現在のﾃｰﾏ
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１．オミックスの実用化
２．人材育成
３．臨床研究、TR
４．グローバルリンケージと連携構築
Gloabal Linkage-Academia
China Medical Univ., Denmark DTU, Dundee Univ., Ecole normale superieure de Lyon, Fudan Univ., Glasgow Univ., Heidelberg Univ., Karolinska institutet, Leeds Univ., MD Anderson Cancer Center, Peking Union Medical College, Stanford Univ., USP, Wistar Institute他。
Gloabal Linkage-Public
Copenhagen Capacity, Germany Biocluster BioRN, Japan America Society of Greater Philadelphia, JETRO Berlin, Sweden VINNOVA, 英国各開発公社、各国大使館、他。
Gloabal Linkage-Industry
国内: アステラス製薬、エーザイ、第一三共、AMR, GSK 他
海外:Denmark Biosys、Denmark CPH Design、Denmark Moller-Jensen Design, Denmark Santaris Pharma, Germany Apogenix、Germany Biocom、Philadelphia - Science Center、UK CXR Biosciences、UK GSK他
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主な論文等
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■主な論文
■Cliical Research
- Comparison of the efficacy of salmeterol/fluticasone propionate combination in Japanese and Caucasian asthmatics., Respiratory Medicine., 101, 2488, 2007
■Basic Research
- Synergism between the Calmodulin-binding and Autoinhibitory domains on Calcineurin Is essential for the Induction of their phosphatase activity., J. Biol. Chem., 275, 11728, 2000
- HS1 Interacts with Lyn and Is critical for erythropoietin-induced differentiation of erythroid cells., J. Biol. Chem., 275, 7887, 2000
- Growth Factor Receptor-Bound Protein 2 (Grb2) Association with Hemopoietic Specific Protein 1: linkage between Lck and Grb2., J. Immunol., 161, 625, 1998
- Aberrant TCR-mediated signaling in CD45-null thymocytes involved dysfunctional regulation of Lck, Fyn, TCR-zeta and ZAP-70., J. Immunol., 158, 5773, 1997
- LckBP1, a proline-rich protein expressed in hematopoietic lineage cells, directly associates with the SH3 domain of protein tyrosine kinase p56lck"., EMBO J., 14, 3403, 1995
- Cell type-specific trans-activation by the B-myb gene product: requirement of the putative cofactor binding to the C-terminal conserved domain., Oncogene, 10, 1699, 1995
- Multiple nuclear localization signals of the B-myb gene product., FEBS Letters, 350., 55, 1994
- Functional domain of the human B-myb gene product., J. Biol.Chem., 268, 14161, 1993
- The promoter of the endoA cytokeratin gene is activated by a 3'downstream enhancer., NAR., 19, 2761, 1991
■総説・著書など
”癌遺伝子myb”, 蛋白質核酸酵素, 37, 1555 (1992)
"Signal transduction of Lck and the Lck association proteins", 免疫96-97, 33, 24-31 (1996)
"医薬品産業におけるクリティカルパス：点から面へのアプローチ提案", CBI: Methods & Solution for Drug Discovery, 13-15 (2006)
"医薬品産業におけるバイオマーカー", バイオインダストリー協会・平成17年度先端健康バイオ産業創出技術調査報告書・第3章先端バイオテクノロジー技術動向－バイオ医薬分野, 28-33 (2006)
"バイオ医薬分野", バイオインダストリー協会・平成18年度先端健康バイオ産業創出技術調査報告書・第3章バイオ産業に関連する技術動向調査, 86-95 (2007)
"魅力的な学生・大学院生になるために－国際産学リンケージプログラムの試み", 生物工学, 87, 397-400 (2009)
"魅力的な学生・大学院生になるために－国際産学リンケージプログラムの試み", 生物工学会誌別冊・キャリアパス 生物工学者の進む道, 125-128 (2009)
 著者最終版(438kb)
■特許
1. Lck binding protein, United States Patent 5891673, 1999
2. A protein kinase (IKK4) involved in the phosphorrylation of IKB, 2000 (WO/2001/044444)
3. IKK3 kinase, 2003, United States Patent 6576439, 2003 |
