kojima T, Arakawa Y, Matsukawa Y, Mizutani T, Sakai T, Ohkubo H, Matsumura H, Moriyama M, Hirayanagi K: Correlation between quantitative-EEG alterations and age in patients with interferon-alpha-treated hepatitis C. J Clin Neurophysiol 22: 49-52, 2005.
  19. Tojo N, Ichioka M, Chida M, Miyazato I, Yoshizawa Y, Miyasaka N:Pulmonary Exercise Testing Predicts Prognosis in Patients with Chronic Obstructive Pulmonary Disease. Internal Medicine 44: 20-25, 2005
  20. Kuriyama K, Uchiyama M, Suzuki H, Tagaya H, Ozaki A, Aritake S, Shibui K, Xin T,Lan L, Kamei Y, Takahashi KFDiurnal fluctuation of time perception under 30-h sustained wakefulness. Neurosci Res. 53(2):123-8. 2005
  21. Matsuura M, Adachi N, Oana Y, Okubo Y, Kato M, Nakano T, Takei N: A polydiagnostic and dimensional comparison of epileptic psychoses and schizophrenia spectrum disorders. Schizophr Res 69: 189-201, 2004
  22. Matsuda T, Matsuura M, Ohkubo T, Ohkubo H, Matsushima E, Inoue K, Taira M, Kojima T: Functional MRI mapping of brain activation during visually guided saccades and antisaccades: cortical and sub-cortical networks. Psychiatry Res: Neuroimaging 131: 147-155, 2004
  23. Ohtsuki T, Tanaka S, Ishiguro H, Noguchi E, Arinami T, Tanabe E, Yara K, Okubo T, Takahashi S, Matsuura M, Sakai T, Muto M, Kojima T, Matsushima E, Toru M, Inada T: Failure to find association between PRODH deletion and schizophrenia. Schizoph Res 69: 111-113, 2004
  24. Takahashi H, Koeda M, Oda K, Matsuda T, Matsushima E, Matsuura M, Asai K, Okubo Y: An fMRI study of differential neural response to affective pictures in schizophrenia. NeuroImage 22: 1247-1254, 2004
  25. Oda K, Okubo Y, Ishida R, Murata Y, Ota K, Matsuda T, Matsushima E, Ichimiya T, Suhara T, Shibuya H, Nishikawa T: Regional cerebral blood flow in depressed patients with MRI white matter hyperintensity.@Biol Psychiat. 53(2):150-6.2003
  26. Hossain AKM Moinul, Murata Y, Zhang L, Taura S, Saitoh Y, Mizusawa H, Oda K, Matsushima E, Okubo Y, Shibuya H: Brain perfusion SPECT in patients with corticobasal degeneration: Analysis using statistical parametric mapping. Movement Disorder. 18(6):697-703.2003
  27. Ako M, Kawara T, Uchida S, Miyazaki S, Nishihara K, Mukai J, Hirao K, Ako J, Okubo Y: Correlation between Electroencephalography and Heart Rate Variability during Sleep. Psychiatry Clin Neurosci. 57: 59-65, 2003
  28. Matsuura M, Oana Y, Kato M, Kawana A, Kan R, Kubota H, Nakano T, Hara T, Horikawa N:A multi-center prevalence study on psychiatric disorders in new referrals of epilepsy in Japan. Epilepsia 44:107-114, 2003
  29. Halldin C, Erixon-Lindroth N, Pauli S, Chou YH, Okubo Y, karlsson P, Lundkvist C, Olsson H, Guilloteau D, Emond P, Farde L: [11C]PE21:a highly selective radioligand for PET examination of the dopamine transporter in monkey and human brain. Eur J Nucl Med Mol Imaging.30:1220-1230.2003
  30. Shioe K, Ichimiya T, Suhara T, Takano A, Sudo Y, Yasuno F, Hirano M, Shinohara M, Kagami M, Okubo Y, Nankai M, Kanba S:No association between genotype of the promotor region of serotonin transporter gene and serotonin transporter binding in human brain measured by PET.Synapse 48: 184-188, 2003
  31. Nakamura M, Uchida S, Maehara T, Kawai K, Hirai N, Nakabayashi T, Arakaki H, Okubo Y, Nishikawa T, Shimizu H: Sleep spindles in human prefrontal cortex: an electrocorticographic study. Neuroscience Res.45(4):419-427.2003
  32. Suhara T, Takano A, Sudo Y, Ichimiya T, Inoue M, Yasuno F, Ikoma Y, Okubo Y: High levels of serotonin transporter occupancy with low dose clomipramine in comparative occupancy study with fluvoxamine using positron emission tomography. Arch Gen Psychiatry. 60:386-391.2003
  33. Yasuno F, Suhara T, Nakayama T, Ichimiya T, Okubo Y, Takano A, Ando T, Inoue M, Maeda J, Suzuki K: Inhibitory role of hippocampal 5-HT1A receptors on human explicit memory. Am J Psychiatry. 160(2):334-40.2003
  34. Loh P, Ho SY, Kawara T, Hauer RNW, Janse MJ, Breithardt G, de Bakker JMT. Reentrant Circuits in the Canine Atrioventricular Node During Atrial and Ventricular Echoes. Electrophysiological and Histological Correlation. Circulation 108: 231-238, 2003
  35. Tan X, Uchiyama M, Shibui K, Tagaya H, Suzuki H, Kamei Y, Kim K, Aritake S, Ozaki A, Takahashi K: Circadian rhythms in humans' delta sleep electroencephalogram. Neuroscience Letters 344: 205-208, 2003
  36. Kuriyama K, Uchiyama M, Suzuki H, Tagaya H, Ozaki A, Aritake S, Kamei Y, Nishikawa T, Takahashi K, 2003. Circadian fluctuation of time perception in human subjects. Neurosci. Res., 46, 23-31. 2003
  37. Sassa T, Suhara T, Ikehira H, Obata T, Girard F, Tanada S, Okubo Y: 19F-magnetic resonance spectroscopy and chemical shift imaging for schizophrenic patients using haloperidol decanoate. Psychiat clin Neuros. 56:637-642,2002
  38. Adachi N, Matsuura M, Hara T, Oana Y, Okubo Y, Kato M, Onuma T: Psychoses and Epilepsy: Are Interictal and Postictal Psychoses Distinct Clinical Entities?. Epilepsia. 43(12):1574-1582,2002
  39. Adachi N, Onuma T, Hara T, Matsuura M, Okubo Y, Kato M, Oana Y: Frequency and age-related variables in interictal psychoses in localization-related epilepsies. Epilepsy Res. 48:25-31,2002.
  40. Nakayama T , Suhara T, Okubo Y, Ichimiya T, Yasuno F, Maeda J, Takano A, Saijou T, Suzuki K: In vivo drug action of tandospirone at 5-HT1A receptor examined with PET and neuroendocrine response. Psychopharmacology. 165:37-42.2002
  41. Ichimiya T, Suhara T, Sudo Y, Okubo Y, Nakayama K, Nankai M, Inoue M, Yasuno F, Takano A, Maeda J, Shibuya H: Serotonin transporter binding in patients with mood disorders: a PET study with [11C](+)McN5652. Biol Psychiat. 51:715-22,2002
  42. Yamamoto M, Suhara T, Okubo Y, Ichimiya T, Sudo Y, Inoue M, Takano A, Yasuno F, Yoshikawa K, Tanada S: Age-related decline of serotonin transporters in living human brain of healthy males. Life Sci. 71:751-757,2002
  43. Suhara T, Okubo Y, Yasuno F, Sudo Y, Inoue M, Ichimiya T, Nakashima Y, Nakayama K, Tanada S, Suzuki K, Halldin C, Farde L: Decreased dopamine D2 receptor binding in the anterior cingulate cortex in schizophrenia. Arch Gen Psychiatry. 59:25-30,2002
  44. Ishiguro H, Okubo Y, Ohtsuki T, Yamakawa-Kobayashi K, Arinami T: Mutation analysis of the retinoid X receptor beta, nuclear-related receptor 1, and peroxisome proliferator-activated receptor alpha genes in schizophrenia and alcohol dependence: possible haplotype association of nuclear-related receptor 1 gene to alcohol dependence. Am J Med Genet. 114:15-23,2002
  45. Hocini M, Ho SY, Kawara T, Linnenbank AC, Potse M, Shah D, Jais P, Janse MJ, Haïssaguerre M, de Bakker JMT. Electrical Conduction in Canine Pulmonary Veins. Electrophysiological and Anatomic Correlation. Circulation 105:2442-2448,2002
  46. Ichimiya T, Suhara T, Sudo Y, Takano A, Maeda J, Yamamoto M, Ikoma Y, Yasuno F, Inoue M, Saijo T, Nakayama KAOkubo Y: Positron emission tomography study of affective disorders and evaluation of treatments ? Recent advances in the research of affective disorders in Japan. Okuma T, Kanda S, Inoue Y eds. Elsevier Science. pp63-73,2002
  47. Suhara T, Yasuno F, Okubo Y, Sudo Y,Inoue M, Ichimiya T, Takano A:Dopamine receptors in schizophrenia. Nagatsu T, Nabeshima T, McCarty R, Goldstein DS eds. Catecholamine research:Molecular insights to clinical medicine. Kluwer Academic/Plenum Publishers. New York. pp413-416,2002
  48. Girard F, Suhara T, Sassa T, Okubo Y, Obata T, Ikehira H, Sudo Y, Koga M, Yoshioka H, Yoshida K: 7Li 2D CSI of human brain on a clinical scanner. Magnetic Resonance Materials in Physics, Biology and Medicine 13:1-7,2001
  49. Ichimiya T, Okubo Y, Suhara T, Sudo Y: Reduced Volume of the Cerebellar Vermis in Neuroleptic-Naive Schizophrenia. Biological Psychiatry 49:20-27,2001
  50. Inoue M, Suhara T, Sudo Y, Okubo Y, Yasuno Y, Kishimoto T, Yoshikawa K, Tanada S: Age-related reduction of extrastriatal dopamine D2 receptor measured by PET. Life Science 69:1079-1084,2001
  51. Ito H, Sudo Y, Suhara T, Okubo Y, Halldin C, Farde L: Error analysis for quantification of [11C]FLB 457 binding to extrastriatal D2 dopamine receptors in the human brain. Neuroimage 13:531-539,2001
  52. Nakabayashi T, Uchida S, Maehara T, Hirai N, Nakamura M, Aragaki H, Shimizu H, Okubo Y: Absence of sleep spindles in human medial and basal temporal lobes. Psychiatry and Clinical Neurosciences 55:57-65,2001
  53. Saijo T, Abe T, Someya Y, Sassa T, Sudo Y, Suhara T, Shuno T, Asai K, Okubo Y: Ten year progressive ventricular enlargement in schizophrenia: An MRI morphometrical study. Psychiatry and Clinical Neuroscience 55:41-47,2001
  54. Suhara T, Yasuno F, Sudo Y, Yamamoto M, Inoue M, Okubo Y, Suzuki K: Dopamine D2 receptors in the insular cortex and the personality trait of novelty seeking. Neuroimage 13:891-895,2001
  55. Uchida S, Maehara T, Hirai N, Okubo Y, Shimizu H: Cortical oscillations in human medial temporal lobe during wakefulness and all-night sleep. Brain Research 891:7-19,2001
  56. Yasuno F, Suhara T, Okubo Y, Sudo Y, Inoue M, Ichimiya T, Tanada S: Dose relationship of limbic-cortical D 2 -dopamine receptor occupancy with risperidone. Psychopharmacology 154:112-114,2001
  57. Yoshikawa T, Kikuchi M, Saito K, Watanabe A, Yamada K, Shibuya H, Nankai M, Kurumaji A, Hattori E, Ishiguro H, Shimizu H, Okubo Y, Toru M, SD D-W: Evidence for association of the myo-inositol monophosphatase 2(IMPA2) gene with schizophrenia in japanese samples. Molecular Psychiatry 6:202-210,2001
  58. Kawai M, Yukichi Y, Miyasato I, Seijinn H:Novel, Aberranty Truncated Isoforum of Serum CD13 in a family with High Serum aminopeptidase N(CD13) Activity. Clinical Chemistry 47:223-230,2001
  59. Kawara T, Derksen R, de Groot JR, Coronel R, Tasseron S, Linnenbank AC, Hauer RNW, Kirkels H, Janse MJ, de Bakker JMT: Activation delay after premature stimulation in chronically diseased human myocardium relates to the architecture of interstitial fibrosis. Circulation. 104:3069-3075,2001
  60. Okubo Y, Suhara T, Suzuki K, Kobayashi K, Inoue O, Terasaki O, Someya Y, Sassa T, Sudo Y, Matsushima E, Iyo M, Tateno Y, Toru M: Serotonin 5-HT2 receptors in schizophrenic patients studied by positron emission tomography. Life Sciences. 66:2455-2464,2000
  61. Adachi N, Matsuura M, Okubo Y, Oana Y, Takei N, Kato M, Hara T, Onuma T: Predictive variables of interictal psychosis in epilepsy. Neurology. 55:1310-1314,2000
  62. Hara K, Terasaki O, Okubo Y: Dipole estimation of alpha EEG during alcohol ingestion in males genotypes for ALDH2. Life Sciences. 67:1163-1173,2000
  63. Kurumaji A, Nomoto H, Yoshikawa T, Okubo Y, Toru M: An association study between two missense variations of the benzodiazepine receptor (peripheral) gene and schizophrenia in a Japanese sample. Journal of Neural Transmission. 107:491-500,2000
  64. Matsuura M, Adachi N, Oana Y, Okubo Y, Hara T, Onuma T: Proposal for a new five-axis classification scheme for psychoses of epilepsy. Epilepsy & Behavior. 1:343-352,2000
  65. Someya Y, Obata T, Suhara T, Ota Y, Ikehira H, Tanada S, Hirakawa K, Okubo Y, Sasaki Y: Seizure frequency and bilateral temporal abnormalities: a proton magnetic resonance spectroscopy of temporal lobe epilepsy. Seizure. 9:274-279,2000
  66. Wakimoto H, Izumida N, Asano Y, Hiraoka M, Kawara T, Hiejima K, Hirao K, Suzuki F. Augmentation of QRS-wave Amplitudes in the Precordial Leads during Narrow QRS Tachycardia. J Cardiovasc Electrophysiol 11(1):52-60,2000
  67. Kawabata M, Nawata H, Hirao K, Miyasaka N, Kawara T, Hiejima K, Suzuki F. Marked anterograde decremental conduction over a rapidly conducting accessory pathway after radiofrequency ablation. J Electrocardiol 33(1):71-78,2000
  68. Azegami K, Suzuki F, Kurabayashi M, Horikawa T, Ashikawa H, Motokawa K, Kawara T, Hiejima K. Demonstration of phase-3 and phase-4 retrograde block in a second concealed accessory pathway after an initial successful radiofrequency ablation of a normal concealed accessory pathway . Jpn Circ J 64(2):147-150,2000
  69. Suhara T, Okubo Y, Sudo Y, Tanada S: PET research in pathophysiology and treatment of psychiatric illness. Positron Emission Tomography in the Millennium.33-40,2000
  70. Kurumaji A, Okubo Y: D1 dopamine receptors, schizophrenia, and antipsychotic medications. Lidow MS eds. Neurotransmitter receptors in actions of antipsychotic medications. CRC Press,65-78,2000

[Graduate School of Health Sciences]
[Tokyo Medical and Dental University]

1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Phone: +81-3-5803-5372, Fax: +81-3-5803-0165

Last Updated : 02 May 2008